Joseph Loscalzo

Joseph Loscalzo

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Joseph Loscalzo

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Network medicine and type 2 diabetes mellitus: insights into disease mechanism and guide to precision medicine.

Authors:
Joseph Loscalzo

Endocrine 2019 Dec 13;66(3):456-459. Epub 2019 Aug 13.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s12020-019-02042-4DOI Listing
December 2019

Drug-Placebo Additivity in Randomized Clinical Trials.

Clin Pharmacol Ther 2019 Dec 26;106(6):1191-1197. Epub 2019 Oct 26.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cpt.1626DOI Listing
December 2019

Facing Uncertainty.

N Engl J Med 2019 Dec;381(23):2253-2259

From the Departments of Medicine (C.T., D.J.K., B.L., J.L.) and Dermatology (C.T., R.A.V.), Brigham and Women's Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMcps1906037DOI Listing
December 2019

Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs.

Nat Biotechnol 2019 Nov 23;37(11):1287-1293. Epub 2019 Sep 23.

Optogenetics and Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, Shanghai, China.

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http://dx.doi.org/10.1038/s41587-019-0249-1DOI Listing
November 2019

Identification of Racial Inequities in Access to Specialized Inpatient Heart Failure Care at an Academic Medical Center.

Authors:
Lauren A Eberly Aaron Richterman Anne G Beckett Bram Wispelwey Regan H Marsh Emily C Cleveland Manchanda Cindy Y Chang Robert J Glynn Katherine C Brooks Robert Boxer Rose Kakoza Jennifer Goldsmith Joseph Loscalzo Michelle Morse Eldrin F Lewis Samantha Abel Ayrenne Adams Joseph Anaya Erik H Andrews Benjamin Atkinson Viswatej Avutu Alexandra Bachorik Omar Badri Mariel Bailey Katie Baird Salina Bakshi Denis Balaban Kenneth Barshop Emily Baumrin Omar Bayomy Julia Beamesderfer Nora Becker David D Berg Adam N Berman Steven M Blum Alexander P Boardman Kaeleen Boden Robert A Bonacci Sarah Brown Kirsti Campbell Siobhan Case Emily Cetrone Alexandra Charrow David Chiang Devin Clark Aaron J Cohen Alissa Cooper Tomas Cordova C Nicholas Cuneo Alsina Alejandro de Feria Karen Deffenbacher Ersilia M DeFilippis Geneva DeGregorio Aaron J Deutsch Bradford Diephuis Sanjay Divakaran Peter Dorschner Nicholas Downing Caitlin Drescher Kristin M D'Silva Peter Dunbar David Duong Sarah Earp Christine Eckhardt Scott A Elman Ross England Kay Everett Natalie Fedotova Tamara Feingold-Link Mark Ferreira Herrick Fisher Patricia Foo Michael Foote Idalid Franco Thomas Gilliland Jacqueline Greb Katherine Greco Sungat Grewal Benjamin Grin Matthew E Growdon Brendan Guercio Cynthia K Hahn Brian Hasselfeld Erika J Haydu Zachary Hermes Gordon Hildick-Smith Zachary Holcomb Kathryn Holroyd Laura Horton George Huang Stanley Jablonski Douglas Jacobs Nina Jain Sohan Japa Richard Joseph Mariya Kalashnikova Neil Kalwani Daniel Kang Abraar Karan Joel T Katz Daniel Kellner Khameer Kidia June-Ho Kim Scott M Knowles Laura Kolbe Idil Kore Yiannis Koullias Ifedayo Kuye Joshua Lang Matthew Lawlor Melissa G Lechner Ken Lee Scott Lee Zachary Lee Neha Limaye Stephanie Lin-Beckford Marla Lipsyc Jessica Little Julia Loewenthal Ranjani Logaraj Diana M Lopez Daniel Loriaux Yi Lu Kevin Ma Nareh Marukian Wilfredo Matias Jared R Mayers Ian McConnell Michael McLaughlin Christina Meade Catherine Meador Anish Mehta Elizabeth Messenger Constantinos Michaelidis Jacob Mirsky Emilie Mitten Alisa Mueller Jyotsna Mullur Amir Munir Emily Murphy Ellen Nagami Abirami Natarajan Michelle Nsahlai Chijioke Nze Noreen Okwara Peter Olds Rafael Paez Michael Pardo Siddharth Patel Alec Petersen Laura Phelan Erica Pimenta Daniel Pipilas Molly Plovanich Denise Pong Brian W Powers Anita Rao Haiyan Ramirez Batlle Mattheus Ramsis Anna Reichardt Sheridan Reiger Michelle Rengarajan Stephanie Rico Benjamin N Rome Rachael Rosales Lisa Rotenstein Alexis Roy Sarah Royston Hallie Rozansky Meghan Rudder Christine E Ryan Sanjay Salgado Pablo Sanchez Jennifer Schulte Aswin Sekar Nicholas Semenkovich Evan Shannon Neil Shaw Andrew Ben Shorten William Shrauner Lauren Sinnenberg James W Smithy Gregory Snyder Anirudh Sreekrishnan Hans Stabenau Eleni Stavrou Andrew Stergachis Robert Stern Alexander Stone Shervin Tabrizi Sam Tanyos Cristina Thomas Haley Thun Kristine Torres-Lockhart An Tran Carolyn Treasure Frederick D Tsai Stephen Tsaur Evan Tschirhart Justin Tuwatananurak Ramkumar V Venkateswaran Anastasia Vishnevetsky Lindsay Wahl April Wall Frances Wallace Elisa Walsh Priscilla Wang Heather B Ward Lindsay N Warner Lachelle D Weeks Kipp Weiskopf Jordan Wengrod Jessica N Williams Marisa Winkler Jeffrey L Wong Devin Worster Aileen Wright Caroline Wunsch Jamila S Wynter Chase Yarbrough Wai-Ying Yau Daniel Yazdi Jennifer Yeh Maria A Yialamas Nicholas Yozamp Marina Zambrotta Rebecca Zon

Circ Heart Fail 2019 Nov 29;12(11):e006214. Epub 2019 Oct 29.

Division of Cardiovascular Medicine, and Department of Medicine (E.F..L.), Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.006214DOI Listing
November 2019

The Element of Surprise.

N Engl J Med 2019 10;381(14):1365-1371

From the Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcps1811547DOI Listing
October 2019

Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity.

Circ Res 2019 Sep 15;125(7):707-719. Epub 2019 Aug 15.

Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, China (W.S., H.W., B.L., D.D., Z.J.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742548PMC
September 2019

A genome-wide positioning systems network algorithm for in silico drug repurposing.

Nat Commun 2019 08 2;10(1):3476. Epub 2019 Aug 2.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-019-10744-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677722PMC
August 2019

Network Medicine in Pathobiology.

Am J Pathol 2019 Jul 20;189(7):1311-1326. Epub 2019 Apr 20.

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616999PMC
July 2019

Metabolic Responses to Reductive Stress.

Antioxid Redox Signal 2019 Jul 18. Epub 2019 Jul 18.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1089/ars.2019.7803DOI Listing
July 2019

Reported environmental exposures are inversely associated with obtaining a genetic diagnosis in the Undiagnosed Diseases Network.

Am J Med Genet A 2019 Jun 23;179(6):958-965. Epub 2019 Mar 23.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.61132
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http://dx.doi.org/10.1002/ajmg.a.61132DOI Listing
June 2019

A Disturbing Decline.

N Engl J Med 2019 Jun;380(23):2257-2262

From the Departments of Medicine (D.A.B., P.E.S., A.L.M., J.L.) and Neurology (G.V.H.), Brigham and Women's Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMcps1807619DOI Listing
June 2019

Epigenetic Inheritance Underlying Pulmonary Arterial Hypertension.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):653-664

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.L.).

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http://dx.doi.org/10.1161/ATVBAHA.118.312262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436974PMC
April 2019

A Dangerous Detour.

N Engl J Med 2019 Apr;380(14):1360-1365

From the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMcps1803916DOI Listing
April 2019

Gasping for a Diagnosis.

N Engl J Med 2019 03;380(10):961-967

From the Departments of Medicine (K.D., S.B., G.M.H., J.L.) and Pathology (M.V.), Brigham and Women's Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMcps1809942DOI Listing
March 2019

A Dangerous Detour.

N Engl J Med 2019 Mar;380(13):e18

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http://dx.doi.org/10.1056/NEJMimc1804660DOI Listing
March 2019

Precision Medicine.

Authors:
Joseph Loscalzo

Circ Res 2019 Mar;124(7):987-989

From the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501802PMC
March 2019

A Breath-Taking Diagnosis.

N Engl J Med 2019 01;380(1):81-87

From the Department of Medicine, Brigham and Women's Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMcps1807721DOI Listing
January 2019

Determinants of drug-target interactions at the single cell level.

PLoS Comput Biol 2018 12 20;14(12):e1006601. Epub 2018 Dec 20.

Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319770PMC
December 2018

Dyspnea and Edema in a Woman With Antiphospholipid Syndrome.

JAMA Cardiol 2018 11;3(11):1123-1124

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamacardio.2018.1704DOI Listing
November 2018

Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease.

N Engl J Med 2018 11 10;379(22):2131-2139. Epub 2018 Oct 10.

From Harvard Medical School (K.S., C.E., I.S.K., J.L., A.T.M., D.A.S.), Brigham and Women's Hospital (J.L.), and Massachusetts General Hospital (D.A.S.) - all in Boston; the National Institutes of Health Clinical Center (D.R.A., W.A.G., J.J.M., C.J.T.) and the National Human Genome Research Institute (A.L.W.), Bethesda, and the University of Maryland, College Park (A.M.C.-J., B.K., L.P.) - all in Maryland; Baylor College of Medicine, Houston (C.A.B., H.J.B., C.M.E., B.H.L., X.L., M.F.W., S.Y.); Stanford University, Stanford (J.A.B., C.R., M.T.W., E.A.A.), and the University of California, Los Angeles, Los Angeles (S.F.N., C.G.S.P.) - both in California; Vanderbilt University, Nashville (R.H., J.A.P.); HudsonAlpha Institute for Biotechnology, Huntsville, AL (H.J.J., E.A.W.); Oregon Health and Science University, Portland (D.M.K.); the Pacific Northwest National Laboratory, Richland, WA (T.O.M.); the University of Oregon, Eugene (J.H.P., M.W.); and Duke University, Durham, NC (V.S., N.M.W.).

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http://www.nejm.org/doi/10.1056/NEJMoa1714458
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http://dx.doi.org/10.1056/NEJMoa1714458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481166PMC
November 2018

Complements from the Lung.

N Engl J Med 2018 Nov;379(18):1767-1773

From the Departments of Medicine (N.S.D., C.J.M., B.D.L., J.L.) and Pathology (H.G.R.), Brigham and Women's Hospital and Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcps1802644DOI Listing
November 2018

Systems Biology Approaches to Redox Metabolism in Stress and Disease States.

Antioxid Redox Signal 2018 10 20;29(10):953-972. Epub 2017 Dec 20.

1 Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts.

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http://dx.doi.org/10.1089/ars.2017.7256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104248PMC
October 2018

Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors.

Nat Protoc 2018 10;13(10):2362-2386

Synthetic Biology and Biotechnology Laboratory, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, Shanghai, China.

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http://www.nature.com/articles/s41596-018-0042-5
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http://dx.doi.org/10.1038/s41596-018-0042-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714056PMC
October 2018

Network-Based Disease Module Discovery by a Novel Seed Connector Algorithm with Pathobiological Implications.

J Mol Biol 2018 09 20;430(18 Pt A):2939-2950. Epub 2018 May 20.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222836183042
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http://dx.doi.org/10.1016/j.jmb.2018.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097931PMC
September 2018

GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis.

Nature 2018 09 12;561(7722):263-267. Epub 2018 Sep 12.

Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41586-018-0475-6
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http://dx.doi.org/10.1038/s41586-018-0475-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152935PMC
September 2018

A Headache of a Diagnosis.

N Engl J Med 2018 Aug;379(5):475-479

From the Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School - both in Boston.

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http://www.nejm.org/doi/10.1056/NEJMcps1803584
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http://dx.doi.org/10.1056/NEJMcps1803584DOI Listing
August 2018

A Shocking Turn of Events.

N Engl J Med 2018 Jun;378(23):2225-2230

From the Department of Medicine, Brigham and Women's Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMcps1714590DOI Listing
June 2018

A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks.

EBioMedicine 2018 May 6;31:79-91. Epub 2018 Apr 6.

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, No.16, Nanxiaojie, Dongzhimennei, Dongcheng District, Beijing 100700, China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013753PMC
May 2018

Case 8-2018: A Woman with Shock and Labile Blood Pressure.

N Engl J Med 2018 05;378(22):2146-2147

Massachusetts General Hospital, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1804983DOI Listing
May 2018

Pharmacogenomics and the Placebo Response.

ACS Chem Neurosci 2018 04 2;9(4):633-635. Epub 2018 Mar 2.

Program in Placebo Studies, Beth Israel Deaconess Medical Center , Harvard Medical School , Boston , Massachusetts United States.

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http://dx.doi.org/10.1021/acschemneuro.8b00078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309549PMC
April 2018

Stream of Consciousness.

N Engl J Med 2018 Apr;378(14):1336-1342

From the Departments of Medicine (S.M.B., R.P., A.L.M., J.L.) and Neurology (M.L.P.), Brigham and Women's Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMcps1714950DOI Listing
April 2018

Emerging Role of Precision Medicine in Cardiovascular Disease.

Circ Res 2018 04;122(9):1302-1315

From the Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021027PMC
April 2018

Pulmonary Comorbidity in Lung Cancer.

Trends Mol Med 2018 03 1;24(3):239-241. Epub 2018 Feb 1.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937923PMC
March 2018

Network Analysis to Risk Stratify Patients With Exercise Intolerance.

Circ Res 2018 03 5;122(6):864-876. Epub 2018 Feb 5.

From the Department of Medicine (W.M.O., R.K.F.O., R.-S.W., D.M.R., B.M.W., C.A.M., J.L., A.B.W., D.M.S., J.A.L.), Division of Pulmonary and Critical Care Medicine (W.M.O., B.M.W., A.B.W., D.M.S.), Division of Cardiovascular Medicine (A.R.O., C.A.M., J.L., J.A.L., B.A.M.), and Department of Radiology (J.H.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Division of Respiratory Diseases, Department of Medicine, Federal University of São Paulo (UNIFESP), Brazil (R.K.F.O.); Department of Cardiology, Boston Children's Hospital and Harvard Medical School, MA (A.R.O.); Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston (G.A.A.); Division of Cardiology, Department of Medicine, Providence Veterans Affairs Medical Center and Alpert Medical School of Brown University, Providence, RI (G.C.); Department of Pulmonology, Medical University of Graz, Austria (A.T., H.O., G.K.); Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria (A.T., H.O., G.K.); and Department of Cardiology, Boston VA Healthcare System, MA (B.A.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924425PMC
March 2018

An Unexpected Expectoration.

N Engl J Med 2018 03;378(9):853-858

From the Department of Medicine, Vanderbilt University, Nashville (J.D.C.); the Department of Medicine, Ohio State University, Columbus (J.A.E.); and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (J.T.K., A.L.M., J.L.).

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http://www.nejm.org/doi/10.1056/NEJMcps1711048
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http://dx.doi.org/10.1056/NEJMcps1711048DOI Listing
March 2018

Case 8-2018: A 55-Year-Old Woman with Shock and Labile Blood Pressure.

N Engl J Med 2018 Mar;378(11):1043-1053

From the Department of Medicine, Brigham and Women's Hospital (J.L.), the Departments of Surgery (N.R.), Medicine (R.V.S., J.N.T., J.S.), Radiology (A.M.C.), and Pathology (J.R.S.), Massachusetts General Hospital, and the Departments of Medicine (J.L., R.V.S., J.N.T., J.S.), Surgery (N.R.), Radiology (A.M.C.), and Pathology (J.R.S.), Harvard Medical School - all in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1712225DOI Listing
March 2018

NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism.

Antioxid Redox Signal 2018 Jan 28;28(3):251-272. Epub 2017 Jul 28.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts.

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http://dx.doi.org/10.1089/ars.2017.7216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737637PMC
January 2018

Nitric Oxide Signaling and Atherothrombosis Redux: Evidence From Experiments of Nature and Implications for Therapy.

Authors:
Joseph Loscalzo

Circulation 2018 01;137(3):233-236

Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.032901DOI Listing
January 2018

An Unusual Cause of Leg Pain.

N Engl J Med 2017 12;377(23):2267-2272

From the Department of Medicine, Brigham and Women's Hospital, and the Department of Medicine, Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcps1703534DOI Listing
December 2017

Putting the Patient Back Together - Social Medicine, Network Medicine, and the Limits of Reductionism.

N Engl J Med 2017 12;377(25):2493-2499

From the Departments of Medicine and the History of Medicine and the Center for Medical Humanities and Social Medicine, Johns Hopkins University School of Medicine, Baltimore (J.A.G.); and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (J.L.).

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http://dx.doi.org/10.1056/NEJMms1706744DOI Listing
December 2017

The Role of Nitroglycerin and Other Nitrogen Oxides in Cardiovascular Therapeutics.

J Am Coll Cardiol 2017 Nov;70(19):2393-2410

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.09.1064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687289PMC
November 2017

Hypoxia-induced suppression of c-Myc by HIF-2α in human pulmonary endothelial cells attenuates TFAM expression.

Cell Signal 2017 10 12;38:230-237. Epub 2017 Jul 12.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568858PMC
October 2017

Is Oxygen Therapy Beneficial in Acute Myocardial Infarction? Simple Question, Complicated Mechanism, Simple Answer.

Authors:
Joseph Loscalzo

N Engl J Med 2017 09 28;377(13):1286-1287. Epub 2017 Aug 28.

From the Department of Medicine, Brigham and Women's Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMe1709250DOI Listing
September 2017

Responses to reductive stress in the cardiovascular system.

Free Radic Biol Med 2017 08 8;109:114-124. Epub 2016 Dec 8.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462861PMC
August 2017

Categorizing biomedical research: the basics of translation.

FASEB J 2017 08;31(8):3210-3215

Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA;

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http://dx.doi.org/10.1096/fj.201700303RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503706PMC
August 2017

All That Wheezes….

N Engl J Med 2017 08;377(5):477-484

From the Departments of Medicine and Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMcps1607526DOI Listing
August 2017

Precision Psychiatry Meets Network Medicine: Network Psychiatry.

JAMA Psychiatry 2017 07;74(7):665-666

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.0580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498232PMC
July 2017

Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism.

Nat Methods 2017 Jul 5;14(7):720-728. Epub 2017 Jun 5.

Synthetic Biology and Biotechnology Laboratory, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, Shanghai, China.

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http://dx.doi.org/10.1038/nmeth.4306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555402PMC
July 2017

International Exchange and American Medicine.

N Engl J Med 2017 May 1;376(19):e40. Epub 2017 Feb 1.

From Massachusetts General Hospital (K.A.); Brigham and Women's Hospital (J.L.); and Beth Israel Deaconess Medical Center (M.L.Z.) - all in Boston; Johns Hopkins Medicine, Baltimore (M.E.A.); the University of Michigan Health System, Ann Arbor (J.M.C.); University of Pennsylvania Perelman School of Medicine, Philadelphia (M.S.P.); and the University of California, San Francisco, San Francisco (R.M.W.).

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http://dx.doi.org/10.1056/NEJMp1701339DOI Listing
May 2017

Back to the History.

N Engl J Med 2017 05;376(18):1783-1788

From the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMcps1607608DOI Listing
May 2017

Restoring Balance: Paraneoplastic Cerebellar Degeneration.

Am J Med 2017 Mar 2;130(3):e85-e87. Epub 2016 Nov 2.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.amjmed.2016.09.035DOI Listing
March 2017

Autoimmune Cardiotoxicity of Cancer Immunotherapy.

Trends Immunol 2017 02 2;38(2):77-78. Epub 2016 Dec 2.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://www.cell.com/trends/immunology/pdf/S1471-4906(16)3020
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http://dx.doi.org/10.1016/j.it.2016.11.007DOI Listing
February 2017

Making the Connection.

N Engl J Med 2017 02;376(5):476-482

From Departments of Medicine (A.R.S., C.C.T., A.L.M., J.L.) and Surgery (A.T.), Brigham and Women's Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMcps1602495DOI Listing
February 2017

Just a Cut.

N Engl J Med 2016 Nov;375(18):1780-1786

From the Departments of Medicine (E.P.S., A.L.M., J.L.) and Orthopedics (B.E.E.), Brigham and Women's Hospital and Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcps1512793DOI Listing
November 2016

Precision medicine in cardiology.

Nat Rev Cardiol 2016 10 30;13(10):591-602. Epub 2016 Jun 30.

Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrcardio.2016.101DOI Listing
October 2016

Testing Limits.

N Engl J Med 2016 Oct;375(14):1383-1388

From the Departments of Medicine (E.M.M., P.E.S., B.D.L., J.L.) and Pathology (L.C.), Brigham and Women's Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMcps1414259DOI Listing
October 2016

Tissue Specificity of Human Disease Module.

Sci Rep 2016 10 17;6:35241. Epub 2016 Oct 17.

Center for Complex Networks Research and Department of Physics, Northeastern University, 110 Forsyth Street, 111 Dana Research Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/srep35241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066219PMC
October 2016

CLINICAL PROBLEM-SOLVING. Tip of the Tongue.

N Engl J Med 2016 Sep;375(9):880-6

From the Departments of Medicine (B.L.L., B.D.L., J.L.) and Pathology (E.S.C.), Brigham and Women's Hospital, Dana-Farber Cancer Institute (S.W.G.), and Harvard Medical School (B.L.L., S.W.G., E.S.C., B.D.L., J.L.) - all in Boston.

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http://dx.doi.org/10.1056/NEJMcps1414168DOI Listing
September 2016

Comparison of Protein N-Homocysteinylation in Rat Plasma under Elevated Homocysteine Using a Specific Chemical Labeling Method.

Molecules 2016 Sep 8;21(9). Epub 2016 Sep 8.

Barnett Institute of Chemical and Biological Analysis, Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.

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http://dx.doi.org/10.3390/molecules21091195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292613PMC
September 2016

Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis.

J Am Heart Assoc 2016 09 28;5(10). Epub 2016 Sep 28.

Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.1161/JAHA.116.003845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121487PMC
September 2016

In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD(+)/NADH redox state.

Nat Protoc 2016 08 30;11(8):1345-59. Epub 2016 Jun 30.

Synthetic Biology and Biotechnology Laboratory, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, Shanghai, China.

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http://dx.doi.org/10.1038/nprot.2016.074DOI Listing
August 2016

Adaptions to Hypoxia and Redox Stress: Essential Concepts Confounded by Misleading Terminology.

Authors:
Joseph Loscalzo

Circ Res 2016 08;119(4):511-3

From the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976630PMC
August 2016

CLINICAL PROBLEM-SOLVING. Prevention as Precipitant.

N Engl J Med 2016 Aug;375(5):471-5

From the Departments of Medicine (A.W.A., B.D.L., J.L.) and Dermatology (A.P.S.), Brigham and Women's Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMcps1301580DOI Listing
August 2016

Genetic Misdiagnoses and the Potential for Health Disparities.

N Engl J Med 2016 Aug;375(7):655-65

From the Departments of Biomedical Informatics (A.K.M., D.M.M., I.S.K.), Pathology (B.H.F.), and Medicine (B.A.M., J.L.), Harvard Medical School, the Departments of Pathology, Massachusetts General Hospital (B.H.F.), and the Department of Pathology (H.L.R.), Division of Cardiovascular Medicine (B.A.M.), and Department of Medicine (B.A.M., J.L.), Brigham and Women's Hospital, Boston, and the Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology (MIT) (A.K.M., I.S.K.), the Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine (B.H.F., H.L.R.), and the Computer Science and Artificial Intelligence Laboratory, MIT (P.S.), Cambridge - all in Massachusetts; and the Laboratory of Molecular Cardiology, Department of Cardiology, the Heart Center, University Hospital of Copenhagen, Rigshospitalet, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen (M.S.O.) - both in Copenhagen.

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http://dx.doi.org/10.1056/NEJMsa1507092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292722PMC
August 2016

Quantification of 2-Hydroxyglutarate Enantiomers by Liquid Chromatography-mass Spectrometry.

Bio Protoc 2016 Aug;6(16)

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.21769/BioProtoc.1908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448426PMC
August 2016

CLINICAL PROBLEM-SOLVING. A Bruising Loss.

N Engl J Med 2016 Jul;375(1):76-81

From the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMcps1500127DOI Listing
July 2016

Response by Alexander et al to Letters Regarding Article, "A Shocking Development in a Young Male Athlete With Chest Pain".

Circulation 2016 Jul;134(4):e22-3

From the Cardiovascular Division, Department of Medicine, Heart & Vascular Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023204DOI Listing
July 2016

The Future of Cardiovascular Biomedicine.

Circulation 2016 Jun;133(25):2601-2

From Harvard Medical School/Brigham and Women's Hospital, Cardiovascular Medicine, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.020553DOI Listing
June 2016

The Future of Cardiovascular Therapeutics.

Circulation 2016 Jun;133(25):2610-7

From Cardiovascular Medicine Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (C.A.M., J.L.); Harvard Medical School, Boston, MA (C.A.M., J.L.); and Cardiology Division, Department of Medicine, Vanderbilt University Medical School, Nashville, TN (D.M.R.).

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http://circ.ahajournals.org/content/circulationaha/133/25/26
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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023555DOI Listing
June 2016

CLINICAL PROBLEM-SOLVING. Eye of the Beholder.

N Engl J Med 2016 May;374(18):1774-9

From the Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcps1509470DOI Listing
May 2016

Illuminating drug action by network integration of disease genes: a case study of myocardial infarction.

Mol Biosyst 2016 04;12(5):1653-66

Department of Medicine, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1039/c6mb00052eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846559PMC
April 2016

Randomized Controlled Trial of Social Media: Effect of Increased Intensity of the Intervention.

J Am Heart Assoc 2016 04 27;5(5). Epub 2016 Apr 27.

Circulation Editorial Offices, Boston, MA Department of Biostatistics, Boston University School of Public Health, Boston, MA.

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http://dx.doi.org/10.1161/JAHA.115.003088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889182PMC
April 2016

The Future of Medical Journal Publishing: The Journal Editor's Perspective: Looking Back, Looking Forward.

Authors:
Joseph Loscalzo

Circulation 2016 Apr;133(16):1621-4

From Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022519DOI Listing
April 2016

Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case.

PLoS Comput Biol 2016 Mar 17;12(3):e1004822. Epub 2016 Mar 17.

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795786PMC
March 2016

A Shocking Development in a Young Male Athlete With Chest Pain.

Circulation 2016 Feb;133(8):756-63

From Cardiovascular Division, Department of Medicine, Heart and Vascular Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.019127DOI Listing
February 2016

Opportunities for the Cardiovascular Community in the Precision Medicine Initiative.

Circulation 2016 Jan;133(2):226-31

From Division of Cardiology, Department of Medicine, Duke University, Durham, NC (S.H.S., G.S.G.); Duke Molecular Physiology Institute, Duke University, Durham, NC (S.H.S.); School of Public Health, University of Alabama at Birmingham, Birmingham, AL (D.A.); Division of Cardiology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA (S.R.H.); Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (S.R.H.); Duke Center for Personalized Medicine, Department of Medicine, Duke University, Durham, NC (G.S.G.); Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, MA (C.M., J.L.); Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada (S.M.); and Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN (J.L.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.019475DOI Listing
January 2016