Joseph J Y Sung

Joseph J Y Sung

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Joseph J Y Sung

Publications by authors named "Joseph J Y Sung"

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Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity.

Nat Microbiol 2019 Sep 9. Epub 2019 Sep 9.

Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1038/s41564-019-0541-3DOI Listing
September 2019

Global Increasing Incidence of Young-Onset Colorectal Cancer Across 5 Continents: A Joinpoint Regression Analysis of 1,922,167 Cases.

Cancer Epidemiol Biomarkers Prev 2019 Aug 21;28(8):1275-1282. Epub 2019 May 21.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1111DOI Listing
August 2019

Long-term use of low-dose aspirin for cancer prevention: A 10-year population cohort study in Hong Kong.

Int J Cancer 2019 07 7;145(1):267-273. Epub 2019 Jan 7.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://doi.wiley.com/10.1002/ijc.32083
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http://dx.doi.org/10.1002/ijc.32083DOI Listing
July 2019

Gut mucosal virome alterations in ulcerative colitis.

Gut 2019 07 6;68(7):1169-1179. Epub 2019 Mar 6.

Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

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http://dx.doi.org/10.1136/gutjnl-2018-318131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582748PMC
July 2019

TTPAL Promotes Colorectal Tumorigenesis by Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling.

Cancer Res 2019 Jul 24;79(13):3332-3346. Epub 2019 Apr 24.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2986DOI Listing
July 2019

ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy.

Nat Commun 2019 Jul 29;10(1):3391. Epub 2019 Jul 29.

Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.

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http://dx.doi.org/10.1038/s41467-019-11274-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662851PMC
July 2019

Low-dose aspirin can reduce colorectal cancer mortality after surgery: A 10-year follow-up of 13 528 colorectal cancer patients.

J Gastroenterol Hepatol 2019 Jun 14;34(6):1027-1034. Epub 2019 Jan 14.

Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://doi.wiley.com/10.1111/jgh.14562
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http://dx.doi.org/10.1111/jgh.14562DOI Listing
June 2019

Risk of tuberculosis in patients with immune-mediated diseases on biological therapies: a population-based study in a tuberculosis endemic region.

Rheumatology (Oxford) 2019 May;58(5):803-810

Institute of Digestive Disease, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key364DOI Listing
May 2019

Adenoma detection rates in colonoscopies for positive fecal immunochemical tests versus direct screening colonoscopies.

Gastrointest Endosc 2019 03 16;89(3):607-613.e1. Epub 2018 Nov 16.

Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong.

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https://linkinghub.elsevier.com/retrieve/pii/S00165107183328
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http://dx.doi.org/10.1016/j.gie.2018.11.014DOI Listing
March 2019

Systematic review with meta-analysis: review of donor features, procedures and outcomes in 168 clinical studies of faecal microbiota transplantation.

Aliment Pharmacol Ther 2019 Feb 9;49(4):354-363. Epub 2019 Jan 9.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://doi.wiley.com/10.1111/apt.15116
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http://dx.doi.org/10.1111/apt.15116DOI Listing
February 2019

Increasing Trend in Young-Onset Colorectal Cancer in Asia: More Cancers in Men and More Rectal Cancers.

Am J Gastroenterol 2019 Feb;114(2):322-329

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.14309/ajg.0000000000000133DOI Listing
February 2019

Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features.

Theranostics 2018 12;8(6):1740-1751. Epub 2018 Feb 12.

Institute of Digestive Diseases and Department of Medicine & Therapeutics, State Key Laboratory of Digestive Diseases, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.7150/thno.22010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858179PMC
January 2019

Risk factors for advanced colorectal neoplasms in the proximal colon in 6218 subjects undergoing complete colonoscopy.

J Gastroenterol Hepatol 2019 Jan 12;34(1):113-119. Epub 2018 Jul 12.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/jgh.14357DOI Listing
January 2019

Real-time tracking of fluorescent magnetic spore-based microrobots for remote detection of toxins.

Sci Adv 2019 Jan 11;5(1):eaau9650. Epub 2019 Jan 11.

Department of Mechanical and Automation Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin NT, Hong Kong SAR, China.

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http://dx.doi.org/10.1126/sciadv.aau9650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357761PMC
January 2019

Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial.

Lancet Gastroenterol Hepatol 2018 12 22;3(12):837-844. Epub 2018 Oct 22.

Department of Medicine & Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.

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https://linkinghub.elsevier.com/retrieve/pii/S24681253183030
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http://dx.doi.org/10.1016/S2468-1253(18)30303-0DOI Listing
December 2018

Significant Medical and Surgical Morbidity in Perianal Crohn's Disease: Results from a Territory-Wide Study.

J Crohns Colitis 2018 Nov;12(12):1392-1398

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1093/ecco-jcc/jjy120DOI Listing
November 2018

Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling.

Nat Commun 2018 10 26;9(1):4490. Epub 2018 Oct 26.

Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.

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http://www.nature.com/articles/s41467-018-06931-6
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http://dx.doi.org/10.1038/s41467-018-06931-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203711PMC
October 2018

Association Between Bacteremia From Specific Microbes and Subsequent Diagnosis of Colorectal Cancer.

Gastroenterology 2018 08 3;155(2):383-390.e8. Epub 2018 May 3.

State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, and CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.04.028DOI Listing
August 2018

Mucosal microbiome dysbiosis in gastric carcinogenesis.

Gut 2018 06 1;67(6):1024-1032. Epub 2017 Aug 1.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1136/gutjnl-2017-314281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969346PMC
June 2018

Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-β-Catenin Signaling Axis.

Cancer Res 2018 04 26;78(7):1643-1656. Epub 2018 Jan 26.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease and Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-2403DOI Listing
April 2018

RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.

Cancer Res 2018 04 26;78(8):1958-1971. Epub 2018 Jan 26.

Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-2683DOI Listing
April 2018

A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese population.

J Cell Mol Med 2018 04 14;22(4):2368-2377. Epub 2018 Feb 14.

State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine & Therapeutics, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/jcmm.13530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867068PMC
April 2018

Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers.

Microbiome 2018 04 11;6(1):70. Epub 2018 Apr 11.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1186/s40168-018-0451-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896039PMC
April 2018

Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target.

Sci Transl Med 2018 04;10(437)

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.

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http://dx.doi.org/10.1126/scitranslmed.aap9840DOI Listing
April 2018

Non-variceal upper gastrointestinal bleeding.

Nat Rev Dis Primers 2018 04 19;4:18020. Epub 2018 Apr 19.

Division of Gastroenterology, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1038/nrdp.2018.20DOI Listing
April 2018

A modified colorectal screening score for prediction of advanced neoplasia: A prospective study of 5744 subjects.

J Gastroenterol Hepatol 2018 Jan;33(1):187-194

Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong.

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http://doi.wiley.com/10.1111/jgh.13835
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http://dx.doi.org/10.1111/jgh.13835DOI Listing
January 2018

Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis.

FASEB J 2018 01 25;32(1):37-51. Epub 2017 Aug 25.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China;

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http://www.fasebj.org/doi/10.1096/fj.201601393R
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http://dx.doi.org/10.1096/fj.201601393RDOI Listing
January 2018

Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.

Gastroenterology 2017 12 18;153(6):1621-1633.e6. Epub 2017 Aug 18.

Institute of Digestive Disease, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences and CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.08.022DOI Listing
December 2017

Cancer Risk in 2621 Chinese Patients with Inflammatory Bowel Disease: A Population-based Cohort Study.

Inflamm Bowel Dis 2017 11;23(11):2061-2068

1Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China; 2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China; 3Institute of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China; 4Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China; 5Department of Medicine, Tuen Mun Hospital, Hong Kong, China; 6Department of Medicine, United Christian Hospital, Hong Kong, China 7Department of Medicine, Princess Margaret Hospital, Hong Kong, China; 8Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China; 9Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China; 10Department of Medicine, Tseung Kwan O Hospital, Hong Kong, China; 11Department of Medicine, Caritas Medical Centre, Hong Kong, China; 12Department of Medicine, North District Hospital, Hong Kong, China; 13Department of Medicine, Kwong Wah Hospital, Hong Kong, China; 14Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China; 15Department of Medicine, Yan Chai Hospital, Hong Kong, China; and 16Department of Gastroenterology, Chelsea and Westminster Hospital, London, United Kingdom.

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http://dx.doi.org/10.1097/MIB.0000000000001240DOI Listing
November 2017

Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis.

Gastroenterology 2017 08 27;153(2):420-429. Epub 2017 Apr 27.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese University of Hong Kong, Hong Kong, China. Electronic address:

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https://www.researchgate.net/profile/Milad_Azami2/publicatio
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http://linkinghub.elsevier.com/retrieve/pii/S001650851735531
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http://dx.doi.org/10.1053/j.gastro.2017.04.022DOI Listing
August 2017

Predicted Increases in Incidence of Colorectal Cancer in Developed and Developing Regions, in Association With Ageing Populations.

Clin Gastroenterol Hepatol 2017 Jun 5;15(6):892-900.e4. Epub 2016 Oct 5.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2016.09.155DOI Listing
June 2017

Global temporal patterns of pancreatic cancer and association with socioeconomic development.

Sci Rep 2017 06 9;7(1):3165. Epub 2017 Jun 9.

Institute of Digestive Disease, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1038/s41598-017-02997-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466634PMC
June 2017

Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice.

Gastroenterology 2017 05 23;152(6):1419-1433.e5. Epub 2017 Jan 23.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong-Shenzhen Research Institute, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.01.009DOI Listing
May 2017

Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation.

Cancer Res 2017 04 15;77(8):1968-1982. Epub 2017 Feb 15.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1595DOI Listing
April 2017

Prevalence, distribution, and risk factor for colonic neoplasia in 1133 subjects aged 40-49 undergoing screening colonoscopy.

J Gastroenterol Hepatol 2017 Jan;32(1):92-97

The Chinese University of Hong Kong, Institute of Digestive Disease, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.

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http://dx.doi.org/10.1111/jgh.13450DOI Listing
January 2017

Cancer burden with ageing population in urban regions in China: projection on cancer registry data from World Health Organization.

Br Med Bull 2017 01;121(1):83-94

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

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https://academic.oup.com/bmb/article-lookup/doi/10.1093/bmb/
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http://dx.doi.org/10.1093/bmb/ldw050DOI Listing
January 2017

Use of capsule endoscopy in the emergency department as a triage of patients with GI bleeding.

Gastrointest Endosc 2016 Dec 6;84(6):907-913. Epub 2016 May 6.

Institute of Digestive Diseases, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1016/j.gie.2016.04.043DOI Listing
December 2016

Global Incidence and Mortality for Prostate Cancer: Analysis of Temporal Patterns and Trends in 36 Countries.

Eur Urol 2016 11 8;70(5):862-874. Epub 2016 Jun 8.

Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.05.043DOI Listing
November 2016

SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate.

Gastroenterology 2016 11 21;151(5):945-960.e6. Epub 2016 Jul 21.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.07.011DOI Listing
November 2016

MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.

Gut 2016 10 23;65(10):1619-31. Epub 2015 Jul 23.

Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1136/gutjnl-2015-309276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036270PMC
October 2016

Systematic Review and Meta-analysis: Phenotype and Clinical Outcomes of Older-onset Inflammatory Bowel Disease.

J Crohns Colitis 2016 Oct 29;10(10):1224-36. Epub 2016 Feb 29.

Department of Medicine and Therapeutics, Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1093/ecco-jcc/jjw054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082591PMC
October 2016

Epidemiology of Inflammatory Bowel Disease from 1981 to 2014: Results from a Territory-Wide Population-Based Registry in Hong Kong.

Inflamm Bowel Dis 2016 08;22(8):1954-60

1Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, LKS Institute of Health Science, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China;2Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China;3Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, China;4Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China;5Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China;6Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China;7Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China;8Department of Medicine, Tseung Kwan O Hospital, Hong Kong, China;9Department of Medicine and Geriatrics, Caritas Medical Centre, Hong Kong, China;10Department of Medicine and Geriatrics, Kwong Wah Hospital, Hong Kong, China;11Department of Medicine, North District Hospital, Hong Kong, China;12Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China;13Department of Medicine, Yan Chai Hospital, Hong Kong, China;14Department of Gastroenterology, Chelsea and Westminster Hospital, London, United Kingdom; and15Department of Colorectal Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

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http://dx.doi.org/10.1097/MIB.0000000000000846DOI Listing
August 2016

Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis Through Transcriptional Repression of Interleukin-10.

J Crohns Colitis 2016 Jun 22;10(6):726-34. Epub 2016 Jan 22.

Institute of Digestive Disease and State Key Laboratory of Digestive Disease, Chinese University of Hong Kong, Hong Kong SAR Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong SAR.

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http://dx.doi.org/10.1093/ecco-jcc/jjw020DOI Listing
June 2016

Hemolytic E. coli Promotes Colonic Tumorigenesis in Females.

Cancer Res 2016 05 24;76(10):2891-900. Epub 2016 Mar 24.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2083DOI Listing
May 2016

Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer.

Gut 2016 Apr 6;65(4):635-46. Epub 2015 May 6.

Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1136/gutjnl-2014-308257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819609PMC
April 2016

Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability.

Cancer Res 2016 04 8;76(7):1724-32. Epub 2016 Feb 8.

Institute of Digestive Disease and Department of Medicine & Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

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http://cancerres.aacrjournals.org/content/early/2016/02/06/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-15-2443DOI Listing
April 2016

Stratification of Digestive Cancers with Different Pathological Features and Survival Outcomes by MicroRNA Expression.

Sci Rep 2016 Apr 15;6:24466. Epub 2016 Apr 15.

Institute of Digestive Disease and Department of Medicine &Therapeutics, State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1038/srep24466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832245PMC
April 2016

Association of distal hyperplastic polyps and proximal neoplastic lesions: a prospective study of 5613 subjects.

Gastrointest Endosc 2016 Mar 5;83(3):555-62. Epub 2015 Aug 5.

Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong, HKSAR, China.

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http://dx.doi.org/10.1016/j.gie.2015.06.049DOI Listing
March 2016

Risk of Advanced Adenomas in Siblings of Individuals With Advanced Adenomas: A Cross-Sectional Study.

Gastroenterology 2016 Mar 14;150(3):608-16; quiz e16-7. Epub 2015 Nov 14.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1053/j.gastro.2015.11.003DOI Listing
March 2016

Colorectal Cancer Screening Based on Age and Gender: A Cost-Effectiveness Analysis.

Medicine (Baltimore) 2016 Mar;95(10):e2739

From the Institute of Digestive Disease, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China (MCSW, JYLC, VCWC, TYTL, AKCL, SHW, SCN, SSN, JCYW, FKLC, JJYS), and School of Public Health and Primary Care, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China (MCSW).

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http://dx.doi.org/10.1097/MD.0000000000002739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998853PMC
March 2016

Screening strategies for colorectal cancer among patients with nonalcoholic fatty liver disease and family history.

Int J Cancer 2016 Feb 1;138(3):576-83. Epub 2015 Sep 1.

Institute of Digestive Disease, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, HKSAR, China.

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http://dx.doi.org/10.1002/ijc.29809DOI Listing
February 2016

The discriminatory capability of existing scores to predict advanced colorectal neoplasia: a prospective colonoscopy study of 5,899 screening participants.

Sci Rep 2016 Feb 3;6:20080. Epub 2016 Feb 3.

Institute of Digestive Disease, Chinese University of Hong Kong, 7/F, Lui Che Woo Clinical Science Building, Prince of Wales Hospital, Shatin, NT, HKSAR.

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http://dx.doi.org/10.1038/srep20080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738273PMC
February 2016

CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy.

J Hepatol 2016 Jan 21;64(1):160-70. Epub 2015 Sep 21.

Institute of Digestive Disease and The Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.09.005DOI Listing
January 2016

Effect of immunosuppressive therapy on interferon γ release assay for latent tuberculosis screening in patients with autoimmune diseases: a systematic review and meta-analysis.

Thorax 2016 Jan 11;71(1):64-72. Epub 2015 Dec 11.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong State Key Laboratory of Digestive Diseases, Institute of Digestive Disease, LKS Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1136/thoraxjnl-2015-207811DOI Listing
January 2016

Determinants of Bowel Preparation Quality and Its Association With Adenoma Detection: A Prospective Colonoscopy Study.

Medicine (Baltimore) 2016 Jan;95(2):e2251

From the Institute of Digestive Disease (MCSW, JYLC, VCWC, TYTL, AKCL, RSYT, SHW, SCN, SSMN, JCYW, FKLC, JJYS); and School of Public Health and Primary Care (MCSW), Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR.

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http://dx.doi.org/10.1097/MD.0000000000002251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718228PMC
January 2016

Targeted screening for colorectal cancer in high-risk individuals.

Best Pract Res Clin Gastroenterol 2015 Dec 11;29(6):941-51. Epub 2015 Sep 11.

Institute of Digestive Disease, Chinese University of Hong Kong, 7/F, Lui Che Woo Clinical Science Building, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.

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http://dx.doi.org/10.1016/j.bpg.2015.09.006DOI Listing
December 2015

Autophagy Mediates HBx-Induced Nuclear Factor-κB Activation and Release of IL-6, IL-8, and CXCL2 in Hepatocytes.

J Cell Physiol 2015 Oct;230(10):2382-9

State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1002/jcp.24967DOI Listing
October 2015

Colorectal cancer screening: a global overview of existing programmes.

Gut 2015 Oct 3;64(10):1637-49. Epub 2015 Jun 3.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.

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http://gut.bmj.com/content/64/10/1637.full.pdf
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http://dx.doi.org/10.1136/gutjnl-2014-309086DOI Listing
October 2015

Gut mucosal microbiome across stages of colorectal carcinogenesis.

Nat Commun 2015 Oct 30;6:8727. Epub 2015 Oct 30.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, Hong Kong SAR, China.

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http://dx.doi.org/10.1038/ncomms9727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640069PMC
October 2015

Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis.

J Pathol 2015 Sep 28;237(1):38-49. Epub 2015 May 28.

Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, China.

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http://dx.doi.org/10.1002/path.4554DOI Listing
September 2015

The comparative cost-effectiveness of colorectal cancer screening using faecal immunochemical test vs. colonoscopy.

Sci Rep 2015 Sep 4;5:13568. Epub 2015 Sep 4.

Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong, HKSAR, China.

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http://dx.doi.org/10.1038/srep13568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559662PMC
September 2015

Diagnostic Accuracy of a Qualitative Fecal Immunochemical Test Varies With Location of Neoplasia But Not Number of Specimens.

Clin Gastroenterol Hepatol 2015 Aug 24;13(8):1472-9. Epub 2015 Feb 24.

Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong, HKSAR, China. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2015.02.021DOI Listing
August 2015

Management of Patients with Rebleeding.

Gastrointest Endosc Clin N Am 2015 Jul;25(3):569-81

State Key Laboratory of Digestive Disease, Faculty of Medicine, Institute of Digestive Disease, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, Hong Kong, China; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.giec.2015.02.007DOI Listing
July 2015

A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients.

J Hepatol 2015 May 9;62(5):1100-11. Epub 2014 Dec 9.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Disease and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.11.040DOI Listing
May 2015

Factors associated with mucosal healing in patients with ulcerative colitis in clinical remission.

Inflamm Bowel Dis 2015 Apr;21(4):840-6

*Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China; †Department of Medicine, Tseung Kwan O Hospital, Hong Kong, China; ‡Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China; §Department of Medicine, The University of Hong Kong, Hong Kong, China; ||Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China; ¶Department of Medicine and Geriatrics, Caritas Medical Center, Hong Kong, China; and **Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, China.

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http://dx.doi.org/10.1097/MIB.0000000000000334DOI Listing
April 2015

Serrated polyps and the risk of synchronous colorectal advanced neoplasia: a systematic review and meta-analysis.

Am J Gastroenterol 2015 Apr 10;110(4):501-9; quiz 510. Epub 2015 Mar 10.

Institute of Digestive Disease, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1038/ajg.2015.49DOI Listing
April 2015

Factors associated with false-positive and false-negative fecal immunochemical test results for colorectal cancer screening.

Gastrointest Endosc 2015 Mar 5;81(3):596-607. Epub 2014 Oct 5.

Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong, HKSAR, China.

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http://dx.doi.org/10.1016/j.gie.2014.08.006DOI Listing
March 2015

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway.

Oncotarget 2015 Mar;6(9):7325-38

Institute of Digestive Disease and The Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466688PMC
http://dx.doi.org/10.18632/oncotarget.2621DOI Listing
March 2015

Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis.

Cancer Res 2015 Feb 12;75(4):754-65. Epub 2014 Dec 12.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong. Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1301DOI Listing
February 2015

Identification of subjects at risk of proximal advanced neoplasia for colorectal cancer screening.

Eur J Cancer 2015 Jan 6;51(1):37-44. Epub 2014 Nov 6.

Institute of Digestive Disease, Chinese University of Hong Kong, 7/F, Lui Che Woo Clinical Science Building, Prince of Wales Hospital, Shatin, NT, Hong Kong Special Administrative Region. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.10.003DOI Listing
January 2015

The past 10 years of gastroenterology and hepatology-reflections and predictions.

Nat Rev Gastroenterol Hepatol 2014 Nov 7;11(11):692-700. Epub 2014 Oct 7.

Department of Medicine, Cell Biology &Molecular Physiology and Human Genetics, University of Pittsburgh and UPMC, Room 401.4, 3708 Fifth Avenue, Pittsburgh, PA 15231, USA.

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http://dx.doi.org/10.1038/nrgastro.2014.167DOI Listing
November 2014

Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway.

Oncotarget 2014 Sep;5(18):8330-40

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226686PMC
http://dx.doi.org/10.18632/oncotarget.2212DOI Listing
September 2014