Joseph Heitman

Joseph Heitman

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Joseph Heitman

Publications by authors named "Joseph Heitman"

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5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus.

Nat Commun 2020 Jan 8;11(1):127. Epub 2020 Jan 8.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1038/s41467-019-13890-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949227PMC
January 2020

Loss of centromere function drives karyotype evolution in closely related species.

Elife 2020 Jan 20;9. Epub 2020 Jan 20.

Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.

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http://dx.doi.org/10.7554/eLife.53944DOI Listing
January 2020

The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Human Pathogenic Fungi.

Annu Rev Genet 2019 Dec 19;53:417-444. Epub 2019 Sep 19.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA; email:

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http://dx.doi.org/10.1146/annurev-genet-120116-024755DOI Listing
December 2019

Epigenetic mechanisms of drug resistance in fungi.

Fungal Genet Biol 2019 Nov 17;132:103253. Epub 2019 Jul 17.

Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.fgb.2019.103253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858951PMC
November 2019

Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides.

mBio 2019 11 5;10(6). Epub 2019 Nov 5.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Duke University, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.02579-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831780PMC
November 2019

Recovered From Olive Trees () in Turkey Reveal Allopatry With African and South American Lineages.

Front Cell Infect Microbiol 2019 8;9:384. Epub 2019 Nov 8.

Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, Adana, Turkey.

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http://dx.doi.org/10.3389/fcimb.2019.00384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856141PMC
November 2019

Genetic and genomic evolution of sexual reproduction: echoes from LECA to the fungal kingdom.

Curr Opin Genet Dev 2019 Oct 29;58-59:70-75. Epub 2019 Aug 29.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2019.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889014PMC
October 2019

She Loves Me, She Loves Me Not: On the Dualistic Asexual/Sexual Nature of Dermatophyte Fungi.

Mycopathologia 2019 Oct 1. Epub 2019 Oct 1.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1007/s11046-019-00390-3DOI Listing
October 2019

Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens.

Cell Host Microbe 2019 10;26(4):453-462

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788756PMC
October 2019

Pbp1-Interacting Protein Mkt1 Regulates Virulence and Sexual Reproduction in .

Front Cell Infect Microbiol 2019 17;9:355. Epub 2019 Oct 17.

School of Food Science and Biotechnology, Institute of Agricultural Science and Technology, Kyungpook National University, Daegu, South Korea.

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http://dx.doi.org/10.3389/fcimb.2019.00355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811503PMC
October 2019

: The Fungal Kingdom as a Rosetta Stone for Biology and Medicine.

Authors:
Joseph Heitman

Genetics 2019 09;213(1):1-7

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina 27710

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http://dx.doi.org/10.1534/genetics.119.302537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727799PMC
September 2019

Convergent evolution of linked mating-type loci in basidiomycete fungi.

PLoS Genet 2019 09 6;15(9):e1008365. Epub 2019 Sep 6.

Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1008365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730849PMC
September 2019

Unisexual reproduction promotes competition for mating partners in the global human fungal pathogen Cryptococcus deneoformans.

PLoS Genet 2019 09 19;15(9):e1008394. Epub 2019 Sep 19.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772093PMC
September 2019

Advancing Functional Genetics Through -Mediated Insertional Mutagenesis and CRISPR/Cas9 in the Commensal and Pathogenic Yeast .

Genetics 2019 08 26;212(4):1163-1179. Epub 2019 Jun 26.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710

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http://dx.doi.org/10.1534/genetics.119.302329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707463PMC
August 2019

Mating-System Evolution: All Roads Lead to Selfing.

Curr Biol 2019 Aug;29(15):R743-R746

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.06.073DOI Listing
August 2019

Cryptococcus neoformans Mating and Genetic Crosses.

Curr Protoc Microbiol 2019 06 20;53(1):e75. Epub 2019 Jan 20.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1002/cpmc.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586516PMC
June 2019

Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model.

J Microbiol 2019 Jun 27;57(6):509-520. Epub 2019 May 27.

South Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USA.

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http://link.springer.com/10.1007/s12275-019-8682-x
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http://dx.doi.org/10.1007/s12275-019-8682-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737537PMC
June 2019

Mating type (MAT) locus and possible sexuality of the opportunistic pathogen Exophiala dermatitidis.

Fungal Genet Biol 2019 03 3;124:29-38. Epub 2019 Jan 3.

Division of Mycology, Department of Microbiology, Faculty of Medicine, Çukurova University, Adana, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.fgb.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417501PMC
March 2019

Nutrient and Stress Sensing in Pathogenic Yeasts.

Front Microbiol 2019 8;10:442. Epub 2019 Mar 8.

Public Health Research Institute, Rutgers University, Newark, NJ, United States.

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http://dx.doi.org/10.3389/fmicb.2019.00442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423903PMC
March 2019

Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides.

PLoS Genet 2019 02 11;15(2):e1007957. Epub 2019 Feb 11.

Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1007957
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http://dx.doi.org/10.1371/journal.pgen.1007957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386414PMC
February 2019

and Assessment of FK506 Analogs as Novel Antifungal Drug Candidates.

Antimicrob Agents Chemother 2018 11 24;62(11). Epub 2018 Oct 24.

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea

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http://aac.asm.org/lookup/doi/10.1128/AAC.01627-18
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http://dx.doi.org/10.1128/AAC.01627-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201060PMC
November 2018

An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease.

Cell Host Microbe 2018 08;24(2):308-323.e6

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093297PMC
August 2018

A High-Resolution Map of Meiotic Recombination in Demonstrates Decreased Recombination in Unisexual Reproduction.

Genetics 2018 06 6;209(2):567-578. Epub 2018 Apr 6.

Department of Biology, Duke University, Durham, North Carolina 27708

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http://dx.doi.org/10.1534/genetics.118.300996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972427PMC
June 2018

The Skin Commensal Yeast Malassezia globosa Thwarts Bacterial Biofilms to Benefit the Host.

J Invest Dermatol 2018 05;138(5):1026-1029

Science for Life Laboratory, Department of Clinical Science and Education, Karolinska Institutet, and Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.01.008DOI Listing
May 2018

RNAi is a critical determinant of centromere evolution in closely related fungi.

Proc Natl Acad Sci U S A 2018 03 5;115(12):3108-3113. Epub 2018 Mar 5.

Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India;

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http://dx.doi.org/10.1073/pnas.1713725115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866544PMC
March 2018

Pearls collections: What we can learn about infectious disease and cancer.

PLoS Pathog 2018 03 29;14(3):e1006915. Epub 2018 Mar 29.

Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875890PMC
March 2018

Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in .

Genetics 2018 02 12;208(2):639-653. Epub 2017 Dec 12.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710

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http://dx.doi.org/10.1534/genetics.117.300422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788528PMC
February 2018

Had1 Is Required for Cell Wall Integrity and Fungal Virulence in .

G3 (Bethesda) 2018 02 2;8(2):643-652. Epub 2018 Feb 2.

School of Food Science and Biotechnology, Institute of Agricultural Science and Technology, Kyungpook National University, Daegu 41566, Republic of Korea

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http://dx.doi.org/10.1534/g3.117.300444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919746PMC
February 2018

Erratum for Ianiri et al., "FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in ".

mBio 2017 12 5;8(6). Epub 2017 Dec 5.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.02055-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717396PMC
December 2017

PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex.

PLoS Genet 2017 Nov 27;13(11):e1007113. Epub 2017 Nov 27.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720818PMC
November 2017

Dynamics of parasitophorous vacuoles formed by the microsporidian pathogen Encephalitozoon cuniculi.

Fungal Genet Biol 2017 10 25;107:20-23. Epub 2017 Jul 25.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.fgb.2017.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861352PMC
October 2017

FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in .

mBio 2017 10 24;8(5). Epub 2017 Oct 24.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.01752-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654937PMC
October 2017

Eukaryotic Sexual Reproduction Evoked "with a Little Help from My Friends".

Cell 2017 09;170(6):1059-1061

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.08.038DOI Listing
September 2017

Genetic and epigenetic engines of diversity in pathogenic microbes.

PLoS Pathog 2017 09 14;13(9):e1006468. Epub 2017 Sep 14.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599048PMC
September 2017

Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in .

Elife 2017 09 26;6. Epub 2017 Sep 26.

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Duke University Medical Center, Durham, United States.

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https://elifesciences.org/articles/28802
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http://dx.doi.org/10.7554/eLife.28802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614558PMC
September 2017

Plants promote mating and dispersal of the human pathogenic fungus Cryptococcus.

PLoS One 2017 17;12(2):e0171695. Epub 2017 Feb 17.

Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171695PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315327PMC
August 2017

MTL genotypes, phenotypic switching, and susceptibility profiles of Candida parapsilosis species group compared to Lodderomyces elongisporus.

PLoS One 2017 3;12(8):e0182653. Epub 2017 Aug 3.

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182653PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542550PMC
August 2017

Construction of a Recyclable Genetic Marker and Serial Gene Deletions in the Human Pathogenic Mucorales .

G3 (Bethesda) 2017 07 5;7(7):2047-2054. Epub 2017 Jul 5.

Department of Biology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, Texas 78249

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http://dx.doi.org/10.1534/g3.117.041095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499115PMC
July 2017

Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans.

PLoS Genet 2017 04 4;13(4):e1006667. Epub 2017 Apr 4.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380312PMC
April 2017

A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides.

PLoS Genet 2017 03 24;13(3):e1006686. Epub 2017 Mar 24.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384783PMC
March 2017

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.

Virulence 2017 02 20;8(2):186-197. Epub 2016 Jun 20.

a Department of Pediatrics , Division of Pediatric Infectious Diseases, Duke University School of Medicine , Durham , NC , USA.

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http://dx.doi.org/10.1080/21505594.2016.1201250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354160PMC
February 2017

Sexual Reproduction in Dermatophytes.

Mycopathologia 2017 Feb 30;182(1-2):45-55. Epub 2016 Sep 30.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1007/s11046-016-0072-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285299PMC
February 2017

New facets of antifungal therapy.

Virulence 2017 02 7;8(2):222-236. Epub 2016 Nov 7.

a Department of Plant Pathology and Microbiology , National Taiwan University , Taipei , Taiwan.

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http://dx.doi.org/10.1080/21505594.2016.1257457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354158PMC
February 2017

Gene Function Analysis in the Ubiquitous Human Commensal and Pathogen Malassezia Genus.

mBio 2016 11 29;7(6). Epub 2016 Nov 29.

School of BioSciences, University of Melbourne, Victoria, Australia

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http://dx.doi.org/10.1128/mBio.01853-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137500PMC
November 2016

Calcineurin Targets Involved in Stress Survival and Fungal Virulence.

PLoS Pathog 2016 09 9;12(9):e1005873. Epub 2016 Sep 9.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017699PMC
September 2016

Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.

Hum Mol Genet 2016 08 17;25(16):3524-3538. Epub 2016 Jul 17.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1093/hmg/ddw195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179947PMC
August 2016

Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication.

Curr Biol 2016 06 26;26(12):1577-1584. Epub 2016 May 26.

US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089372PMC
http://dx.doi.org/10.1016/j.cub.2016.04.038DOI Listing
June 2016

On the Discovery of TOR As the Target of Rapamycin.

Authors:
Joseph Heitman

PLoS Pathog 2015 5;11(11):e1005245. Epub 2015 Nov 5.

Departments of Molecular Genetics and Microbiology (MGM), Pharmacology and Cancer Biology, and Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634758PMC
April 2016

Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.

mBio 2016 Apr 26;7(2):e00492-16. Epub 2016 Apr 26.

Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.00492-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850266PMC
April 2016

Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex.

PLoS Genet 2016 Mar 4;12(3):e1005868. Epub 2016 Mar 4.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1005868
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http://dx.doi.org/10.1371/journal.pgen.1005868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778953PMC
March 2016

From Two to One: Unipolar Sexual Reproduction.

Fungal Biol Rev 2015 Dec 10;29(3-4):118-125. Epub 2015 Jul 10.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.

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http://dx.doi.org/10.1016/j.fbr.2015.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698900PMC
December 2015

Evolution of sexual reproduction: a view from the Fungal Kingdom supports an evolutionary epoch with sex before sexes.

Authors:
Joseph Heitman

Fungal Biol Rev 2015 Dec;29(3-4):108-117

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710 USA.

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http://dx.doi.org/10.1016/j.fbr.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730888PMC
December 2015

Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis.

PLoS One 2014 5;9(8):e104432. Epub 2014 Aug 5.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104432PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122496PMC
November 2015

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens.

Cell Rep 2015 Nov 5;13(7):1481-1492. Epub 2015 Nov 5.

Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654976PMC
November 2015

Unisexual reproduction of Cryptococcus gattii.

PLoS One 2014 22;9(10):e111089. Epub 2014 Oct 22.

Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111089PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206507PMC
July 2015

Cryptococcal osteomyelitis in an adolescent survivor of T-cell acute lymphoblastic leukemia.

Pediatr Infect Dis J 2015 Jun;34(6):662-6

From the *Saul Krugman Division of Pediatric Infectious Diseases, Department of Pediatrics, New York University Medical School, New York, NY; †Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA; ‡Division of Pediatric Hematology and Oncology, Department of Pediatrics, New York University Medical School, New York, NY; §Department of Molecular Genetics and Microbiology (MGM), ¶Department of Pharmacology and Cancer Biology, and ‖Department of Medicine, Duke University Medical Center, Durham, NC; **Department of Pathology, New York University Medical School, New York, NY; and ††Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT.

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http://dx.doi.org/10.1097/INF.0000000000000687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431918PMC
June 2015

Unisexual versus bisexual mating in Cryptococcus neoformans: Consequences and biological impacts.

Fungal Genet Biol 2015 May 27;78:65-75. Epub 2014 Aug 27.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10871845140014
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http://dx.doi.org/10.1016/j.fgb.2014.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344436PMC
May 2015

Sex in the Mucoralean fungi.

Mycoses 2014 Dec 31;57 Suppl 3:18-24. Epub 2014 Aug 31.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1111/myc.12244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374171PMC
December 2014

Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating.

Fungal Genet Biol 2014 Dec 28;73:20-8. Epub 2014 Sep 28.

Institut Pasteur, Unité Biologie et Pathogénicité Fongiques - INRA USC2019, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.fgb.2014.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382001PMC
December 2014

Unisexual reproduction drives meiotic recombination and phenotypic and karyotypic plasticity in Cryptococcus neoformans.

PLoS Genet 2014 Dec 11;10(12):e1004849. Epub 2014 Dec 11.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263396PMC
December 2014

Unisexual reproduction.

Adv Genet 2014 ;85:255-305

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1016/B978-0-12-800271-1.00005-6DOI Listing
November 2014

Unisexual reproduction reverses Muller's ratchet.

Genetics 2014 Nov 11;198(3):1059-69. Epub 2014 Sep 11.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710

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http://dx.doi.org/10.1534/genetics.114.170472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224152PMC
November 2014

Antifungal drug resistance evoked via RNAi-dependent epimutations.

Nature 2014 Sep 27;513(7519):555-8. Epub 2014 Jul 27.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/nature13575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177005PMC
September 2014

Sexual reproduction of human fungal pathogens.

Cold Spring Harb Perspect Med 2014 Aug 1;4(8). Epub 2014 Aug 1.

Department of Biology, University of Iowa, Iowa City, Iowa 52242.

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http://dx.doi.org/10.1101/cshperspect.a019281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109574PMC
August 2014

Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal.

PLoS Pathog 2014 Aug 21;10(8):e1004285. Epub 2014 Aug 21.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America; Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1004285
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http://dx.doi.org/10.1371/journal.ppat.1004285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140843PMC
August 2014

Calcineurin controls hyphal growth, virulence, and drug tolerance of Candida tropicalis.

Eukaryot Cell 2014 Jul 17;13(7):844-54. Epub 2014 Jan 17.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/EC.00302-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135728PMC
July 2014

Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae.

Genetics 2014 Apr 10;196(4):1077-89. Epub 2014 Feb 10.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710.

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http://dx.doi.org/10.1534/genetics.114.161646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982701PMC
April 2014

Origins of eukaryotic sexual reproduction.

Cold Spring Harb Perspect Biol 2014 Mar 1;6(3). Epub 2014 Mar 1.

Department of Biology, Washington University, St. Louis, Missouri 63130.

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http://dx.doi.org/10.1101/cshperspect.a016154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949356PMC
March 2014