Publications by authors named "Joseph Heitman"

100Publications

Development of molecular tools for the yeast LS28 and identification of Yap1 as a transcription factor involved in biocontrol activity.

Appl Environ Microbiol 2021 Jan 15. Epub 2021 Jan 15.

Department of Agricultural, Environmental and Food Sciences, University of Molise, via Francesco de Sanctis, 86100 Campobasso, Italy.

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January 2021

Erratum: Microbe Profile: species complex.

Microbiology (Reading) 2020 Dec;166(12):1191

Department of Microbiology, University of Georgia, Athens, GA 30602, USA.

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December 2020

The Untapped Australasian Diversity of Astaxanthin-Producing Yeasts with Biotechnological Potential- sp. nov. and sp. nov.

Microorganisms 2020 Oct 24;8(11). Epub 2020 Oct 24.

UCIBIO, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.

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October 2020

Fungal pathogens.

Curr Biol 2020 Oct;30(19):R1163-R1169

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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October 2020

Microbe Profile: species complex.

Microbiology (Reading) 2020 09;166(9):797-799

Department of Microbiology, University of Georgia, Athens, GA 30602, USA.

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September 2020

A Novel Mycovirus Evokes Transcriptional Rewiring in the Fungus and Stimulates Beta Interferon Production in Macrophages.

mBio 2020 09 1;11(5). Epub 2020 Sep 1.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

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September 2020

Approaches for Genetic Discoveries in the Skin Commensal and Pathogenic Yeasts.

Front Cell Infect Microbiol 2020 7;10:393. Epub 2020 Aug 7.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, United States.

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August 2020

Expression of a Codon Optimized mCherry Fluorescent Protein in a Bicistronic Vector.

Front Cell Infect Microbiol 2020 22;10:367. Epub 2020 Jul 22.

Skin Research Institute of Singapore, Agency of Science, Technology and Research, Singapore, Singapore.

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July 2020

Advances in understanding the evolution of fungal genome architecture.

F1000Res 2020 27;9. Epub 2020 Jul 27.

Department of Molecular Genetics and Microbiology, Duke University Medical Centre, Durham, NC, USA.

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October 2020

The Rise of Fungi: A Report on the CIFAR Program Inaugural Meeting.

G3 (Bethesda) 2020 06 1;10(6):1837-1842. Epub 2020 Jun 1.

Department of Molecular Genetics, University of Toronto, Ontario, Canada, M5G 1M1 and

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June 2020

Centromere deletion in leads to neocentromere formation and chromosome fusions.

Elife 2020 Apr 20;9. Epub 2020 Apr 20.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.

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April 2020

Transposon mobilization in the human fungal pathogen is mutagenic during infection and promotes drug resistance in vitro.

Proc Natl Acad Sci U S A 2020 05 17;117(18):9973-9980. Epub 2020 Apr 17.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710;

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May 2020

Centromere scission drives chromosome shuffling and reproductive isolation.

Proc Natl Acad Sci U S A 2020 04 19;117(14):7917-7928. Epub 2020 Mar 19.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710

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April 2020

FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.

Biochem Biophys Res Commun 2020 05 16;526(1):48-54. Epub 2020 Mar 16.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address:

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May 2020

A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides.

mBio 2020 01 28;11(1). Epub 2020 Jan 28.

South Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA

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January 2020

5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus.

Nat Commun 2020 01 8;11(1):127. Epub 2020 Jan 8.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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January 2020

The Pheromone and Pheromone Receptor Mating-Type Locus Is Involved in Controlling Uniparental Mitochondrial Inheritance in .

Genetics 2020 03 30;214(3):703-717. Epub 2019 Dec 30.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710

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March 2020

Mating-Type-Specific Ribosomal Proteins Control Aspects of Sexual Reproduction in .

Genetics 2020 03 27;214(3):635-649. Epub 2019 Dec 27.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710

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March 2020

Recovered From Olive Trees () in Turkey Reveal Allopatry With African and South American Lineages.

Front Cell Infect Microbiol 2019 8;9:384. Epub 2019 Nov 8.

Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, Adana, Turkey.

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August 2020

Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides.

mBio 2019 11 5;10(6). Epub 2019 Nov 5.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Duke University, Durham, North Carolina, USA

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November 2019

Pbp1-Interacting Protein Mkt1 Regulates Virulence and Sexual Reproduction in .

Front Cell Infect Microbiol 2019 17;9:355. Epub 2019 Oct 17.

School of Food Science and Biotechnology, Institute of Agricultural Science and Technology, Kyungpook National University, Daegu, South Korea.

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June 2020

Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens.

Cell Host Microbe 2019 10;26(4):453-462

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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October 2019

She Loves Me, She Loves Me Not: On the Dualistic Asexual/Sexual Nature of Dermatophyte Fungi.

Mycopathologia 2020 Feb 1;185(1):87-101. Epub 2019 Oct 1.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA.

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February 2020

The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Human Pathogenic Fungi.

Annu Rev Genet 2019 12 19;53:417-444. Epub 2019 Sep 19.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA; email:

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December 2019

Unisexual reproduction promotes competition for mating partners in the global human fungal pathogen Cryptococcus deneoformans.

PLoS Genet 2019 09 19;15(9):e1008394. Epub 2019 Sep 19.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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September 2019

Convergent evolution of linked mating-type loci in basidiomycete fungi.

PLoS Genet 2019 09 6;15(9):e1008365. Epub 2019 Sep 6.

Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr-Universität Bochum, Bochum, Germany.

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September 2019

: The Fungal Kingdom as a Rosetta Stone for Biology and Medicine.

Authors:
Joseph Heitman

Genetics 2019 09;213(1):1-7

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina 27710

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September 2019

Genetic and genomic evolution of sexual reproduction: echoes from LECA to the fungal kingdom.

Curr Opin Genet Dev 2019 10 29;58-59:70-75. Epub 2019 Aug 29.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address:

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October 2019

Mating-System Evolution: All Roads Lead to Selfing.

Curr Biol 2019 08;29(15):R743-R746

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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August 2019

Epigenetic mechanisms of drug resistance in fungi.

Fungal Genet Biol 2019 11 17;132:103253. Epub 2019 Jul 17.

Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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November 2019

Advancing Functional Genetics Through -Mediated Insertional Mutagenesis and CRISPR/Cas9 in the Commensal and Pathogenic Yeast .

Genetics 2019 08 26;212(4):1163-1179. Epub 2019 Jun 26.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710

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August 2019

Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model.

J Microbiol 2019 Jun 27;57(6):509-520. Epub 2019 May 27.

South Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USA.

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June 2019

Nutrient and Stress Sensing in Pathogenic Yeasts.

Front Microbiol 2019 8;10:442. Epub 2019 Mar 8.

Public Health Research Institute, Rutgers University, Newark, NJ, United States.

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March 2019

Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides.

PLoS Genet 2019 02 11;15(2):e1007957. Epub 2019 Feb 11.

Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, North Carolina, United States of America.

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February 2019

Cryptococcus neoformans Mating and Genetic Crosses.

Curr Protoc Microbiol 2019 06 20;53(1):e75. Epub 2019 Jan 20.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina.

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June 2019

Mating type (MAT) locus and possible sexuality of the opportunistic pathogen Exophiala dermatitidis.

Fungal Genet Biol 2019 03 3;124:29-38. Epub 2019 Jan 3.

Division of Mycology, Department of Microbiology, Faculty of Medicine, Çukurova University, Adana, Turkey. Electronic address:

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March 2019

and Assessment of FK506 Analogs as Novel Antifungal Drug Candidates.

Antimicrob Agents Chemother 2018 11 24;62(11). Epub 2018 Oct 24.

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea

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November 2018

An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease.

Cell Host Microbe 2018 08;24(2):308-323.e6

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA. Electronic address:

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August 2018

The Skin Commensal Yeast Malassezia globosa Thwarts Bacterial Biofilms to Benefit the Host.

J Invest Dermatol 2018 05;138(5):1026-1029

Science for Life Laboratory, Department of Clinical Science and Education, Karolinska Institutet, and Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden. Electronic address:

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May 2018

A High-Resolution Map of Meiotic Recombination in Demonstrates Decreased Recombination in Unisexual Reproduction.

Genetics 2018 06 6;209(2):567-578. Epub 2018 Apr 6.

Department of Biology, Duke University, Durham, North Carolina 27708

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June 2018

Pearls collections: What we can learn about infectious disease and cancer.

PLoS Pathog 2018 03 29;14(3):e1006915. Epub 2018 Mar 29.

Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America.

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March 2018

RNAi is a critical determinant of centromere evolution in closely related fungi.

Proc Natl Acad Sci U S A 2018 03 5;115(12):3108-3113. Epub 2018 Mar 5.

Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India;

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March 2018

Had1 Is Required for Cell Wall Integrity and Fungal Virulence in .

G3 (Bethesda) 2018 02 2;8(2):643-652. Epub 2018 Feb 2.

School of Food Science and Biotechnology, Institute of Agricultural Science and Technology, Kyungpook National University, Daegu 41566, Republic of Korea

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February 2018

Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in .

Genetics 2018 02 12;208(2):639-653. Epub 2017 Dec 12.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710

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February 2018

Erratum for Ianiri et al., "FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in ".

mBio 2017 12 5;8(6). Epub 2017 Dec 5.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

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December 2017

PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex.

PLoS Genet 2017 Nov 27;13(11):e1007113. Epub 2017 Nov 27.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, United States of America.

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November 2017

FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in .

mBio 2017 10 24;8(5). Epub 2017 Oct 24.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

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October 2017

Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in .

Elife 2017 09 26;6. Epub 2017 Sep 26.

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Duke University Medical Center, Durham, United States.

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September 2017

Genetic and epigenetic engines of diversity in pathogenic microbes.

PLoS Pathog 2017 09 14;13(9):e1006468. Epub 2017 Sep 14.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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September 2017

Eukaryotic Sexual Reproduction Evoked "with a Little Help from My Friends".

Cell 2017 09;170(6):1059-1061

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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September 2017

MTL genotypes, phenotypic switching, and susceptibility profiles of Candida parapsilosis species group compared to Lodderomyces elongisporus.

PLoS One 2017 3;12(8):e0182653. Epub 2017 Aug 3.

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.

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August 2017

Dynamics of parasitophorous vacuoles formed by the microsporidian pathogen Encephalitozoon cuniculi.

Fungal Genet Biol 2017 10 25;107:20-23. Epub 2017 Jul 25.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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October 2017

Construction of a Recyclable Genetic Marker and Serial Gene Deletions in the Human Pathogenic Mucorales .

G3 (Bethesda) 2017 07 5;7(7):2047-2054. Epub 2017 Jul 5.

Department of Biology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, Texas 78249

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July 2017

Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans.

PLoS Genet 2017 04 4;13(4):e1006667. Epub 2017 Apr 4.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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April 2017

A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides.

PLoS Genet 2017 03 24;13(3):e1006686. Epub 2017 Mar 24.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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March 2017

Plants promote mating and dispersal of the human pathogenic fungus Cryptococcus.

PLoS One 2017 17;12(2):e0171695. Epub 2017 Feb 17.

Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America.

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August 2017

Gene Function Analysis in the Ubiquitous Human Commensal and Pathogen Malassezia Genus.

mBio 2016 11 29;7(6). Epub 2016 Nov 29.

School of BioSciences, University of Melbourne, Victoria, Australia

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November 2016

New facets of antifungal therapy.

Virulence 2017 02 7;8(2):222-236. Epub 2016 Nov 7.

a Department of Plant Pathology and Microbiology , National Taiwan University , Taipei , Taiwan.

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February 2017

Sexual Reproduction in Dermatophytes.

Mycopathologia 2017 Feb 30;182(1-2):45-55. Epub 2016 Sep 30.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA.

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February 2017

Calcineurin Targets Involved in Stress Survival and Fungal Virulence.

PLoS Pathog 2016 09 9;12(9):e1005873. Epub 2016 Sep 9.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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September 2016

Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.

Hum Mol Genet 2016 08 17;25(16):3524-3538. Epub 2016 Jul 17.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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August 2016

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.

Virulence 2017 02 20;8(2):186-197. Epub 2016 Jun 20.

a Department of Pediatrics , Division of Pediatric Infectious Diseases, Duke University School of Medicine , Durham , NC , USA.

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February 2017

Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.

mBio 2016 Apr 26;7(2):e00492-16. Epub 2016 Apr 26.

Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA

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April 2016

Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex.

PLoS Genet 2016 Mar 4;12(3):e1005868. Epub 2016 Mar 4.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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March 2016

Evolution of sexual reproduction: a view from the Fungal Kingdom supports an evolutionary epoch with sex before sexes.

Authors:
Joseph Heitman

Fungal Biol Rev 2015 Dec;29(3-4):108-117

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710 USA.

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December 2015

From Two to One: Unipolar Sexual Reproduction.

Fungal Biol Rev 2015 Dec 10;29(3-4):118-125. Epub 2015 Jul 10.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.

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December 2015

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens.

Cell Rep 2015 Nov 5;13(7):1481-1492. Epub 2015 Nov 5.

Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada. Electronic address:

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November 2015

On the Discovery of TOR As the Target of Rapamycin.

Authors:
Joseph Heitman

PLoS Pathog 2015 5;11(11):e1005245. Epub 2015 Nov 5.

Departments of Molecular Genetics and Microbiology (MGM), Pharmacology and Cancer Biology, and Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.

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April 2016

Cryptococcal osteomyelitis in an adolescent survivor of T-cell acute lymphoblastic leukemia.

Pediatr Infect Dis J 2015 Jun;34(6):662-6

From the *Saul Krugman Division of Pediatric Infectious Diseases, Department of Pediatrics, New York University Medical School, New York, NY; †Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA; ‡Division of Pediatric Hematology and Oncology, Department of Pediatrics, New York University Medical School, New York, NY; §Department of Molecular Genetics and Microbiology (MGM), ¶Department of Pharmacology and Cancer Biology, and ‖Department of Medicine, Duke University Medical Center, Durham, NC; **Department of Pathology, New York University Medical School, New York, NY; and ††Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT.

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June 2015