Joseph E Italiano

Joseph E Italiano

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Joseph E Italiano

Joseph E Italiano

Publications by authors named "Joseph E Italiano"

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Anti-apoptotic increases megakaryocyte proplatelet formation in cultures of human cord blood.

Haematologica 2019 Oct 7;104(10):2075-2083. Epub 2019 Feb 7.

Program in Molecular Medicine and Department of Internal Medicine, University of Utah, Salt Lake City, UT

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http://dx.doi.org/10.3324/haematol.2018.204685DOI Listing
October 2019

Unlocking the Molecular Secrete(s) of α-Granule Biogenesis.

Arterioscler Thromb Vasc Biol 2018 11;38(11):2539-2541

From the Brigham and Women's Hospital, Boston Children's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/ATVBAHA.118.311614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287256PMC
November 2018

Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets.

Blood Adv 2017 Sep 8;1(20):1773-1785. Epub 2017 Sep 8.

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/bloodadvances.2017007021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728336PMC
September 2017

Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis.

Arterioscler Thromb Vasc Biol 2017 04 2;37(4):664-674. Epub 2017 Feb 2.

From the Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA (K.E.J., J.A.F., M.D.T., J.R.C., S.E.-H., R.K., K.R.M., J.E.I., E.M.B.); Department of Medicine, Harvard Medical School, Boston, MA (K.E.J., K.R.M., E.L.M., J.E.I., E.M.B.); Vascular Biology Program, Department of Surgery, Children's Hospital Boston, MA (J.E.I.); and Division of Hematology, Dana-Farber Cancer Institute, Boston, MA (E.L.M.).

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http://dx.doi.org/10.1161/ATVBAHA.116.308791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364056PMC
April 2017

DREAM plays an important role in platelet activation and thrombogenesis.

Blood 2017 01 30;129(2):209-225. Epub 2016 Nov 30.

Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL.

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http://dx.doi.org/10.1182/blood-2016-07-724419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234218PMC
January 2017

Human thrombopoiesis depends on Protein kinase Cδ/protein kinase Cε functional couple.

Haematologica 2016 07 14;101(7):812-20. Epub 2016 Apr 14.

Department of Biomedical, Biotechnological and Translational Sciences (SBiBiT), University of Parma, Italy

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http://dx.doi.org/10.3324/haematol.2015.137984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004460PMC
July 2016

Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation.

Blood 2016 Mar 7;127(11):1468-80. Epub 2016 Jan 7.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA; Vascular Biology Program, Department of Surgery, Children's Hospital Boston, Boston, MA.

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http://dx.doi.org/10.1182/blood-2015-08-663146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797023PMC
March 2016

Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia.

Haematologica 2016 Jan 9;101(1):46-56. Epub 2015 Oct 9.

Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy

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http://dx.doi.org/10.3324/haematol.2015.130849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697891PMC
January 2016

Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice.

Thromb Haemost 2015 Nov 13;114(6):1218-29. Epub 2015 Aug 13.

Silvia S. Barbieri, PhD, Centro Cardiologico Monzino, IRCCS, Via Parea 4, 20138 Milano, Italy, Tel.: +39 02 50318357, Fax: +39 02 50318250, E-mail:

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http://dx.doi.org/10.1160/TH14-10-0872DOI Listing
November 2015

Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation.

Br J Haematol 2014 Apr 6;165(2):227-36. Epub 2014 Feb 6.

Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/bjh.12758DOI Listing
April 2014

Animating platelet production adds physiological context.

Trends Mol Med 2013 Oct 14;19(10):583-5. Epub 2013 Aug 14.

Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2013.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418476PMC
October 2013

The incredible journey: From megakaryocyte development to platelet formation.

J Cell Biol 2013 Jun;201(6):785-96

Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.201304054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678154PMC
June 2013

Unraveling mechanisms that control platelet production.

Semin Thromb Hemost 2013 Feb 24;39(1):15-24. Epub 2012 Dec 24.

Division of Hematology, Brigham and Women's Hospital, Boston Children's Hospital, Harvard Medical School, Massachusetts, USA.

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http://dx.doi.org/10.1055/s-0032-1331157DOI Listing
February 2013

Platelets: production, morphology and ultrastructure.

Handb Exp Pharmacol 2012 (210):3-22

Department of Medicine, Brigham and Women's Hospital, 1 Blackfan Circle, Karp 6, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-3-642-29423-5_1DOI Listing
January 2013

Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis.

Exp Hematol 2013 Jan 11;41(1):91-101.e4. Epub 2012 Sep 11.

Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1016/j.exphem.2012.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638753PMC
January 2013

High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production.

Blood 2012 Sep 4;120(10):1975-84. Epub 2012 Jun 4.

Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2012-04-420968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437592PMC
September 2012

Does size matter in platelet production?

Blood 2012 Aug 4;120(8):1552-61. Epub 2012 Jun 4.

Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2012-04-408724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429301PMC
August 2012

The origin and function of platelet glycosyltransferases.

Blood 2012 Jul 21;120(3):626-35. Epub 2012 May 21.

Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark.

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http://dx.doi.org/10.1182/blood-2012-02-409235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401214PMC
July 2012

VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients.

Angiogenesis 2012 Jun 9;15(2):265-73. Epub 2012 Mar 9.

Department of Research and Development, Ortho Clinical Diagnostics, Rochester, NY 14626, USA.

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http://dx.doi.org/10.1007/s10456-012-9259-zDOI Listing
June 2012

Microtubule and cortical forces determine platelet size during vascular platelet production.

Nat Commun 2012 May 22;3:852. Epub 2012 May 22.

Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms1838DOI Listing
May 2012

Visualization and manipulation of the platelet and megakaryocyte cytoskeleton.

Methods Mol Biol 2012 ;788:109-25

Hematology Division, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-61779-307-3_9DOI Listing
April 2012

Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis.

Blood 2011 Aug 16;118(5):1359-69. Epub 2011 Jun 16.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2011-02-334524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152500PMC
August 2011

Platelets and the immune continuum.

Nat Rev Immunol 2011 Apr;11(4):264-74

Toronto Platelet Immunobiology Group, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8.

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http://dx.doi.org/10.1038/nri2956DOI Listing
April 2011

Clinical relevance of microparticles from platelets and megakaryocytes.

Curr Opin Hematol 2010 Nov;17(6):578-84

Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1097/MOH.0b013e32833e77eeDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082287PMC
November 2010

Platelet- and megakaryocyte-derived microparticles.

Semin Thromb Hemost 2010 Nov 3;36(8):881-7. Epub 2010 Nov 3.

Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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https://www.thieme-connect.com/products/ejournals/pdf/10.105
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http://pdfs.journals.lww.com/aidsonline/2003/01030/Platelet_
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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0030-1267042
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http://dx.doi.org/10.1055/s-0030-1267042DOI Listing
November 2010

Serum response factor is an essential transcription factor in megakaryocytic maturation.

Blood 2010 Sep 4;116(11):1942-50. Epub 2010 Jun 4.

Department of Internal Medicine and Yale Cancer Center, Section of Hematology, 333 Cedar Street, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1182/blood-2010-01-261743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173990PMC
September 2010

Normal ranges of angiogenesis regulatory proteins in human platelets.

Am J Hematol 2010 Jul;85(7):487-93

Department of Research and Development, Ortho Clinical Diagnostics, Rochester, New York, USA.

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http://dx.doi.org/10.1002/ajh.21732DOI Listing
July 2010

Platelet formation.

Semin Hematol 2010 Jul;47(3):220-6

Translational Medicine Division, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1053/j.seminhematol.2010.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904625PMC
July 2010

Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis.

Blood 2010 Jun 19;115(22):4605-13. Epub 2010 Jan 19.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2009-09-242065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881490PMC
June 2010

ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells.

J Biol Chem 2008 Oct 25;283(40):27230-8. Epub 2008 Jul 25.

Vascular Biology Program, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M804520200
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http://dx.doi.org/10.1074/jbc.M804520200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555994PMC
October 2008

Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells.

Cell Cycle 2008 Aug 21;7(15):2352-6. Epub 2008 May 21.

Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861775PMC
http://dx.doi.org/10.4161/cc.6325DOI Listing
August 2008

Cytoskeletal mechanisms for platelet production.

Blood Cells Mol Dis 2006 Mar-Apr;36(2):99-103. Epub 2006 Feb 7.

Hematology Division, Brigham and Women's Hospital, 1 Blackfan Circle, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bcmd.2005.12.007DOI Listing
September 2007

Dynamic visualization of thrombopoiesis within bone marrow.

Science 2007 Sep;317(5845):1767-70

Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1146304DOI Listing
September 2007

Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis.

Curr Opin Hematol 2007 Sep;14(5):419-26

Translational Medicine Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1097/MOH.0b013e3282bad151DOI Listing
September 2007

Mechanisms of organelle transport and capture along proplatelets during platelet production.

Blood 2005 Dec 23;106(13):4066-75. Epub 2005 Aug 23.

Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2005-06-2206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895242PMC
December 2005

Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes.

Blood 2005 Dec 23;106(13):4076-85. Epub 2005 Aug 23.

Division of Hematology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-06-22
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http://dx.doi.org/10.1182/blood-2005-06-2204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895246PMC
December 2005

The biogenesis of platelets from megakaryocyte proplatelets.

J Clin Invest 2005 Dec;115(12):3348-54

Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI26891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297261PMC
December 2005

A role for Rab27b in NF-E2-dependent pathways of platelet formation.

Blood 2003 Dec 7;102(12):3970-9. Epub 2003 Aug 7.

Dana-Farber Cancer Institute, One Jimmy Fund Way, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2003-03-0977DOI Listing
December 2003

Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change.

Am J Physiol Cell Physiol 2003 Oct 4;285(4):C797-805. Epub 2003 Jun 4.

Division of Hematology, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1152/ajpcell.00165.2003DOI Listing
October 2003

Mechanisms and implications of platelet discoid shape.

Blood 2003 Jun 13;101(12):4789-96. Epub 2003 Feb 13.

Division of Hematology and Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://www.bloodjournal.org/content/101/12/4789.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-11-34
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http://dx.doi.org/10.1182/blood-2002-11-3491DOI Listing
June 2003

Alpha-adducin dissociates from F-actin and spectrin during platelet activation.

J Cell Biol 2003 May;161(3):557-70

Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.200211122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172952PMC
May 2003

Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.

Proc Natl Acad Sci U S A 2002 Dec 3;99(26):16782-7. Epub 2002 Dec 3.

Division of Hematology, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 221 Longwood Avenue, LMRC 301, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.222652499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139221PMC
December 2002