Publications by authors named "Joseph Ciccolini"

100Publications

Like a Rolling Stone: Sting-Cgas Pathway and Cell-Free DNA as Biomarkers for Combinatorial Immunotherapy.

Pharmaceutics 2020 Aug 11;12(8). Epub 2020 Aug 11.

SMARTc Unit, CRCM Inserm U1068, Aix Marseille University, 13007 Marseille, France.

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http://dx.doi.org/10.3390/pharmaceutics12080758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464249PMC
August 2020

Towards Rational Cancer Therapeutics: Optimizing Dosing, Delivery, Scheduling, and Combinations.

Clin Pharmacol Ther 2020 Jun 18. Epub 2020 Jun 18.

SMARTc Unit, CRCM Inserm U1068, Aix Marseille Univ and APHM, Marseille, France.

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http://dx.doi.org/10.1002/cpt.1954DOI Listing
June 2020

Deciphering the response and resistance to immune-checkpoint inhibitors in lung cancer with artificial intelligence-based analysis: when PIONeeR meets QUANTIC.

Br J Cancer 2020 Aug 16;123(3):337-338. Epub 2020 Jun 16.

Centre de Recherche en Cancérologie de Marseille, Aix-Marseille Université, Inserm U1068, CNRS UMR 7258, Institut Paoli Calmettes, 13009, Marseille, France.

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http://dx.doi.org/10.1038/s41416-020-0918-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403333PMC
August 2020

A Simple and Rapid UPLC-UV Method for Detecting DPD Deficiency in Patients With Cancer.

Clin Transl Sci 2020 Jul 7;13(4):761-768. Epub 2020 Apr 7.

Laboratoire de Pharmacologie et Toxicologie, La Timone University Hospital of Marseille, Assistance Publique Hôpitaux de Marseille, Marseille, France.

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http://dx.doi.org/10.1111/cts.12762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359930PMC
July 2020

Pharmacogenetics and pharmacokinetics modeling of unexpected and extremely severe toxicities after sorafenib intake.

Pharmacogenomics 2020 02;21(3):173-179

Medical Oncology Unit, La Timone University Hospital of Marseille Assistance Publique Hôpitaux de Marseille, Marseille, France.

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http://dx.doi.org/10.2217/pgs-2019-0127DOI Listing
February 2020

A simple and rapid liquid chromatography-mass spectrometry method to assay cabozantinib in plasma: Application to therapeutic drug monitoring in patients with renal cell carcinoma.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Feb 7;1138:121968. Epub 2020 Jan 7.

SMARTc Unit, Centre de Recherche en Cancérologie de Marseille, Inserm U1068, Aix Marseille Université, Marseille, France; Laboratoire de Pharmacocinétique et Toxicologie, La Timone University Hospital of Marseille, Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2020.121968DOI Listing
February 2020

Simultaneous determination of cytosine arabinoside and its metabolite uracil arabinoside in human plasma by LC-MS/MS: Application to pharmacokinetics-pharmacogenetics pilot study in AML patients.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Sep 19;1126-1127:121770. Epub 2019 Aug 19.

SMARTc: Simulation & Modeling: Adaptative Response for Therapeutics in Cancer, CRCM Inserm UMR 1068 CNRS Faculté de Pharmacie de Marseille, 27 boulevard Jean-Moulin, 13385 Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2019.121770DOI Listing
September 2019

Is There Any Room for Pharmacometrics With Immuno-Oncology Drugs? Input from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology.

Anticancer Res 2019 Jul;39(7):3419-3422

SMARTc Unit, CRCM, Inserm UMR1068, CNRS UMR7258, Aix-Marseille University, Marseille, France

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http://dx.doi.org/10.21873/anticanres.13486DOI Listing
July 2019

Pharmacodynamic Therapeutic Drug Monitoring for Cancer: Challenges, Advances, and Future Opportunities.

Ther Drug Monit 2019 04;41(2):142-159

Institut Claudius-Regaud and Cancer Research Center of Toulouse, Inserm U1037, Université Paul Sabatier, Toulouse, France.

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http://dx.doi.org/10.1097/FTD.0000000000000606DOI Listing
April 2019

Can cytidine deaminase be used as predictive biomarker for gemcitabine toxicity and response?

Br J Clin Pharmacol 2019 06 23;85(6):1213-1214. Epub 2019 Apr 23.

SMARTc Unit, CRCM Inserm U1068 Aix Marseille Université, and La Timone University Hospital of Marseille, Marseille, France.

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http://dx.doi.org/10.1111/bcp.13921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533421PMC
June 2019

Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors.

Clin Pharmacokinet 2019 07;58(7):835-857

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://link.springer.com/10.1007/s40262-019-00748-2
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http://dx.doi.org/10.1007/s40262-019-00748-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584248PMC
July 2019

From 3D spheroids to tumor bearing mice: efficacy and distribution studies of trastuzumab-docetaxel immunoliposome in breast cancer.

Int J Nanomedicine 2018 23;13:6677-6688. Epub 2018 Oct 23.

SMARTc Unit, Laboratory of Pharmacokinetics and Toxicology UFR Pharmacy, Center for Research on Cancer of Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille University, Marseille, France,

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http://dx.doi.org/10.2147/IJN.S179290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204867PMC
December 2018

Turning cold tumors into hot tumors: harnessing the potential of tumor immunity using nanoparticles.

Expert Opin Drug Metab Toxicol 2018 Nov 29;14(11):1139-1147. Epub 2018 Oct 29.

a SMARTc Unit, Centre de Recherche en Cancérologie de Marseille UMR Inserm U1068 , Aix Marseille University , Marseille , France.

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https://www.tandfonline.com/doi/full/10.1080/17425255.2018.1
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http://dx.doi.org/10.1080/17425255.2018.1540588DOI Listing
November 2018

[5-fluorouracil therapeutic drug monitoring: Update and recommendations of the STP-PT group of the SFPT and the GPCO-Unicancer].

Bull Cancer 2018 Sep 10;105(9):790-803. Epub 2018 Aug 10.

Centre Georges-François-Leclerc, service pharmacie, 1, rue Pr.-Marion, 21000 Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/j.bulcan.2018.06.008DOI Listing
September 2018

Pharmacokinetics variability: Why nanoparticles are not just magic-bullets in oncology.

Crit Rev Oncol Hematol 2018 Sep 19;129:1-12. Epub 2018 Jun 19.

SMARTc unit, Center for Research on Cancer of Marseille (CRCM): UMR Inserm 1068, CNRS UMR 7258, Aix Marseille Université, Marseille, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10408428183016
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http://dx.doi.org/10.1016/j.critrevonc.2018.06.008DOI Listing
September 2018

Seek and destroy: improving PK/PD profiles of anticancer agents with nanoparticles.

Expert Rev Clin Pharmacol 2018 Jun 24;11(6):599-610. Epub 2018 May 24.

a SMARTc Unit, Pharmacokinetics Laboratory, Inserm UMR U1068 Centre de Recherche en Cancérologie de Marseille , Aix-Marseille Universite , Marseille , France.

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http://dx.doi.org/10.1080/17512433.2018.1477586DOI Listing
June 2018

Drug repurposing in malignant pleural mesothelioma: a breath of fresh air?

Eur Respir Rev 2018 Mar 14;27(147). Epub 2018 Mar 14.

Aix Marseille University, Assistance Publique Hôpitaux de Marseille, Multidisciplinary Oncology and Therapeutic Innovations Dept, Marseille, France

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http://dx.doi.org/10.1183/16000617.0098-2017DOI Listing
March 2018

PRIMUM NON NOCERE: now and again an echo of DPD with capecitabine.

Cancer Chemother Pharmacol 2017 12 13;80(6):1265-1266. Epub 2017 Oct 13.

Oncopharmacology Unit, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06102, Nice cedex, France.

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http://dx.doi.org/10.1007/s00280-017-3437-zDOI Listing
December 2017

Population Pharmacokinetics of Gemcitabine and dFdU in Pancreatic Cancer Patients Using an Optimal Design, Sparse Sampling Approach.

Ther Drug Monit 2017 06;39(3):290-296

*SMARTc, CRO2, UMR S_911, Aix-Marseille Université, Marseille, France; †IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, ICM, Université de Montpellier, Montpellier, France; ‡Digestive Oncology Unit, La Timone Hospital, AP-HM, Aix-Marseille Université, Marseille, France; §Gastroenterology Department, CHRU Besançon, Besançon, France; ¶Digestive Pathologies Department, CHU Clermont-Ferrand, Clermont-Ferrand, France; ‖Pôle de Médecine, Centre Antoine Lacassagne, Nice, France; **Institut Arnault Tzanck, Saint Laurent du Var, France; and ††Service Interdisciplinaire de Cancérologie, Riviera-Chablais Hospital, Vevey, Switzerland.

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http://dx.doi.org/10.1097/FTD.0000000000000399DOI Listing
June 2017

Dose Effect of Rhenium (I)-diselenoether as Anticancer Drug in Resistant Breast Tumor-bearing Mice After Repeated Administrations.

Anticancer Res 2016 11;36(11):6051-6057

UMR CNRS 8612, Galien Institute, Faculty of Pharmacy, University Paris-Saclay, Châtenay-Malabry, France.

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http://dx.doi.org/10.21873/anticanres.11194DOI Listing
November 2016

Mathematical Modeling of Cancer Immunotherapy and Its Synergy with Radiotherapy.

Cancer Res 2016 09 14;76(17):4931-40. Epub 2016 Jun 14.

Aix Marseille University, SMARTc Unit, Inserm S 911 CRO2, Marseille, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3567DOI Listing
September 2016

Women at a Disadvantage in Fluorouracil Treatment.

JAMA Oncol 2016 Jun;2(6):829-30

Oncopharmacology Unit, Centre Antoine Lacassagne, Nice, France.

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http://dx.doi.org/10.1001/jamaoncol.2016.1086DOI Listing
June 2016

Nucleoside analogs: ready to enter the era of precision medicine?

Expert Opin Drug Metab Toxicol 2016 Aug 30;12(8):865-77. Epub 2016 May 30.

a SMARTc Unit , Inserm S_911 CRO2 Aix-Marseille University , Marseille , France.

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http://dx.doi.org/10.1080/17425255.2016.1192128DOI Listing
August 2016

Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective.

Cancer Chemother Pharmacol 2016 07 23;78(1):1-12. Epub 2016 Mar 23.

Department of Medical Oncology, VUmc, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00280-016-3003-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921117PMC
July 2016

Monoclonal antibodies for treating gastric cancer: promises and pitfalls.

Expert Opin Biol Ther 2016 06 25;16(6):759-69. Epub 2016 Mar 25.

a Department of Digestive Oncology , Aix-Marseille University - Assistance Publique Hôpitaux de Marseille , Marseille , France.

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http://dx.doi.org/10.1517/14712598.2016.1164137DOI Listing
June 2016

Revisiting Dosing Regimen Using Pharmacokinetic/Pharmacodynamic Mathematical Modeling: Densification and Intensification of Combination Cancer Therapy.

Clin Pharmacokinet 2016 08;55(8):1015-25

Pharmacokinetics Unit, Faculty of Pharmacy, Aix Marseille University, SMARTc, Inserm CRO2 UMR_S 911, 27, bd. Jean Moulin, CS 30064, 13385, Marseille, France.

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http://dx.doi.org/10.1007/s40262-016-0374-7DOI Listing
August 2016

DPD deficiency in patients treated with fluorouracil.

Authors:
Joseph Ciccolini

Lancet Oncol 2015 Dec 23;16(16):1574-6. Epub 2015 Oct 23.

Clinical Pharmacokinetics Laboratory, La Timone University Hospital of Marseille, 13385 Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)00360-5DOI Listing
December 2015

Computational oncology--mathematical modelling of drug regimens for precision medicine.

Nat Rev Clin Oncol 2016 Apr 24;13(4):242-54. Epub 2015 Nov 24.

Aix Marseille Université, INSERM, CRO2 UMR_S 911, Marseille 13005, France.

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http://dx.doi.org/10.1038/nrclinonc.2015.204DOI Listing
April 2016

Yin and yang of cytidine deaminase roles in clinical response to azacitidine in the elderly: a pharmacogenetics tale.

Pharmacogenomics 2015 Nov 10;16(17):1907-12. Epub 2015 Nov 10.

Onco-Hematology Unit, La Conception University Hospital of Marseille, APHM, Marseille, France.

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http://dx.doi.org/10.2217/pgs.15.135DOI Listing
November 2015

Metronomic reloaded: Theoretical models bringing chemotherapy into the era of precision medicine.

Semin Cancer Biol 2015 Dec 7;35:53-61. Epub 2015 Sep 7.

Metronomics Global Health Initiative, Marseille, France; INSERM UMR S_911 CRO2, Aix Marseille Univ., Marseille, France; Clinical Pharmacokinetics, La Timone University Hospital of Marseille, Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2015.09.002DOI Listing
December 2015

Improving efficacy of the combination between antiangiogenic and chemotherapy: Time for mathematical modeling support.

Proc Natl Acad Sci U S A 2015 Jul 16;112(27):E3453. Epub 2015 Jun 16.

SMARTc Unit, Pharmacokinetics Laboratory, Inserm S_911 CRO2 Aix Marseille University, and La Timone University Hospital of Marseille, 13000 Marseille, France; Multidisciplinary Oncology and Therapeutic Innovations Unit, Nord University Hospital of Marseille, 13000 Marseille, France

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http://dx.doi.org/10.1073/pnas.1506689112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500227PMC
July 2015

Lethal toxicity after administration of azacytidine: implication of the cytidine deaminase-deficiency syndrome.

Pharmacogenet Genomics 2015 Jun;25(6):317-21

aSMARTc Unit, Pharmacokinetics Laboratory, UMR_911 CRO2 AMU bPharmacy Unit cOnco-Hematology Unit dHematology Laboratory, La Conception University Hospital of Marseille eTransfer Oncology Laboratory, Nord University Hospital of Marseille, APHM, Marseille, France.

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http://dx.doi.org/10.1097/FPC.0000000000000139DOI Listing
June 2015

Ang1 and Tie2 are predictive biomarkers for bevacizumab-letter.

Clin Cancer Res 2015 Feb;21(4):934

Aix Marseille University, Simulation and Modelling, Adaptive Response for Therapeutics in Cancer (SMARTc), Inserm U911 CRO2, Marseille, France. Aix Marseille University, Assistance Publique Hôpitaux de Marseille, Multidisciplinary Oncology and Therapeutic Innovations Department, Marseille, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2832DOI Listing
February 2015

Pharmacogenetics and breast cancer management: current status and perspectives.

Expert Opin Drug Metab Toxicol 2015 May 18;11(5):719-29. Epub 2015 Feb 18.

SMARTc Pharmacokinetics Unit, UMR S_911 CRO2, AMU , Marseille , France.

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http://www.tandfonline.com/doi/full/10.1517/17425255.2015.10
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http://dx.doi.org/10.1517/17425255.2015.1008447DOI Listing
May 2015

Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs.

Expert Opin Drug Metab Toxicol 2015 May 13;11(5):665-72. Epub 2014 Dec 13.

INSERM UMR_S911 Aix-Marseille University, SMARTc, CRO2, Pharmacokinetics Unit , UFR Pharmacie 27 Bd Jean Moulin 13385 Marseille , France

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http://dx.doi.org/10.1517/17425255.2015.985648DOI Listing
May 2015

Trastuzumab-induced cardiotoxicity: is it a personalized risk?

Curr Drug Targets 2014 ;15(13):1200-4

Head Oncopharmacology Unit and EA UNS 3836, Centre Antoine Lacassagne, 33 Av Valombrose, 06189 Nice Cedex 2, France.

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http://dx.doi.org/10.2174/1389450115666141114151911DOI Listing
August 2015

[Clinical application, limits and perspectives of pharmacogenetic and pharmacokinetic analysis of anticancer drugs].

Ann Biol Clin (Paris) 2014 Sep-Oct;72(5):527-42

Service de pharmacocinétique et toxicologie, Laboratoire de biologie médicale, Assistance Publique-Hôpitaux de Marseille (AP-HM), Hôpital de la Timone, Marseille, France.

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http://dx.doi.org/10.1684/abc.2014.0993DOI Listing
November 2015

Metronomics chemotherapy: time for computational decision support.

Cancer Chemother Pharmacol 2014 Sep 1;74(3):647-52. Epub 2014 Aug 1.

SMARTc Pharmacokinetics Unit, School of Pharmacy, Inserm S_911 CRO2 Aix-Marseille University, 27 Bd Jean Moulin, 13385, Marseille 05, France.

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http://dx.doi.org/10.1007/s00280-014-2546-1DOI Listing
September 2014

Recipient/donor contradictory genotypes with impact on drug pharmacogenetics after liver transplant: a deadly gift?

Pharmacogenet Genomics 2014 Oct;24(10):527-9

aTransfert Oncology Unit, Nord Hospital bSurgery Unit, La Timone Hospital cPediatric Oncology Unit, La Timone Hospital dUMR S 911 - CRO2, Aix-Marseille Université, Marseille, France.

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http://dx.doi.org/10.1097/FPC.0000000000000076DOI Listing
October 2014

Biodistribution, tumor uptake and efficacy of 5-FU-loaded liposomes: why size matters.

Pharm Res 2014 Oct 22;31(10):2677-84. Epub 2014 Apr 22.

Pharmacokinetics Unit, UMR S_911, CRO2, Aix Marseille University, Marseille, France,

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http://dx.doi.org/10.1007/s11095-014-1364-9DOI Listing
October 2014

Challenges, expectations and limits for nanoparticles-based therapeutics in cancer: a focus on nano-albumin-bound drugs.

Crit Rev Oncol Hematol 2013 Dec 18;88(3):504-13. Epub 2013 Jul 18.

Hospital Pharmacy Unit, La Conception University Hospital of Marseille, Marseille, France.

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http://dx.doi.org/10.1016/j.critrevonc.2013.06.010DOI Listing
December 2013

Rapid deaminator status is associated with poor clinical outcome in pancreatic cancer patients treated with a gemcitabine-based regimen.

Pharmacogenomics 2013 Jul;14(9):1047-51

Transfer Oncology Laboratory, Nord University Hospital of Marseille, Inserm S_911 CRO2, Aix-Marseille University, Marseille, France.

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http://dx.doi.org/10.2217/pgs.13.93DOI Listing
July 2013

Gender, cytidine deaminase, and 5-aza/decitabine--letter.

Clin Cancer Res 2013 Jun 8;19(11):3105. Epub 2013 May 8.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0483DOI Listing
June 2013

Optimization of trans-Resveratrol bioavailability for human therapy.

Biochimie 2013 Jun 31;95(6):1233-8. Epub 2013 Jan 31.

University Aix Marseille, INRA UMR 1260, 13385 Marseille, France.

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http://dx.doi.org/10.1016/j.biochi.2013.01.008DOI Listing
June 2013

100% human monoclonal antibodies in oncology: hype or breakthrough?

Curr Top Med Chem 2012 ;12(15):1643-8

Laboratoire de Pharmacocinetique - UFR Pharmacie, 27 Bd Jean Moulin, 13385 Marseille, France.

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http://dx.doi.org/10.2174/156802612803531351DOI Listing
April 2013

Optimizing Druggability through Liposomal Formulations: New Approaches to an Old Concept.

ISRN Pharm 2012 9;2012:738432. Epub 2012 Feb 9.

UMR 911 CRO2, Pharmacokinetics Laboratory, Aix-Marseille University, 13385 Marseille, France.

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http://dx.doi.org/10.5402/2012/738432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302123PMC
August 2012

CDA deficiency as a possible culprit for life-threatening toxicities after cytarabine plus 6-mercaptopurine therapy: pharmacogenetic investigations.

Pharmacogenomics 2012 Mar;13(4):393-7

Laboratoire de Pharmacocinétique, La Timone University Hospital of Marseille, UMR 911, Aix-Marseille University, Marseille, France.

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http://dx.doi.org/10.2217/pgs.11.175DOI Listing
March 2012

5-FU-induced neurotoxicity in cancer patients with profound DPD deficiency syndrome: a report of two cases.

Cancer Chemother Pharmacol 2011 Sep 8;68(3):823-6. Epub 2011 May 8.

Hôpital d'Instruction des Armées Laveran, Marseille, France.

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http://dx.doi.org/10.1007/s00280-011-1666-0DOI Listing
September 2011

Integrating pharmacogenetics into gemcitabine dosing--time for a change?

Nat Rev Clin Oncol 2011 02 8;8(7):439-44. Epub 2011 Feb 8.

Pôle Oncologie, La Timone University Hospital of Marseille, 267 Rue St Pierre, 13385 Marseille, France.

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http://dx.doi.org/10.1038/nrclinonc.2011.1DOI Listing
February 2011

Routine dihydropyrimidine dehydrogenase testing for anticipating 5-fluorouracil-related severe toxicities: hype or hope?

Clin Colorectal Cancer 2010 Oct;9(4):224-8

La Timone University Hospital, Marseille, France.

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http://dx.doi.org/10.3816/CCC.2010.n.033DOI Listing
October 2010

Cytotoxic effects of haplamine and its major metabolites on human cancer cell lines.

Planta Med 2008 Aug 29;74(10):1265-8. Epub 2008 Jul 29.

Laboratory of Pharmacokinetics and Toxicokinetics, EA3286, Faculty of Pharmacy, Aix-Marseille University, Marseille, France.

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http://dx.doi.org/10.1055/s-2008-1081298DOI Listing
August 2008

Alpha-hederin potentiates 5-FU antitumor activity in human colon adenocarcinoma cells.

Phytother Res 2008 Oct;22(10):1299-302

Laboratory of Pharmacognosy, UMR-D3, Faculty of Pharmacy, Marseille, France.

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http://dx.doi.org/10.1002/ptr.2483DOI Listing
October 2008

Severe or lethal toxicities upon capecitabine intake: is DPYD genetic polymorphism the ideal culprit?

Trends Pharmacol Sci 2007 Dec 14;28(12):597-8. Epub 2007 Nov 14.

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http://dx.doi.org/10.1016/j.tips.2007.09.009DOI Listing
December 2007