Joseph A Trapani

Joseph A Trapani

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Joseph A Trapani

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Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies.

J Immunol 2020 Apr 9;204(8):2308-2315. Epub 2020 Mar 9.

Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia; and

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http://dx.doi.org/10.4049/jimmunol.1901396DOI Listing
April 2020

Cross-talk between tumors at anatomically distinct sites.

FEBS J 2020 Apr 4. Epub 2020 Apr 4.

Cancer Immunology Program, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/febs.15316DOI Listing
April 2020

Antigen-specific CD4 CD25 T cells induced by locally expressed ICOS-Ig: the role of Foxp3, Perforin, Granzyme B and IL-10 - an experimental study.

Transpl Int 2019 Nov 16;32(11):1203-1215. Epub 2019 Jul 16.

Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Vic., Australia.

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http://dx.doi.org/10.1111/tri.13474DOI Listing
November 2019

Lipid order and charge protect killer T cells from accidental death.

Nat Commun 2019 11 27;10(1):5396. Epub 2019 Nov 27.

Killer Cell Biology Laboratory, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC, 3000, Australia.

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http://dx.doi.org/10.1038/s41467-019-13385-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881447PMC
November 2019

Distinguishing perforin-mediated lysis and granzyme-dependent apoptosis.

Methods Enzymol 2019 21;629:291-306. Epub 2019 Aug 21.

Killer Cell Biology Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2019.07.034DOI Listing
August 2019

Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer.

Cell Death Dis 2018 05 1;9(5):442. Epub 2018 May 1.

Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1038/s41419-018-0470-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906598PMC
May 2018

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation.

EMBO Rep 2017 10 14;18(10):1775-1785. Epub 2017 Aug 14.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia

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http://dx.doi.org/10.15252/embr.201744351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623865PMC
October 2017

Immunotherapy of cancer.

Aust Fam Physician 2017 ;46(4):194-199

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September 2017

Substituted arylsulphonamides as inhibitors of perforin-mediated lysis.

Eur J Med Chem 2017 Sep 26;137:139-155. Epub 2017 May 26.

Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052 Australia.

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http://dx.doi.org/10.1016/j.ejmech.2017.05.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500991PMC
September 2017

Real-time visualization of perforin nanopore assembly.

Nat Nanotechnol 2017 05 6;12(5):467-473. Epub 2017 Feb 6.

London Centre for Nanotechnology, University College London, London WC1H 0AH, UK.

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http://dx.doi.org/10.1038/nnano.2016.303DOI Listing
May 2017

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2 Tumors.

Cancer Res 2017 05 1;77(10):2594-2606. Epub 2017 Mar 1.

Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre (VCCC), Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2247DOI Listing
May 2017

Benzenesulphonamide inhibitors of the cytolytic protein perforin.

Bioorg Med Chem Lett 2017 02 23;27(4):1050-1054. Epub 2016 Dec 23.

Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X163133
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http://dx.doi.org/10.1016/j.bmcl.2016.12.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303009PMC
February 2017

Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition.

Oncoimmunology 2016 Jul 2;5(7):e1179415. Epub 2016 Jun 2.

Cancer Immunology Program, Peter MacCallum Cancer Center , East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1080/2162402X.2016.1179415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006901PMC
July 2016

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.

FEBS J 2016 Mar 22;283(5):947-61. Epub 2016 Jan 22.

Cancer Cell Death/Killer Cell Biology Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/febs.13649DOI Listing
March 2016

Diarylthiophenes as inhibitors of the pore-forming protein perforin.

Bioorg Med Chem Lett 2016 Jan 7;26(2):355-360. Epub 2015 Dec 7.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, A New Zealand Centre for Research Excellence, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706532PMC
January 2016

CAR-T cells are serial killers.

Oncoimmunology 2015 Dec 1;4(12):e1053684. Epub 2015 Jun 1.

Cancer Immunology Research; Peter MacCallum Cancer Center , East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne , Parkville, VIC Australia.

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http://dx.doi.org/10.1080/2162402X.2015.1053684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635863PMC
December 2015

Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.

J Biol Chem 2015 Oct 25;290(42):25213-26. Epub 2015 Aug 25.

From the Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052,

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http://dx.doi.org/10.1074/jbc.M115.668384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646173PMC
October 2015

Perforin-dependent cytotoxicity: 'Kiss of death' or prolonged embrace with darker elocation-idnseque11es?

Oncoimmunology 2015 Sep 14;4(9):e1036215. Epub 2015 Apr 14.

Cancer immunology Program; Peter MacCallum Cancer Centre ; East Melbourne, VIC, Australia.

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http://dx.doi.org/10.1080/2162402X.2015.1036215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570094PMC
September 2015

Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib.

Oncoimmunology 2015 Sep 27;4(9):e1038011. Epub 2015 May 27.

Cancer Immunology Research; Peter MacCallum Cancer Center ; East Melbourne, VIC, Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne ; Parkville, VIC, Australia ; The University of Melbourne ; Parkville, VIC, Australia ; The ACRF Translational Research Laboratory; Royal Melbourne Hospital ; Parkville, VIC, Australia ; Department of Clinical Hematology and Bone Marrow Transplantation; Royal Melbourne Hospital ; Parkville, VIC, Australia.

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http://dx.doi.org/10.1080/2162402X.2015.1038011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570118PMC
September 2015

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals.

Immunol Cell Biol 2015 Jul 17;93(6):575-80. Epub 2015 Mar 17.

1] Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology, Parkville, Victoria, Australia [3] Department of Pathology, University of Melbourne, Parkville, Victoria, Australia [4] Department of Genetics, University of Melbourne, Parkville, Victoria, Australia.

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http://doi.wiley.com/10.1038/icb.2015.1
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http://dx.doi.org/10.1038/icb.2015.1DOI Listing
July 2015

B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis.

Clin Transl Immunology 2015 Jun 26;4(6):e38. Epub 2015 Jun 26.

Cancer Immunology Program, Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre , East Melbourne, Victoria, Australia ; Sir Peter MacCallum Department of Oncology, The University of Melbourne , Parkvillie, Victoria, Australia ; Victorian Comprehensive Cancer Centre , Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/cti.2015.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491623PMC
June 2015

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells.

Cancer Immunol Res 2015 May 24;3(5):483-94. Epub 2015 Feb 24.

Cancer Immunology Research, Peter MacCallum Cancer Center, East Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0048DOI Listing
May 2015

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

J Exp Med 2015 Mar 2;212(3):307-17. Epub 2015 Mar 2.

Cancer Cell Death and Killer Cell Biology Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia The Sir Peter MacCallum Department of Oncology; Department of Genetics; and Department of Medicine, St. Vincent's Hospital; The University of Melbourne, Parkville, Victoria 3010, Australia

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http://dx.doi.org/10.1084/jem.20140964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354371PMC
March 2015

Granzyme H is a novel protease expressed by human mast cells.

Int Arch Allergy Immunol 2014 21;165(1):68-74. Epub 2014 Oct 21.

Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.

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http://dx.doi.org/10.1159/000368403DOI Listing
February 2015

A radio-resistant perforin-expressing lymphoid population controls allogeneic T cell engraftment, activation, and onset of graft-versus-host disease in mice.

Biol Blood Marrow Transplant 2015 Feb 12;21(2):242-9. Epub 2014 Nov 12.

ACRF Translational Research Laboratory, The Department of Research, The Royal Melbourne Hospital, Melbourne, Victoria, Australia; Haematology and Immunology Translational Research Laboratory, Cancer Immunology Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia; Clinical Haematology and Bone Marrow Transplantation Service, Department of Clinical Oncology and Haematology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.bbmt.2014.11.003DOI Listing
February 2015

Conformational changes during pore formation by the perforin-related protein pleurotolysin.

PLoS Biol 2015 Feb 5;13(2):e1002049. Epub 2015 Feb 5.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, Australia; The ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, Australia; Department of Microbiology, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1371/journal.pbio.1002049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318580PMC
February 2015

A method for detecting intracellular perforin in mouse lymphocytes.

J Immunol 2014 Dec 27;193(11):5744-50. Epub 2014 Oct 27.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia; and Department of Genetics, University of Melbourne, Parkville, Victoria 3010, Australia

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http://dx.doi.org/10.4049/jimmunol.1402207DOI Listing
December 2014

A natural genetic variant of granzyme B confers lethality to a common viral infection.

PLoS Pathog 2014 Dec 11;10(12):e1004526. Epub 2014 Dec 11.

Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Western Australia, Australia; Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1004526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263754PMC
December 2014

A colorimetric assay that specifically measures Granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl.

J Vis Exp 2014 Nov 28(93):e52419. Epub 2014 Nov 28.

Cancer Immunology Program, Peter MacCallum Cancer Centre;

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http://dx.doi.org/10.3791/52419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354391PMC
November 2014

TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity.

Immunity 2014 Oct;41(4):646-56

Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, WA 6009, Australia; Centre for Experimental Immunology, Lions Eye Institute, Nedlands, WA 6009, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.09.013DOI Listing
October 2014

B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21.

Int Immunol 2014 Jul 4;26(7):383-95. Epub 2014 Feb 4.

Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service Baden-Württemberg - Hessen and Institute of Transfusion Medicine,

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http://dx.doi.org/10.1093/intimm/dxu001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133571PMC
July 2014

Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function.

Front Immunol 2013 Dec 12;4:441. Epub 2013 Dec 12.

Sir Peter MacCallum Department of Oncology, The University of Melbourne , Melbourne, VIC , Australia ; Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre , East Melbourne, VIC , Australia.

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http://dx.doi.org/10.3389/fimmu.2013.00441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860100PMC
December 2013

Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia.

Mol Ther 2013 Nov 8;21(11):2122-9. Epub 2013 Jul 8.

1] Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia [2] Hematology Immunology Translational Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia [3] Cancer Immunology Research Program, Peter MacCallum Cancer Centre, East Melbourne, Australia [4] Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Australia [5] Centre for Blood Cell Therapies, Peter MacCallum Cancer Centre, East Melbourne, Australia.

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http://dx.doi.org/10.1038/mt.2013.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831035PMC
November 2013

Cloning and characterising an unusual perforin from chicken (Gallus gallus).

Dev Comp Immunol 2013 Oct 13;41(2):105-9. Epub 2013 May 13.

Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia.

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http://dx.doi.org/10.1016/j.dci.2013.05.003DOI Listing
October 2013

Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

J Immunol 2013 Sep 24;191(5):2328-34. Epub 2013 Jul 24.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.4049/jimmunol.1301205DOI Listing
September 2013

Human perforin mutations and susceptibility to multiple primary cancers.

Oncoimmunology 2013 Apr;2(4):e24185

Cancer Immunology Program; Peter MacCallum Cancer Institute; East Melbourne, VIC Australia; and Sir Peter MacCallum Department of Oncology; The University of Melbourne; Melbourne, VIC Australia ; Research Division; Peter MacCallum Cancer Centre; East Melbourne, VIC Australia.

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http://dx.doi.org/10.4161/onci.24185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654607PMC
April 2013

Surprisingly variable "dangers, toils, and snares" faced by humans and mice.

Blood 2013 Jan;121(4):568-70

Peter MacCallum Cancer Centre.

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http://dx.doi.org/10.1182/blood-2012-11-468652DOI Listing
January 2013

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi.

BMC Evol Biol 2012 May 2;12:59. Epub 2012 May 2.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, VIC, 3800, Australia.

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http://dx.doi.org/10.1186/1471-2148-12-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477005PMC
May 2012

Activated mouse B cells lack expression of granzyme B.

J Immunol 2012 Apr 16;188(8):3886-92. Epub 2012 Mar 16.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.4049/jimmunol.1103285DOI Listing
April 2012

A novel role for granzymes in anti-tumor immunity.

Oncoimmunology 2012 Mar;1(2):219-221

Ludwig Maximilian University of Munich; Division of Clinical Pharmacology and Medical Clinic; Munich, Germany.

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http://www.tandfonline.com/doi/full/10.4161/onci.1.2.18102
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http://dx.doi.org/10.4161/onci.1.2.18102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377003PMC
March 2012

Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin.

Blood 2012 Feb 20;119(7):1713-6. Epub 2011 Dec 20.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1182/blood-2011-08-374355DOI Listing
February 2012

Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones.

Bioorg Med Chem 2012 Feb 22;20(3):1319-36. Epub 2011 Dec 22.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

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http://dx.doi.org/10.1016/j.bmc.2011.12.011DOI Listing
February 2012

Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin.

Immunol Cell Biol 2011 Aug 25;89(6):739-46. Epub 2011 Jan 25.

Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/icb.2010.168DOI Listing
August 2011

Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles.

Bioorg Med Chem 2011 Jul 18;19(13):4091-100. Epub 2011 May 18.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1016/j.bmc.2011.05.013DOI Listing
July 2011

Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function.

Immunol Cell Biol 2011 May 26;89(4):540-8. Epub 2010 Oct 26.

Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1038/icb.2010.115DOI Listing
May 2011

The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy.

Blood 2011 Feb 26;117(5):1605-13. Epub 2010 Oct 26.

Hematology Immunology Translational Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia.

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http://dx.doi.org/10.1182/blood-2010-04-278432DOI Listing
February 2011

Tumor ablation by gene-modified T cells in the absence of autoimmunity.

Cancer Res 2010 Dec 23;70(23):9591-8. Epub 2010 Nov 23.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2884DOI Listing
December 2010

A role for granzyme M in TLR4-driven inflammation and endotoxicosis.

J Immunol 2010 Aug 28;185(3):1794-803. Epub 2010 Jun 28.

Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, 8006, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.4049/jimmunol.1000430DOI Listing
August 2010

Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining.

Biol Chem 2010 Aug;391(8):873-9

Peter MacCallum Cancer Centre, Melbourne, Australia.

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https://www.degruyter.com/view/j/bchm.2010.391.issue-8/bc.20
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http://dx.doi.org/10.1515/BC.2010.088DOI Listing
August 2010

Cathepsin H is an additional convertase of pro-granzyme B.

J Biol Chem 2010 Jul 30;285(27):20514-9. Epub 2010 Apr 30.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800 Victoria, Australia.

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http://dx.doi.org/10.1074/jbc.M109.094573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898313PMC
July 2010

Perforin: structure, function, and role in human immunopathology.

Immunol Rev 2010 May;235(1):35-54

Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Vic. 8006, Australia.

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http://dx.doi.org/10.1111/j.0105-2896.2010.00896.xDOI Listing
May 2010

Functional dissection of the granzyme family: cell death and inflammation.

Immunol Rev 2010 May;235(1):73-92

Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Vic., Australia.

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http://dx.doi.org/10.1111/j.0105-2896.2010.00907.xDOI Listing
May 2010

The battlefield of perforin/granzyme cell death pathways.

J Leukoc Biol 2010 Feb 13;87(2):237-43. Epub 2009 Nov 13.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1189/jlb.0909608DOI Listing
February 2010

Incentives: encouraging adventurous ideas.

Science 2010 Jan;327(5962):145

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http://dx.doi.org/10.1126/science.327.5962.145-aDOI Listing
January 2010

Endolysosomal proteases and their inhibitors in immunity.

Nat Rev Immunol 2009 Dec;9(12):871-82

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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http://dx.doi.org/10.1038/nri2671DOI Listing
December 2009

Proteolytic activation of the cytotoxic phenotype during human NK cell development.

J Immunol 2009 Jul 1;183(2):803-13. Epub 2009 Jul 1.

Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, University of Leeds, St. James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.0713829DOI Listing
July 2009

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer.

Proc Natl Acad Sci U S A 2009 Jun 1;106(24):9809-14. Epub 2009 Jun 1.

Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1073/pnas.0903815106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701033PMC
June 2009

The molecular basis for perforin oligomerization and transmembrane pore assembly.

Immunity 2009 May 14;30(5):684-95. Epub 2009 May 14.

Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1016/j.immuni.2009.03.016DOI Listing
May 2009

Perforin-mediated suppression of B-cell lymphoma.

Proc Natl Acad Sci U S A 2009 Feb 5;106(8):2723-8. Epub 2009 Feb 5.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1073/pnas.0809008106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650333PMC
February 2009

Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin.

J Med Chem 2008 Dec;51(23):7614-24

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

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http://dx.doi.org/10.1021/jm801063nDOI Listing
December 2008

A renaissance in understanding the multiple and diverse functions of granzymes?

Immunity 2008 Nov;29(5):665-7

Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1016/j.immuni.2008.10.002DOI Listing
November 2008

The MACPF/CDC family of pore-forming toxins.

Cell Microbiol 2008 Sep 28;10(9):1765-74. Epub 2008 Jun 28.

Department of Biochemistry, Monash University, Clayton, Victoria 3800, Australia.

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http://dx.doi.org/10.1111/j.1462-5822.2008.01191.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654483PMC
September 2008

Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice.

Viral Immunol 2008 Sep;21(3):341-6

Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1089/vim.2008.0036DOI Listing
September 2008

Cloning and characterisation of Ifi206: a new murine HIN-200 family member.

J Cell Biochem 2008 Mar;103(4):1270-82

Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/jcb.21512DOI Listing
March 2008

Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules.

Methods 2008 Mar;44(3):241-9

Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, Vic. 8006, Australia.

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http://dx.doi.org/10.1016/j.ymeth.2007.11.011DOI Listing
March 2008

The role of p202 in regulating hematopoietic cell proliferation and differentiation.

J Interferon Cytokine Res 2008 Jan;28(1):5-11

Gene Regulation Laboratory, Peter MacCallum Cancer Centre, East Melbourne VIC 3002, Australia.

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http://dx.doi.org/10.1089/jir.2007.0070DOI Listing
January 2008

Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells.

Cancer Res 2007 Dec;67(23):11428-37

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1141DOI Listing
December 2007