Joseph A Mindell

Joseph A Mindell

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Joseph A Mindell

Joseph A Mindell

Publications by authors named "Joseph A Mindell"

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Characterizing chloride-dependent acidification in brain clathrin-coated vesicles .

Biochem Cell Biol 2019 06 1;97(3):315-324. Epub 2018 Nov 1.

Membrane Transport Biophysics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.nrcresearchpress.com/doi/10.1139/bcb-2018-0142
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http://dx.doi.org/10.1139/bcb-2018-0142DOI Listing
June 2019

Lysosomal Storage and Albinism Due to Effects of a De Novo CLCN7 Variant on Lysosomal Acidification.

Am J Hum Genet 2019 Jun 30;104(6):1127-1138. Epub 2019 May 30.

Undiagnosed Diseases Program, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Common Fund, Office of the Director, NIH, Bethesda, MD 20892, USA; Human Biochemical Genetics Section, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA; Office of the Clinical Director, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562152PMC
June 2019

Pinning Down the Mechanism of Transport: Probing the Structure and Function of Transporters Using Cysteine Cross-Linking and Site-Specific Labeling.

Methods Enzymol 2017 24;594:165-202. Epub 2017 Jul 24.

Membrane Transport Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.1016/bs.mie.2017.05.012DOI Listing
January 2018

The prokaryotic Na/Ca exchanger NCX_Mj transports Na and Ca in a 3:1 stoichiometry.

J Gen Physiol 2018 01 13;150(1):51-65. Epub 2017 Dec 13.

Membrane Transport Biophysics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD

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http://www.jgp.org/lookup/doi/10.1085/jgp.201711897
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http://dx.doi.org/10.1085/jgp.201711897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749117PMC
January 2018

A general method for determining secondary active transporter substrate stoichiometry.

Elife 2017 01 25;6. Epub 2017 Jan 25.

Membrane Transport Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.

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http://dx.doi.org/10.7554/eLife.21016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305207PMC
January 2017

A mathematical model of osteoclast acidification during bone resorption.

Bone 2016 12 17;93:167-180. Epub 2016 Sep 17.

Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077641PMC
http://dx.doi.org/10.1016/j.bone.2016.09.007DOI Listing
December 2016

The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism.

Nat Struct Mol Biol 2016 Mar 1;23(3):256-63. Epub 2016 Feb 1.

Membrane Transport Biophysics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/nsmb.3166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215794PMC
March 2016

Family resemblances: A common fold for some dimeric ion-coupled secondary transporters.

J Gen Physiol 2015 Nov;146(5):423-34

Computational Structural Biology Unit and Membrane Transport Biophysics Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824

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http://jgp.rupress.org/content/146/5/423.full.pdf
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http://www.jgp.org/lookup/doi/10.1085/jgp.201511481
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http://dx.doi.org/10.1085/jgp.201511481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621753PMC
November 2015

Thermodynamic evidence for a dual transport mechanism in a POT peptide transporter.

Elife 2014 Dec 2;3. Epub 2014 Dec 2.

Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.7554/eLife.04273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271188PMC
December 2014

Functional characterization of a Na+-dependent dicarboxylate transporter from Vibrio cholerae.

J Gen Physiol 2014 Jun 12;143(6):745-59. Epub 2014 May 12.

Membrane Transport Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892

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http://dx.doi.org/10.1085/jgp.201311141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035743PMC
June 2014

Cell biology. A SWELL channel indeed.

Authors:
Joseph A Mindell

Science 2014 May;344(6184):585-6

Membrane Transport Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/science.1254591DOI Listing
May 2014

Mechanism of transport modulation by an extracellular loop in an archaeal excitatory amino acid transporter (EAAT) homolog.

J Biol Chem 2013 Dec 23;288(49):35266-76. Epub 2013 Oct 23.

From the Membrane Transport Biophysics Section, Porter Neuroscience Research Center, NINDS, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1074/jbc.M113.508408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853275PMC
December 2013

A model of lysosomal pH regulation.

J Gen Physiol 2013 Jun;141(6):705-20

Department of History and Philosophy of Science, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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http://dx.doi.org/10.1085/jgp.201210930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664703PMC
June 2013

Three-Dimensional Spot Detection in Ratiometric Fluorescence Imaging For Measurement of Subcellular Organelles.

ACM Conf Bioinform Comput Biol Biomed Inform (2013) 2013;2013:722

Membrane Transport Biophysics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1145/2506583.2512387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300956PMC
January 2013

Lysosomal acidification mechanisms.

Authors:
Joseph A Mindell

Annu Rev Physiol 2012 ;74:69-86

Membrane Transport Biophysics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1146/annurev-physiol-012110-142317DOI Listing
June 2012

Structural biology. The Tao of chloride transporter structure.

Authors:
Joseph A Mindell

Science 2010 Oct;330(6004):601-2

Membrane Transport Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/science.1198306DOI Listing
October 2010

Bacterial Ion Channels.

EcoSal Plus 2010 Sep;4(1)

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http://dx.doi.org/10.1128/ecosalplus.3.3.2DOI Listing
September 2010

The 3-4 loop of an archaeal glutamate transporter homolog experiences ligand-induced structural changes and is essential for transport.

Proc Natl Acad Sci U S A 2010 Jul 6;107(29):12840-5. Epub 2010 Jul 6.

Membrane Transport Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1003046107
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http://dx.doi.org/10.1073/pnas.1003046107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919967PMC
July 2010

Structural biology: Molecular coin slots for urea.

Nature 2009 Dec;462(7274):733-4

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http://dx.doi.org/10.1038/462733aDOI Listing
December 2009

Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii.

J Biol Chem 2009 Jun 20;284(26):17540-8. Epub 2009 Apr 20.

Membrane Transport Biophysics Unit, Porter Neuroscience Center, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.005926
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http://dx.doi.org/10.1074/jbc.M109.005926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719393PMC
June 2009

Insights into the ClC-4 transport mechanism from studies of Zn2+ inhibition.

Biophys J 2008 Nov 25;95(10):4668-75. Epub 2008 Jul 25.

Membrane Transport Biophysics Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1529/biophysj.108.137158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576391PMC
November 2008

The twain shall meet: channels, transporters and things between. Meeting on Membrane Transport in Flux: the Ambiguous Interface Between Channels and Pumps.

EMBO Rep 2008 Oct 5;9(10):960-5. Epub 2008 Sep 5.

Department of Medical Biochemistry, Semmelweis University, Puskin u. 9, H-1088 Budapest, Hungary.

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http://dx.doi.org/10.1038/embor.2008.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572114PMC
October 2008

The chloride channel's appendix.

Authors:
Joseph A Mindell

Nat Struct Mol Biol 2008 Aug;15(8):781-3

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http://dx.doi.org/10.1038/nsmb0808-781DOI Listing
August 2008

The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes.

Nature 2008 Jun 30;453(7196):788-92. Epub 2008 Apr 30.

Membrane Transport Biophysics Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Building 35, MSC 3701, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature06907DOI Listing
June 2008

The uncoupled chloride conductance of a bacterial glutamate transporter homolog.

Nat Struct Mol Biol 2007 May 15;14(5):365-71. Epub 2007 Apr 15.

Membrane Transport Biophysics Unit, Porter Neuroscience Center, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, 35 Convent Drive, Building 35, MSC 3701, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nsmb1230DOI Listing
May 2007

Site-directed fluorescence studies of a prokaryotic ClC antiporter.

Biochemistry 2006 Jun;45(22):6773-82

Membrane Transport Biophysics Unit, Porter Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/bi0523815DOI Listing
June 2006

Voltage-sensor activation with a tarantula toxin as cargo.

Nature 2005 Aug;436(7052):857-60

Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, MSC 3701 Bethesda, Maryland 20892-3701, USA.

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http://www.nature.com/articles/nature03873
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http://dx.doi.org/10.1038/nature03873DOI Listing
August 2005

Accurate determination of local defocus and specimen tilt in electron microscopy.

J Struct Biol 2003 Jun;142(3):334-47

Membrane Transport Biophysics Unit, National Institute of Neurological Disease and Stroke, National Institutes of Health, 36 Convent Drive, MSC4066, Bethesda, MD 20892-4066, USA.

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June 2003

The poststructural festivities begin.

Neuron 2003 Apr;38(1):1-3

Stanford University, Department of Molecular and Cellular Physiology, B155 Beckman Center, 279 Campus Drive, Stanford, California 94305, USA.

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http://dx.doi.org/10.1016/s0896-6273(03)00204-6DOI Listing
April 2003

Electron diffraction of a bacterial ClC-type chloride channel.

Novartis Found Symp 2002 ;245:193-203; discussion 203-6, 261-4

Rosenteil Basic Medical Science Research Center, W.M. Keck Institute for Cellular Visualization, Brandeis University, Waltham, MA 02478, USA.

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November 2002