Joseph A Loo

Joseph A Loo

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Joseph A Loo

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Time-Dependent Measurement of Nrf2-Regulated Antioxidant Response to Ionizing Radiation Toward Identifying Potential Protein Biomarkers for Acute Radiation Injury.

Proteomics Clin Appl 2019 Nov 4;13(6):e1900035. Epub 2019 Sep 4.

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1002/prca.201900035DOI Listing
November 2019

34 ASMS Asilomar Conference on Quantitative Analysis of Posttranslational Modifications by Mass Spectrometry.

Authors:
Joseph A Loo

J Am Soc Mass Spectrom 2019 Nov 11. Epub 2019 Nov 11.

Department of Chemistry and Biochemistry, Department of Biological Chemistry, David Geffen School of Medicine at UCLA, University of California-Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/s13361-019-02351-yDOI Listing
November 2019

Mass Spectrometry-Based Tissue Imaging of Small Molecules.

Adv Exp Med Biol 2019 ;1140:99-109

Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/978-3-030-15950-4_5DOI Listing
September 2019

The l-isoaspartate modification within protein fragments in the aging lens can promote protein aggregation.

J Biol Chem 2019 Aug 25;294(32):12203-12219. Epub 2019 Jun 25.

Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095

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http://dx.doi.org/10.1074/jbc.RA119.009052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690693PMC
August 2019

Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches.

J Am Soc Mass Spectrom 2019 Jul 9;30(7):1149-1157. Epub 2019 May 9.

Department of Chemistry and Biochemistry, Department of Biological Chemistry, David Geffen School of Medicine, and UCLA/DOE Institute of Genomics and Proteomics, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/s13361-019-02201-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591204PMC
July 2019

Top-Down Protein Identification using a Time-of-Flight Mass Spectrometer and Data Independent Acquisition.

Int J Mass Spectrom 2019 Jan 22;435:136-144. Epub 2018 Oct 22.

Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA 90095.

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http://dx.doi.org/10.1016/j.ijms.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519736PMC
January 2019

Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure.

Mass Spectrom Rev 2018 11 9;37(6):750-771. Epub 2018 Feb 9.

Biomolecular and Analytical Mass Spectrometry Group, Department of Chemistry, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1002/mas.21560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131092PMC
November 2018

Rapid LC-MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins.

Anal Chem 2018 11 31;90(22):13616-13623. Epub 2018 Oct 31.

Amgen Discovery Research , Amgen , Thousand Oaks , California 91320 , United States.

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http://dx.doi.org/10.1021/acs.analchem.8b03843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580849PMC
November 2018

Extracting Charge and Mass Information from Highly Congested Mass Spectra Using Fourier-Domain Harmonics.

J Am Soc Mass Spectrom 2018 Oct 12;29(10):2067-2080. Epub 2018 Jul 12.

Department of Chemistry and Biochemistry, 1253 University of Oregon, Eugene, OR, 97403-1253, USA.

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http://dx.doi.org/10.1007/s13361-018-2018-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330157PMC
October 2018

Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein.

J Am Soc Mass Spectrom 2018 09 27;29(9):1870-1880. Epub 2018 Jun 27.

Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1007/s13361-018-2002-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087494PMC
September 2018

Focus on Application of Photons and Radicals for Mass Spectrometry, Honoring Dr. Ryan Julian, Recipient of the 2017 ASMS Biemann Medal.

Authors:
Joseph A Loo

J Am Soc Mass Spectrom 2018 09;29(9):1757-1759

Department of Chemistry and Biochemistry, Department of Biological Chemistry, University of California-Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/s13361-018-2017-8DOI Listing
September 2018

Protein Labeling via a Specific Lysine-Isopeptide Bond Using the Pilin Polymerizing Sortase from Corynebacterium diphtheriae.

J Am Chem Soc 2018 07 28;140(27):8420-8423. Epub 2018 Jun 28.

Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics and the Molecular Biology Institute , University of California, Los Angeles , Los Angeles , California 90095 , United States.

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http://dx.doi.org/10.1021/jacs.8b05200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230430PMC
July 2018

Enhancing Sensitivity of Liquid Chromatography-Mass Spectrometry of Peptides and Proteins Using Supercharging Agents.

Int J Mass Spectrom 2018 Apr 24;427:157-164. Epub 2017 Dec 24.

Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA 90095.

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https://linkinghub.elsevier.com/retrieve/pii/S13873806173035
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http://dx.doi.org/10.1016/j.ijms.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937529PMC
April 2018

Supramolecular Modulation of Structural Polymorphism in Pathogenic α-Synuclein Fibrils Using Copper(II) Coordination.

Angew Chem Int Ed Engl 2018 03 16;57(12):3099-3103. Epub 2018 Feb 16.

Department of Chemistry, Korea University, Seoul, 02841, Republic of Korea.

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http://dx.doi.org/10.1002/anie.201712286DOI Listing
March 2018

Improving Proteome Coverage and Sample Recovery with Enhanced FASP (eFASP) for Quantitative Proteomic Experiments.

Methods Mol Biol 2017 ;1550:11-18

Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1007/978-1-4939-6747-6_2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205185PMC
February 2018

An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes.

Nat Chem 2018 02 1;10(2):139-148. Epub 2018 Jan 1.

Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/nchem.2908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784781PMC
February 2018

Fixed-Charge Trimethyl Pyrilium Modification for Enabling Enhanced Top-Down Mass Spectrometry Sequencing of Intact Protein Complexes.

Anal Chem 2018 02 2;90(4):2756-2764. Epub 2018 Feb 2.

Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acs.analchem.7b04806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340295PMC
February 2018

Submicrometer Emitter ESI Tips for Native Mass Spectrometry of Membrane Proteins in Ionic and Nonionic Detergents.

J Am Soc Mass Spectrom 2018 01 12;29(1):203-206. Epub 2017 Oct 12.

Department of Chemistry, University of California, Berkeley, CA, 94720-1460, USA.

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http://dx.doi.org/10.1007/s13361-017-1793-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786471PMC
January 2018

Native-MS Analysis of Monoclonal Antibody Conjugates by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.

Anal Chem 2018 01 18;90(1):745-751. Epub 2017 Dec 18.

Department of Chemistry and Biochemistry, and Department of Biological Chemistry, University of California-Los Angeles , Los Angeles, California 90095, United States.

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http://pubs.acs.org/doi/10.1021/acs.analchem.7b03021
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http://dx.doi.org/10.1021/acs.analchem.7b03021DOI Listing
January 2018

To Improve is to Change.

Authors:
Joseph A Loo

J Am Soc Mass Spectrom 2018 01;29(1):1-3

University of California, Los Angeles, CA, Los Angeles, USA.

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http://dx.doi.org/10.1007/s13361-017-1848-zDOI Listing
January 2018

New astroglial injury-defined biomarkers for neurotrauma assessment.

J Cereb Blood Flow Metab 2017 Oct 17;37(10):3278-3299. Epub 2017 Aug 17.

1 Semel Institute for Neuroscience and Human Behavior, 12222 University of California , Los Angeles, CA, USA.

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http://dx.doi.org/10.1177/0271678X17724681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624401PMC
October 2017

Structural Characterization of a Thrombin-Aptamer Complex by High Resolution Native Top-Down Mass Spectrometry.

J Am Soc Mass Spectrom 2017 09 28;28(9):1815-1822. Epub 2017 Jul 28.

Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1007/s13361-017-1751-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711526PMC
September 2017

Top-down/Bottom-up Mass Spectrometry Workflow Using Dissolvable Polyacrylamide Gels.

Anal Chem 2017 08 2;89(16):8244-8250. Epub 2017 Aug 2.

Department of Chemistry and Biochemistry, University of California-Los Angeles , Los Angeles, California 90095, United States.

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http://dx.doi.org/10.1021/acs.analchem.7b00357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590889PMC
August 2017

Keystone predation and molecules of keystone significance.

Ecology 2017 Jun 15;98(6):1710-1721. Epub 2017 May 15.

Department of Chemistry and Biochemistry, University of California, Los Angeles, California, 90095, USA.

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http://dx.doi.org/10.1002/ecy.1849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598783PMC
June 2017

Editorial and Review: 28th ASMS Sanibel Conference on Mass Spectrometry-Characterization of Protein Therapeutics by Mass Spectrometry.

J Am Soc Mass Spectrom 2017 05;28(5):781-785

Department of Chemistry and Biochemistry, Department of Biological Chemistry, David Geffen School of Medicine at UCLA, University of California-Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1007/s13361-017-1629-8DOI Listing
May 2017

Identification of protein targets in cerebral endothelial cells for brain arteriovenous malformation (AVMs) molecular therapies.

Clin Proteomics 2017 16;14:17. Epub 2017 May 16.

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, NSW 2109 Australia.

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http://dx.doi.org/10.1186/s12014-017-9151-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434588PMC
May 2017

Structural Characterization of Native Proteins and Protein Complexes by Electron Ionization Dissociation-Mass Spectrometry.

Anal Chem 2017 03 22;89(5):2731-2738. Epub 2017 Feb 22.

Department of Biological Chemistry, David Geffen School of Medicine, University of California , Los Angeles, California 90095, United States.

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http://dx.doi.org/10.1021/acs.analchem.6b02377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495147PMC
March 2017

Editorial and Review: 31 ASMS Asilomar Conference on Native Mass Spectrometry-Based Structural Biology.

J Am Soc Mass Spectrom 2017 01;28(1):1-4

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s13361-016-1540-8DOI Listing
January 2017

Native MS Analysis of Bacteriorhodopsin and an Empty Nanodisc by Orthogonal Acceleration Time-of-Flight, Orbitrap and Ion Cyclotron Resonance.

Anal Chem 2016 12 1;88(24):12427-12436. Epub 2016 Dec 1.

Department of Chemistry and Biochemistry, and Department of Biological Chemistry, University of California-Los Angeles , Los Angeles, California 90095, United States.

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http://dx.doi.org/10.1021/acs.analchem.6b03762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505737PMC
December 2016

MULTIFUNCin: A Multifunctional Protein Cue Induces Habitat Selection by, and Predation on, Barnacles.

Integr Comp Biol 2016 11 1;56(5):901-913. Epub 2016 Jul 1.

*Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, USA

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http://dx.doi.org/10.1093/icb/icw076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455042PMC
November 2016

Focus on Bioinformatics, Software, and MS-Based "Omics," Honoring Dr. Michael J. MacCoss, Recipient of the 2015 ASMS Biemann Medal.

J Am Soc Mass Spectrom 2016 11;27(11):1715-1718

Chemical Physiology and Molecular and Cellular Neurobiology, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/s13361-016-1502-1DOI Listing
November 2016

A multifunctional chemical cue drives opposing demographic processes and structures ecological communities.

Ecology 2016 Sep;97(9):2232-2239

Department of Chemistry and Biochemistry, University of California, Los Angeles, California, 90095, USA.

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http://dx.doi.org/10.1002/ecy.1455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116919PMC
September 2016

Combining high-throughput MALDI-TOF mass spectrometry and isoelectric focusing gel electrophoresis for virtual 2D gel-based proteomics.

Methods 2016 07 28;104:163-9. Epub 2016 Jan 28.

Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; DOE/UCLA Institute of Genomics and Proteomics and UCLA Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2016.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930893PMC
July 2016

Salt Bridge Rearrangement (SaBRe) Explains the Dissociation Behavior of Noncovalent Complexes.

J Am Soc Mass Spectrom 2016 06 6;27(6):975-90. Epub 2016 Apr 6.

Department of Biological Chemistry, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1007/s13361-016-1375-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865452PMC
June 2016

Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival.

Glia 2016 May 19;64(5):668-94. Epub 2015 Dec 19.

Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1002/glia.22953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805454PMC
May 2016

Outstanding JASMS Manuscript Reviewers, 2014-2015.

J Am Soc Mass Spectrom 2016 Apr;27(4):565

Washington University, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1007/s13361-016-1352-xDOI Listing
April 2016

Fibroblast growth factor 2 dimer with superagonist in vitro activity improves granulation tissue formation during wound healing.

Biomaterials 2016 Mar 15;81:157-168. Epub 2015 Dec 15.

Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive South, Los Angeles, CA 90095-1569, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715972PMC
March 2016

Focus on Mass Spectrometry-Based Strategies for Neuroproteomics and Peptidomics, Honoring Dr. Lingjun Li, Recipient of the 2014 ASMS Biemann Medal.

Authors:
Joseph A Loo

J Am Soc Mass Spectrom 2015 Dec;26(12):1967-9

Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/s13361-015-1281-0DOI Listing
December 2015

Enhancing Performance of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry Using Trap and Capillary Columns.

Int J Mass Spectrom 2015 Dec;392:73-79

Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Edison Biotechnology Institute, Ohio University, Athens, OH, 45701, USA.

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http://dx.doi.org/10.1016/j.ijms.2015.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878830PMC
December 2015

Native top-down mass spectrometry for the structural characterization of human hemoglobin.

Eur J Mass Spectrom (Chichester) 2015 ;21(3):221-31

De partment of Chemistry and Biochemistry, Department of Biological Chemistry, David Geffen School of Medicine, UCLA/DOE Institute of Genomics and Proteomics, University of California, Los Angeles, California, 90095, United States.

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http://dx.doi.org/10.1255/ejms.1340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731028PMC
November 2015

Integration of electrochemistry with ultra-performance liquid chromatography/mass spectrometry.

Eur J Mass Spectrom (Chichester) 2015 ;21(3):341-51

Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Edison Biotechnology Institute, Ohio University, Athens, OH, 45701 USA.

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https://www.impublications.com/subs/ejms/v21/E21_0341.pdf
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http://www.impublications.com/content/abstract?code=E21_0341
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http://dx.doi.org/10.1255/ejms.1318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552337PMC
November 2015

Enhancing Protein Disulfide Bond Cleavage by UV Excitation and Electron Capture Dissociation for Top-Down Mass Spectrometry.

Int J Mass Spectrom 2015 Nov 23;390:137-145. Epub 2015 Jul 23.

Department of Chemistry and Biochemistry, University of California-Los Angeles Los Angeles, CA 90095 ; Department of Biological Chemistry, University of California-Los Angeles Los Angeles, CA 90095 ; UCLA/DOE Institute of Genomics and Proteomics, University of California-Los Angeles Los Angeles, CA 90095.

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http://dx.doi.org/10.1016/j.ijms.2015.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669582PMC
November 2015

Investigation of the Mechanism of Electron Capture and Electron Transfer Dissociation of Peptides with a Covalently Attached Free Radical Hydrogen Atom Scavenger.

Int J Mass Spectrom 2015 Nov 29;390:49-55. Epub 2015 Jul 29.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125.

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http://dx.doi.org/10.1016/j.ijms.2015.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892187PMC
November 2015

Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.

Science 2015 Oct 15;350(6260):aab4070. Epub 2015 Oct 15.

Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. California Nanosystems Institute, UCLA, Los Angeles, CA 90095, USA. UCLA-U.S. Department of Energy (DOE) Institute of Genomics and Proteomics, UCLA, Los Angeles, CA 90095, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.aab4070
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http://dx.doi.org/10.1126/science.aab4070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687456PMC
October 2015

Drug affinity responsive target stability (DARTS) for small-molecule target identification.

Methods Mol Biol 2015 ;1263:287-98

Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/978-1-4939-2269-7_22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442491PMC
September 2015

Significance of filamin A in mTORC2 function in glioblastoma.

Mol Cancer 2015 Jul 2;14:127. Epub 2015 Jul 2.

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1186/s12943-015-0396-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489161PMC
July 2015

Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly.

Proc Natl Acad Sci U S A 2015 Jun 8;112(25):E3179-88. Epub 2015 Jun 8.

Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; Molecular Biology Institute, University of California, Los Angeles, CA 90095

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http://dx.doi.org/10.1073/pnas.1422363112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485115PMC
June 2015

Outstanding JASMS manuscript reviewers, 2013-2014.

J Am Soc Mass Spectrom 2015 May;26(5):699-700

University of California, Los Angeles, Los Angeles, CA, USA,

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http://link.springer.com/content/pdf/10.1007%2Fs13361-015-11
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http://link.springer.com/10.1007/s13361-015-1106-1
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http://dx.doi.org/10.1007/s13361-015-1106-1DOI Listing
May 2015

Mining proteomic data to expose protein modifications in Methanosarcina mazei strain Gö1.

Front Microbiol 2015 5;6:149. Epub 2015 Mar 5.

Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA ; UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles Los Angeles, CA, USA.

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http://journal.frontiersin.org/Article/10.3389/fmicb.2015.00
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http://dx.doi.org/10.3389/fmicb.2015.00149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350412PMC
March 2015

Surface induced dissociation yields substructure of 20S proteasome complexes.

Int J Mass Spectrom 2015 Feb;377:201-204

Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441206PMC
http://dx.doi.org/10.1016/j.ijms.2014.09.011DOI Listing
February 2015

Increasing Fragmentation of Disulfide-Bonded Proteins for Top-Down Mass Spectrometry by Supercharging.

Int J Mass Spectrom 2015 Feb;377:546-556

Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California, 90095, United States ; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, University of California-Los Angeles, Los Angeles, California, 90095, United States ; UCLA/DOE Institute for Genomics and Proteomics, University of California-Los Angeles, Los Angeles, California, 90095, United States.

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http://dx.doi.org/10.1016/j.ijms.2014.07.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448141PMC
February 2015

Revealing ligand binding sites and quantifying subunit variants of noncovalent protein complexes in a single native top-down FTICR MS experiment.

J Am Soc Mass Spectrom 2014 Dec 10;25(12):2060-8. Epub 2014 Jun 10.

Department of Biological Chemistry, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1007/s13361-014-0928-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444062PMC
December 2014

Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas.

Nat Chem Biol 2014 Dec 26;10(12):1034-42. Epub 2014 Oct 26.

1] Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California, USA. [2] Institute for Genomics and Proteomics, University of California-Los Angeles, Los Angeles, USA.

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http://dx.doi.org/10.1038/nchembio.1662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232477PMC
December 2014

A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1A.

Biochem Biophys Res Commun 2014 Dec 15;455(3-4):382-9. Epub 2014 Nov 15.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263273PMC
December 2014

Mass spectrometry-based tissue imaging of small molecules.

Adv Exp Med Biol 2014 ;806:283-99

Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1007/978-3-319-06068-2_12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183127PMC
October 2014

What protein charging (and supercharging) reveal about the mechanism of electrospray ionization.

J Am Soc Mass Spectrom 2014 Oct 19;25(10):1675-93. Epub 2014 Aug 19.

Department of Biological Chemistry, David Geffen School of Medicine at UCLA, University of California-Los Angeles, Los Angeles, CA, 90095, USA,

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http://link.springer.com/content/pdf/10.1007/s13361-014-0965
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http://link.springer.com/10.1007/s13361-014-0965-1
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http://dx.doi.org/10.1007/s13361-014-0965-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163133PMC
October 2014

Translational roles of elongation factor 2 protein lysine methylation.

J Biol Chem 2014 Oct 17;289(44):30511-24. Epub 2014 Sep 17.

From the Department of Chemistry and Biochemistry and the Molecular Biology Institute and

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http://dx.doi.org/10.1074/jbc.M114.605527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215232PMC
October 2014

Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery.

ACS Nano 2014 Aug 31;8(8):7723-32. Epub 2014 Jul 31.

Department of Biological Chemistry, David Geffen School of Medicine at University of California Los Angeles , Los Angeles, California 90095, United States.

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http://dx.doi.org/10.1021/nn5002694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148163PMC
August 2014

Top-down protein identification of proteasome proteins with nanoLC-FT-ICR-MS employing data-independent fragmentation methods.

Proteomics 2014 May 26;14(10):1271-82. Epub 2014 Mar 26.

Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California-Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1002/pmic.201300339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045009PMC
May 2014

Enhanced FASP (eFASP) to increase proteome coverage and sample recovery for quantitative proteomic experiments.

J Proteome Res 2014 Apr 6;13(4):1885-95. Epub 2014 Mar 6.

Department of Chemistry and Biochemistry and ‡Department of Biological Chemistry, University of California-Los Angeles , Los Angeles, California 90095, United States.

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http://dx.doi.org/10.1021/pr4010019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993969PMC
April 2014

Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.

J Biol Chem 2014 Apr 24;289(15):10727-37. Epub 2014 Feb 24.

From the Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48823.

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http://dx.doi.org/10.1074/jbc.M113.524520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036189PMC
April 2014

Addressing the needs of traumatic brain injury with clinical proteomics.

Clin Proteomics 2014 Mar 28;11(1):11. Epub 2014 Mar 28.

Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1186/1559-0275-11-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976360PMC
March 2014

Native top-down electrospray ionization-mass spectrometry of 158 kDa protein complex by high-resolution Fourier transform ion cyclotron resonance mass spectrometry.

Anal Chem 2014 Jan 10;86(1):317-20. Epub 2013 Dec 10.

Department of Biological Chemistry, David Geffen School of Medicine and ‡Department of Chemistry and Biochemistry, University of California , Los Angeles, California, 90095, United States.

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http://dx.doi.org/10.1021/ac4033214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908771PMC
January 2014

Decoy plasminogen receptor containing a selective Kunitz-inhibitory domain.

Biochemistry 2014 Jan 13;53(3):505-17. Epub 2014 Jan 13.

Department of Orthopaedic Surgery, UCLA School of Medicine , Los Angeles, California 90095, United States.

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http://dx.doi.org/10.1021/bi401584bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985851PMC
January 2014

Measuring protein-ligand interactions using liquid sample desorption electrospray ionization mass spectrometry.

Anal Chem 2013 Dec 22;85(24):11966-72. Epub 2013 Nov 22.

Department of Chemistry and Biochemistry and ‡Department of Biological Chemistry, David Geffen School of Medicine, University of California-Los Angeles , Los Angeles, California 90095, United States.

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http://pubs.acs.org/doi/10.1021/ac402906d
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901310PMC
December 2013

Integrating Native Mass Spectrometry and Top-Down MS for Defining Protein Interactions Important in Biology and Medicine.

Mass Spectrom (Tokyo) 2013 15;2(Spec Iss):S0013. Epub 2013 Apr 15.

Department of Biological Chemistry, David Geffen School of Medicine Department of Chemistry and Biochemistry University of California-Los Angeles Los Angeles.

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http://jlc.jst.go.jp/DN/JST.JSTAGE/massspectrometry/S0013?la
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http://dx.doi.org/10.5702/massspectrometry.S0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809962PMC
December 2013

Thermal-stable proteins of fruit of long-living Sacred Lotus Gaertn var. China Antique.

Trop Plant Biol 2013 Sep;6(2-3)

Department of Chemistry and Biochemistry University of California, Los Angeles 402 Boyer Hall, Hilgard Avenue Los Angeles, CA 90095-1569, USA.

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http://dx.doi.org/10.1007/s12042-013-9124-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869599PMC
September 2013

Cofilin-induced changes in F-actin detected via cross-linking with benzophenone-4-maleimide.

Biochemistry 2013 Aug 31;52(32):5503-9. Epub 2013 Jul 31.

Department of Chemistry and Biochemistry, Molecular Biology Institute and Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1021/bi400715zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017919PMC
August 2013

Protein complexes: breaking up is hard to do well.

Structure 2013 Aug;21(8):1265-6

Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.str.2013.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775335PMC
August 2013

A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor.

Nat Chem 2013 Mar 17;5(3):221-7. Epub 2013 Feb 17.

Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E Young Drive East, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/nchem.1573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579505PMC
March 2013

Outstanding JASMS manuscript reviewers, 2011-2012.

J Am Soc Mass Spectrom 2013 Mar;24(3):315

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http://dx.doi.org/10.1007/s13361-013-0584-2DOI Listing
March 2013

Investigation of stable and transient protein-protein interactions: Past, present, and future.

Proteomics 2013 Feb 18;13(3-4):538-57. Epub 2013 Jan 18.

Biochemistry & Proteomics Group, Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA.

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http://dx.doi.org/10.1002/pmic.201200328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813600PMC
February 2013

Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme.

J Biol Chem 2013 Jan 6;288(2):1065-78. Epub 2012 Nov 6.

Department of Chemistry and Biochemistry and the UCLA-Department of Energy Institute for Genomics and Proteomics, UCLA, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1074/jbc.M112.419119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542992PMC
January 2013

EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection.

Proc Natl Acad Sci U S A 2012 Aug 13;109(35):14194-9. Epub 2012 Aug 13.

Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles Medical Center, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1073/pnas.1117676109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435201PMC
August 2012

Signal and Charge Enhancement for Protein Analysis by Liquid Chromatography-Mass Spectrometry with Desorption Electrospray Ionization.

Int J Mass Spectrom 2012 Jul;325-327:161-166

Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Ohio University, Athens, OH, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394628PMC
http://dx.doi.org/10.1016/j.ijms.2012.06.006DOI Listing
July 2012

Network organization of the huntingtin proteomic interactome in mammalian brain.

Neuron 2012 Jul;75(1):41-57

Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432264PMC
July 2012

Fe sparing and Fe recycling contribute to increased superoxide dismutase capacity in iron-starved Chlamydomonas reinhardtii.

Plant Cell 2012 Jun 8;24(6):2649-65. Epub 2012 Jun 8.

Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, USA.

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http://dx.doi.org/10.1105/tpc.112.098962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406916PMC
June 2012