Joseph A Baur

Joseph A Baur

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Joseph A Baur

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A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate.

Cell Metab 2019 Jul 30;30(1):174-189.e5. Epub 2019 May 30.

Institute for Diabetes, Obesity & Metabolism, University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.05.005DOI Listing
July 2019

The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms.

Aging Cell 2019 Jun 1;18(3):e12874. Epub 2019 Mar 1.

Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/acel.12874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516176PMC
June 2019

Role of endothelial NAD deficiency in age-related vascular dysfunction.

Am J Physiol Heart Circ Physiol 2019 Jun 15;316(6):H1253-H1266. Epub 2019 Mar 15.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma.

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https://www.physiology.org/doi/10.1152/ajpheart.00039.2019
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http://dx.doi.org/10.1152/ajpheart.00039.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620681PMC
June 2019

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.

Cell Metab 2019 Jun 28;29(6):1274-1290.e9. Epub 2019 Mar 28.

Department of Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.03.001DOI Listing
June 2019

Optical Redox Imaging of Fixed Unstained Muscle Slides Reveals Useful Biological Information.

Mol Imaging Biol 2019 Jun;21(3):417-425

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://link.springer.com/10.1007/s11307-019-01348-z
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http://dx.doi.org/10.1007/s11307-019-01348-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581512PMC
June 2019

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.

Redox Biol 2019 Jun 10;24:101192. Epub 2019 Apr 10.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary; Department of Public Health, Semmelweis University, Budapest, Hungary; Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2019.101192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477631PMC
June 2019

Blockade of MCU-Mediated Ca Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation.

Cell Rep 2019 Mar;26(13):3709-3725.e7

Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Department of Medicine and Nephrology, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193029
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http://dx.doi.org/10.1016/j.celrep.2019.02.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512325PMC
March 2019

Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock.

JCI Insight 2018 Sep 6;3(17). Epub 2018 Sep 6.

Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.120182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171817PMC
September 2018

Nicotinamide adenine dinucleotide is transported into mammalian mitochondria.

Elife 2018 06 12;7. Epub 2018 Jun 12.

Department of Physiology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

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https://elifesciences.org/articles/33246
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http://dx.doi.org/10.7554/eLife.33246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013257PMC
June 2018

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.

Cell Metab 2018 May;27(5):1067-1080.e5

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, Princeton University, Princeton, NJ 08540, USA; Diabetes Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932087PMC
May 2018

NAD Intermediates: The Biology and Therapeutic Potential of NMN and NR.

Cell Metab 2018 03 14;27(3):513-528. Epub 2017 Dec 14.

Department of Developmental Biology, Department of Medicine (Joint), Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St. Louis, MO 63110, USA; Japan Agency for Medical Research and Development, Project for Elucidating and Controlling Mechanisms of Aging and Longevity, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842119PMC
March 2018

Imaging Redox State in Mouse Muscles of Different Ages.

Adv Exp Med Biol 2017 ;977:51-57

Molecular Imaging Laboratory, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-3-319-55231-6_8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690582PMC
January 2018

Supplemental arginine vasopressin during the resuscitation of severe hemorrhagic shock preserves renal mitochondrial function.

PLoS One 2017 24;12(10):e0186339. Epub 2017 Oct 24.

Penn Acute Research Collaboration (PARC), University of Pennsylvania, Philadelphia, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186339PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655425PMC
November 2017

Stable isotope labeling by essential nutrients in cell culture (SILEC) for accurate measurement of nicotinamide adenine dinucleotide metabolism.

Analyst 2017 Nov;142(23):4431-4437

Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://xlink.rsc.org/?DOI=C7AN01378G
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http://dx.doi.org/10.1039/c7an01378gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849469PMC
November 2017

Conditional ablation of in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes.

FASEB J 2017 09 10;31(9):3934-3949. Epub 2017 May 10.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China;

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http://dx.doi.org/10.1096/fj.201700251RDOI Listing
September 2017

The grapes and wrath: using resveratrol to treat the pathophysiology of hemorrhagic shock.

Ann N Y Acad Sci 2017 09 27;1403(1):70-81. Epub 2017 Aug 27.

Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/nyas.13444DOI Listing
September 2017

Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments.

Cell Metab 2017 Jun 13;25(6):1282-1293.e7. Epub 2017 Apr 13.

Division of Nephrology and Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462872PMC
June 2017

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge.

Nature 2017 06 14;546(7659):544-548. Epub 2017 Jun 14.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nature22819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826652PMC
June 2017

Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism.

Cell Metab 2017 Apr;25(4):961-974.e4

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://www.cell.com/cell-metabolism/pdf/S1550-4131(17)30171-
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http://linkinghub.elsevier.com/retrieve/pii/S155041311730171
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http://dx.doi.org/10.1016/j.cmet.2017.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479132PMC
April 2017

Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration.

Hepatology 2017 02 24;65(2):616-630. Epub 2016 Dec 24.

Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1002/hep.28912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258848PMC
February 2017

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.

Genes Dev 2016 11 2;30(22):2551-2564. Epub 2016 Dec 2.

Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.287953.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159669PMC
November 2016

A NEET Way to Impair Mitochondrial Function in α- and β-Cells.

Diabetes 2016 06;65(6):1484-6

Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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http://dx.doi.org/10.2337/dbi16-0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878424PMC
June 2016

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue.

Diabetes 2016 04 8;65(4):927-41. Epub 2016 Feb 8.

Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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http://dx.doi.org/10.2337/db15-0502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806661PMC
April 2016

Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex.

Am J Physiol Heart Circ Physiol 2015 Dec 9;309(11):H1837-45. Epub 2015 Oct 9.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Szentagothai Research Center, Medical School, University of Pecs, Pecs, Hungary; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

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http://dx.doi.org/10.1152/ajpheart.00463.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698379PMC
December 2015

Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?

Mol Metab 2015 Dec 8;4(12):926-39. Epub 2015 Oct 8.

Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, United States; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, United States.

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http://dx.doi.org/10.1016/j.molmet.2015.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731732PMC
December 2015

Resveratrol Rescues Kidney Mitochondrial Function Following Hemorrhagic Shock.

Shock 2015 Aug;44(2):173-80

*Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China; †The Trauma Center at Penn and ‡The Center for Resuscitation Science, University of Pennsylvania, Philadelphia, Pennsylvania; §Department of Emergency Medicine, Gazi University School of Medicine, Ankara, Turkey; and ∥Institute for Diabetes, Obesity, and Metabolism and Department of Physiology, Perelman School of Medicine, University of Pennsylvania; and ¶Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/SHK.0000000000000390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504763PMC
August 2015

Essential role of mitochondrial energy metabolism in Foxp3⁺ T-regulatory cell function and allograft survival.

FASEB J 2015 Jun 13;29(6):2315-26. Epub 2015 Feb 13.

*Department of Pediatrics, Division of Nephrology, Center for Mitochondrial and Epigenomic Medicine, and Department of Pathology and Laboratory Medicine, Division of Transplant Immunology, and Biesecker Center for Pediatric Liver Disease, Children's Hospital of Philadelphia and University of Pennsylvania; Department of Medicine, Center for Sleep and Circadian Neurobiology, and Department of Physiology and Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania; and Division of Traumatology and Surgical Critical Care, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1096/fj.14-268409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447222PMC
June 2015

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.

Nat Med 2015 May 6;21(5):498-505. Epub 2015 Apr 6.

1] Toronto General Research Institute and Department of Medicine, University Health Network, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. [3] Department of Medicine, University of Toronto, Toronto, Ontario, Canada. [4] Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nm.3821DOI Listing
May 2015

Resveratrol ameliorates mitochondrial dysfunction but increases the risk of hypoglycemia following hemorrhagic shock.

J Trauma Acute Care Surg 2014 Dec;77(6):926-33

From the Department of Critical Care Medicine (H.W.), Qilu Hospital of Shandong University, Jinan, China; The Trauma Center at Penn (H.W., Y.G., P.M.R., C.A.S.), University of Pennsylvania, Philadelphia, Pennsylvania; The Center for Resuscitation Science (Y.G., L.B.B., C.A.S.), University of Pennsylvania, Philadelphia, Pennsylvania; Institute for Diabetes, Obesity, and Metabolism and Department of Physiology (A.L.W., J.A.B., C.A.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Science, Systems and Models (A.L.W.), Roskilde University, Roskilde, Denmark; Department of Emergency Medicine (L.B.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Biochemistry and Molecular Biophysics Graduate Group (C.A.S.), University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000000358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474478PMC
December 2014

Rapamycin-induced metabolic defects are reversible in both lean and obese mice.

Aging (Albany NY) 2014 Sep;6(9):742-54

The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio TX 78245, USA. The Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA. Departments of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio TX 78245, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221917PMC
http://dx.doi.org/10.18632/aging.100688DOI Listing
September 2014

Control of gluconeogenesis by metformin: does redox trump energy charge?

Cell Metab 2014 Aug;20(2):197-9

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154964PMC
August 2014

Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons.

J Neurosci 2014 Mar;34(12):4418-31

Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China, Center for Sleep and Circadian Neurobiology, Department of Medicine, Institute for Diabetes, Obesity and Metabolism, and Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1523/JNEUROSCI.5025-12.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960479PMC
March 2014

Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism.

Aging Cell 2014 Feb 12;13(1):131-41. Epub 2013 Nov 12.

Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/acel.12158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009977PMC
February 2014

mTOR: more targets of resveratrol?

Expert Rev Mol Med 2013 Sep 23;15:e10. Epub 2013 Sep 23.

Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark.

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http://dx.doi.org/10.1017/erm.2013.11DOI Listing
September 2013

Rapalogs and mTOR inhibitors as anti-aging therapeutics.

J Clin Invest 2013 Mar 1;123(3):980-9. Epub 2013 Mar 1.

Whitehead Institute for Biomedical Research, Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI64099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582126PMC
March 2013

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.

Front Genet 2012 11;3:177. Epub 2012 Sep 11.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA.

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http://journal.frontiersin.org/article/10.3389/fgene.2012.00
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http://dx.doi.org/10.3389/fgene.2012.00177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438685PMC
October 2012

Are sirtuins viable targets for improving healthspan and lifespan?

Nat Rev Drug Discov 2012 Jun 1;11(6):443-61. Epub 2012 Jun 1.

Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.nature.com/articles/nrd3738
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http://dx.doi.org/10.1038/nrd3738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684642PMC
June 2012

Pharmacologic Means of Extending Lifespan.

J Clin Exp Pathol 2012 May;Suppl 4

Department of Physiology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA.

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http://dx.doi.org/10.4172/2161-0681.S4-002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219537PMC
May 2012

Challenges of translating basic research into therapeutics: resveratrol as an example.

J Gerontol A Biol Sci Med Sci 2012 Feb 11;67(2):158-67. Epub 2011 Jul 11.

Department of Health and Physical Education, Human Physiology Laboratory, Marywood University, Scranton, Pennsylvania, USA.

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https://academic.oup.com/biomedgerontology/article-lookup/do
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http://dx.doi.org/10.1093/gerona/glr062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261440PMC
February 2012

Resveratrol and health--a comprehensive review of human clinical trials.

Mol Nutr Food Res 2011 Aug 20;55(8):1129-41. Epub 2011 Jun 20.

Human Physiology Laboratory, Department of Health and Physical Education, Marywood University, Scranton, PA 18509, USA.

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http://dx.doi.org/10.1002/mnfr.201100143DOI Listing
August 2011

Mitochondrial protection by resveratrol.

Exerc Sport Sci Rev 2011 Jul;39(3):128-32

Reynolds Oklahoma Center on Aging, Departments of Geriatric Medicine and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

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http://dx.doi.org/10.1097/JES.0b013e3182141f80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123408PMC
July 2011

Resveratrol and life extension.

Ann N Y Acad Sci 2011 Jan;1215:138-43

Institute for Diabetes, Obesity, and Metabolism, Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05850.xDOI Listing
January 2011

Biochemical effects of SIRT1 activators.

Authors:
Joseph A Baur

Biochim Biophys Acta 2010 Aug 6;1804(8):1626-34. Epub 2009 Nov 6.

Institute for Diabetes, Obesity, and Metabolism, and Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.bbapap.2009.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886178PMC
August 2010

Resveratrol, sirtuins, and the promise of a DR mimetic.

Authors:
Joseph A Baur

Mech Ageing Dev 2010 Apr 26;131(4):261-9. Epub 2010 Feb 26.

Institute for Diabetes, Obesity, and Metabolism, Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.mad.2010.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862768PMC
April 2010

Telomere length regulates ISG15 expression in human cells.

Aging (Albany NY) 2009 Jul 17;1(7):608-21. Epub 2009 Jul 17.

Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

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http://www.aging-us.com/article/100066
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806043PMC
http://dx.doi.org/10.18632/aging.100066DOI Listing
July 2009

Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy.

Aging (Albany NY) 2009 Jun 3;1(6):515-28. Epub 2009 Jun 3.

Department of Pathology and Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA.

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http://www.aging-us.com/article/100056
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806030PMC
http://dx.doi.org/10.18632/aging.100056DOI Listing
June 2009

What is Xenohormesis?

Am J Pharmacol Toxicol 2008 Mar;3(1):152-159

Department of Pathology, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115.

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http://dx.doi.org/10.3844/ajptsp.2008.152.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775249PMC
March 2008

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

EMBO J 2007 Jul 21;26(13):3169-79. Epub 2007 Jun 21.

Howard Hughes Medical Institute, Picower Insitute for Learning and Memory, Riken-MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Boston, MA, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914106PMC
July 2007

Obesity: do grapes hold the answer?

Authors:
Joseph A Baur

Pediatr Res 2007 Jun;61(6):633

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http://dx.doi.org/10.1203/pdr.0b013e31805d8562DOI Listing
June 2007

Therapeutic potential of resveratrol: the in vivo evidence.

Nat Rev Drug Discov 2006 Jun 26;5(6):493-506. Epub 2006 May 26.

Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrd2060DOI Listing
June 2006

Analysis of mammalian telomere position effect.

Methods Mol Biol 2004 ;287:121-36

Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1385/1-59259-828-5:121DOI Listing
October 2004

Spontaneous reactivation of a silent telomeric transgene in a human cell line.

Chromosoma 2004 Feb 20;112(5):240-6. Epub 2004 Jan 20.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA.

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http://dx.doi.org/10.1007/s00412-003-0269-xDOI Listing
February 2004