Josep Bassaganya-Riera

Josep Bassaganya-Riera

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Josep Bassaganya-Riera

Josep Bassaganya-Riera

Publications by authors named "Josep Bassaganya-Riera"

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High-resolution computational modeling of immune responses in the gut.

Gigascience 2019 06;8(6)

Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute of Virginia Tech, 1015 Life Science Circle, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1093/gigascience/giz062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559340PMC
June 2019

Challenges in Personalized Nutrition and Health.

Front Nutr 2018 29;5:117. Epub 2018 Nov 29.

Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute of Virginia Tech, Blacksburg, VA, United States.

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http://dx.doi.org/10.3389/fnut.2018.00117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281760PMC
November 2018

Reconstruction of endosomal organization and function by a combination of ODE and agent-based modeling strategies.

Biol Direct 2018 11 23;13(1):25. Epub 2018 Nov 23.

Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute, Virginia Tech, Blacksburg, VA, USA.

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http://dx.doi.org/10.1186/s13062-018-0227-4DOI Listing
November 2018

Agents and networks to model the dynamic interactions of intracellular transport.

Cell Logist 2017 29;7(4):e1392401. Epub 2017 Nov 29.

Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute, Virginia Tech, Blacksburg, VA, USA.

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http://dx.doi.org/10.1080/21592799.2017.1392401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739099PMC
November 2017

Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection.

PLoS One 2016 9;11(12):e0167440. Epub 2016 Dec 9.

Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute of Virginia Tech, Blacksburg, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167440PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147901PMC
July 2017

Novel Screening Tool for Stroke Using Artificial Neural Network.

Stroke 2017 06 24;48(6):1678-1681. Epub 2017 Apr 24.

From the Biocomplexity Institute (V.A., R.Z.), Department of Industrial and Systems Engineering (G.T.), and Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute (R.H., J.B.-R.), Virginia Tech, Blacksburg; Biomedical and Translational Informatics Institute (V.A.) and Department of Neurology (R.Z.), Geisinger Health System, Danville, PA; Department of Neurology, University of Tennessee Health Science Center, Memphis (N.G., G.T., L.E., J.E.M., A.W.A., A.V.A., R.Z.); Second Department of Neurology, "Attikon University Hospital," School of Medicine, University of Athens, Greece (N.H.); and Neurovascular Imaging Research Core and UCLA Stroke Center, University of California, Los Angeles (D.S.L.).

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http://dx.doi.org/10.1161/STROKEAHA.117.017033DOI Listing
June 2017

Modeling new immunoregulatory therapeutics as antimicrobial alternatives for treating Clostridium difficile infection.

Artif Intell Med 2017 05 9;78:1-13. Epub 2017 May 9.

Nutritional Immunology and Molecular Medicine Laboratory(1), Biocomplexity Institute, Virginia Tech, Blacksburg, VA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.artmed.2017.05.003DOI Listing
May 2017

Cooperation of Gastric Mononuclear Phagocytes with during Colonization.

J Immunol 2017 04 6;198(8):3195-3204. Epub 2017 Mar 6.

Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute of Virginia Tech, Blacksburg, VA 24061

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1601902
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http://dx.doi.org/10.4049/jimmunol.1601902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380565PMC
April 2017

NLRX1 Regulates Effector and Metabolic Functions of CD4 T Cells.

J Immunol 2017 03 3;198(6):2260-2268. Epub 2017 Feb 3.

Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute of Virginia Tech, Blacksburg, VA 24061;

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http://dx.doi.org/10.4049/jimmunol.1601547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340590PMC
March 2017

Solving Immunology?

Trends Immunol 2017 02 13;38(2):116-127. Epub 2016 Dec 13.

Center for Advanced Research on Diagnostic Assays, Immunology Institute, Friedman Brain Institute, and Departments of Neurology, Neuroscience, Pharmacology, and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2016.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695553PMC
February 2017

Lanthionine Synthetase C-Like 2 Modulates Immune Responses to Influenza Virus Infection.

Front Immunol 2017 21;8:178. Epub 2017 Feb 21.

Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute, Virginia Tech , Blacksburg, VA , USA.

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http://dx.doi.org/10.3389/fimmu.2017.00178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318425PMC
February 2017

Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis.

Gut Microbes 2016 ;7(1):3-21

a Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens; Virginia Bioinformatics Institute; Virginia Tech ; Blacksburg , VA , USA.

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http://dx.doi.org/10.1080/19490976.2015.1116673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856448PMC
December 2016

Translating nutritional immunology into drug development for inflammatory bowel disease.

Curr Opin Gastroenterol 2016 11;32(6):443-449

Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute of Virginia Tech, Blacksburg, Virginia, USA.

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http://dx.doi.org/10.1097/MOG.0000000000000317DOI Listing
November 2016

An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease.

J Med Chem 2016 11 15;59(22):10113-10126. Epub 2016 Nov 15.

Biotherapeutics Inc. , 1800 Kraft Drive, Suite 200, Blacksburg, Virginia 24060, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00412DOI Listing
November 2016

Modulation of inflammation and immunity by dietary conjugated linoleic acid.

Eur J Pharmacol 2016 Aug 15;785:87-95. Epub 2015 May 15.

Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA; Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.03.095DOI Listing
August 2016

Modeling-Enabled Characterization of Novel NLRX1 Ligands.

PLoS One 2015 29;10(12):e0145420. Epub 2015 Dec 29.

The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145420PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694766PMC
July 2016

Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection.

PLoS One 2015 14;10(9):e0137839. Epub 2015 Sep 14.

Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute at Virginia Tech, Blacksburg, VA, United States of America; Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute at Virginia Tech, Blacksburg, VA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137839PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569576PMC
June 2016

Bistability analyses of CD4+ T follicular helper and regulatory cells during Helicobacter pylori infection.

J Theor Biol 2016 06 3;398:74-84. Epub 2016 Mar 3.

Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute of Virginia Tech, Blacksburg, VA, USA; Center for Modeling Immunity to Enteric Pathogens, Biocomplexity Institute of Virginia Tech, Blacksburg, VA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2016.02.036DOI Listing
June 2016

Systems Modeling of Interactions between Mucosal Immunity and the Gut Microbiome during Clostridium difficile Infection.

PLoS One 2015 31;10(7):e0134849. Epub 2015 Jul 31.

The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America; Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134849PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521955PMC
May 2016

Sensitivity Analysis of an ENteric Immunity SImulator (ENISI)-Based Model of Immune Responses to Helicobacter pylori Infection.

PLoS One 2015 1;10(9):e0136139. Epub 2015 Sep 1.

Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America; Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America; Department of Computer Science, Virginia Tech, Blacksburg, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136139PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556515PMC
May 2016

Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex.

PLoS One 2015 8;10(5):e0123984. Epub 2015 May 8.

Department of Biochemistry, Virginia Tech, Blacksburg, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123984PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425662PMC
April 2016

Modeling-Enabled Systems Nutritional Immunology.

Front Nutr 2016 16;3. Epub 2016 Feb 16.

Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Biocomplexity Institute, Virginia Tech, Blacksburg, VA, USA; The Center for Modeling Immunity to Enteric Pathogens, Biocomplexity Institute, Virginia Tech, Blacksburg, VA, USA.

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http://dx.doi.org/10.3389/fnut.2016.00005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754447PMC
February 2016

Supervised learning methods in modeling of CD4+ T cell heterogeneity.

BioData Min 2015 4;8:27. Epub 2015 Sep 4.

The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061 USA ; Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061 USA.

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http://dx.doi.org/10.1186/s13040-015-0060-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559362PMC
September 2015

Novel insights on the role of CD8+ T cells and cytotoxic responses during Helicobacter pylori infection.

Gut Microbes 2014 May-Jun;5(3):357-62. Epub 2014 Apr 22.

Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens; Virginia Bioinformatics Institute; Virginia Tech; Blacksburg, VA USA.

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http://www.tandfonline.com/doi/abs/10.4161/gmic.28899
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http://dx.doi.org/10.4161/gmic.28899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153774PMC
May 2015

Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands.

J Comput Aided Mol Des 2015 May 24;29(5):421-39. Epub 2015 Jan 24.

Genetics, Bioinformatics, and Computational Biology Program, Virginia Tech, Blacksburg, VA, USA,

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http://dx.doi.org/10.1007/s10822-015-9831-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395532PMC
May 2015

Emerging significance of NLRs in inflammatory bowel disease.

Inflamm Bowel Dis 2014 Dec;20(12):2412-32

*Department of Biology, Franklin and Marshall College, Lancaster, Pennsylvania; †Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia; and ‡Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia.

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http://dx.doi.org/10.1097/MIB.0000000000000151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396872PMC
December 2014

Computational modeling of heterogeneity and function of CD4+ T cells.

Front Cell Dev Biol 2014 29;2:31. Epub 2014 Jul 29.

Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech Blacksburg, VA, USA ; Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech Blacksburg, VA, USA ; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech Blacksburg, VA, USA.

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http://dx.doi.org/10.3389/fcell.2014.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207042PMC
November 2014

Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection.

PLoS One 2013 5;8(9):e73365. Epub 2013 Sep 5.

Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America ; Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073365PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764126PMC
June 2014

Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes.

Curr Drug Targets 2014 Jun;15(6):565-72

Laboratory of Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.2174/1389450115666140313123714DOI Listing
June 2014

Stopping anti-TNF agents in patients with Crohn's disease in remission: is it a feasible long-term strategy?

Inflamm Bowel Dis 2014 Apr;20(4):757-66

*IBD Center, Division of Gastroenterology, Virginia Tech-Carilion School of Medicine, Roanoke, Virginia; †Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia; ‡Department of Clinical and Experimental Medical Sciences, University of Udine Medical School, Udine, Italy; and §Department of Medicine, University of Queensland-Brisbane, Brisbane, Australia.

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http://dx.doi.org/10.1097/01.MIB.0000442680.47427.bfDOI Listing
April 2014

Translational research and efficacy of biologics in Crohn's disease: a cautionary tale.

Expert Rev Clin Immunol 2014 Feb;10(2):219-29

Sunshine Coast Clinical School, Nambour, QLD 4560, Australia.

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http://dx.doi.org/10.1586/1744666X.2014.877839DOI Listing
February 2014

Animal models of enteroaggregative Escherichia coli infection.

Gut Microbes 2013 Jul-Aug;4(4):281-91. Epub 2013 May 2.

Nutritional Immunology and Molecular Medicine Laboratory; Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA USA.

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http://dx.doi.org/10.4161/gmic.24826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744513PMC
December 2013

Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses.

Infect Immun 2013 Oct 29;81(10):3803-13. Epub 2013 Jul 29.

Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, USA.

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http://dx.doi.org/10.1128/IAI.00660-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811743PMC
October 2013

The role of peroxisome proliferator-activated receptor γ in immune responses to enteroaggregative Escherichia coli infection.

PLoS One 2013 28;8(2):e57812. Epub 2013 Feb 28.

Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057812PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585146PMC
August 2013

Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents.

Evid Based Complement Alternat Med 2013 30;2013:789764. Epub 2013 Apr 30.

Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA ; Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA.

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http://dx.doi.org/10.1155/2013/789764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657449PMC
July 2013

Dietary abscisic acid ameliorates influenza-virus-associated disease and pulmonary immunopathology through a PPARγ-dependent mechanism.

J Nutr Biochem 2013 Jun 17;24(6):1019-27. Epub 2012 Sep 17.

Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org), Virginia Bioinformatics Institute, Virginia Tech., Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1016/j.jnutbio.2012.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529771PMC
June 2013

Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide.

J Med Microbiol 2013 Jun 8;62(Pt 6):896-905. Epub 2013 Mar 8.

Center for Global Health, Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1099/jmm.0.046300-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709553PMC
June 2013

Nutritional protective mechanisms against gut inflammation.

J Nutr Biochem 2013 Jun 27;24(6):929-39. Epub 2013 Mar 27.

Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Blacksburg, VA 24060, USA.

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http://dx.doi.org/10.1016/j.jnutbio.2013.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730123PMC
June 2013

Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria.

PLoS One 2012 12;7(4):e34676. Epub 2012 Apr 12.

Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034676PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325233PMC
December 2012

Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease.

Clin Nutr 2012 Oct 20;31(5):721-7. Epub 2012 Apr 20.

Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA.

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http://dx.doi.org/10.1016/j.clnu.2012.03.002DOI Listing
October 2012

Expression of PPAR γ in intestinal epithelial cells is dispensable for the prevention of colitis by dietary abscisic acid.

ESPEN J 2012 Oct;7(5):e189-e195

Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24060, United States of America.

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http://dx.doi.org/10.1016/j.clnme.2012.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691880PMC
October 2012

Dietary modulation of inflammation-induced colorectal cancer through PPARγ.

PPAR Res 2009 22;2009:498352. Epub 2009 Apr 22.

Cell and Organism Section, Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1155/2009/498352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672162PMC
September 2012

ENteric Immunity SImulator: a tool for in silico study of gastroenteric infections.

IEEE Trans Nanobioscience 2012 Sep;11(3):273-88

Network Dynamics and Simulation Science Laboratory, and Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1109/TNB.2012.2211891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715318PMC
September 2012

Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis.

PLoS One 2012 21;7(2):e31238. Epub 2012 Feb 21.

Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031238PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283634PMC
June 2012

Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: importance of peroxisome proliferator-activated receptor γ expression.

J Nutr Biochem 2011 Dec 4;22(12):1160-71. Epub 2011 Feb 4.

Department of Human Nutrition, Foods and Exercise, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S095528631000246
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http://dx.doi.org/10.1016/j.jnutbio.2010.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135670PMC
December 2011

Deletion of PPAR-γ in immune cells enhances susceptibility to antiglomerular basement membrane disease.

J Inflamm Res 2010 28;3:127-34. Epub 2010 Oct 28.

Department of Biomedical Sciences and Pathobiology, Virginia- Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

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http://dx.doi.org/10.2147/JIR.S13394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218741PMC
November 2011

T cell PPARγ is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD.

J Nutr Biochem 2011 Sep 15;22(9):812-9. Epub 2010 Dec 15.

Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09552863100017
Publisher Site
http://dx.doi.org/10.1016/j.jnutbio.2010.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117068PMC
September 2011

Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice.

Br J Nutr 2011 Sep 31;106(6):878-86. Epub 2011 May 31.

Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1017/S0007114511001188DOI Listing
September 2011

Virtual Screening as a Technique for PPAR Modulator Discovery.

PPAR Res 2010 2;2010:861238. Epub 2009 Sep 2.

Genetics, Bioinformatics, and Computational Biology Program, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1155/2010/861238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738858PMC
July 2011

Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists.

J Obes 2011 28;2011:897894. Epub 2010 Dec 28.

Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1155/2011/897894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021882PMC
July 2011

Soluble fibers and resistant starch ameliorate disease activity in interleukin-10-deficient mice with inflammatory bowel disease.

J Nutr 2011 Jul 11;141(7):1318-25. Epub 2011 May 11.

Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.3945/jn.111.139022DOI Listing
July 2011

Systemic effects of white adipose tissue dysregulation and obesity-related inflammation.

Obesity (Silver Spring) 2011 Apr 7;19(4):689-700. Epub 2010 Oct 7.

Nutritional Immunology and Molecular Medicine Laboratory, CyberInfrastructure Division, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.

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http://dx.doi.org/10.1038/oby.2010.230DOI Listing
April 2011

Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics.

J Mol Model 2011 Mar 30;17(3):543-53. Epub 2010 May 30.

Genetics, Bioinformatics, and Computational Biology Program, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://link.springer.com/10.1007/s00894-010-0748-y
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http://dx.doi.org/10.1007/s00894-010-0748-yDOI Listing
March 2011

Abscisic acid regulates inflammation via ligand-binding domain-independent activation of peroxisome proliferator-activated receptor gamma.

J Biol Chem 2011 Jan 18;286(4):2504-16. Epub 2010 Nov 18.

Nutritional Immunology and Molecular Medicine Group, Virginia Bioinformatics Institute, Blacksburg, Virginia 24061, USA.

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http://dx.doi.org/10.1074/jbc.M110.160077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024745PMC
January 2011

Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall.

J Nutr Biochem 2010 Dec 25;21(12):1178-85. Epub 2010 Jan 25.

Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1016/j.jnutbio.2009.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891372PMC
December 2010

Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration.

Clin Nutr 2010 Dec 16;29(6):824-31. Epub 2010 Mar 16.

Laboratory of Nutritional Immunology & Molecular Nutrition, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1016/j.clnu.2010.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894983PMC
December 2010

Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: possible action of the cAMP/PKA/PPAR γ axis.

Clin Nutr 2010 Oct 5;29(5):646-53. Epub 2010 Mar 5.

Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1016/j.clnu.2010.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888662PMC
October 2010

Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension.

BMC Med Genomics 2010 Oct 13;3:45. Epub 2010 Oct 13.

Department of Genetic Engineering and Biotechnology, University of Dhaka, Bangladesh.

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http://dx.doi.org/10.1186/1755-8794-3-45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965702PMC
October 2010

Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease.

Curr Opin Clin Nutr Metab Care 2010 Sep;13(5):569-73

Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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https://insights.ovid.com/crossref?an=00075197-201009000-000
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http://dx.doi.org/10.1097/MCO.0b013e32833b648eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947030PMC
September 2010

PPAR-gamma activation as an anti-inflammatory therapy for respiratory virus infections.

Viral Immunol 2010 Aug;23(4):343-52

Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.

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https://www.liebertpub.com/doi/10.1089/vim.2010.0016
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http://dx.doi.org/10.1089/vim.2010.0016DOI Listing
August 2010

Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice.

Endocrinology 2010 Jul 19;151(7):3026-37. Epub 2010 May 19.

Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.

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http://dx.doi.org/10.1210/en.2009-1294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903942PMC
July 2010

Green tea extract decreases muscle pathology and NF-kappaB immunostaining in regenerating muscle fibers of mdx mice.

Clin Nutr 2010 Jun 7;29(3):391-8. Epub 2009 Nov 7.

Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, 338 Wallace Hall, Blacksburg, VA 24061, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S026156140900208
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http://dx.doi.org/10.1016/j.clnu.2009.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882522PMC
June 2010

Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease.

J Theor Biol 2010 Jun 1;264(4):1225-39. Epub 2010 Apr 1.

Virginia Bioinformatics Institute, Virginia Polytechnic Institute and University, Washington Street, MC 0477 Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1016/j.jtbi.2010.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878745PMC
June 2010

The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease.

BMC Gastroenterol 2010 Jun 10;10:60. Epub 2010 Jun 10.

Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1186/1471-230X-10-60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891618PMC
June 2010

Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease.

PLoS One 2010 Apr 20;5(4):e10215. Epub 2010 Apr 20.

Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010215PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857885PMC
April 2010

Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma.

J Nutr 2010 Mar 20;140(3):515-21. Epub 2010 Jan 20.

Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.3945/jn.109.115642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821885PMC
March 2010

Early evidence of increased risk for metabolic syndrome in young men with latent obstructive sleep apnea.

Metab Syndr Relat Disord 2010 Feb;8(1):33-8

Laboratory for Health and Exercise Science, Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia 24061, USA

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http://www.liebertpub.com/doi/10.1089/met.2009.0041
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http://dx.doi.org/10.1089/met.2009.0041DOI Listing
February 2010

PPAR gamma is highly expressed in F4/80(hi) adipose tissue macrophages and dampens adipose-tissue inflammation.

Cell Immunol 2009 6;258(2):138-46. Epub 2009 May 6.

Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, 24061, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S000887490900063
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http://dx.doi.org/10.1016/j.cellimm.2009.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706276PMC
August 2009

Immune-mediated mechanisms potentially regulate the disease time-course of duchenne muscular dystrophy and provide targets for therapeutic intervention.

PM R 2009 Aug;1(8):755-68

Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0002, USA.

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http://dx.doi.org/10.1016/j.pmrj.2009.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779711PMC
August 2009

Dysregulated intracellular signaling and inflammatory gene expression during initial disease onset in Duchenne muscular dystrophy.

Am J Phys Med Rehabil 2009 Jun;88(6):502-22

Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.

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http://dx.doi.org/10.1097/PHM.0b013e3181a5a24fDOI Listing
June 2009

Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation.

J Am Coll Nutr 2009 Apr;28(2):184-95

Laboratory of Nutritional Immunology & Molecular Nutrition, Virginia Bioinformatics Institute, Virginia Tech, 1 Washington Street, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1080/07315724.2009.10719770DOI Listing
April 2009