Publications by authors named "Jose de Leon"

93Publications

Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents.

Pharmaceuticals (Basel) 2020 Dec 2;13(12). Epub 2020 Dec 2.

Mental Health Research Center at Eastern State Hospital, University of Kentucky, Lexington, KY 40511-1269, USA.

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December 2020

Amerindians may need clozapine dosing similar to that of Asians.

Rev Psiquiatr Salud Ment 2020 Nov 28. Epub 2020 Nov 28.

Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain. Electronic address:

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November 2020

Self-Report for Measuring and Predicting Medication Adherence: Experts' Experience in Predicting Adherence in Stable Psychiatric Outpatients and in Pharmacokinetics.

Patient Prefer Adherence 2020 9;14:1823-1842. Epub 2020 Oct 9.

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA.

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October 2020

Edentulousness in severely mentally ill patients: A pilot study of sex-specific patterns for risk factors including the glutathione S-transferase M1 gene.

Schizophr Res 2020 Oct 14;224:178-179. Epub 2020 Oct 14.

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain. Electronic address:

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October 2020

CYP2D6 pharmacogenetics and risperidone: reflections after 25 years of research.

Pharmacogenomics 2020 11 15;21(16):1139-1144. Epub 2020 Oct 15.

The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, NY, USA.

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November 2020

Creating a Colocation Unit for End-of-Life Care during a Pandemic.

J Palliat Med 2020 Sep 15. Epub 2020 Sep 15.

The Brookdale Department of Geriatrics and Palliative Medicine at the Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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September 2020

CYP2D6 Genetic Polymorphisms and Risperidone Pharmacokinetics: A Systematic Review and Meta-analysis.

Pharmacotherapy 2020 07 12;40(7):632-647. Epub 2020 Jul 12.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA.

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July 2020

Measuring individual benefits of psychiatric treatment using longitudinal binary outcomes: Application to antipsychotic benefits in non-cannabis and cannabis users.

J Biopharm Stat 2020 09 8;30(5):916-940. Epub 2020 Jun 8.

Department of Biostatistics, The University of Kansas Medical Center , Kansas City, KS, United States.

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September 2020

High Doses of Drugs Extensively Metabolized by CYP3A4 Were Needed to Reach Therapeutic Concentrations in Two Patients Taking Inducers.

Rev Colomb Psiquiatr 2020 Apr - Jun;49(2):84-95. Epub 2018 Sep 2.

University of Kentucky Mental Health Research Center, Eastern State Hospital, Lexington, Kentucky, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Álava, Spain. Electronic address:

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September 2018

Clozapine is strongly associated with the risk of pneumonia and inflammation.

Gen Psychiatr 2020 16;33(2):e100183. Epub 2020 Apr 16.

Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing, China.

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April 2020

The association of clozapine and haematological malignancies needs to be replicated by other studies and more importantly by analyses of subsamples from VigiBase.

Psychol Med 2020 May 6:1-2. Epub 2020 May 6.

Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, F-33000 Bordeaux, France.

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May 2020

Adding Oral Contraceptives to Clozapine May Require Halving the Clozapine Dose: A New Case and a Literature Review.

J Clin Psychopharmacol 2020 May/Jun;40(3):308-310

The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, NY The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, NY. Hofstra Northwell School of Medicine, Hempstead, NY, The Feinstein Institute for Medical Research, Manhasset, NY University of Kentucky Mental Health Research, Center, Eastern State Hospital, Lexington, KY Psychiatry and Neurosciences Research Group, (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain, and Biomedical Research Centre in Mental Health, Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain.

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January 2021

Is there a future for pharmacogenetics in the optimal dosing of clozapine?

Pharmacogenomics 2020 04 20;21(6):369-373. Epub 2020 Apr 20.

Mental Health Research Center, Eastern State Hospital, Lexington, KY 40511, USA.

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April 2020

A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology.

Psychother Psychosom 2020 14;89(4):200-214. Epub 2020 Apr 14.

Department of Internal Medicine, Dermatology and Psychiatry, University of La Laguna, San Cristóbal de La Laguna, Spain.

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July 2020

Using therapeutic drug monitoring to personalize clozapine dosing in Asians.

Asia Pac Psychiatry 2020 Jun 2;12(2):e12384. Epub 2020 Mar 2.

Laboratory of Clinical Psychopharmacology & The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.

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June 2020

Lack of ECT effects on clozapine plasma levels in patients with treatment-resistant schizophrenia: Pharmacokinetic evidence from a randomized clinical trial.

Schizophr Res 2020 04 24;218:309-311. Epub 2020 Feb 24.

The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, NY, USA; The Hofstra Northwell School of Medicine, Hempstead, NY, USA; The Feinstein Institute for Medical Research, Manhasset, NY, USA.

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April 2020

WITHDRAWN: Corrigendum to "Dose and safety concerns of clozapine: Worldwide package inserts need revisions" [Schizophr. Res. 08619].

Schizophr Res 2020 02 2. Epub 2020 Feb 2.

Department of Psychiatry, Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA. Electronic address:

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February 2020

Do Asian Patients Require Only Half of the Clozapine Dose Prescribed for Caucasians? A Critical Overview.

Indian J Psychol Med 2020 Jan-Feb;42(1):4-10. Epub 2020 Jan 6.

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

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January 2020

Dose and safety concerns of clozapine: Worldwide package inserts need revisions.

Schizophr Res 2020 02 8;216:2-4. Epub 2020 Jan 8.

Department of Psychiatry, Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA. Electronic address:

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February 2020

Pneumonia may be more frequent and have more fatal outcomes with clozapine than with other second-generation antipsychotics.

World Psychiatry 2020 Feb;19(1):120-121

Department of Internal Medicine, Dermatology and Psychiatry, School of Medicine, University of La Laguna, Canary Islands, Spain.

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February 2020

Data From the World Health Organization's Pharmacovigilance Database Supports the Prominent Role of Pneumonia in Mortality Associated With Clozapine Adverse Drug Reactions.

Schizophr Bull 2020 01;46(1):1-3

Department of Internal Medicine, Dermatology and Psychiatry, School of Medicine, University of La Laguna, Canary Islands, Spain.

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January 2020

Clinically relevant drug interactions between newer antidepressants and oral anticoagulants.

Expert Opin Drug Metab Toxicol 2020 Jan 10;16(1):31-44. Epub 2019 Dec 10.

University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA.

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January 2020

Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13.

J Clin Psychopharmacol 2019 Nov/Dec;39(6):644-648

Mental Health Research Center, Eastern State Hospital, Lexington, KY and Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada.

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April 2020

Rapid Titration and Decreased Clozapine Clearance May Help Explain Five Cases of Clozapine-Induced Myocarditis in a New York Hospital.

Psychosomatics 2020 Jan - Feb;61(1):102-103. Epub 2019 Sep 4.

New York University School of Medicine, Bellevue Hospital, New York, NY.

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September 2019

Clinical determinants of fever in clozapine users and implications for treatment management: A narrative review.

Schizophr Res 2019 09 1;211:1-9. Epub 2019 Aug 1.

Mental Health Research Center at Eastern State Hospital, Lexington, KY and Psychiatry and Neurosciences Research Group (CTS-549), USA; Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain.

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September 2019

Gemfibrozil May Decrease Norclozapine Elimination: A Case Report.

J Clin Psychopharmacol 2019 Jul/Aug;39(4):405-407

Eastern State Hospital Lexington, KY. The Zucker Hillside Hospital Psychiatry Research, Northwell Health Glen Oaks Hofstra Northwell School of Medicine Hempstead and The Feinstein Institute for Medical Research Manhasset, New York University of Kentucky Mental Health Research Center Eastern State Hospital Lexington, KY

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April 2020

Personalizing dosing of risperidone, paliperidone and clozapine using therapeutic drug monitoring and pharmacogenetics.

Authors:
Jose de Leon

Neuropharmacology 2020 05 28;168:107656. Epub 2019 May 28.

University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain. Electronic address:

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May 2020

A comprehensive review of the clinical utility of and a combined analysis of the clozapine/norclozapine ratio in therapeutic drug monitoring for adult patients.

Expert Rev Clin Pharmacol 2019 Jul 31;12(7):603-621. Epub 2019 May 31.

g University of Kentucky Mental Health Research Center at Eastern State Hospital , Lexington , KY , USA.

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July 2019

Letter to the Editor: Clinical versus statistical significance of pharmacogenomic-guided antidepressant therapy: What's really being measured and marketed?

J Psychiatr Res 2019 07 5;114:208-209. Epub 2019 Apr 5.

University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain.

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July 2019

Development and validation of the Patient's Health Belief Questionnaire on Psychiatric Treatment.

Patient Prefer Adherence 2019 10;13:527-536. Epub 2019 Apr 10.

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA.

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April 2019

Genetics Guideline Is Excellent, but the Pharmacogenetics Section Is Weak.

Authors:
Jose de Leon

J Clin Psychiatry 2019 04 9;80(3). Epub 2019 Apr 9.

Mental Health Research Center at Eastern State Hospital, Lexington, Kentucky, USA.

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April 2019

Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.

Clin Pharmacol Ther 2019 07 13;106(1):94-102. Epub 2019 Apr 13.

Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.

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July 2019

A comprehensive review of swallowing difficulties and dysphagia associated with antipsychotics in adults.

Expert Rev Clin Pharmacol 2019 Mar 8;12(3):219-234. Epub 2019 Feb 8.

b Mental Health Research Center at Eastern State Hospital , University of Kentucky , Lexington , KY , USA.

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March 2019

Ethnopsychopharmacology study of patients' beliefs regarding concerns about and necessity of taking psychiatric medications.

Hum Psychopharmacol 2019 03 30;34(2):e2688. Epub 2019 Jan 30.

Mental Health Research Center at Eastern State Hospital, Lexington, Kentucky, United States of America.

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March 2019

A Clinimetric Approach for Improving the Measurement of Pharmacophobia with Replication in Two Other Samples.

Psychother Psychosom 2019 16;88(2):116-118. Epub 2019 Jan 16.

Mental Health Research Center at Eastern State Hospital, Lexington, Kentucky, USA,

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June 2019

Predictive validity of the Sidorkiewicz instrument in Spanish: Assessing individual drug adherence in psychiatric patients.

Int J Clin Health Psychol 2018 May-Aug;18(2):133-142. Epub 2017 Dec 11.

Mental Health Research Center at Eastern State Hospital, USA.

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December 2017

A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting paliperidone.

Expert Rev Clin Pharmacol 2018 Dec 4;11(12):1237-1253. Epub 2018 Dec 4.

e University of Kentucky Mental Health Research Center at Eastern State Hospital , Lexington , KY , USA.

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December 2018

Clozapine Addition Following Brain Surgery in Severe Primary Obsessive-Compulsive Disorder With Tardive Movement Disorder.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):86-87

Department of Physiology, Los Andes University Medical School, Mérida, Venezuela Department of Neurology, Los Andes University Medical School, érida, Venezuela University of Kentucky Mental Health, Research Center, Eastern State Hospital, Lexington, KY, Psychiatry and Neurosciences, Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada and Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain

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February 2019

Studies of Half-Lives of Long-Acting Antipsychotics are Needed.

Pharmacopsychiatry 2019 Jan 22;52(1):45-46. Epub 2018 Oct 22.

Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain, and Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain.

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January 2019

Thirty Years of Both Ignorance and Clinical Experience Suggest That Clozapine Intoxication During Co-Occurring Infections and Inflammation May Have Higher Morbidity and Mortality Than Is Currently Believed.

Psychosomatics 2019 Mar - Apr;60(2):221-222. Epub 2018 Jul 25.

Mental Health Research Center, Eastern State Hospital, Lexington, KY; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain, and Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain. Electronic address:

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April 2019

Why Do You Keep Telling Me That Drug-Drug Interactions Are Important in Psychopharmacology When I Do Not See Them in My Clinical Practice?: My Failure to Convince Clinicians.

Authors:
Jose de Leon

J Clin Psychopharmacol 2019 Jan/Feb;39(1):1-4

From the University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; and Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain.

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February 2019

Catatonia Following Abrupt Cessation of Oxcarbazepine in a Patient With Prader-Willi Syndrome.

Psychosomatics 2019 May - Jun;60(3):311-315. Epub 2018 Jul 31.

College of Medicine, University of Kentucky, Lexington, KY; University of Kentucky Mental Health Research Center, Eastern State Hospital, Lexington, KY; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain. Electronic address:

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March 2020

Teaching Medical Students How To Think: Narrative, Mechanistic and Mathematical Thinking.

Authors:
Jose de Leon

Actas Esp Psiquiatr 2018 Jul 1;46(4):133-45. Epub 2018 Jul 1.

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain, and Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain.

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July 2018

Periodic Catatonia Marked by Hypercortisolemia and Exacerbated by the Menses: A Case Report and Literature Review.

Case Rep Psychiatry 2018 4;2018:4264763. Epub 2018 Jul 4.

College of Medicine, University of Kentucky, Lexington, KY 40506, USA.

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July 2018

Prolactin levels: sex differences in the effects of risperidone, 9-hydroxyrisperidone levels, CYP2D6 and ABCB1 variants.

Pharmacogenomics 2018 07 19;19(10):815-823. Epub 2018 Jun 19.

Department of Biostatistics, The University of Kansas Medical Center, Kansas City, KS, USA.

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July 2018

Positive response to clozapine augmentation in a patient with obsessive-compulsive disorder complicated by a tardive movement disorder.

Braz J Psychiatry 2018 06;40(2):229-230

Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA.

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June 2018

A systematic review and combined analysis of therapeutic drug monitoring studies for oral paliperidone.

Expert Rev Clin Pharmacol 2018 Jun 18;11(6):625-639. Epub 2018 Jun 18.

e University of Kentucky Mental Health Research Center at Eastern State Hospital , Lexington , KY , USA.

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June 2018

A systematic review and combined analysis of therapeutic drug monitoring studies for oral paliperidone.

Expert Rev Clin Pharmacol 2018 Jun 18;11(6):625-639. Epub 2018 Jun 18.

e University of Kentucky Mental Health Research Center at Eastern State Hospital , Lexington , KY , USA.

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June 2018

Possible Pharmacodynamic and Pharmacokinetic Drug-Drug Interactions That Are Likely to Be Clinically Relevant and/or Frequent in Bipolar Disorder.

Curr Psychiatry Rep 2018 03 12;20(3):17. Epub 2018 Mar 12.

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

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March 2018

Unexpected Falls During Clozapine Treatment Explained by Myoclonus.

Prim Care Companion CNS Disord 2018 Jan 18;20(1). Epub 2018 Jan 18.

UK Mental Health Research Center, Eastern State Hospital, Lexington, Kentucky, USA.

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January 2018

Dealing with Difficult Medical Colleagues.

Psychother Psychosom 2018 6;87(1):5-11. Epub 2018 Jan 6.

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA.

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September 2018

Young Researchers and Young Clinicians Should Not Pay Much Attention to the Journal Impact Factor When Selecting a Journal for Publishing Articles: Comment on the Editorial "The Impact Non-Factor" by Greenblatt and Shader.

Authors:
Jose de Leon

J Clin Psychopharmacol 2018 02;38(1):86-87

University of Kentucky Mental Health, Research Center, Eastern State Hospital, Lexington, KY; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences University of Granada, Granada, Spain and Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain

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February 2018

Have we successfully implemented CYP2D6 genotyping in psychiatry?

Authors:
Jose de Leon

Expert Opin Drug Metab Toxicol 2017 12 22;13(12):1201-1203. Epub 2017 Nov 22.

a University of Kentucky Mental Health Research Center at Eastern State Hospital , Lexington , KY , USA.

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December 2017

Pharmacokinetics of risperidone in different application forms - Comparing long-acting injectable and oral formulations.

Eur Neuropsychopharmacol 2018 01 17;28(1):130-137. Epub 2017 Nov 17.

Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany; JARA - Translational Brain Medicine, Germany.

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January 2018

A Critical Commentary on the 2017 AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology.

Authors:
Jose de Leon

Pharmacopsychiatry 2018 Jan 18;51(1-02):63-68. Epub 2017 Sep 18.

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA.

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January 2018

Potentially Clinically Relevant Pharmacodynamic Interactions Between Antiepileptic Drugs and Psychotropic Drugs: An Update.

Curr Pharm Des 2017 ;23(37):5625-5638

University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA.

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July 2019

Moria: An Unrecognized Frontal Lobe Symptom.

Prim Care Companion CNS Disord 2017 Aug 3;19(4). Epub 2017 Aug 3.

College of Medicine, University of Kentucky, Lexington, Kentucky, USA.

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August 2017

Pulmonary Embolism during Stuporous Episodes of Catatonia Was Found to Be the Most Frequent Cause of Preventable Death According to a State Mortality Review: 6 Deaths in 15 Years.

Clin Schizophr Relat Psychoses 2017 Aug 4. Epub 2017 Aug 4.

Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY 40509, USA.

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August 2017

A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting risperidone.

Expert Rev Clin Pharmacol 2017 Sep 12;10(9):965-981. Epub 2017 Jul 12.

e University of Kentucky Mental Health Research Center at Eastern State Hospital , Lexington , KY.

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September 2017

A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting risperidone.

Expert Rev Clin Pharmacol 2017 Sep 12;10(9):965-981. Epub 2017 Jul 12.

e University of Kentucky Mental Health Research Center at Eastern State Hospital , Lexington , KY.

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September 2017

Pneumonia Can Cause Clozapine Intoxication: A Case Report.

Psychosomatics 2017 Nov - Dec;58(6):652-656. Epub 2017 May 17.

Mental Health Research Center, Eastern State Hospital, Lexington, KY; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain. Electronic address:

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February 2019

Possible Oxcarbazepine Inductive Effects on Aripiprazole Metabolism: A Case Report.

J Pharm Pract 2018 Jun 24;31(3):361-363. Epub 2017 May 24.

3 Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA.

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June 2018

Factors influencing adherence to psychopharmacological medications in psychiatric patients: a structural equation modeling approach.

Patient Prefer Adherence 2017 28;11:681-690. Epub 2017 Mar 28.

Departamento de Psicología Clínica, Psicobiología y Metodología, Universidad de La Laguna, Canary Islands, Spain.

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March 2017

Catatonia Secondary to Sudden Clozapine Withdrawal: A Case with Three Repeated Episodes and a Literature Review.

Case Rep Psychiatry 2017 15;2017:2402731. Epub 2017 Mar 15.

College of Medicine, University of Kentucky, Lexington, KY 40506, USA; University of Kentucky Mental Health Research Center, Eastern State Hospital, Lexington, KY 40511, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, 18971 Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, 01004 Vitoria-Gasteiz, Spain.

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March 2017

Reviving Research on Medication Attitudes for Improving Pharmacotherapy: Focusing on Adherence.

Psychother Psychosom 2017 10;86(2):73-79. Epub 2017 Feb 10.

Mental Health Research Center at Eastern State Hospital, Lexington, Ky., USA.

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February 2017

The Art of Pharmacotherapy: Reflections on Pharmacophobia.

J Clin Psychopharmacol 2017 Apr;37(2):131-137

From the *University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, Kentucky; and †Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada; ‡Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria; and §Department of Internal Medicine, Dermatology and Psychiatry, University of La Laguna, Canary Islands, Spain.

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April 2017

Efficacy and Safety of Adjunctive Aripiprazole in Schizophrenia: Meta-Analysis of Randomized Controlled Trials.

J Clin Psychopharmacol 2016 Dec;36(6):628-636

From *The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China; †Beijing Key Laboratory of Mental Disorders, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, China; ‡Center of Schizophrenia, Beijing Institute for Brain Disorders, Laboratory of Brain Disorders (Capital Medical University), Ministry of Science and Technology, Beijing, China; §Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA; ‖University of Kentucky, Mental Health Research Center at Eastern State Hospital, Lexington, KY; ¶Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada; and #Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain.

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December 2016

Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of Intramuscular Antipsychotics.

Case Rep Psychiatry 2016 15;2016:9406813. Epub 2016 Aug 15.

Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY 40509, USA; Eastern State Hospital, University of Kentucky Mental Health Research Center, Lexington, KY 40511, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, 18971 Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, 01004 Vitoria, Spain.

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September 2016

Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of Intramuscular Antipsychotics.

Case Rep Psychiatry 2016 15;2016:9406813. Epub 2016 Aug 15.

Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY 40509, USA; Eastern State Hospital, University of Kentucky Mental Health Research Center, Lexington, KY 40511, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, 18971 Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, 01004 Vitoria, Spain.

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September 2016

Ibuprofen May Increase Pharmacological Action of Valproate by Displacing It From Plasma Proteins: A Case Report.

Am J Psychiatry 2016 09;173(9):941-2

From the Institute of Neuropsychiatry and Addictions (INAD), Parc de Salut Mar, and the Department of Psychiatry, Autonomous University of Barcelona, Spain; the Mental Health Research Center, Eastern State Hospital, University of Kentucky, Lexington, Ky.; the Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Spain; and the Center for Biomedical Research Mental Health Network (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain.

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September 2016

Ibuprofen May Increase Pharmacological Action of Valproate by Displacing It From Plasma Proteins: A Case Report.

Am J Psychiatry 2016 09;173(9):941-2

From the Institute of Neuropsychiatry and Addictions (INAD), Parc de Salut Mar, and the Department of Psychiatry, Autonomous University of Barcelona, Spain; the Mental Health Research Center, Eastern State Hospital, University of Kentucky, Lexington, Ky.; the Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Spain; and the Center for Biomedical Research Mental Health Network (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain.

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September 2016

Adjunctive Electroconvulsive Therapy for Schizophrenia: A Meta-analysis of Randomized Rater-Masked Controlled Trials [RETRACTED].

J ECT 2016 08 3. Epub 2016 Aug 3.

From the *The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou; †The National Clinical Research Center for Mental Disorders, China and Center of Depression, Beijing Institute for Brain Disorders, Beijing Anding Hospital, Capital Medical University, Beijing; ‡Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China; §Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA; ∥Shenzhen Key Laboratory for Psychological Healthcare and Shenzhen Institute of Mental Health, Shenzhen Kangning Hospital and Shenzhen Mental Health Center, Shenzhen; ¶Department of Psychiatry, the Chinese University of Hong Kong, Hong Kong SAR; #Mental Hospital of Guangzhou Civil Administration, Guangzhou, China; **The University of Notre Dame Australia/Marian Centre; ††School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia; ‡‡University of Kentucky, Mental Health Research Center at Eastern State Hospital, Lexington, KY; §§Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada; and ∥∥Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain.

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August 2016

Reduction in serum concentration of valproic acid secondary to the intake of ibuprofen as an example of valproic acid auto-induction metabolism.

Actas Esp Psiquiatr 2016 Jul 1;44(4):136-44. Epub 2016 Jul 1.

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain, and Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain.

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July 2016

Pharmacogenetic Tests in Psychiatry: From Fear to Failure to Hype.

Authors:
Jose de Leon

J Clin Psychopharmacol 2016 Aug;36(4):299-304

From the University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada; and Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain.

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August 2016

Beyond the corrupting influence of pharmaceutical companies on antidepressant meta-analyses (Letter commenting on: J Clin Epidemiol. 70, 2016, 155-163).

Authors:
Jose de Leon

J Clin Epidemiol 2016 10 14;78:127-128. Epub 2016 Mar 14.

University of Kentucky Mental Health Research Center at Eastern State Hospital, Room 3A15A, 1350 Bull Lea Road, Lexington, KY 40511, USA. Electronic address:

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October 2016

Clinically significant pharmacokinetic drug interactions of antiepileptic drugs with new antidepressants and new antipsychotics.

Pharmacol Res 2016 Apr 16;106:72-86. Epub 2016 Feb 16.

University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY, United States; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain.

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April 2016

Assessing drug-drug interactions through therapeutic drug monitoring when administering oral second-generation antipsychotics.

Expert Opin Drug Metab Toxicol 2016 29;12(4):407-22. Epub 2016 Feb 29.

c University of Kentucky Mental Health Research Center at Eastern State Hospital , Lexington , KY , USA.

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January 2017

Assessing drug-drug interactions through therapeutic drug monitoring when administering oral second-generation antipsychotics.

Expert Opin Drug Metab Toxicol 2016 29;12(4):407-22. Epub 2016 Feb 29.

c University of Kentucky Mental Health Research Center at Eastern State Hospital , Lexington , KY , USA.

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January 2017

Adjunctive metformin for antipsychotic-induced hyperprolactinemia: A systematic review.

Psychiatry Res 2016 Mar 16;237:257-63. Epub 2016 Jan 16.

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain.

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March 2016

Adjunctive metformin for antipsychotic-induced hyperprolactinemia: A systematic review.

Psychiatry Res 2016 Mar 16;237:257-63. Epub 2016 Jan 16.

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain.

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March 2016

Pathophysiology and clinical trials have limitations in some areas of medicine: focus on psychiatry (letter commenting: J Clin Epidemiol. 2014;67(4):361-363.).

J Clin Epidemiol 2016 07 22;75:126-7. Epub 2016 Jan 22.

University of Kentucky Mental Health Research Center at Eastern State Hospital, Room 3A15A, 1350 Bull Lea Road, Lexington, KY 40511, USA.

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July 2016

Clozapine-induced myocarditis may be associated with rapid titration: A case report verified with autopsy.

Int J Psychiatry Med 2016;51(1):104-15

Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY, USA University of Kentucky Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain

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June 2017

Single- and Multiple-Dose Milnacipran Pharmacokinetics in Healthy Han Chinese Volunteers.

Clin Pharmacokinet 2016 07;55(7):889-896

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA.

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July 2016

What is needed to incorporate clinical pharmacogenetic tests into the practice of psychopharmacotherapy?

Expert Rev Clin Pharmacol 2016 18;9(3):351-4. Epub 2015 Nov 18.

d Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy.

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October 2016

Catatonia in Older Adult Individuals with Intellectual Disabilities.

Case Rep Psychiatry 2015 1;2015:120617. Epub 2015 Oct 1.

Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY 40509, USA ; University of Kentucky Mental Health Research Center, Eastern State Hospital, Lexington, KY 40511, USA ; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, 18971 Granada, Spain ; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, 01004 Vitoria, Spain.

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October 2015

A Case Report That Suggested That the Patient Was Very Sensitive to Induction and Needed 1600 mg/d of Lamotrigine to Get Therapeutic Concentrations.

J Clin Psychopharmacol 2015 Dec;35(6):745-7

Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY Pharmacy, Eastern State Hospital, Lexington, KY Madison State Hospital, Madison, IN Department of Psychiatry, College of Medicine, University of Kentucky and University of Kentucky Mental Health, Research Center, Eastern State Hospital, Lexington, KY

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December 2015

A Case Report That Suggested That the Patient Was Very Sensitive to Induction and Needed 1600 mg/d of Lamotrigine to Get Therapeutic Concentrations.

J Clin Psychopharmacol 2015 Dec;35(6):745-7

Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY Pharmacy, Eastern State Hospital, Lexington, KY Madison State Hospital, Madison, IN Department of Psychiatry, College of Medicine, University of Kentucky and University of Kentucky Mental Health, Research Center, Eastern State Hospital, Lexington, KY

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December 2015