Jose R Lopez

Jose R Lopez

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Cyclooxygenase inhibition prior to ventricular fibrillation induced ischemia reperfusion injury impairs survival and outcomes.

Med Hypotheses 2020 Feb 11;135:109485. Epub 2019 Nov 11.

Mt Sinai Medical Center Division of Neonatology, Miami Beach, FL, United States.

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http://dx.doi.org/10.1016/j.mehy.2019.109485DOI Listing
February 2020

Contribution of TRPC Channels to Intracellular Ca Dyshomeostasis in Smooth Muscle From mdx Mice.

Front Physiol 2020 20;11:126. Epub 2020 Feb 20.

Department of Neonatology, Mount Sinai Medical Center, Miami, FL, United States.

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http://dx.doi.org/10.3389/fphys.2020.00126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044154PMC
February 2020

Holistic approach to opioid use disorder: Think nitric oxide!

J Opioid Manag 2019 Nov/Dec;15(6):521-555

Chief, Division of Neonatology, Mt Sinai Medical Center of Greater Miami, Miami Beach, Florida.

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http://dx.doi.org/10.5055/jom.2019.0543DOI Listing
January 2020

Portable Gentle Jogger Improves Glycemic Indices in Type 2 Diabetic and Healthy Subjects Living at Home: A Pilot Study.

J Diabetes Res 2020 21;2020:8317973. Epub 2020 Jan 21.

Medical Services, Mt. Sinai Medical Center of Greater Miami, Miami Beach, Florida, USA.

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http://dx.doi.org/10.1155/2020/8317973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081036PMC
January 2020

Whole body periodic acceleration improves survival and microvascular leak in a murine endotoxin model.

PLoS One 2019 25;14(1):e0208681. Epub 2019 Jan 25.

Emeritus Director Medical Services, Mount Sinai Medical Center, Miami Beach, FL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208681PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347233PMC
September 2019

Enhancing Endogenous Nitric Oxide by Whole Body Periodic Acceleration Elicits Neuroprotective Effects in Dystrophic Neurons.

Mol Neurobiol 2018 Nov 26;55(11):8680-8694. Epub 2018 Mar 26.

Division of Neonatology, Mount Sinai Medical Center, Miami, FL, 33140, USA.

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http://dx.doi.org/10.1007/s12035-018-1018-8DOI Listing
November 2018

The Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in a Heterogeneous Group of Human Subjects.

J Sports Med (Hindawi Publ Corp) 2018 1;2018:4340925. Epub 2018 Oct 1.

Emeritus Director of Medical Services, Mount Sinai Medical Center, Miami Beach, Florida, USA.

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https://www.hindawi.com/journals/jsm/2018/4340925/
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http://dx.doi.org/10.1155/2018/4340925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191954PMC
October 2018

Functional and structural characterization of a novel malignant hyperthermia-susceptible variant of DHPR-β subunit (CACNB1).

Am J Physiol Cell Physiol 2018 03 6;314(3):C323-C333. Epub 2017 Dec 6.

John Curtin School of Medical Research, Australian National University , Canberra , Australia.

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http://dx.doi.org/10.1152/ajpcell.00187.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335014PMC
March 2018

Dysregulation of Intracellular Ca in Dystrophic Cortical and Hippocampal Neurons.

Mol Neurobiol 2018 01 15;55(1):603-618. Epub 2016 Dec 15.

Division of Neonatology, Mount Sinai Medical Center, Miami, FL, 33140, USA.

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http://dx.doi.org/10.1007/s12035-016-0311-7DOI Listing
January 2018

Increased constitutive nitric oxide production by whole body periodic acceleration ameliorates alterations in cardiomyocytes associated with utrophin/dystrophin deficiency.

J Mol Cell Cardiol 2017 07 13;108:149-157. Epub 2017 Jun 13.

Division of Neonatology, Mount Sinai Medical Center, Miami, FL 33140, United States.

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http://dx.doi.org/10.1016/j.yjmcc.2017.06.004DOI Listing
July 2017

Characterization of Aliivibrio fischeri strains associated with disease outbreak in brill Scophthalmus rhombus.

Dis Aquat Organ 2017 05;124(3):215-222

IFAPA Centro Agua del Pino, Junta de Andalucía, Carretera El Rompido-Punta Umbría km 3.8, CP21450 Cartaya, Huelva, Spain.

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http://dx.doi.org/10.3354/dao03123DOI Listing
May 2017

Isolation of Lacinutrix venerupis strains associated with disease outbreaks in sea bream Sparus aurata and European sea bass Dicentrarchus labrax.

Dis Aquat Organ 2017 03;124(1):85-90

IFAPA Centro Agua del Pino, Junta de Andalucía, Carretera El Rompido-Punta Umbría km 3.8., CP21450, Cartaya, Huelva, Spain.

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http://dx.doi.org/10.3354/dao03103DOI Listing
March 2017

Antioxidant Properties of Whole Body Periodic Acceleration (pGz).

PLoS One 2015 2;10(7):e0131392. Epub 2015 Jul 2.

Division of Neonatology, Mount Sinai Medical Center, Miami Beach, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131392PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489838PMC
April 2016

Climate and Developmental Plasticity: Interannual Variability in Grapevine Leaf Morphology.

Plant Physiol 2016 Mar 29;170(3):1480-91. Epub 2016 Jan 29.

Donald Danforth Plant Science Center, St. Louis, Missouri 63132 (D.H.C., S.M.R., D.Y.L., Q.L.W., T.T.Y., D.G.); University of Northern Iowa, Department of Biology, Cedar Falls, Iowa 50614 (J.R.L., J.K.); andU.S. Department of Agriculture, Agriculture Research Service, Grape Genetics Research Unit, Geneva, New York 14456 (J.P.L.).

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http://dx.doi.org/10.1104/pp.15.01825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775139PMC
March 2016

Whole body periodic acceleration (pGz) preserves heart rate variability after cardiac arrest.

Resuscitation 2016 Feb 12;99:20-5. Epub 2015 Dec 12.

Department of Molecular Biosciences, University of California Davis, Davis, CA, USA.

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http://dx.doi.org/10.1016/j.resuscitation.2015.11.018DOI Listing
February 2016

Altered ROS production, NF-κB activation and interleukin-6 gene expression induced by electrical stimulation in dystrophic mdx skeletal muscle cells.

Biochim Biophys Acta 2015 Jul 7;1852(7):1410-9. Epub 2015 Apr 7.

Centro de Estudios Moleculares de la Célula, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8389100, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433763PMC
July 2015

Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice.

PLoS One 2014 2;9(9):e106590. Epub 2014 Sep 2.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America; Department of Anesthesiology Perioperative and Pain Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106590PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152333PMC
April 2015

Evidence of reversible bradycardia and arrhythmias caused by immunogenic proteins secreted by T. cruzi in isolated rat hearts.

PLoS Negl Trop Dis 2015 Feb 3;9(2):e0003512. Epub 2015 Feb 3.

Laboratorio de Fisiología de Parásitos, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.

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http://dx.doi.org/10.1371/journal.pntd.0003512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315581PMC
February 2015

Age-dependent changes in diastolic Ca(2+) and Na(+) concentrations in dystrophic cardiomyopathy: Role of Ca(2+) entry and IP3.

Biochem Biophys Res Commun 2014 Oct 19;452(4):1054-9. Epub 2014 Sep 19.

Instituto Venezolano de Investigaciones Científicas, Centro de Biofísica y Bioquímica, Caracas, Venezuela; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.09.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275309PMC
October 2014

Will the DSM-5 changes in criteria for premenstrual dysphoric disorder impact clinical practice?

Braz J Psychiatry 2014 Sep;36(3):271

Laboratory of Panic & Respiration, Institute of Psychiatry, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1590/1516-4446-2013-1332DOI Listing
September 2014

Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle.

J Biol Chem 2014 Jul 20;289(27):19180-90. Epub 2014 May 20.

From the Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, the Department of Anesthesiology Perioperative and Pain Medicine, Brigham & Women's Hospital, Boston, Massachusetts 02115, and the Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas 1020-A, Venezuela,

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http://dx.doi.org/10.1074/jbc.M114.550764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081953PMC
July 2014

Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor.

Biochem J 2014 Jun;460(2):261-71

‡Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, U.S.A.

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http://biochemj.org/lookup/doi/10.1042/BJ20131553
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http://dx.doi.org/10.1042/BJ20131553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019983PMC
June 2014

Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia.

FASEB J 2013 Mar 16;27(3):991-1000. Epub 2012 Nov 16.

Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia, USA.

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http://dx.doi.org/10.1096/fj.12-218354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574284PMC
March 2013

Mitochondrial dysfunction in skeletal muscle of amyloid precursor protein-overexpressing mice.

J Biol Chem 2012 Jun 19;287(24):20534-44. Epub 2012 Apr 19.

CeSI-Centro Scienze dell'Invecchiamento and DNI-Department of Neuroscience and Imaging, University Gabriele d'Annunzio, I-66100 Chieti, Italy.

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http://dx.doi.org/10.1074/jbc.M112.359588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370238PMC
June 2012

Increased resting intracellular calcium modulates NF-κB-dependent inducible nitric-oxide synthase gene expression in dystrophic mdx skeletal myotubes.

J Biol Chem 2012 Jun 1;287(25):20876-87. Epub 2012 May 1.

From the Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago 8389100, Chile.

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http://dx.doi.org/10.1074/jbc.M112.344929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375511PMC
June 2012

Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor.

Proc Natl Acad Sci U S A 2012 May 30;109(20):7923-8. Epub 2012 Apr 30.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1119207109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356662PMC
May 2012

Pseudomonas baetica sp. nov., a fish pathogen isolated from wedge sole, Dicologlossa cuneata (Moreau).

Int J Syst Evol Microbiol 2012 Apr 3;62(Pt 4):874-82. Epub 2011 Jun 3.

IFAPA Centro Agua del Pino, Junta de Andalucia, Carretera El Portil-El Rompido s/n, 21450 Cartaya, Huelva, Spain.

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http://dx.doi.org/10.1099/ijs.0.030601-0DOI Listing
April 2012

[Dysfunction of diastolic [Ca²⁺] in cardiomyocytes isolated from chagasic patients].

Rev Esp Cardiol 2011 Jun 20;64(6):456-62. Epub 2011 Apr 20.

Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.

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http://dx.doi.org/10.1016/j.recesp.2011.01.008DOI Listing
June 2011

Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak.

Proc Natl Acad Sci U S A 2011 Apr 11;108(17):7046-51. Epub 2011 Apr 11.

Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1018380108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084091PMC
April 2011

Altered Ca2+ homeostasis in the skeletal muscle of DJ-1 null mice.

Neurobiol Aging 2011 Jan 15;32(1):125-32. Epub 2009 Aug 15.

Department of Neurology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge St., CBR-406, Boston, MA 02135, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2009.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888942PMC
January 2011

Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle.

Neurobiol Aging 2010 Dec 23;31(12):2080-90. Epub 2008 Dec 23.

Department of Neurology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge St., Boston, MA 02135, United States.

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http://dx.doi.org/10.1016/j.neurobiolaging.2008.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901770PMC
December 2010

Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes.

J Biol Chem 2010 Dec 11;285(50):39171-9. Epub 2010 Oct 11.

Department of Anesthesiology Perioperative and Pain Medicine, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M110.149690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998103PMC
December 2010

Intracellular β-amyloid accumulation leads to age-dependent progression of Ca2+ dysregulation in skeletal muscle.

Muscle Nerve 2010 Nov;42(5):731-8

Department of Anesthesia, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mus.21745DOI Listing
November 2010

Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1).

Biochem Pharmacol 2010 Aug 22;80(4):512-21. Epub 2010 May 22.

Department of Molecular Biosciences, University of California, Davis, 95616, United States of America.

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http://dx.doi.org/10.1016/j.bcp.2010.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907350PMC
August 2010

A malignant hyperthermia-inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channels.

J Gen Physiol 2010 Jun 17;135(6):629-40. Epub 2010 May 17.

Department of Physiology and Biophysics, School of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1085/jgp.200910329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888063PMC
June 2010

A malignant hyperthermia-inducing mutation in RYR1 (R163C): alterations in Ca2+ entry, release, and retrograde signaling to the DHPR.

J Gen Physiol 2010 Jun 17;135(6):619-28. Epub 2010 May 17.

Department of Anesthesiology Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1085/jgp.200910328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888056PMC
June 2010

RyR1-mediated Ca2+ leak and Ca2+ entry determine resting intracellular Ca2+ in skeletal myotubes.

J Biol Chem 2010 Apr 5;285(18):13781-7. Epub 2010 Mar 5.

Department of Anesthesiology Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M110.107300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859541PMC
April 2010

Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice.

J Neurochem 2008 Apr 16;105(1):262-71. Epub 2007 Nov 16.

Department of Anesthesia, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2007.05135.xDOI Listing
April 2008

Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene.

Mol Pharmacol 2008 Apr 2;73(4):1203-12. Epub 2008 Jan 2.

Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.107.04
Publisher Site
http://dx.doi.org/10.1124/mol.107.043299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735873PMC
April 2008

Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant hyperthermia mutations.

J Biol Chem 2007 Dec 16;282(52):37471-8. Epub 2007 Oct 16.

Department of Anesthesiology Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M701379200
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http://dx.doi.org/10.1074/jbc.M701379200DOI Listing
December 2007

Elevated resting [Ca(2+)](i) in myotubes expressing malignant hyperthermia RyR1 cDNAs is partially restored by modulation of passive calcium leak from the SR.

Am J Physiol Cell Physiol 2007 May 20;292(5):C1591-8. Epub 2006 Dec 20.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, USA.

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http://www.physiology.org/doi/10.1152/ajpcell.00133.2006
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http://dx.doi.org/10.1152/ajpcell.00133.2006DOI Listing
May 2007

Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse.

Anesthesiology 2006 Dec;105(6):1164-75

Department of Anesthesia, Perioperative and Pain Medicine, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1097/00000542-200612000-00016DOI Listing
December 2006

Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology.

FASEB J 2006 Oct 29;20(12):2165-7. Epub 2006 Aug 29.

Department of Neurology, Caritas St. Elizabeth's Medical Center of Boston, Tufts University School of Medicine, 736 Cambridge St., Boston, MA, USA.

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http://dx.doi.org/10.1096/fj.06-5763fjeDOI Listing
October 2006

Altered Ca2+ homeostasis in human uremic skeletal muscle: possible involvement of cADPR in elevation of intracellular resting [Ca2+].

Nephron Physiol 2005 25;100(4):p51-60. Epub 2005 Apr 25.

Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.

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http://dx.doi.org/10.1159/000085444DOI Listing
March 2006

Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]i.

Am J Physiol Cell Physiol 2005 Mar 10;288(3):C606-12. Epub 2004 Nov 10.

Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.

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http://dx.doi.org/10.1152/ajpcell.00297.2004DOI Listing
March 2005

Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle.

Am J Physiol Cell Physiol 2005 Mar 17;288(3):C640-9. Epub 2004 Nov 17.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 20 Shattuck St., Rm. SR 153, Boston, MA 02115, USA.

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http://dx.doi.org/10.1152/ajpcell.00407.2004DOI Listing
March 2005

Calcium dyshomeostasis in beta-amyloid and tau-bearing skeletal myotubes.

J Biol Chem 2004 Dec 22;279(51):53524-32. Epub 2004 Sep 22.

Department of Neurology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge St., Boston, MA 02135, USA.

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http://dx.doi.org/10.1074/jbc.M408473200DOI Listing
December 2004

Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle.

Am J Physiol Cell Physiol 2004 Jan 3;286(1):C73-8. Epub 2003 Sep 3.

Department of Anesthesia Research, Brigham and Women's Hospital, Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1152/ajpcell.00194.2003DOI Listing
January 2004