Jose N Nobrega

Jose N Nobrega

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Jose N Nobrega

Publications by authors named "Jose N Nobrega"

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A Key Role for Prefrontocortical Small Conductance Calcium-Activated Potassium Channels in Stress Adaptation and Rapid Antidepressant Response.

Cereb Cortex 2019 Sep 3. Epub 2019 Sep 3.

Behavioural Neurobiology Laboratory, Research Imaging Center, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.

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http://dx.doi.org/10.1093/cercor/bhz187DOI Listing
September 2019

In Vivo Brain Sampling Using a Microextraction Probe Reveals Metabolic Changes in Rodents after Deep Brain Stimulation.

Anal Chem 2019 Aug 17;91(15):9875-9884. Epub 2019 Jul 17.

Department of Chemistry , University of Waterloo , Waterloo , Ontario , Canada N2L 3G1.

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http://dx.doi.org/10.1021/acs.analchem.9b01540DOI Listing
August 2019

Ethanol-induced changes in synaptic amino acid neurotransmitter levels in the nucleus accumbens of differentially sensitized mice.

Psychopharmacology (Berl) 2019 Jul 13. Epub 2019 Jul 13.

Behavioural Neurobiology Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

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http://dx.doi.org/10.1007/s00213-019-05324-xDOI Listing
July 2019

Rostrocaudal subregions of the ventral tegmental area are differentially impacted by chronic stress.

Psychopharmacology (Berl) 2019 Jun 22;236(6):1917-1929. Epub 2019 Feb 22.

Behavioural Neurobiology Laboratory, Campbell Family Mental Health Research Institute and Research Imaging Center, Centre for Addiction and Mental Health, Toronto, Ontario, M5T 1R82, Canada.

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http://link.springer.com/10.1007/s00213-019-5177-8
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http://dx.doi.org/10.1007/s00213-019-5177-8DOI Listing
June 2019

Deep brain stimulation induces antidepressant-like effects in serotonin transporter knockout mice.

Brain Stimul 2018 Mar - Apr;11(2):423-425. Epub 2017 Nov 15.

Behavioural Neurobiology Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Centre of Neuromodulation, Hurvitz Brain Science Program, Sunnybrook Research Institute, University of Toronto, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2017.11.008DOI Listing
January 2019

High frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe?

Neurobiol Dis 2018 08 2;116:166-178. Epub 2018 May 2.

Behavioural Neurobiology Laboratory, Campbell Family Mental Health Research Institute and Research Imaging Center, Center for Addiction and Mental Health, Toronto, Ontario M5T 1R82, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S09699961183008
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http://dx.doi.org/10.1016/j.nbd.2018.03.011DOI Listing
August 2018

Deep brain stimulation and fluoxetine exert different long-term changes in the serotonergic system.

Neuropharmacology 2018 06 2;135:63-72. Epub 2018 Mar 2.

Behavioural Neurobiology Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Harqauil Neuromodulation Centre, Hurvitz Brain Science Program, Sunnybrook Research Institute, University of Toronto, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.03.005DOI Listing
June 2018

Prefrontal Cortex Deep Brain Stimulation Improves Fear and Anxiety-Like Behavior and Reduces Basolateral Amygdala Activity in a Preclinical Model of Posttraumatic Stress Disorder.

Neuropsychopharmacology 2018 04 1;43(5):1099-1106. Epub 2017 Sep 1.

Behavioural Neurobiology Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/npp.2017.207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854795PMC
April 2018

Antidepressant effects of focused ultrasound induced blood-brain-barrier opening.

Behav Brain Res 2018 04 8;342:57-61. Epub 2018 Jan 8.

Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01664328173173
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http://dx.doi.org/10.1016/j.bbr.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207941PMC
April 2018

A role for nucleus accumbens glutamate in the expression but not the induction of behavioural sensitization to ethanol.

Behav Brain Res 2018 01 14;336:269-281. Epub 2017 Sep 14.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Behavioural Neurobiology Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Departments of Psychiatry and Psychology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.bbr.2017.09.024DOI Listing
January 2018

Rat brain CYP2D enzymatic metabolism alters acute and chronic haloperidol side-effects by different mechanisms.

Prog Neuropsychopharmacol Biol Psychiatry 2017 08 26;78:140-148. Epub 2017 Apr 26.

Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Canada; Department of Pharmacology and Toxicology, University of Toronto, Canada; Department of Psychiatry, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2017.04.030DOI Listing
August 2017

Alterations of M1 and M4 acetylcholine receptors in the genetically dystonic (dt) hamster and moderate antidystonic efficacy of M1 and M4 anticholinergics.

Neuroscience 2017 08 9;357:84-98. Epub 2017 Jun 9.

Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 15, Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2017.05.051DOI Listing
August 2017

An improved, high-efficiency assay for assessing serum anticholinergic activity using cultured cells stably expressing M1 receptors.

J Pharmacol Toxicol Methods 2017 Jul 6;86:28-33. Epub 2017 Mar 6.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S10568719163017
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http://dx.doi.org/10.1016/j.vascn.2017.03.001DOI Listing
July 2017

Basal forebrain mediated increase in brain CRF is associated with increased cholinergic tone and depression.

Psychiatry Res Neuroimaging 2017 Jun 23;264:76-81. Epub 2017 Apr 23.

Department of Psychiatry, Steven and Alexandra Cohen Veterans Center, New York University Langone Medical Center, New York, 10962 USA; Geriatric Psychiatry Division, Nathan S. Kline Institute, 40 Old Orangeburg Road, Bldg 35, Orangeburg, NY 10962, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pscychresns.2017.04.009DOI Listing
June 2017

Lipoic acid and haloperidol-induced vacuous chewing movements: Implications for prophylactic antioxidant use in tardive dyskinesia.

Prog Neuropsychopharmacol Biol Psychiatry 2017 01 24;72:23-29. Epub 2016 Aug 24.

Centre for Addiction and Mental Health, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2016.08.010DOI Listing
January 2017

Deep Brain Stimulation in Animal Models of Fear, Anxiety, and Posttraumatic Stress Disorder.

Neuropsychopharmacology 2016 11 2;41(12):2810-2817. Epub 2016 Mar 2.

Behavioural Neurobiology Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/npp.2016.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061888PMC
November 2016

Strong interactions between learned helplessness and risky decision-making in a rat gambling model.

Sci Rep 2016 11 18;6:37304. Epub 2016 Nov 18.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/srep37304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114549PMC
November 2016

Lower KV7.5 Potassium Channel Subunit Expression in an Animal Model of Paroxysmal Dystonia.

CNS Neurol Disord Drug Targets 2016 ;15(1):95-101

Institute of Pharmacology and Toxicology, Department of Veterinary Medicine, Freie Universität Berlin, Koserstr. 20, 14195 Berlin, Germany.

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October 2016

Reply to: Deep Brain Stimulation for Depression: Is It a Gray or White "Matter"?

Biol Psychiatry 2016 09 26;80(6):e45. Epub 2016 Jan 26.

Biopsychology Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2016.01.007DOI Listing
September 2016

Increased Seasonal Variation in Serotonin Transporter Binding in Seasonal Affective Disorder.

Neuropsychopharmacology 2016 09 18;41(10):2447-54. Epub 2016 Apr 18.

Departments of Psychiatry, Pharmacology and Toxicology, CAMH Research Imaging Centre, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, and Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/npp.2016.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987850PMC
September 2016

Localized brain differences in Arc expression between mice showing low vs. high propensity to ethanol sensitization.

Pharmacol Biochem Behav 2016 Mar 18;142:15-22. Epub 2015 Dec 18.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Behavioural Neurobiology Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2015.12.006DOI Listing
March 2016

The fatty acid amide hydrolase inhibitor URB597 modulates serotonin-dependent emotional behaviour, and serotonin1A and serotonin2A/C activity in the hippocampus.

Eur Neuropsychopharmacol 2016 Mar 18;26(3):578-90. Epub 2015 Dec 18.

Neurobiological Psychiatry Unit, McGill University, McGill University Health Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.euroneuro.2015.12.027DOI Listing
March 2016

Antidepressant-like Effects of Medial Forebrain Bundle Deep Brain Stimulation in Rats are not Associated With Accumbens Dopamine Release.

Brain Stimul 2015 Jul-Aug;8(4):708-13. Epub 2015 Mar 10.

Behavioural Neurobiology Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8; Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2015.02.007DOI Listing
February 2016

Deep brain stimulation of the ventromedial prefrontal cortex causes reorganization of neuronal processes and vasculature.

Neuroimage 2016 Jan 23;125:422-427. Epub 2015 Oct 23.

Program in Neuroscience and Mental Health, The Hospital for Sick Children, Canada; Mouse Imaging Centre (MICe), The Hospital for Sick Children, Canada; Department of Medical Biophysics, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.neuroimage.2015.10.049DOI Listing
January 2016

Changes in dendritic spine density in the nucleus accumbens do not underlie ethanol sensitization.

Synapse 2015 Dec 14;69(12):607-10. Epub 2015 Oct 14.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/syn.21862DOI Listing
December 2015

Rapid anti-depressant and anxiolytic actions following dopamine D1-D2 receptor heteromer inactivation.

Eur Neuropsychopharmacol 2015 Dec 18;25(12):2437-48. Epub 2015 Sep 18.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2015.09.004DOI Listing
December 2015

Acute high frequency stimulation of the prefrontal cortex or nucleus accumbens does not increase hippocampal neurogenesis in rats.

J Psychiatr Res 2015 Sep 30;68:27-9. Epub 2015 May 30.

Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada; Campbell Family Mental Health Research Institute, CAMH, Canada; Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2015.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303012PMC
September 2015

Behavioral effects of food-derived opioid-like peptides in rodents: Implications for schizophrenia?

Pharmacol Biochem Behav 2015 Jul 7;134:70-8. Epub 2015 Feb 7.

Centre for Addiction and Mental Health, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2015.01.020DOI Listing
July 2015

Chronic deep brain stimulation of the rat ventral medial prefrontal cortex disrupts hippocampal-prefrontal coherence.

Exp Neurol 2015 Jul 1;269:1-7. Epub 2015 Apr 1.

Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T1R8, Canada; Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Campbell Family Mental Health Research Institute, CAMH, Canada.

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http://dx.doi.org/10.1016/j.expneurol.2015.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633366PMC
July 2015

Supraorbital stimulation does not induce an antidepressant-like response in rats.

Brain Stimul 2014 Mar-Apr;7(2):301-3. Epub 2013 Nov 14.

Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada; Division of Neurosurgery, University of Toronto, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2013.11.002DOI Listing
May 2015

Effects of high-frequency stimulation of the nucleus accumbens on the development and expression of ethanol sensitization in mice.

Behav Pharmacol 2015 Feb;26(1-2):184-92

Departments of aPharmacology and Toxicology bPsychiatry cPsychology, University of Toronto dBehavioural Neurobiology Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health eDivision of Neurosurgery, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/FBP.0000000000000033DOI Listing
February 2015

Towards a better preclinical model of PTSD: characterizing animals with weak extinction, maladaptive stress responses and low plasma corticosterone.

J Psychiatr Res 2015 Feb 26;61:158-65. Epub 2014 Dec 26.

Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2014.12.017DOI Listing
February 2015

Effects of anterior thalamic nucleus deep brain stimulation in chronic epileptic rats.

PLoS One 2014 3;9(6):e97618. Epub 2014 Jun 3.

Disciplina de Neurofisiologia, Universidade Federal de São Paulo, São Paulo, Brazil; Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097618PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043725PMC
January 2015

A dopamine D2 receptor-DISC1 protein complex may contribute to antipsychotic-like effects.

Neuron 2014 Dec 26;84(6):1302-16. Epub 2014 Nov 26.

Department of Neuroscience, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada; Psychiatry, University of Toronto, Toronto, ON M5S 2J7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.11.007DOI Listing
December 2014

Deep brain stimulation in rats: different targets induce similar antidepressant-like effects but influence different circuits.

Neurobiol Dis 2014 Nov 13;71:205-14. Epub 2014 Aug 13.

Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.nbd.2014.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756089PMC
November 2014

Changes in brain functional connectivity after chronic haloperidol in rats: a network analysis.

Int J Neuropsychopharmacol 2014 Aug 14;17(8):1129-38. Epub 2014 Feb 14.

Research Imaging Centre, Centre for Addiction and Mental Health,Canada.

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http://dx.doi.org/10.1017/S1461145714000042DOI Listing
August 2014

Augmentative therapies do not potentiate the antidepressant-like effects of deep brain stimulation in rats.

J Affect Disord 2014 Jun 15;161:87-90. Epub 2014 Mar 15.

Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8; Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2014.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756073PMC
June 2014

Oxidative stress and the antipsychotic-induced vacuous chewing movement model of tardive dyskinesia: evidence for antioxidant-based prevention strategies.

Psychopharmacology (Berl) 2014 Jun 22;231(11):2237-49. Epub 2014 Apr 22.

Centre for Addiction and Mental Health, 250 College St., Toronto, ON, M5T 1R8, Canada,

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http://dx.doi.org/10.1007/s00213-014-3582-6DOI Listing
June 2014

Altered NMDA receptor subunit gene expression in brains of mice showing high vs. low sensitization to ethanol.

Behav Brain Res 2014 Mar 4;260:58-66. Epub 2013 Dec 4.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01664328130072
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http://dx.doi.org/10.1016/j.bbr.2013.11.037DOI Listing
March 2014

Neurobiological basis of dyskinetic effects induced by antipsychotics: the contribution of animal models.

Curr Med Chem 2013 ;20(3):389-96

Center for Addiction and Mental Health, Behavioural Neurobiology Laboratory, 250 College Street, Toronto, Ontario M5T 1R8 Canada.

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http://dx.doi.org/10.2174/0929867311320030010DOI Listing
January 2014

Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects.

Neurosci Biobehav Rev 2014 Jan 1;38:173-92. Epub 2013 Dec 1.

Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.neubiorev.2013.11.009DOI Listing
January 2014

AMPA receptors mediate passive avoidance deficits induced by sleep deprivation.

Behav Brain Res 2013 Nov 28;257:189-96. Epub 2013 Sep 28.

Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.bbr.2013.09.037DOI Listing
November 2013

Effects of repeated deep brain stimulation on depressive- and anxiety-like behavior in rats: comparing entopeduncular and subthalamic nuclei.

Brain Stimul 2013 Jul 13;6(4):506-14. Epub 2012 Oct 13.

Department of Pharmacology and Toxicology, University of Toronto, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S1935861X120018
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http://dx.doi.org/10.1016/j.brs.2012.09.012DOI Listing
July 2013

Deep brain stimulation and memory.

Expert Rev Med Devices 2013 Jul;10(4):429-31

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http://dx.doi.org/10.1586/17434440.2013.811838DOI Listing
July 2013

Deep brain stimulation of the subthalamic nucleus increases premature responding in a rat gambling task.

Behav Brain Res 2013 May 19;245:76-82. Epub 2013 Feb 19.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.bbr.2013.02.011DOI Listing
May 2013

Susceptibility to ethanol sensitization is differentially associated with changes in pCREB, trkB and BDNF mRNA expression in the mouse brain.

Behav Brain Res 2013 Apr 2;242:25-33. Epub 2013 Jan 2.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.bbr.2012.12.035DOI Listing
April 2013

Electrical stimulation of the insular region attenuates nicotine-taking and nicotine-seeking behaviors.

Neuropsychopharmacology 2013 Mar 15;38(4):690-8. Epub 2012 Nov 15.

Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.

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http://www.nature.com/articles/npp2012235
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http://dx.doi.org/10.1038/npp.2012.235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572467PMC
March 2013

Preclinical studies modeling deep brain stimulation for depression.

Biol Psychiatry 2012 Dec 29;72(11):916-23. Epub 2012 Jun 29.

Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2012.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633367PMC
December 2012

Early gene mapping after deep brain stimulation in a rat model of tardive dyskinesia: comparison with transient local inactivation.

Eur Neuropsychopharmacol 2012 Jul 7;22(7):506-17. Epub 2011 Dec 7.

Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.euroneuro.2011.11.004DOI Listing
July 2012

Deep brain stimulation reverses anhedonic-like behavior in a chronic model of depression: role of serotonin and brain derived neurotrophic factor.

Biol Psychiatry 2012 Jan 14;71(1):30-5. Epub 2011 Oct 14.

Neuroimaging Research Section, Centre for Addiction and Mental Health, Toronto Western Hospital, 250 College Street, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2011.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756076PMC
January 2012

Modeling chronic olanzapine exposure using osmotic minipumps: pharmacological limitations.

Pharmacol Biochem Behav 2011 Nov 3;100(1):86-9. Epub 2011 Aug 3.

Department of Psychiatry, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.pbb.2011.07.019DOI Listing
November 2011

Partial agonists in schizophrenia--why some work and others do not: insights from preclinical animal models.

Int J Neuropsychopharmacol 2011 Oct 19;14(9):1165-78. Epub 2010 Nov 19.

King's College London, Department of Psychosis Studies, Institute of Psychiatry, London, UK.

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http://dx.doi.org/10.1017/S1461145710001343DOI Listing
October 2011

Effects of 5-HT(2A) and 5-HT(2C) receptor antagonists on acute and chronic dyskinetic effects induced by haloperidol in rats.

Behav Brain Res 2011 Jun 22;219(2):273-9. Epub 2011 Jan 22.

Neuroimaging Research Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.bbr.2011.01.025DOI Listing
June 2011

Deep brain stimulation of the subthalamic or entopeduncular nucleus attenuates vacuous chewing movements in a rodent model of tardive dyskinesia.

Eur Neuropsychopharmacol 2011 May 10;21(5):393-400. Epub 2010 Jul 10.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.euroneuro.2010.06.012DOI Listing
May 2011

Dopamine D3 receptor knock-out mice exhibit increased behavioral sensitivity to the anxiolytic drug diazepam.

Eur Neuropsychopharmacol 2011 Apr 8;21(4):325-32. Epub 2010 Jun 8.

Department of Experimental and Clinical Pharmacology, University of Catania, V.le A. Doria 6, 95125 Catania, Italy.

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http://dx.doi.org/10.1016/j.euroneuro.2010.05.006DOI Listing
April 2011

Aged dogs demonstrate both increased sensitivity to scopolamine impairment and decreased muscarinic receptor density.

Pharmacol Biochem Behav 2011 Apr 14;98(2):203-9. Epub 2011 Jan 14.

Department of Pharmacology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.pbb.2011.01.005DOI Listing
April 2011

Central injections of noradrenaline induce reinstatement of cocaine seeking and increase c-fos mRNA expression in the extended amygdala.

Behav Brain Res 2011 Mar 7;217(2):472-6. Epub 2010 Oct 7.

Centre for the Neurobiology of Stress, University of Toronto Scarborough, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.bbr.2010.09.025DOI Listing
March 2011

Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects.

Nat Med 2010 Dec 28;16(12):1393-5. Epub 2010 Nov 28.

Department of Neuroscience, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nm.2263DOI Listing
December 2010

Deep brain stimulation in clinical trials and animal models of depression.

Eur J Neurosci 2010 Oct;32(7):1109-17

Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

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http://doi.wiley.com/10.1111/j.1460-9568.2010.07414.x
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http://dx.doi.org/10.1111/j.1460-9568.2010.07414.xDOI Listing
October 2010

Effects of different stimulation parameters on the antidepressant-like response of medial prefrontal cortex deep brain stimulation in rats.

J Psychiatr Res 2010 Aug 22;44(11):683-7. Epub 2010 Jan 22.

Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8.

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http://dx.doi.org/10.1016/j.jpsychires.2009.12.010DOI Listing
August 2010

Autoradiographic and pharmacological studies on the role of dopamine D3 receptors in genetically dystonic (dt(sz)) hamsters.

Pharmacol Biochem Behav 2010 Aug 6;96(2):136-40. Epub 2010 May 6.

Institute of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Freie Universität Berlin, Koserstr. 20, 14195 Berlin, Germany.

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http://dx.doi.org/10.1016/j.pbb.2010.04.021DOI Listing
August 2010

The antipsychotics olanzapine, risperidone, clozapine, and haloperidol are D2-selective ex vivo but not in vitro.

Neuropsychopharmacology 2010 Jul 21;35(8):1826-35. Epub 2010 Apr 21.

Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/npp.2010.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055486PMC
July 2010

The effects of adolescent methylphenidate self-administration on responding for a conditioned reward, amphetamine-induced locomotor activity, and neuronal activation.

Psychopharmacology (Berl) 2010 Feb 18;208(3):455-68. Epub 2009 Dec 18.

Department of Psychology, University of Toronto, 100 St. George Street, Toronto, ON M5S3G3, Canada.

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http://dx.doi.org/10.1007/s00213-009-1745-7DOI Listing
February 2010

Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats.

Biol Psychiatry 2010 Jan;67(2):117-24

Neuroimaging Research Section, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2009.08.025DOI Listing
January 2010

Inverse benzodiazepine agonist beta-CCM does not reverse learning deficit induced by sleep deprivation.

Neurosci Lett 2010 Jan 3;469(1):169-73. Epub 2009 Dec 3.

Psychobiology Department, Universidade Federal de São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.neulet.2009.11.070DOI Listing
January 2010

A functional role for the dopamine D3 receptor in the induction and expression of behavioural sensitization to ethanol in mice.

Psychopharmacology (Berl) 2009 Nov 7;207(1):47-56. Epub 2009 Aug 7.

Psychology Department, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00213-009-1629-xDOI Listing
November 2009

Differential susceptibility to ethanol and amphetamine sensitization in dopamine D3 receptor-deficient mice.

Psychopharmacology (Berl) 2009 May 19;204(1):49-59. Epub 2008 Dec 19.

Psychology Department, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00213-008-1435-xDOI Listing
May 2009

Chronic mild stress induces widespread decreases in thyroid hormone alpha1 receptor mRNA levels in brain--reversal by imipramine.

Psychoneuroendocrinology 2009 Feb 17;34(2):281-6. Epub 2008 Oct 17.

Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ont., M5T 1R8 Canada.

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http://dx.doi.org/10.1016/j.psyneuen.2008.09.005DOI Listing
February 2009

Amisulpride the 'atypical' atypical antipsychotic--comparison to haloperidol, risperidone and clozapine.

Schizophr Res 2008 Oct 16;105(1-3):224-35. Epub 2008 Aug 16.

Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health (CAMH), Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.schres.2008.07.005DOI Listing
October 2008

Insulin resistance and decreased glucose-stimulated insulin secretion after acute olanzapine administration.

J Clin Psychopharmacol 2008 Oct;28(5):494-9

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JCP.0b013e318184b4c5DOI Listing
October 2008

The antipsychotic potential of l-stepholidine--a naturally occurring dopamine receptor D1 agonist and D2 antagonist.

Psychopharmacology (Berl) 2008 Aug 3;199(2):275-89. Epub 2008 Jun 3.

Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College, De Crespigny Park, Denmark Hill, London, UK.

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http://dx.doi.org/10.1007/s00213-008-1172-1DOI Listing
August 2008

Less is more: antipsychotic drug effects are greater with transient rather than continuous delivery.

Biol Psychiatry 2008 Jul 4;64(2):145-52. Epub 2008 Mar 4.

Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2008.01.010DOI Listing
July 2008

Evaluation of N-desmethylclozapine as a potential antipsychotic--preclinical studies.

Neuropsychopharmacology 2007 Jul 13;32(7):1540-9. Epub 2006 Dec 13.

1Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/sj.npp.1301279DOI Listing
July 2007

Pain hypersensitivity induced by paradoxical sleep deprivation is not due to altered binding to brain mu-opioid receptors.

Behav Brain Res 2007 Mar 21;178(2):216-20. Epub 2006 Dec 21.

Department of Psychobiology, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), R. Napoleão de Barros, 925, V. Clementino 04024-002, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.bbr.2006.12.016DOI Listing
March 2007

Gestational methylazoxymethanol acetate treatment impairs select cognitive functions: parallels to schizophrenia.

Neuropsychopharmacology 2007 Feb 11;32(2):483-92. Epub 2006 Oct 11.

Section of Biopsychology, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/sj.npp.1301223DOI Listing
February 2007

Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats.

Pharmacol Biochem Behav 2006 Oct 23;85(2):400-7. Epub 2006 Oct 23.

Department of Pediatrics of Universidade Federal de São Paulo-UNIFESP, São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.pbb.2006.09.008DOI Listing
October 2006

Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models.

Neuropsychopharmacology 2006 Sep 30;31(9):1854-63. Epub 2005 Nov 30.

Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/sj.npp.1300983DOI Listing
September 2006

A reassessment of the hyperphagia/weight-loss paradox during sleep deprivation.

Sleep 2006 Sep;29(9):1233-8

Department of Psychobiology of Universidade Federal de São Paulo-UNIFESP, São Paulo, Brazil.

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http://dx.doi.org/10.1093/sleep/29.9.1233DOI Listing
September 2006

Acetylcholine receptor binding and cholinergic interneuron density are unaltered in a genetic animal model of primary paroxysmal dystonia.

Brain Res 2006 Jul 9;1099(1):176-82. Epub 2006 Jun 9.

Freie Universität Berlin, School of Veterinary Medicine, Department of Pharmacology and Toxicology, Berlin, Germany.

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http://dx.doi.org/10.1016/j.brainres.2006.04.100DOI Listing
July 2006

Chronic restraint stress decreases the expression of glutathione S-transferase pi2 in the mouse hippocampus.

Brain Res 2006 May 27;1090(1):156-62. Epub 2006 Apr 27.

The Vivian Rakoff Mood Disorders Laboratory, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada M5T 1R8.

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http://dx.doi.org/10.1016/j.brainres.2006.03.062DOI Listing
May 2006

Fear conditioning performance and NMDA receptor subtypes: NR2A differential expression in the striatum.

Brain Res Bull 2006 Apr 7;69(4):440-6. Epub 2006 Mar 7.

Departamento de Psicobiologia, Universidade Federal de São Paulo, UNIFESP, SP, Brazil.

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http://dx.doi.org/10.1016/j.brainresbull.2006.02.010DOI Listing
April 2006

Contrasting loxapine to its isomer isoloxapine--the critical role of in vivo D2 blockade in determining atypicality.

Schizophr Res 2005 Sep;77(2-3):189-99

Schizophrenia-PET program, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada, M5T 1R8.

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http://linkinghub.elsevier.com/retrieve/pii/S092099640500119
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http://dx.doi.org/10.1016/j.schres.2005.03.009DOI Listing
September 2005

Involvement of dopamine receptors in cocaine-induced genital reflexes after paradoxical sleep deprivation.

Behav Brain Res 2005 May 28;160(1):44-50. Epub 2004 Dec 28.

Department of Psychobiology, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), R. Napoleão de Barros, 925, V. Clementino 04024-002, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.bbr.2004.11.016DOI Listing
May 2005

Opposite effects of sleep rebound on orexin OX1 and OX2 receptor expression in rat brain.

Brain Res Mol Brain Res 2005 May;136(1-2):148-57

Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.molbrainres.2005.02.002DOI Listing
May 2005

Early environmental experience alters baseline and ethanol-induced cognitive impulsivity: relationship to forebrain 5-HT1A receptor binding.

Behav Brain Res 2005 Apr 10;159(2):207-20. Epub 2004 Dec 10.

Department of Psychology, Queen's University, Kingston, Ont., Canada K7L 3N6.

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http://dx.doi.org/10.1016/j.bbr.2004.10.018DOI Listing
April 2005

Learning deficits induced by sleep deprivation and recovery are not associated with altered [(3)H]muscimol and [(3)H]flunitrazepam binding.

Brain Res 2005 Mar;1037(1-2):157-63

Psychobiology Department, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925 Vila Clementino, SP, 04024-002 São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.brainres.2005.01.005DOI Listing
March 2005

Continuous but not intermittent olanzapine infusion induces vacuous chewing movements in rats.

Biol Psychiatry 2005 Feb;57(4):406-11

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2004.10.023DOI Listing
February 2005