Publications by authors named "Jose M P Freije"

50Publications

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice.

Nat Med 2019 08 22;25(8):1234-1242. Epub 2019 Jul 22.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1038/s41591-019-0504-5DOI Listing
August 2019

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome.

Nat Med 2019 03 18;25(3):423-426. Epub 2019 Feb 18.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1038/s41591-018-0338-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546610PMC
March 2019

Retraction Note: NF-κB activation impairs somatic cell reprogramming in ageing.

Nat Cell Biol 2019 Mar;21(3):410

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006, Oviedo, Spain.

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http://www.nature.com/articles/s41556-018-0259-0
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http://dx.doi.org/10.1038/s41556-018-0259-0DOI Listing
March 2019

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism.

Cell Rep 2018 08;24(9):2392-2403

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183122
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http://dx.doi.org/10.1016/j.celrep.2018.07.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130051PMC
August 2018

Protease Silencing to Explore the Molecular Mechanisms of Cancer and Aging.

Methods Mol Biol 2018 ;1731:261-269

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1007/978-1-4939-7595-2_23DOI Listing
January 2019

Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice.

J Biol Chem 2018 02 22;293(6):2183-2194. Epub 2017 Dec 22.

From the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M117.788430
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http://dx.doi.org/10.1074/jbc.M117.788430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808777PMC
February 2018

Deubiquitination in cancer stem cells.

Aging (Albany NY) 2017 Feb;9(2):297-298

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.18632/aging.101182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361662PMC
February 2017

USP39 Deubiquitinase Is Essential for Oncogene-driven Cancer.

J Biol Chem 2017 03 1;292(10):4164-4175. Epub 2017 Feb 1.

From the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain,

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http://dx.doi.org/10.1074/jbc.M116.762757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354494PMC
March 2017

The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis.

Oncotarget 2016 Nov;7(46):74427-74434

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.18632/oncotarget.12769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342676PMC
November 2016

Metabolic Control of Longevity.

Cell 2016 Aug;166(4):802-821

Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; Institut National de la Santé et de la Recherche Médicale, U1138, 75006 Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France; Université Pierre et Marie Curie/Paris VI, 75006 Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France; Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, 171 76 Stockholm, Sweden; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, 94805 Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.07.031DOI Listing
August 2016

The novel tumor suppressor AIRAPL regulates IGF1R proteostasis.

Cell Cycle 2016 22;15(7):873-4. Epub 2016 Feb 22.

a Departamento de Bioquímica y Biología Molecular , Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo , Oviedo , Spain.

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http://dx.doi.org/10.1080/15384101.2016.1151725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889228PMC
April 2017

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.

Nat Med 2016 Jan 21;22(1):91-6. Epub 2015 Dec 21.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1038/nm.4013DOI Listing
January 2016

NF-κB activation impairs somatic cell reprogramming in ageing.

Nat Cell Biol 2015 Aug 27;17(8):1004-13. Epub 2015 Jul 27.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1038/ncb3207DOI Listing
August 2015

Loss of GLUT4 induces metabolic reprogramming and impairs viability of breast cancer cells.

J Cell Physiol 2015 Jan;230(1):191-8

Departamento de Biología Funcional, Área de Fisiología, Universidad de Oviedo, c/ Julian Claveria s/n, Oviedo, 33006, Spain.

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http://dx.doi.org/10.1002/jcp.24698DOI Listing
January 2015

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas.

Oncotarget 2013 Nov;4(11):1931-2

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.18632/oncotarget.1303DOI Listing
November 2013

ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis.

Autophagy 2013 Aug 8;9(8):1188-200. Epub 2013 May 8.

Departamento de Bioquímica y Biología Molecular; Facultad de Medicina; Instituto Universitario de Oncología (IUOPA); Universidad de Oviedo; Oviedo, Spain.

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http://www.tandfonline.com/doi/abs/10.4161/auto.24797
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http://dx.doi.org/10.4161/auto.24797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748191PMC
August 2013

Mutational analysis of BRCA1 and BRCA2 in hereditary breast and ovarian cancer families from Asturias (Northern Spain).

BMC Cancer 2013 May 17;13:243. Epub 2013 May 17.

Unidad de Cáncer Familiar, Servicio de Oncología Médica, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Hospital Universitario Central de Asturias (HUCA), Calle de Celestino Villamil, Oviedo 33006, Spain.

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http://dx.doi.org/10.1186/1471-2407-13-243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662577PMC
May 2013

Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients.

Hum Mol Genet 2013 Jun 14;22(11):2273-82. Epub 2013 Feb 14.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1093/hmg/ddt078DOI Listing
June 2013

NF-kB in premature aging.

Aging (Albany NY) 2012 Nov;4(11):726-7

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560436PMC
http://dx.doi.org/10.18632/aging.100502DOI Listing
November 2012

Reprogramming aging and progeria.

Curr Opin Cell Biol 2012 Dec 6;24(6):757-64. Epub 2012 Sep 6.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09550674120013
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http://dx.doi.org/10.1016/j.ceb.2012.08.009DOI Listing
December 2012

Cell autonomous and systemic factors in progeria development.

Biochem Soc Trans 2011 Dec;39(6):1710-4

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://www.biochemsoctrans.org/content/ppbiost/39/6/1710.ful
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http://biochemsoctrans.org/lookup/doi/10.1042/BST20110677
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http://dx.doi.org/10.1042/BST20110677DOI Listing
December 2011

Lamins, guardians of the soma and the genome.

Cell Cycle 2011 Oct 1;10(19):3236. Epub 2011 Oct 1.

Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.4161/cc.10.19.17129DOI Listing
October 2011

A conserved splicing mechanism of the LMNA gene controls premature aging.

Hum Mol Genet 2011 Dec 29;20(23):4540-55. Epub 2011 Aug 29.

CNRS, UMR 5535, University of Montpellier, Institut de Génétique Moléculaire de Montpellier, 1919 Route de Mende, Montpellier 34293, France.

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http://dx.doi.org/10.1093/hmg/ddr385DOI Listing
December 2011

Protease addiction and synthetic lethality in cancer.

Front Oncol 2011 5;1:25. Epub 2011 Sep 5.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo Oviedo, Spain.

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http://journal.frontiersin.org/article/10.3389/fonc.2011.000
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http://dx.doi.org/10.3389/fonc.2011.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356009PMC
August 2012

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease.

Aging Cell 2010 Dec 21;9(6):947-57. Epub 2010 Oct 21.

Departamento de Bioquímica y Biología Molecular Unidad de Epigenética, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1111/j.1474-9726.2010.00621.xDOI Listing
December 2010

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.

Proc Natl Acad Sci U S A 2010 Sep 30;107(37):16268-73. Epub 2010 Aug 30.

Departamento de Bioquímica y Biología Molecular and Biología Funcional, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1002696107
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http://dx.doi.org/10.1073/pnas.1002696107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941281PMC
September 2010

Autophagy is essential for mouse sense of balance.

J Clin Invest 2010 Jul 23;120(7):2331-44. Epub 2010 Jun 23.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://www.jci.org/articles/view/42601
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http://dx.doi.org/10.1172/JCI42601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898610PMC
July 2010

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells.

J Clin Invest 2009 Aug;119(8):2343-58

Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719930PMC
http://dx.doi.org/10.1172/jci37205DOI Listing
August 2009

Accelerated ageing: from mechanism to therapy through animal models.

Transgenic Res 2009 Feb 18;18(1):7-15. Epub 2008 Nov 18.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, 33006, Oviedo, Spain.

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http://link.springer.com/content/pdf/10.1007/s11248-008-9226
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http://link.springer.com/10.1007/s11248-008-9226-z
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http://dx.doi.org/10.1007/s11248-008-9226-zDOI Listing
February 2009

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

Nat Med 2008 Jul 29;14(7):767-72. Epub 2008 Jun 29.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, calle Fernando, Bongera s/n, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1038/nm1786DOI Listing
July 2008

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

Hum Mol Genet 2008 Jul 28;17(14):2196-211. Epub 2008 Apr 28.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1093/hmg/ddn120DOI Listing
July 2008

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice.

J Cell Biol 2008 Apr 31;181(1):27-35. Epub 2008 Mar 31.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://jcb.rupress.org/content/181/1/27.full.pdf
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http://www.jcb.org/lookup/doi/10.1083/jcb.200801096
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http://dx.doi.org/10.1083/jcb.200801096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287278PMC
April 2008

From immature lamin to premature aging: molecular pathways and therapeutic opportunities.

Cell Cycle 2005 Dec 23;4(12):1732-5. Epub 2005 Dec 23.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.4161/cc.4.12.2202DOI Listing
December 2005

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

Nature 2005 Sep 3;437(7058):564-8. Epub 2005 Aug 3.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1038/nature04019DOI Listing
September 2005

Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias.

Clin Cancer Res 2004 Jun;10(12 Pt 1):4089-95

Servicios de Oncología Médica, Anatomía Patológica, and Traumatología, Instituto Universitario de Oncología, Hospital Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0630DOI Listing
June 2004

AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes.

J Biol Chem 2003 Oct 19;278(43):42091-7. Epub 2003 Aug 19.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Campus del Christo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1074/jbc.M306700200DOI Listing
October 2003

Matrix metalloproteinases and tumor progression.

Adv Exp Med Biol 2003 ;532:91-107

Departamento de Bioquímica, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1007/978-1-4615-0081-0_9DOI Listing
February 2004

Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.

Biochem J 2003 Mar;370(Pt 3):1047-54

Departamento de Bioqumica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Campus del Cristo, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1042/BJ20021514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223240PMC
March 2003

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

Nat Genet 2002 May 1;31(1):94-9. Epub 2002 Apr 1.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://www.nature.com/articles/ng871
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http://dx.doi.org/10.1038/ng871DOI Listing
May 2002