Jose M Lizcano

The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis.

Authors:

Laia París-Coderch Aroa Soriano Carlos Jiménez Tatiana Erazo Pau Muñoz-Guardiola Marc Masanas Roberta Antonelli Ariadna Boloix José Alfón Héctor Pérez-Montoyo Marc Yeste-Velasco Carles Domènech Josep Roma Josep Sánchez de Toledo Lucas Moreno José M Lizcano Soledad Gallego Miguel F Segura

Cell Death Dis 2020 09 17;11(9):773. Epub 2020 Sep 17.

Translational Research in Child and Adolescent Cancer, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain.

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September 2020

STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammation.

Authors:

Paula Granado-Martínez Sara Garcia-Ortega Elena González-Sánchez Kimberley McGrail Rafael Selgas Judit Grueso Rosa Gil Neia Naldaiz-Gastesi Ana C Rhodes Javier Hernandez-Losa Berta Ferrer Francesc Canals Josep Villanueva Olga Méndez Sergio Espinosa-Gil José M Lizcano Eva Muñoz-Couselo Vicenç García-Patos Juan A Recio

Commun Biol 2020 Jul 9;3(1):366. Epub 2020 Jul 9.

Biomedical Research in Melanoma-Animal Models and Cancer Laboratory- Vall d'Hebron Research Institute VHIR-Vall d'Hebron Hospital Barcelona-UAB, Barcelona, 08035, Spain.

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July 2020

The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.

Autophagy 2020 May 25:1-18. Epub 2020 May 25.

Protein Kinases and Signal Transduction Laboratory, Departament De Bioquímica I Biologia Molecular and Institut De Neurociències, Universitat Autònoma De Barcelona (UAB) , Barcelona, Spain.

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May 2020

Discovery of a selective inhibitor of doublecortin like kinase 1.

Nat Chem Biol 2020 06 6;16(6):635-643. Epub 2020 Apr 6.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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June 2020

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer.

J Exp Med 2020 Jun;217(6)

Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), Derio, Spain.

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June 2020

SUMOylation Is Required for ERK5 Nuclear Translocation and ERK5-Mediated Cancer Cell Proliferation.

Authors:

Tatiana Erazo Sergio Espinosa-Gil Nora Diéguez-Martínez Néstor Gómez Jose M Lizcano

Int J Mol Sci 2020 Mar 23;21(6). Epub 2020 Mar 23.

Institut de Neurociències and Departament de Bioquímica i Biología Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

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March 2020

The novel proautophagy anticancer drug ABTL0812 potentiates chemotherapy in adenocarcinoma and squamous nonsmall cell lung cancer.

Int J Cancer 2020 Aug 6;147(4):1163-1179. Epub 2020 Feb 6.

Molecular and Translational Oncology Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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August 2020

Neuronal Growth Factor regulates Brain Specific Kinase 1 expression by inhibiting promoter methylation and promoting Sp1 recruitment.

Authors:

Leticia Ramírez Martínez Miguel Vargas Mejía Josep Espadamala Néstor Gomez José M Lizcano Esther López-Bayghen

Neurochem Int 2018 11 6;120:213-223. Epub 2018 Sep 6.

Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apartado Postal 14-740, Ciudad de México, 07360, Mexico. Electronic address:

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November 2018

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.

ACS Chem Biol 2018 09 31;13(9):2438-2448. Epub 2018 Aug 31.

Department of Cancer Biology , Dana-Farber Cancer Institute , Boston , Massachusetts 02215 , United States.

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September 2018

Editorial: Mitogen Activated Protein Kinases.

Authors:

Ana Cuenda José M Lizcano José Lozano

Front Cell Dev Biol 2017 14;5:80. Epub 2017 Sep 14.

Department of Molecular Biology and Biochemistry, Universidad de MálagaMálaga, Spain.

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September 2017

ERK5 and Cell Proliferation: Nuclear Localization Is What Matters.

Authors:

Nestor Gomez Tatiana Erazo Jose M Lizcano

Front Cell Dev Biol 2016 22;4:105. Epub 2016 Sep 22.

Protein Kinases and Signal Transduction Laboratory, Institut de Neurociencies and Departament de Bioquimica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona Barcelona, Spain.

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September 2016

Mutation of the 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Substrate-Docking Site in the Developing Brain Causes Microcephaly with Abnormal Brain Morphogenesis Independently of Akt, Leading to Impaired Cognition and Disruptive Behaviors.

Authors:

Lluís Cordón-Barris Sònia Pascual-Guiral Shaobin Yang Lydia Giménez-Llort Silvia Lope-Piedrafita Carlota Niemeyer Enrique Claro Jose M Lizcano Jose R Bayascas

Mol Cell Biol 2016 Dec 14;36(23):2967-2982. Epub 2016 Nov 14.

Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Unitat de Bioquímica de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain

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December 2016

Correction for Zurashvili et al., Interaction of PDK1 with Phosphoinositides Is Essential for Neuronal Differentiation but Dispensable for Neuronal Survival.

Authors:

Tinatin Zurashvili Lluís Cordón-Barris Gerard Ruiz-Babot Xiangyu Zhou Jose M Lizcano Nestor Gómez Lydia Giménez-Llort Jose R Bayascas

Mol Cell Biol 2016 06 31;36(12):1818. Epub 2016 May 31.

Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain.

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June 2016

The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase.

Clin Cancer Res 2016 05 15;22(10):2508-19. Epub 2015 Dec 15.

Protein Kinases and Signal Transduction Laboratory, Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.

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May 2016

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones.

Authors:

Xianming Deng Jonathan M Elkins Jinwei Zhang Qingkai Yang Tatiana Erazo Nestor Gomez Hwan Geun Choi Jinhua Wang Nicolas Dzamko Jiing-Dwan Lee Taebo Sim NamDoo Kim Dario R Alessi Jose M Lizcano Stefan Knapp Nathanael S Gray

Eur J Med Chem 2013 29;70:758-67. Epub 2013 Oct 29.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 250 Longwood Ave, SGM 628, Boston, MA 02115, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave, SGM 628, Boston, MA 02115, USA.

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September 2014

Functional characterization of the human mariner transposon Hsmar2.

Authors:

Estel Gil Assumpcio Bosch David Lampe Jose M Lizcano Jose C Perales Olivier Danos Miguel Chillon

PLoS One 2013 11;8(9):e73227. Epub 2013 Sep 11.

Department of Biochemistry and Molecular Biology, Edifici H, Center of Animal Biotechnology and Gene Therapy (CBATEG), Universitat Autònoma de Barcelona, Bellaterra, Spain.

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June 2014

X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor.

Authors:

Jonathan M Elkins Jing Wang Xianming Deng Michael J Pattison J Simon C Arthur Tatiana Erazo Nestor Gomez Jose M Lizcano Nathanael S Gray Stefan Knapp

J Med Chem 2013 Jun 17;56(11):4413-21. Epub 2013 May 17.

Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.

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June 2013

Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.

Authors:

Tatiana Erazo Ana Moreno Gerard Ruiz-Babot Arantza Rodríguez-Asiain Nicholas A Morrice Josep Espadamala Jose R Bayascas Nestor Gómez Jose M Lizcano

Mol Cell Biol 2013 Apr 19;33(8):1671-86. Epub 2013 Feb 19.

Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain.

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April 2013

Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.

Authors:

Tinatin Zurashvili Lluís Cordón-Barris Gerard Ruiz-Babot Xiangyu Zhou Jose M Lizcano Nestor Gómez Lydia Giménez-Llort Jose R Bayascas

Mol Cell Biol 2013 Mar 28;33(5):1027-40. Epub 2012 Dec 28.

Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain.

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March 2013

Brain specific kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment.

Authors:

Arantza Rodríguez-Asiain Gerard Ruiz-Babot Walter Romero Roger Cubí Tatiana Erazo Ricardo M Biondi Jose R Bayascas Jose Aguilera Nestor Gómez Carles Gil Enrique Claro Jose M Lizcano

Biochim Biophys Acta 2011 Dec 12;1811(12):1124-35. Epub 2011 Oct 12.

Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain.

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December 2011

Alternative ERK5 regulation by phosphorylation during the cell cycle.

Authors:

Francisco A Iñesta-Vaquera David G Campbell Cathy Tournier Nestor Gómez Jose M Lizcano A Cuenda

Cell Signal 2010 Dec 25;22(12):1829-37. Epub 2010 Jul 25.

Departamento de Inmunología y Oncología, Centro Nacional de Biotecnología/CSIC, Campus de Cantoblanco, E-28049 Madrid, Spain.

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December 2010

High-content peptide microarrays for deciphering kinase specificity and biology.

Authors:

Mike Schutkowski Ulf Reimer Sören Panse Liying Dong Jose M Lizcano Dario R Alessi Jens Schneider-Mergener

Angew Chem Int Ed Engl 2004 May;43(20):2671-4

Jerini AG, Berlin, Germany.

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May 2004

Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.

Authors:

Mahaboobi Jaleel Andrew McBride Jose M Lizcano Maria Deak Rachel Toth Nick A Morrice Dario R Alessi

FEBS Lett 2005 Feb;579(6):1417-23

MRC Protein Phosphorylation Unit, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.

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February 2005

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

Authors:

Jose M Lizcano Olga Göransson Rachel Toth Maria Deak Nick A Morrice Jérôme Boudeau Simon A Hawley Lina Udd Tomi P Mäkelä D Grahame Hardie Dario R Alessi

EMBO J 2004 Feb 19;23(4):833-43. Epub 2004 Feb 19.

MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.

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February 2004

Neuregulin signaling on glucose transport in muscle cells.

Authors:

Carles Cantó Elisabeth Suárez José M Lizcano Elisenda Griñó Peter R Shepherd Lee G D Fryer David Carling Joan Bertran Manuel Palacín Antonio Zorzano Anna Gumà

J Biol Chem 2004 Mar 6;279(13):12260-8. Epub 2004 Jan 6.

Departament de Bioquímica i Biologia Molecular and Parc Científic de Barcelona, Universitat de Barcelona, Avda. Diagonal 645, E-08028 Barcelona, Spain.

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March 2004