Jose Lopez-Barneo

Jose Lopez-Barneo

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Jose Lopez-Barneo

Publications by authors named "Jose Lopez-Barneo"

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Physiology of the Carotid Body: From Molecules to Disease.

Annu Rev Physiol 2020 Feb 16;82:127-149. Epub 2019 Oct 16.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla 41013, Spain; email:

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http://dx.doi.org/10.1146/annurev-physiol-020518-114427DOI Listing
February 2020

Acute O sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.

Sci Signal 2020 Jan 21;13(615). Epub 2020 Jan 21.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville 41013, Spain.

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http://dx.doi.org/10.1126/scisignal.aay9452DOI Listing
January 2020

Role of glial cell line-derived neurotrophic factor in the maintenance of adult mesencephalic catecholaminergic neurons.

Mov Disord 2020 Jan 13. Epub 2020 Jan 13.

Institute of Biomedicine of Seville, Virgen del Rocío University Hospital,/CSIC/University of Seville, Seville, Spain.

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http://dx.doi.org/10.1002/mds.27986DOI Listing
January 2020

Cellular adaptation to oxygen deficiency beyond the Nobel award.

Nat Commun 2020 Jan 30;11(1):607. Epub 2020 Jan 30.

Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104-6160, USA.

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http://dx.doi.org/10.1038/s41467-020-14469-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992614PMC
January 2020

Differential deletion of GDNF in the auditory system leads to altered sound responsiveness.

J Neurosci Res 2019 Oct 30. Epub 2019 Oct 30.

Instituto de Biología y Genética Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Científicas, Valladolid, Spain.

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http://dx.doi.org/10.1002/jnr.24544DOI Listing
October 2019

Acute oxygen sensing-Role of metabolic specifications in peripheral chemoreceptor cells.

Respir Physiol Neurobiol 2019 07 30;265:100-111. Epub 2018 Aug 30.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.resp.2018.08.007DOI Listing
July 2019

Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation.

Front Neurosci 2019 26;13:664. Epub 2019 Jun 26.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.3389/fnins.2019.00664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607990PMC
June 2019

Monitoring Functional Responses to Hypoxia in Single Carotid Body Cells.

Methods Mol Biol 2018 ;1742:125-137

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

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http://link.springer.com/10.1007/978-1-4939-7665-2_12
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http://dx.doi.org/10.1007/978-1-4939-7665-2_12DOI Listing
January 2019

Testing Acute Oxygen Sensing in Genetically Modified Mice: Plethysmography and Amperometry.

Methods Mol Biol 2018 ;1742:139-153

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.1007/978-1-4939-7665-2_13DOI Listing
January 2019

Glial-derived neurotrophic factor is essential for blood-nerve barrier functional recovery in an experimental murine model of traumatic peripheral neuropathy.

Tissue Barriers 2018 5;6(2):1-22. Epub 2018 Sep 5.

a Neuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, Department of Neurology , University of Alabama at Birmingham , Birmingham , Alabama , United States of America.

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http://dx.doi.org/10.1080/21688370.2018.1479570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179132PMC
December 2018

The role of Olfr78 in the breathing circuit of mice.

Nature 2018 09 26;561(7724):E33-E40. Epub 2018 Sep 26.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.1038/s41586-018-0545-9DOI Listing
September 2018

All for one - O -sensitive K channels that mediate carotid body activation.

J Physiol 2018 08 15;596(15):2951-2952. Epub 2018 Jan 15.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain.

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http://dx.doi.org/10.1113/JP275591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068221PMC
August 2018

Acute O Sensing: Role of Coenzyme QH/Q Ratio and Mitochondrial ROS Compartmentalization.

Cell Metab 2018 Jul 7;28(1):145-158.e4. Epub 2018 Jun 7.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, Avenida Manuel Siurot s/n, Seville, Spain; Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, Seville, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.05.009DOI Listing
July 2018

Oxygen sensing and stem cell activation in the hypoxic carotid body.

Cell Tissue Res 2018 05 24;372(2):417-425. Epub 2018 Jan 24.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avenida Manuel Siurot s/n, 41013, Seville, Spain.

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http://dx.doi.org/10.1007/s00441-017-2783-9DOI Listing
May 2018

HIF-2α is essential for carotid body development and function.

Elife 2018 04 19;7. Epub 2018 Apr 19.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.34681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916566PMC
April 2018

Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia.

EMBO Rep 2018 03 15;19(3). Epub 2018 Jan 15.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain

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http://dx.doi.org/10.15252/embr.201744598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836101PMC
March 2018

ablation promotes thyroid tumorigenesis by inducing a stem-like phenotype.

Endocr Relat Cancer 2017 11 19;24(11):579-591. Epub 2017 Sep 19.

Department of Cancer Biology and GeneticsThe Ohio State University, Columbus, Ohio, USA

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http://dx.doi.org/10.1530/ERC-17-0229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650926PMC
November 2017

Gene expression analyses reveal metabolic specifications in acute O -sensing chemoreceptor cells.

J Physiol 2017 09 8;595(18):6091-6120. Epub 2017 Aug 8.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain.

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http://dx.doi.org/10.1113/JP274684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599487PMC
September 2017

Redox signaling in acute oxygen sensing.

Redox Biol 2017 08 26;12:908-915. Epub 2017 Apr 26.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain; Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, Seville, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.04.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426049PMC
August 2017

Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan-Neuronal Activation in the Female Mouse.

PLoS One 2016 14;11(10):e0164391. Epub 2016 Oct 14.

Instituto de Biomedicina de Sevilla (IBIS), Departamento de Fisiología Médica y Biofísica, Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164391PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065215PMC
May 2017

Oxygen-sensing by arterial chemoreceptors: Mechanisms and medical translation.

Mol Aspects Med 2016 Feb-Mar;47-48:90-108. Epub 2015 Dec 18.

Instituto de Biomedicina de Sevilla (IBiS), Departamento de Fisiología Médica y Biofísica, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2015.12.002DOI Listing
October 2016

Hypoxia in health and disease.

Mol Aspects Med 2016 Feb-Mar;47-48:1-2

Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío/CSIC /Universidad de Sevilla. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2016.02.001DOI Listing
October 2016

Gene Expression Profiling Supports the Neural Crest Origin of Adult Rodent Carotid Body Stem Cells and Identifies CD10 as a Marker for Mesectoderm-Committed Progenitors.

Stem Cells 2016 06 2;34(6):1637-50. Epub 2016 Mar 2.

Departamento de Fisiología Médica y Biofísica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain.

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http://dx.doi.org/10.1002/stem.2331DOI Listing
June 2016

Mature neurons modulate neurogenesis through chemical signals acting on neural stem cells.

Dev Growth Differ 2016 Jun 21;58(5):456-62. Epub 2016 Apr 21.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1111/dgd.12283DOI Listing
June 2016

Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia.

Am J Physiol Cell Physiol 2016 Apr 13;310(8):C629-42. Epub 2016 Jan 13.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, Seville, Spain; Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, Seville, Spain; and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

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http://ajpcell.physiology.org/content/ajpcell/early/2016/01/
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http://ajpcell.physiology.org/lookup/doi/10.1152/ajpcell.002
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http://dx.doi.org/10.1152/ajpcell.00265.2015DOI Listing
April 2016

Tissue Dynamics of the Carotid Body Under Chronic Hypoxia: A Computational Study.

Adv Exp Med Biol 2015 ;860:25-39

Section of Human Anatomy, Department of Molecular Medicine, University of Padova, Via A. Gabelli 65, 35121, Padova, Italy,

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http://dx.doi.org/10.1007/978-3-319-18440-1_4DOI Listing
January 2016

Neurotrophic Properties, Chemosensory Responses and Neurogenic Niche of the Human Carotid Body.

Adv Exp Med Biol 2015 ;860:139-52

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avenida Manuel Siurot s/n, 41013, Seville, Spain.

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http://dx.doi.org/10.1007/978-3-319-18440-1_16DOI Listing
January 2016

Carotid body oxygen sensing and adaptation to hypoxia.

Pflugers Arch 2016 Jan 16;468(1):59-70. Epub 2015 Sep 16.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avenida Manuel Siurot s/n, 41013, Seville, Spain.

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http://link.springer.com/content/pdf/10.1007%2Fs00424-015-17
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http://link.springer.com/10.1007/s00424-015-1734-0
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http://dx.doi.org/10.1007/s00424-015-1734-0DOI Listing
January 2016

Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients.

EMBO Mol Med 2015 Dec;7(12):1529-46

Laboratory of Neurodegenerative Disorders, Department of Neurology, Hospital Clínic of Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) University of Barcelona (UB), Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain Cell Therapy Program, Faculty of Medicine, University of Barcelona (UB), Barcelona, Spain Movement Disorders Unit, Department of Neurology, Hospital Clínic of Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) University of Barcelona (UB), Barcelona, Spain.

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http://dx.doi.org/10.15252/emmm.201505439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693505PMC
December 2015

Resistance of glia-like central and peripheral neural stem cells to genetically induced mitochondrial dysfunction--differential effects on neurogenesis.

EMBO Rep 2015 Nov 21;16(11):1511-9. Epub 2015 Sep 21.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Seville, Spain Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, Sevilla, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

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http://dx.doi.org/10.15252/embr.201540982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641503PMC
November 2015

Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling.

Cell Metab 2015 Nov 1;22(5):825-37. Epub 2015 Oct 1.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Campus Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot, s/n, 41013 Seville, Spain; Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, Avenida Sánchez Pizjuan, 4, 41009 Seville, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Campus Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot, s/n, 41013 Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.09.004DOI Listing
November 2015

Commentaries on Viewpoint: Why do some patients stop breathing after taking narcotics? Ventilatory chemosensitivity as a predictor of opioid-induced respiratory depression.

J Appl Physiol (1985) 2015 Aug;119(4):423-5

Division of Respiratory and Critical Care Physiology and Medicine Los Angeles Biomedical Research Institute Harbor-UCLA Medical Center David Geffen School of Medicine University of California at Los AngelesLaboratory of Developmental and Integrative Physiology University of IowaDepartment of Pediatrics The Women & Children's Hospital of Buffalo University at BuffaloProfessor of Physiology Instituto de Biomedicina de Sevilla (IBiS) Hospital Universitario Virgen del Rocio/CSIC/Universidad de SevillaAssistant ProfessorSchool of Health and Rehabilitation Sciences The Ohio State University College of MedicineHarvard University.

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http://jap.physiology.org/content/jap/119/4/423.full.pdf
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http://jap.physiology.org/lookup/doi/10.1152/japplphysiol.00
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http://dx.doi.org/10.1152/japplphysiol.00434.2015DOI Listing
August 2015

Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival.

Hypoxia (Auckl) 2015 8;3:15-33. Epub 2015 Jun 8.

Medical Physiology and Biophysics Department, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital/CSIC/University of Seville, Seville, Spain; Network Center of Biomedical Research on Neurodegenerative Diseases (CIBERNED), Spain.

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http://dx.doi.org/10.2147/HP.S78248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045070PMC
June 2015

Reply to "GDNF is not required for catecholaminergic neuron survival in vivo".

Nat Neurosci 2015 Mar;18(3):322-3

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/ Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.1038/nn.3942DOI Listing
March 2015

GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson's disease.

Front Neuroanat 2015 13;9:10. Epub 2015 Feb 13.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla Seville, Spain ; Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla Seville, Spain ; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) Madrid, Spain.

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http://dx.doi.org/10.3389/fnana.2015.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327623PMC
March 2015

A conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction.

PLoS One 2014 20;9(1):e85528. Epub 2014 Jan 20.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla. Seville, Spain ; Departamento de Hematología. Hospital Universitario Virgen del Rocío. Seville, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085528PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896393PMC
January 2015

Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia.

EMBO Mol Med 2014 Dec;6(12):1577-92

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

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http://dx.doi.org/10.15252/emmm.201404153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287976PMC
December 2014

Glucose sensing by carotid body glomus cells: potential implications in disease.

Front Physiol 2014 15;5:398. Epub 2014 Oct 15.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla Seville, Spain ; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Seville, Spain ; Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla Seville, Spain.

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http://dx.doi.org/10.3389/fphys.2014.00398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197775PMC
October 2014

Low-dose combination of Rho kinase and L-type Ca(2+) channel antagonists for selective inhibition of depolarization-induced sustained arterial contraction.

Eur J Pharmacol 2014 Jun 27;732:130-8. Epub 2014 Mar 27.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Dpto. de Fisiología Médica y Biofísica. Avenida Manuel Siurot s/n, E-41013, Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2014.02.046DOI Listing
June 2014

An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia.

Cell 2014 Jan;156(1-2):291-303

Departamento de Fisiología Médica y Biofísica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.12.013DOI Listing
January 2014

Cellular properties and chemosensory responses of the human carotid body.

J Physiol 2013 Dec 28;591(24):6157-73. Epub 2013 Oct 28.

J. López-Barneo: Instituto de Biomedicina de Sevilla (IBiS), Campus Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain.

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http://dx.doi.org/10.1113/jphysiol.2013.263657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892469PMC
December 2013

Age-mediated transcriptomic changes in adult mouse substantia nigra.

PLoS One 2013 30;8(4):e62456. Epub 2013 Apr 30.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062456PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640071PMC
November 2013

Direct confocal acquisition of fluorescence from X-gal staining on thick tissue sections.

Sci Rep 2013 Oct 14;3:2937. Epub 2013 Oct 14.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1038/srep02937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796308PMC
October 2013

GDNF is required for neural colonization of the pancreas.

Development 2013 Sep 31;140(17):3669-79. Epub 2013 Jul 31.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.1242/dev.091256DOI Listing
September 2013

A new metabotropic role for L-type Ca(2+) channels in vascular smooth muscle contraction.

Curr Vasc Pharmacol 2013 Jul;11(4):490-6

Instituto de Biomedicina de Sevilla and Departamento de Fisiología Médica y Biofísica, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.2174/1570161111311040012DOI Listing
July 2013

Tonic arterial contraction mediated by L-type Ca2+ channels requires sustained Ca2+ influx, G protein-associated Ca2+ release, and RhoA/ROCK activation.

Eur J Pharmacol 2012 Dec 7;697(1-3):88-96. Epub 2012 Oct 7.

Instituto de Biomedicina de Sevilla and Dpto. Fisiología Médica y Biofísica, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain.

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http://dx.doi.org/10.1016/j.ejphar.2012.09.047DOI Listing
December 2012

Differential impairment of catecholaminergic cell maturation and survival by genetic mitochondrial complex II dysfunction.

Mol Cell Biol 2012 Aug 18;32(16):3347-57. Epub 2012 Jun 18.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.1128/MCB.00128-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434551PMC
August 2012

Metabotropic regulation of RhoA/Rho-associated kinase by L-type Ca2+ channels.

Trends Cardiovasc Med 2012 Aug 16;22(6):155-60. Epub 2012 Aug 16.

Instituto de Biomedicina de Sevilla (IBiS) and Departamento de Fisiología Médica y Biofísica, Hospital Universitario Virgen de Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain.

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http://dx.doi.org/10.1016/j.tcm.2012.07.013DOI Listing
August 2012

Neural stem cells and transplantation studies in Parkinson's disease.

Adv Exp Med Biol 2012 ;741:206-16

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain.

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http://dx.doi.org/10.1007/978-1-4614-2098-9_14DOI Listing
June 2012

Functional and transcriptional induction of aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1α.

PLoS One 2011 7;6(12):e28385. Epub 2011 Dec 7.

Departamento de Fisiología Médica y Biofísica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, Seville, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028385PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233559PMC
April 2012

Mitochondrial complex II is essential for hypoxia-induced pulmonary vasoconstriction of intra- but not of pre-acinar arteries.

Cardiovasc Res 2012 Mar 2;93(4):702-10. Epub 2012 Jan 2.

Institute of Anatomy and Cell Biology, Excellence Cluster Cardio-Pulmonary System, Justus-Liebig-University, Aulweg 123, 35385 Giessen, Germany.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvr359DOI Listing
March 2012

T-type Ca2+ channels in mouse embryonic stem cells: modulation during cell cycle and contribution to self-renewal.

Am J Physiol Cell Physiol 2012 Feb 2;302(3):C494-504. Epub 2011 Nov 2.

Instituto de Biomedicina de Sevilla, Campus Hospital Universitario Virgen del Rocío, Seville, Spain.

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http://dx.doi.org/10.1152/ajpcell.00267.2011DOI Listing
February 2012

α-Haemoglobin regulates sympathoadrenal cell metabolism to maintain a catecholaminergic phenotype.

Biochem J 2012 Feb;441(3):843-50

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain.

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http://dx.doi.org/10.1042/BJ20111640DOI Listing
February 2012

GDNF is predominantly expressed in the PV+ neostriatal interneuronal ensemble in normal mouse and after injury of the nigrostriatal pathway.

J Neurosci 2012 Jan;32(3):864-72

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, 41013 Sevilla, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.2693-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621168PMC
January 2012

GDNF and protection of adult central catecholaminergic neurons.

J Mol Endocrinol 2011 Jun 8;46(3):R83-92. Epub 2011 Jun 8.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain.

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http://dx.doi.org/10.1530/JME-10-0125DOI Listing
June 2011

Intermediate alleles at the FRAXA and FRAXE loci in Parkinson's disease.

Parkinsonism Relat Disord 2011 May 22;17(4):281-4. Epub 2011 Jan 22.

Departamento de Bioquímica Médica y Biología Molecular, Servicio de Biología Molecular, Hospital Universitario Virgen Macarena, Universidad de Sevilla, Av. Sánchez Pizjuán 4, Seville, Spain.

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http://dx.doi.org/10.1016/j.parkreldis.2010.12.013DOI Listing
May 2011

Metabotropic regulation of RhoA/Rho-associated kinase by L-type Ca2+ channels: new mechanism for depolarization-evoked mammalian arterial contraction.

Circ Res 2011 May 14;108(11):1348-57. Epub 2011 Apr 14.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1161/CIRCRESAHA.111.240127DOI Listing
May 2011

Mesencephalic and striatal protein profiles in mice over-expressing glucose-6-phosphate dehydrogenase in dopaminergic neurons.

J Proteomics 2010 Aug 1;73(9):1747-57. Epub 2010 Jun 1.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.1016/j.jprot.2010.05.014DOI Listing
August 2010

AQP1 mediates water transport in the carotid body.

Pflugers Arch 2010 Apr 5;459(5):775-83. Epub 2010 Jan 5.

Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville 41013, Spain.

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http://dx.doi.org/10.1007/s00424-009-0774-8DOI Listing
April 2010

Short communication: genetic ablation of L-type Ca2+ channels abolishes depolarization-induced Ca2+ release in arterial smooth muscle.

Circ Res 2010 Apr 18;106(7):1285-9. Epub 2010 Mar 18.

Instituto de Biomedicina de Sevilla, Edificio de Laboratorios, 2 planta, Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Sevilla, Spain.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.213967DOI Listing
April 2010

Carotid body chemosensory responses in mice deficient of TASK channels.

J Gen Physiol 2010 Apr;135(4):379-92

Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Cientificas, Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1085/jgp.200910302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847918PMC
April 2010

Oxygen sensing in the carotid body.

Ann N Y Acad Sci 2009 Oct;1177:119-31

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05033.xDOI Listing
October 2009

The neurogenic niche in the carotid body and its applicability to antiparkinsonian cell therapy.

J Neural Transm (Vienna) 2009 Aug 5;116(8):975-82. Epub 2009 Mar 5.

Instituto de Biomedicina de Sevilla, Edificio de Laboratorios, 2a planta, Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, Avenida Manuel Siurot s/n, 41013 Seville, Spain.

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http://dx.doi.org/10.1007/s00702-009-0201-5DOI Listing
August 2009

Differential proteomic analysis of adrenal gland during postnatal development.

Proteomics 2009 Jun;9(11):2946-54

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1002/pmic.200800748DOI Listing
June 2009

Hypoxia inducible factor-2alpha stabilization and maxi-K+ channel beta1-subunit gene repression by hypoxia in cardiac myocytes: role in preconditioning.

Circ Res 2009 Jun 21;104(12):1364-72. Epub 2009 May 21.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot s/n, 41013-Sevilla, Spain.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.190645DOI Listing
June 2009

Developmental change of T-type Ca2+ channel expression and its role in rat chromaffin cell responsiveness to acute hypoxia.

J Physiol 2009 May 9;587(Pt 9):1917-29. Epub 2009 Mar 9.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1113/jphysiol.2009.168989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689333PMC
May 2009

Hypoxia inhibits vasoconstriction induced by metabotropic Ca2+ channel-induced Ca2+ release in mammalian coronary arteries.

Cardiovasc Res 2009 Apr 8;82(1):115-24. Epub 2009 Jan 8.

Instituto de Biomedicina de Sevilla , Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avenida Manuel Siurot s/n, Seville E-41013, Spain.

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http://dx.doi.org/10.1093/cvr/cvp006DOI Listing
April 2009

Maxi-K+ channel beta1 expression in sleep apnea patients and its modulation by CPAP treatment.

Am J Hypertens 2009 Feb 4;22(2):197-202. Epub 2008 Dec 4.

Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1038/ajh.2008.342DOI Listing
February 2009

Absolute requirement of GDNF for adult catecholaminergic neuron survival.

Nat Neurosci 2008 Jul 8;11(7):755-61. Epub 2008 Jun 8.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Avenida Manuel Siurot s/n, 41013 Sevilla, Spain.

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http://dx.doi.org/10.1038/nn.2136DOI Listing
July 2008

Metabotropic Ca2+ channel-induced calcium release in vascular smooth muscle.

Cell Calcium 2007 Oct-Nov;42(4-5):513-20. Epub 2007 Jun 7.

Laboratorio de Investigaciones Biomédicas, Departamento de Fisiología and Hospital Universitario Virgen del Rocío, Universidad de Sevilla, E-41013 Seville, Spain.

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http://dx.doi.org/10.1016/j.ceca.2007.04.010DOI Listing
December 2007

Mechanisms of low-glucose sensitivity in carotid body glomus cells.

Diabetes 2007 Dec 7;56(12):2893-900. Epub 2007 Sep 7.

Laboratorio de Investigaciones Biomédicas, Departamento de Fisiología Médica y Biofísica, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.2337/db07-0122DOI Listing
December 2007

Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression.

J Biol Chem 2007 Oct 2;282(41):30207-15. Epub 2007 Aug 2.

Laboratorio de Investigaciones Biomédicas, Departamento de Fisiología Médica y Biofísica, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, 41013 Spain.

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http://dx.doi.org/10.1074/jbc.M702639200DOI Listing
October 2007

Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body.

Cell 2007 Oct;131(2):364-77

Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Avenida Manuel Siurot s/n, Sevilla 41013, Spain.

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http://dx.doi.org/10.1016/j.cell.2007.07.043DOI Listing
October 2007

Mechanisms of acute oxygen sensing by the carotid body: lessons from genetically modified animals.

Respir Physiol Neurobiol 2007 Jul 14;157(1):140-7. Epub 2007 Feb 14.

Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S15699048070006
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http://dx.doi.org/10.1016/j.resp.2007.02.009DOI Listing
July 2007

Developmental changes of chromaffin cell secretory response to hypoxia studied in thin adrenal slices.

Pflugers Arch 2007 Apr 13;454(1):93-100. Epub 2006 Dec 13.

Laboratorio de Investigaciones Biomédicas, Edificio de Laboratorios, Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain.

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http://dx.doi.org/10.1007/s00424-006-0186-yDOI Listing
April 2007

Acute oxygen sensing in heme oxygenase-2 null mice.

J Gen Physiol 2006 Oct 11;128(4):405-11. Epub 2006 Sep 11.

Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla 41013, Spain.

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http://dx.doi.org/10.1085/jgp.200609591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151578PMC
October 2006

Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells.

Novartis Found Symp 2006 ;272:54-64; discussion 64-72, 131-40

Laboratorio de Investigaciones Biomédicas, Departamento de Fisiología and Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1002/9780470035009.ch6DOI Listing
July 2006

Metabotropic Ca(2+) channel-induced Ca(2+) release and ATP-dependent facilitation of arterial myocyte contraction.

Proc Natl Acad Sci U S A 2006 Mar 7;103(11):4316-21. Epub 2006 Mar 7.

Laboratorio de Investigaciones Biomédicas and Unidad de Cirugía Cardiovascular, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, E-41013, Seville, Spain.

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http://dx.doi.org/10.1073/pnas.0508781103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449690PMC
March 2006

Oxygen tension regulates mitochondrial DNA-encoded complex I gene expression.

J Biol Chem 2005 Dec 28;280(52):42676-84. Epub 2005 Oct 28.

Laboratorio de Investigaciones Biomédicas, Departamento de Fisiología, Seville, Spain.

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http://dx.doi.org/10.1074/jbc.M507044200DOI Listing
December 2005

Acute oxygen-sensing mechanisms.

N Engl J Med 2005 Nov;353(19):2042-55

Department of Medicine, Minneapolis Veterans Affairs Medical Center and University of Minnesota, Minneapolis 55417, USA.

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http://dx.doi.org/10.1056/NEJMra050002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803102PMC
November 2005

Decreased expression of maxi-K+ channel beta1-subunit and altered vasoregulation in hypoxia.

Circulation 2005 Aug 22;112(9):1309-15. Epub 2005 Aug 22.

Laboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.104.529404DOI Listing
August 2005

Multiple facets of maxi-k+ channels: the heme connection.

J Gen Physiol 2005 Jul 13;126(1):1-5. Epub 2005 Jun 13.

Laboratorio de Investigaciones Biomédicas, Hospital Universiteario Virgen del Rocio, Universidad de Sevilla, Seville, Spain.

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http://dx.doi.org/10.1085/jgp.200509338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266619PMC
July 2005

Rat adrenal chromaffin cells are neonatal CO2 sensors.

J Neurosci 2005 Jul;25(28):6631-40

Departamento de Fisiología, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, E-41013 Seville, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.1139-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725439PMC
July 2005

Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation.

J Neurosci 2005 Apr;25(16):4091-8

Laboratorio de Investigaciones Biomédicas, Departamento de Fisiología and Hospital Universitario Virgen del Rocío, Universidad de Sevilla, 41013 Sevilla, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.4312-04.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724965PMC
April 2005

The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia.

Mol Cell Biol 2004 Dec;24(24):10933-40

Laboratorio de Investigaciones Biomédicas, Edificio de Laboratorios, 2 Planta, Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot s/n, E-41013 Seville, Spain.

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http://dx.doi.org/10.1128/MCB.24.24.10933-10940.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533988PMC
December 2004