Jose J Lucas

Jose J Lucas

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Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome.

Neurobiol Dis 2019 07 1;127:210-222. Epub 2019 Mar 1.

Instituto de Biología Molecular de Barcelona (IBMB), CSIC, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.02.022DOI Listing
July 2019

Differential regulation of Kidins220 isoforms in Huntington's disease.

Brain Pathol 2019 Jul 2. Epub 2019 Jul 2.

Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.

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http://dx.doi.org/10.1111/bpa.12761DOI Listing
July 2019

Pharmacokinetic evaluation of marbofloxacin after intravenous administration at different ages in llama crias, and pharmacokinetic/pharmacodynamic analysis by Monte Carlo simulation.

J Vet Pharmacol Ther 2018 Dec 18;41(6):861-870. Epub 2018 Jul 18.

Facultad de Ciencias Agropecuarias, IRNASUS CONICET-Universidad Católica de Córdoba, Córdoba, Argentina.

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http://dx.doi.org/10.1111/jvp.12698DOI Listing
December 2018

Profiling of Argonaute-2-loaded microRNAs in a mouse model of frontotemporal dementia with parkinsonism-17.

Int J Physiol Pathophysiol Pharmacol 2018 25;10(6):172-183. Epub 2018 Dec 25.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland Dublin 2, Ireland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334219PMC
December 2018

The regulation of proteostasis in glial cells by nucleotide receptors is key in acute neuroinflammation.

FASEB J 2018 06 11;32(6):3020-3032. Epub 2018 Jan 11.

Department of Biochemistry and Molecular Biology, Universidad Complutense of Madrid, Madrid, Spain.

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http://dx.doi.org/10.1096/fj.201701064RRDOI Listing
June 2018

Targeting the proteasome in epilepsy.

Oncotarget 2017 Jul;8(28):45042-45043

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.18632/oncotarget.18418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542164PMC
July 2017

Tau-positive nuclear indentations in P301S tauopathy mice.

Brain Pathol 2017 05 2;27(3):314-322. Epub 2016 Aug 2.

Center for Molecular Biology "Severo Ochoa" (CBMSO) CSIC/UAM, 28049, Madrid, Spain.

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http://dx.doi.org/10.1111/bpa.12407DOI Listing
May 2017

MAP2 Splicing is Altered in Huntington's Disease.

Brain Pathol 2017 03 7;27(2):181-189. Epub 2016 Jul 7.

Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM), Madrid, 28049, Spain.

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http://dx.doi.org/10.1111/bpa.12387DOI Listing
March 2017

Regulation of proteasome activity by P2Y receptor underlies the neuroprotective effects of extracellular nucleotides.

Biochim Biophys Acta Mol Basis Dis 2017 01 18;1863(1):43-51. Epub 2016 Oct 18.

Department of Biochemistry and Molecular Biology, Veterinary School, Complutense University of Madrid, Avda. Puerta de Hierro S/N, 28040 Madrid, Spain; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.10.012DOI Listing
January 2017

Faulty splicing and cytoskeleton abnormalities in Huntington's disease.

Brain Pathol 2016 11;26(6):772-778

Center for Molecular Biology "Severo Ochoa" (CBMSO) CSIC/UAM, Madrid, 28049, Spain.

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http://dx.doi.org/10.1111/bpa.12430DOI Listing
November 2016

Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.

Brain Pathol 2016 09 14;26(5):593-605. Epub 2015 Dec 14.

Institute of Neuropathology, Service of Pathologic Anatomy, IDIBELL-Bellvitge University Hospital, University of Barcelona, Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1111/bpa.12335DOI Listing
September 2016

Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice.

Metab Brain Dis 2016 06 14;31(3):579-86. Epub 2015 Dec 14.

Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, IRBLleida, Av. Rovira Roure 80, 25198, Lleida, Catalonia, Spain.

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http://dx.doi.org/10.1007/s11011-015-9777-7DOI Listing
June 2016

Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system.

Acta Neuropathol 2016 Mar 8;131(3):411-25. Epub 2015 Dec 8.

Department of Neurodegenerative Disease, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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http://link.springer.com/10.1007/s00401-015-1508-y
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http://dx.doi.org/10.1007/s00401-015-1508-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752964PMC
March 2016

Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.

Hum Mol Genet 2015 Sep 16;24(17):5040-52. Epub 2015 Jun 16.

Center for Molecular Biology "Severo Ochoa" (CBMSO) CSIC/UAM, 28049 Madrid, Spain, Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain,

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http://dx.doi.org/10.1093/hmg/ddv224DOI Listing
September 2015

Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus.

Mol Neurobiol 2015 Aug 15;52(1):120-9. Epub 2014 Aug 15.

Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda/Diagonal 643, E-08028, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12035-014-8836-0DOI Listing
August 2015

Comparison of pharmacokinetics of marbofloxacin after subcutaneous administration of various multiple-dose regimens to water buffalo calves (Bubalus bubalis).

Am J Vet Res 2014 Dec;75(12):1049-55

Department of Pharmacology, Faculty of Veterinary Science, Universidad Nacional del Litoral, 2805, Esperanza 3000, Santa Fe, Argentina.

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http://dx.doi.org/10.2460/ajvr.75.12.1049DOI Listing
December 2014

Ubiquitin-proteasome system involvement in Huntington's disease.

Front Mol Neurosci 2014 29;7:77. Epub 2014 Sep 29.

Department of Molecular Biology, Centro de Biología Molecular "Severo Ochoa," Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Centro Investigación Biomédica en Red Enfermedades Neurodegenerativa (CIBERNED), Madrid, Spain.

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http://dx.doi.org/10.3389/fnmol.2014.00077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179678PMC
October 2014

Reduced striatal dopamine DA D2 receptor function in dominant-negative GSK-3 transgenic mice.

Eur Neuropsychopharmacol 2014 Sep 21;24(9):1524-33. Epub 2014 Jul 21.

Centro de Biología Molecular "Severo Ochoa" (CBM"SO"), CSIC/UAM, 28049 Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2014.07.004DOI Listing
September 2014

Huntington's disease is a four-repeat tauopathy with tau nuclear rods.

Nat Med 2014 Aug 20;20(8):881-5. Epub 2014 Jul 20.

1] Center for Molecular Biology "Severo Ochoa" (CBMSO) Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC/UAM), Madrid, Spain. [2] Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Spain.

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http://dx.doi.org/10.1038/nm.3617DOI Listing
August 2014

Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders.

Front Behav Neurosci 2014 30;8:253. Epub 2014 Jul 30.

Centro de Biología Molecular "Severo Ochoa", (CBMSO) CSIC/UAM Madrid, Spain ; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III Madrid, Spain.

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http://dx.doi.org/10.3389/fnbeh.2014.00253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115618PMC
August 2014

In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning.

EMBO J 2014 Apr 12;33(7):762-78. Epub 2014 Feb 12.

Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.

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http://dx.doi.org/10.1002/embj.201386392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000092PMC
April 2014

GSK3 and tau: two convergence points in Alzheimer's disease.

J Alzheimers Dis 2013 ;33 Suppl 1:S141-4

Department of Neuroscience, Centro de Biologia Molecular Severo Ochoa CSIC/UAM, Universidad Autonoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.3233/JAD-2012-129025DOI Listing
June 2013

Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus.

Brain 2013 Apr 20;136(Pt 4):1161-76. Epub 2013 Mar 20.

Centro de Biología Molecular 'Severo Ochoa' (CSIC/UAM), C/ Nicolás Cabrera, 1, Campus UAM de Cantoblanco, 28049 Madrid, Spain.

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http://dx.doi.org/10.1093/brain/awt044DOI Listing
April 2013

Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes.

Exp Neurol 2013 Mar 5;241:75-83. Epub 2012 Dec 5.

Laboratorio de Biología y Fisiología Celular Dr. Francisco Bertini, Instituto de Histología y Embriología-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.

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http://dx.doi.org/10.1016/j.expneurol.2012.11.025DOI Listing
March 2013

CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures.

Brain 2013 Feb 29;136(Pt 2):577-92. Epub 2013 Jan 29.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1093/brain/aws337DOI Listing
February 2013

Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels.

Exp Neurol 2012 Oct 6;237(2):335-45. Epub 2012 Jul 6.

Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.expneurol.2012.06.033DOI Listing
October 2012

Looking for novel functions of tau.

Biochem Soc Trans 2012 Aug;40(4):653-5

Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.

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http://dx.doi.org/10.1042/BST20120006DOI Listing
August 2012

GSK-3 Mouse Models to Study Neuronal Apoptosis and Neurodegeneration.

Front Mol Neurosci 2011 16;4:45. Epub 2011 Nov 16.

Centro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas/Universidad Autónoma de Madrid Madrid, Spain.

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http://dx.doi.org/10.3389/fnmol.2011.00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217194PMC
November 2011

GSK3β overexpression induces neuronal death and a depletion of the neurogenic niches in the dentate gyrus.

Hippocampus 2011 Aug 23;21(8):910-22. Epub 2010 Jun 23.

Departamento de Neurobiología Comparada, Instituto Cavanilles, Universidad de Valencia, Spain.

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http://dx.doi.org/10.1002/hipo.20805DOI Listing
August 2011

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity.

J Neurosci 2011 Jun;31(22):8150-62

Departament de Biologia Cellular, Facultat de Medicina, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi-Sunyer, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.3446-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472648PMC
June 2011

Impaired ATF6α processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease.

Neurobiol Dis 2011 Jan 21;41(1):23-32. Epub 2010 Aug 21.

Centro de Biología Molecular Severo Ochoa-CSIC, UAM and CIBERNED, C/Nicolás Cabrera, 1 28049 Cantoblanco, Madrid, Spain.

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http://dx.doi.org/10.1016/j.nbd.2010.08.014DOI Listing
January 2011

Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease.

J Neurosci 2011 Jan;31(3):1106-13

Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Sevilla, Departamento de Fisiología Médica y Biofísica Universidad de Sevilla, 41009 Sevilla, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.2011-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632945PMC
January 2011

Centro de Biologia Molecular "Severo Ochoa": a center for basic research into Alzheimer's disease.

J Alzheimers Dis 2010 ;21(2):325-35

Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.3233/JAD-2010-100912DOI Listing
December 2010

Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism.

Free Radic Biol Med 2010 Aug;49(4):612-21

Departament de Ciències Mèdiques Bàsiques, IRBLLEIDA, Universitat de Lleida, 25008 Lleida, Spain.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.05.016DOI Listing
August 2010

Tau phosphorylation in hippocampus results in toxic gain-of-function.

Biochem Soc Trans 2010 Aug;38(4):977-80

Centro de Biología Molecular Severo Ochoa CSIC-UAM, Campus de la Universidad Autónoma de Madrid, 28049 Madrid, Spain.

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http://dx.doi.org/10.1042/BST0380977DOI Listing
August 2010

Tau kinase I overexpression induces dentate gyrus degeneration.

Neurodegener Dis 2010 13;7(1-3):13-5. Epub 2010 Feb 13.

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1159/000283476DOI Listing
July 2010

NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy.

J Clin Invest 2010 Jul 7;120(7):2432-45. Epub 2010 Jun 7.

Centro de Biología Molecular Severo Ochoa (CBM SO), CSIC/UAM, 28049 Madrid, Spain.

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http://dx.doi.org/10.1172/JCI37873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898581PMC
July 2010

GSK3: a possible link between beta amyloid peptide and tau protein.

Exp Neurol 2010 Jun 24;223(2):322-5. Epub 2009 Sep 24.

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/Nicolás Cabrera, 1 Campus Cantoblanco, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

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http://dx.doi.org/10.1016/j.expneurol.2009.09.011DOI Listing
June 2010

Presynaptic dysfunction in Huntington's disease.

Biochem Soc Trans 2010 Apr;38(2):488-92

Instituto de Biomedicina de Sevilla (IBiS) Hosp. Univ. Virgen del Rocío/CSIC/Universidad de Sevilla, Dpto. de Fisiología Médica y Biofísica Universidad de Sevilla, Avda. Sánchez-Pizjuán 4, 41009 Sevilla, Spain.

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http://dx.doi.org/10.1042/BST0380488DOI Listing
April 2010

Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits.

Neurobiol Dis 2010 Mar 11;37(3):622-9. Epub 2009 Dec 11.

Centro de Biología Molecular Severo Ochoa, C/Nicolás Cabrera, 1. Universidad Autónoma de Madrid, Campus Cantoblanco. 28049 Madrid, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S09699961090033
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http://dx.doi.org/10.1016/j.nbd.2009.11.017DOI Listing
March 2010

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

J Neurosci 2010 Mar;30(10):3675-88

Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autonoma de Madrid and CiberNed, Madrid, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.5673-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632247PMC
March 2010

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

Neurobiol Dis 2009 Dec 4;36(3):461-9. Epub 2009 Sep 4.

Departament de Biologia Cel.lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Casanova 143, E-08036 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.nbd.2009.08.012DOI Listing
December 2009

The role of GSK3 in Alzheimer disease.

Brain Res Bull 2009 Oct 27;80(4-5):248-50. Epub 2009 May 27.

Centro de Bioligía Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Campus Cantoblanco, 28049 Madrid, Spain.

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http://dx.doi.org/10.1016/j.brainresbull.2009.05.017DOI Listing
October 2009

Pharmacokinetic behavior and pharmacokinetic/pharmacodynamic integration of marbofloxacin after subcutaneous administration in goats.

Vet J 2007 Sep 27;174(2):425-7. Epub 2006 Jun 27.

Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.tvjl.2006.05.004DOI Listing
September 2007

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease.

J Neurosci Res 2007 Sep;85(12):2756-69

Departament de Biologia Cellular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Barcelona, Spain.

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http://dx.doi.org/10.1002/jnr.21258DOI Listing
September 2007

N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation.

J Biol Chem 2007 Aug 14;282(31):22406-13. Epub 2007 Jun 14.

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas/Universidad Autónoma(CSIC/UAM), Fac. Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

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http://dx.doi.org/10.1074/jbc.M702793200DOI Listing
August 2007

A mouse model to study tau pathology related with tau phosphorylation and assembly.

J Neurol Sci 2007 Jun 23;257(1-2):250-4. Epub 2007 Mar 23.

Centro de Biología Molecular "Severo Ochoa", CSIC/UAM, 28049 Madrid, Spain.

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http://dx.doi.org/10.1016/j.jns.2007.01.047DOI Listing
June 2007

Testing the possible inhibition of proteasome by direct interaction with ubiquitylated and aggregated huntingtin.

Brain Res Bull 2007 Apr 20;72(2-3):121-3. Epub 2006 Nov 20.

Centro de Biologia Molecular Severo Ochoa, CSIC/UAM, Campus UAM de Cantoblanco, Madrid, Spain.

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http://dx.doi.org/10.1016/j.brainresbull.2006.10.030DOI Listing
April 2007

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.

Eur J Neurosci 2007 Jan;25(1):81-6

MRC Centre for Neurodegeneration Research, Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2006.05245.xDOI Listing
January 2007

Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration.

Neurobiol Aging 2006 Sep 27;27(9):1258-68. Epub 2005 Jul 27.

Centro de Biología Molecular Severo Ochoa, CSIC/UAM, Fac. Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

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http://dx.doi.org/10.1016/j.neurobiolaging.2005.06.010DOI Listing
September 2006

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

J Neurosci 2006 May;26(19):5083-90

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.0604-06.2006DOI Listing
May 2006

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain.

Eur J Neurosci 2006 Feb;23(3):649-58

Departament de Biologia Cel.lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Casanova 143, E-08036 Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1460-9568.2006.04590.xDOI Listing
February 2006

Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease.

J Neurosci 2005 Oct;25(42):9773-81

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.3183-05.2005DOI Listing
October 2005

Enhanced induction of the immunoproteasome by interferon gamma in neurons expressing mutant Huntingtin.

Neurotox Res 2004 ;6(6):463-8

Centro de Biología Molecular Severo Ochao, CSIC/UAM, Fac. Ciencias, Universidad Autónoma de Madrid, Spain.

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March 2005

Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

J Neurosci 2004 Oct;24(42):9361-71

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28029 Madrid, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.2365-04.2004DOI Listing
October 2004

Proteasomal expression, induction of immunoproteasome subunits, and local MHC class I presentation in myofibrillar myopathy and inclusion body myositis.

J Neuropathol Exp Neurol 2004 May;63(5):484-98

Instituto de Neuropatología, Servicio de Anatomía Patológica, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1093/jnen/63.5.484DOI Listing
May 2004

Assembly in vitro of tau protein and its implications in Alzheimer's disease.

Curr Alzheimer Res 2004 May;1(2):97-101

Centro de Biología Molecular "Severo Ochoa", Facultad de Ciencias, Campus de Cantoblanco, Universidad Autónoma de Madrid, 28049 - Madrid, Spain.

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May 2004

Role of tau protein in both physiological and pathological conditions.

Physiol Rev 2004 Apr;84(2):361-84

Centro de Biología Molecular "Severo Ochoa", Facultad de Ciencias, Campus de Cantoblanco, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

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http://physrev.physiology.org/content/physrev/84/2/361.full.
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http://physrev.physiology.org/cgi/doi/10.1152/physrev.00024.
Publisher Site
http://dx.doi.org/10.1152/physrev.00024.2003DOI Listing
April 2004

Testing the ubiquitin-proteasome hypothesis of neurodegeneration in vivo.

Trends Neurosci 2004 Feb;27(2):66-9

Centro de Biología Molecular Severo Ochoa, CSIC/UAM, Madrid, Spain.

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http://dx.doi.org/10.1016/j.tins.2003.12.002DOI Listing
February 2004

Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.

J Biol Chem 2004 Jan 5;279(5):3801-6. Epub 2003 Nov 5.

Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas/CSIC/Universidad Autónoma, Fac. Ciencias. Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

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http://dx.doi.org/10.1074/jbc.M311512200DOI Listing
January 2004

GSK-3 dependent phosphoepitopes recognized by PHF-1 and AT-8 antibodies are present in different tau isoforms.

Neurobiol Aging 2003 Dec;24(8):1087-94

Centro de Biología Molecular "Severo Ochoa", CSIC/UAM, Fac. Ciencias Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

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December 2003

Neuronal induction of the immunoproteasome in Huntington's disease.

J Neurosci 2003 Dec;23(37):11653-61

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Contoblanco, 28049 Madrid, Spain.

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December 2003

Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments.

J Neurochem 2002 Dec;83(6):1529-33

Centro de Biología Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid (UAM), Madrid, Spain.

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http://dx.doi.org/10.1046/j.1471-4159.2002.01269.xDOI Listing
December 2002

Nuclear localization of N-terminal mutant huntingtin is cell cycle dependent.

Eur J Neurosci 2002 Jul;16(2):355-9

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC)/UAM, 28049 Madrid, Spain.

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http://dx.doi.org/10.1046/j.1460-9568.2002.02075.xDOI Listing
July 2002

Sulfo-glycosaminoglycan content affects PHF-tau solubility and allows the identification of different types of PHFs.

Brain Res 2002 May;935(1-2):65-72

Severo Ochoa Center for Molecular Biology, CSIC/UAM, Faculty of Sciences, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

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http://dx.doi.org/10.1016/s0006-8993(02)02455-1DOI Listing
May 2002

Transgenic mouse models with tau pathology to test therapeutic agents for Alzheimer's disease.

Mini Rev Med Chem 2002 Feb;2(1):51-8

Centro de Biología Molecular Severo Ochoa, CSIC/UAM. Madrid, Spain.

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February 2002