Jose C García-Borrón

Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase.

Authors:

Marta Abrisqueta Concepción Olivares Cecilia Herraiz María Castejón-Griñán Julia Sirés-Campos José C García-Borrón Celia Jiménez-Cervantes

Biochim Biophys Acta Mol Cell Res 2018 Jan 22;1865(1):76-94. Epub 2017 Sep 22.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB), El Palmar-30120 Murcia, Spain. Electronic address:

View Article and Find Full Text PDF

January 2018

Functional interplay between secreted ligands and receptors in melanoma.

Authors:

Cecilia Herraiz Celia Jiménez-Cervantes Berta Sánchez-Laorden José C García-Borrón

Semin Cell Dev Biol 2018 06 1;78:73-84. Epub 2017 Jul 1.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, and Instituto Murciano de Investigación Biosanitaria (IMIB), Campus de Ciencias de la Salud, El Palmar, Murcia, Spain. Electronic address:

View Article and Find Full Text PDF

June 2018

MC1R signaling. Intracellular partners and pathophysiological implications.

Authors:

Cecilia Herraiz Jose C Garcia-Borron Celia Jiménez-Cervantes Conchi Olivares

Biochim Biophys Acta Mol Basis Dis 2017 10 1;1863(10 Pt A):2448-2461. Epub 2017 Mar 1.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB), 30120 El Palmar, Murcia, Spain.

View Article and Find Full Text PDF

October 2017

Association of Melanocortin-1 Receptor Variants with Pigmentary Traits in Humans: A Pooled Analysis from the M-Skip Project.

J Invest Dermatol 2016 09 29;136(9):1914-1917. Epub 2016 May 29.

Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy. Electronic address:

View Article and Find Full Text PDF

September 2016

Identification and functional characterization of natural human melanocortin 1 receptor mutant alleles in Pakistani population.

Pigment Cell Melanoma Res 2015 Nov 22;28(6):730-5. Epub 2015 Sep 22.

Department of Otorhinolaryngology Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA.

View Article and Find Full Text PDF

November 2015

MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project.

Int J Cancer 2015 Feb 18;136(3):618-31. Epub 2014 Jun 18.

Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.

View Article and Find Full Text PDF

February 2015

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.

Authors:

Jose C García-Borrón Zalfa Abdel-Malek Celia Jiménez-Cervantes

Pigment Cell Melanoma Res 2014 Sep 30;27(5):699-720. Epub 2014 May 30.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Murcia, Spain; Instituto Murciano de Investigación Biomédica (IMIB), El Palmar, Murcia, Spain.

View Article and Find Full Text PDF

September 2014

The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis.

Authors:

María Contador-Troca Alberto Alvarez-Barrientos Eva Barrasa Eva M Rico-Leo Inmaculada Catalina-Fernández Mauricio Menacho-Márquez Xosé R Bustelo José C García-Borrón Aurea Gómez-Durán Javier Sáenz-Santamaría Pedro M Fernández-Salguero

Carcinogenesis 2013 Dec 10;34(12):2683-93. Epub 2013 Jul 10.

Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias and.

View Article and Find Full Text PDF

December 2013

Differential and competitive regulation of human melanocortin 1 receptor signaling by β-arrestin isoforms.

Authors:

Marta Abrisqueta Cecilia Herraiz Ana B Pérez Oliva Berta L Sanchez-Laorden Concepción Olivares Celia Jiménez-Cervantes José C García-Borrón

J Cell Sci 2013 Aug 7;126(Pt 16):3724-37. Epub 2013 Jun 7.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Murcia 30100, Spain.

View Article and Find Full Text PDF

August 2013

Functional status and relationships of melanocortin 1 receptor signaling to the cAMP and extracellular signal-regulated protein kinases 1 and 2 pathways in human melanoma cells.

Authors:

Cecilia Herraiz Fabrice Journé Ghanem Ghanem Celia Jiménez-Cervantes José C García-Borrón

Int J Biochem Cell Biol 2012 Dec 19;44(12):2244-52. Epub 2012 Sep 19.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Campus de Espinardo, Murcia, Spain.

View Article and Find Full Text PDF

December 2012

Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies.

BMC Med Res Methodol 2012 Aug 3;12:116. Epub 2012 Aug 3.

Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ramusio 1, Milan, 20141, Italy.

View Article and Find Full Text PDF

August 2012

N-glycosylation of the human melanocortin 1 receptor: occupancy of glycosylation sequons and functional role.

Authors:

Cecilia Herraiz Berta L Sánchez-Laorden Celia Jiménez-Cervantes José C García-Borrón

Pigment Cell Melanoma Res 2011 Jun 5;24(3):479-89. Epub 2011 Apr 5.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Murcia, Spain.

View Article and Find Full Text PDF

June 2011

Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT.

Authors:

Cecilia Herraiz Fabrice Journé Zalfa Abdel-Malek Ghanem Ghanem Celia Jiménez-Cervantes José C García-Borrón

Mol Endocrinol 2011 Jan 17;25(1):138-56. Epub 2010 Nov 17.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Campus de Espinardo, 30100 Espinardo, Murcia, Spain.

View Article and Find Full Text PDF

January 2011

Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways.

Authors:

Cecilia Herraiz Celia Jiménez-Cervantes Paola Zanna José C García-Borrón

FEBS Lett 2009 Oct 13;583(19):3269-74. Epub 2009 Sep 13.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, 30100 Espinardo, Spain.

View Article and Find Full Text PDF

October 2009

Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas.

Authors:

Ana B Pérez-Oliva Concepción Olivares Celia Jiménez-Cervantes José C García-Borrón

J Biol Chem 2009 Nov 8;284(46):31714-25. Epub 2009 Sep 8.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, 30100 Murcia, Spain.

View Article and Find Full Text PDF

November 2009

Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi.

Authors:

Berta L Sánchez-Laorden Cecilia Herraiz Julio C Valencia Vincent J Hearing Celia Jiménez-Cervantes José C García-Borrón

J Cell Physiol 2009 Sep;220(3):640-54

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Murcia, Spain.

View Article and Find Full Text PDF

September 2009

Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients.

Authors:

Ana B Pérez Oliva Lara P Fernéndez Carlos Detorre Cecilia Herráiz Jorge A Martínez-Escribano Javier Benítez José A Lozano Teruel José C García-Borrón Celia Jiménez-Cervantes Gloria Ribas

Hum Mutat 2009 May;30(5):811-22

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Murcia, Spain.

View Article and Find Full Text PDF

May 2009

Molecular cloning and biochemical characterization of the skin tyrosinase from Rana esculenta L.

Authors:

Paola T Zanna Immacolata Maida Marcella Arciuli Celia Jimenez-Cervantes José C Garcia-Borron Rosa Cicero Gabriella Guida

Comp Biochem Physiol B Biochem Mol Biol 2009 Mar 6;152(3):234-42. Epub 2008 Dec 6.

Dipartimento di Biochimica Medica, Biologia Medica e Fisica Medica, Facoltà di Medicina e Chirurgia, Università degli Studi di Bari, Policlinico-Piazza Giulio Cesare, Bari, Italy.

View Article and Find Full Text PDF

March 2009