Publications by authors named "Jose A Gonzalez-Martin"

2 Publications

  • Page 1 of 1

Corneal endothelial dysfunction in Pearson syndrome.

Ophthalmic Genet 2013 Mar-Jun;34(1-2):55-7. Epub 2011 Sep 21.

Department of Ophthalmology, Southport and Ormskirk Hospital NHS Trust, Southport, UK.

Mitochondrial disorders are associated with well recognized ocular manifestations. Pearson syndrome is an often fatal, multisystem, mitochondrial disorder that causes variable bone marrow, hepatic, renal and pancreatic exocrine dysfunction. Phenotypic progression of ocular disease in a 12-year-old male with Pearson syndrome is described. This case illustrates phenotypic drift from Pearson syndrome to Kearns-Sayre syndrome given the patient's longevity. Persistent corneal endothelial failure was noted in addition to ptosis, chronic external ophthalmoplegia and mid-peripheral pigmentary retinopathy. We propose that corneal edema resulting from corneal endothelial metabolic pump failure occurs within a spectrum of mitochondrial disorders.
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August 2013

Recovery of contour integration in relation to LogMAR visual acuity during treatment of amblyopia in children.

Invest Ophthalmol Vis Sci 2004 Nov;45(11):4016-22

Vision Assessment Unit, Department of Paediatric Ophthalmology, Alder Hey Childrens Hospital, Eaton Road, Liverpool, United Kingdom.

Purpose: In several studies, researchers have found that integration of orientation information along contours defined by Gabor patches is abnormal in patients with strabismus and in untreated patients with anisometropic amblyopia. In this study, the rate and degree of recovery of contour-integration deficits were compared with the recovery of logMAR (logarithm of the minimum angle of resolution) visual acuity deficits in patients newly diagnosed with amblyopia secondary to anisometropia, strabismus, or both.

Method: Contour-detection thresholds and optotype acuity were measured in 17 newly diagnosed anisometropic amblyopes, in 6 patients with strabismic amblyopia, and in 4 patients with combined anisometropic and strabismic amblyopia. Contour-detection thresholds were measured with a card-based procedure. Treatment comprised full refractive correction and full-time total occlusion therapy, when necessary. Visual function was measured at monthly visits during the course of treatment, with an average follow-up period of 16 weeks (12-24 weeks) for the entire group. Complete data were obtained from 23 patients through 8 weeks of follow-up.

Results: Significant interocular differences in contour-detection thresholds were present in 16 of the 27 patients at the first visit after initial refractive correction. Interocular differences in contour-detection thresholds declined to normal levels in most of the patients within 8 weeks of the initiation of treatment. Interocular acuity differences remained significant in many of the patients (19/23) at 8 weeks of follow-up and continued to decline, but did not fully normalize, over the remainder of the follow-up period.

Conclusions: Refractive correction alone or in combination with occlusion therapy produces a normalization of contour-integration thresholds in amblyopia that is more rapid and complete than that achieved for visual acuity.
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November 2004