Publications by authors named "Jos Jonkers"

100Publications

The use of CRISPR/Cas9-based gene editing strategies to explore cancer gene function in mice.

Curr Opin Genet Dev 2021 Jan 7;66:57-62. Epub 2021 Jan 7.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom. Electronic address:

View Article and Find Full Text PDF
January 2021

How the COVID-19 pandemic highlights the necessity of animal research.

Curr Biol 2020 Nov;30(21):4328

View Article and Find Full Text PDF
November 2020

How the COVID-19 pandemic highlights the necessity of animal research.

Curr Biol 2020 09 10;30(18):R1014-R1018. Epub 2020 Aug 10.

Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands. Electronic address:

View Article and Find Full Text PDF
September 2020

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.

Cell Rep 2020 08;32(8):108068

Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland; Division of Molecular Pathology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Bern Center for Precision Medicine, University of Bern, 3012 Bern, Switzerland. Electronic address:

View Article and Find Full Text PDF
August 2020

Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms.

Cancer Res 2020 04 14;80(7):1486-1497. Epub 2020 Feb 14.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article and Find Full Text PDF
April 2020

Exogenous ERα Expression in the Mammary Epithelium Decreases Over Time and Does Not Contribute to p53-Deficient Mammary Tumor Formation in Mice.

J Mammary Gland Biol Neoplasia 2019 12 15;24(4):305-321. Epub 2019 Nov 15.

Division of Molecular Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
December 2019

Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin.

Nat Commun 2019 08 23;10(1):3800. Epub 2019 Aug 23.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
August 2019

Ductal carcinoma in situ: to treat or not to treat, that is the question.

Br J Cancer 2019 08 9;121(4):285-292. Epub 2019 Jul 9.

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
August 2019

GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice.

J Mammary Gland Biol Neoplasia 2019 09 19;24(3):271-284. Epub 2019 Jun 19.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
September 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

View Article and Find Full Text PDF
February 2019

BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling.

J Pathol 2018 09 4;246(1):41-53. Epub 2018 Jul 4.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
September 2018

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

Br J Cancer 2018 06 8;118(12):1586-1595. Epub 2018 May 8.

Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands.

View Article and Find Full Text PDF
June 2018

Easy quantification of template-directed CRISPR/Cas9 editing.

Nucleic Acids Res 2018 06;46(10):e58

Division of Gene Regulation, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.

View Article and Find Full Text PDF
June 2018

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance.

Nat Methods 2018 02 11;15(2):134-140. Epub 2017 Dec 11.

Division of Molecular Pathology and Cancer Genomics Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
February 2018

Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer.

Oncotarget 2017 Aug 29;8(33):54364-54377. Epub 2017 Apr 29.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

View Article and Find Full Text PDF
August 2017

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.

Nat Commun 2017 07 17;8:15981. Epub 2017 Jul 17.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

View Article and Find Full Text PDF
July 2017

Identifying transposon insertions and their effects from RNA-sequencing data.

Nucleic Acids Res 2017 Jul;45(12):7064-7077

Division of Molecular Pathology and Cancer Genomics Netherlands, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands.

View Article and Find Full Text PDF
July 2017

Genetically engineered mouse models in oncology research and cancer medicine.

EMBO Mol Med 2017 02;9(2):137-153

Division of Molecular Pathology and Cancer Genomics Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands

View Article and Find Full Text PDF
February 2017

Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice.

J Pathol 2017 03 23;241(4):511-521. Epub 2017 Jan 23.

Division of Molecular Pathology and Cancer Genomics Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
March 2017

Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer.

Cold Spring Harb Symp Quant Biol 2016 4;81:141-150. Epub 2016 Nov 4.

Division of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

View Article and Find Full Text PDF
February 2018

PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma.

Cell Rep 2016 08 11;16(8):2087-2101. Epub 2016 Aug 11.

Division of Molecular Pathology, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Cancer Genomics Netherlands, 3584 CG Utrecht, the Netherlands. Electronic address:

View Article and Find Full Text PDF
August 2016

p120-Catenin Is Critical for the Development of Invasive Lobular Carcinoma in Mice.

J Mammary Gland Biol Neoplasia 2016 12 13;21(3-4):81-88. Epub 2016 Jul 13.

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article and Find Full Text PDF
December 2016

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer.

J Natl Cancer Inst 2016 11 5;108(11). Epub 2016 Jul 5.

Affiliations of authors: Division of Molecular Pathology and Cancer Genomics Centre Netherlands (PtB, PK, EvdB, UB, MdM, EL, LM, JdR, JW, JJ), Division of Molecular Carcinogenesis (IM), Department of Epidemiology and Biostatistics (KJ), and Family Cancer Clinic and Department of Pathology (FH), The Netherlands Cancer Institute, Amsterdam, the Netherlands; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain (CM, ME); The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK (HG, NT); Laboratory of Preclinical Investigation, Translational Research Department, Curie Institute, Paris, France (EM); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (WK, MvR, KD, EC); Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain (ME); Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain (ME).

View Article and Find Full Text PDF
November 2016

Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland.

Genes Dev 2016 06;30(12):1470-80

Division of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; Cancer Genomics Netherlands, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

View Article and Find Full Text PDF
June 2016

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

View Article and Find Full Text PDF
June 2016

HELB Is a Feedback Inhibitor of DNA End Resection.

Mol Cell 2016 Feb 7;61(3):405-418. Epub 2016 Jan 7.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, ON M5S 1A8, Canada. Electronic address:

View Article and Find Full Text PDF
February 2016

Using the GEMM-ESC strategy to study gene function in mouse models.

Nat Protoc 2015 Nov 15;10(11):1755-85. Epub 2015 Oct 15.

Division of Molecular Pathology and Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
November 2015

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors.

Clin Cancer Res 2016 Jan 15;22(1):96-106. Epub 2015 Sep 15.

Department of Molecular Cell Biology and Cancer Genomics Centre Netherlands, Leiden University Medical Center, Leiden, the Netherlands. Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden.

View Article and Find Full Text PDF
January 2016

Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells.

Radiother Oncol 2015 Sep 13;116(3):358-65. Epub 2015 May 13.

Division of Biological Stress Response, Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands. Electronic address:

View Article and Find Full Text PDF
September 2015

Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2⁺ breast cancer.

Pain 2015 Aug;156(8):1424-1432

Division of Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands Department of Anesthesiology, Academic Medical Center, Amsterdam, the Netherlands Division of Molecular Pathology and Cancer Genomics Center, Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article and Find Full Text PDF
August 2015

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression.

Cell Rep 2015 Jan 15;10(3):383-397. Epub 2015 Jan 15.

Division of Molecular Genetics, Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

View Article and Find Full Text PDF
January 2015

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.

EMBO J 2015 Feb 12;34(3):410-24. Epub 2015 Jan 12.

Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Oxford, UK

View Article and Find Full Text PDF
February 2015

The use of mass spectrometry imaging to predict treatment response of patient-derived xenograft models of triple-negative breast cancer.

J Proteome Res 2015 Feb 20;14(2):1069-75. Epub 2015 Jan 20.

Biomolecular Imaging Mass Spectrometry, FOM Institute AMOLF , Science Park 104, 1098 XG Amsterdam, The Netherlands.

View Article and Find Full Text PDF
February 2015

BRCA2-deficient sarcomatoid mammary tumors exhibit multidrug resistance.

Cancer Res 2015 Feb 15;75(4):732-41. Epub 2014 Dec 15.

Division of Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands. Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

View Article and Find Full Text PDF
February 2015

Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and growth inhibition of breast cancer cells and cancer stem-like cells.

Oncotarget 2014 Dec;5(23):11827-46

Laboratory of Genomic Applications, Department of Surgical Oncology, Sheba Medical Center, Ramat-Gan 52621, Israel. Sheba Cancer Research Center, Sheba Medical Center, Ramat-Gan 52621, Israel. Department of Human Science, Georgetown University Medical Center, Washington DC 20057, USA. Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NW Washington DC 20057, USA.

View Article and Find Full Text PDF
December 2014

Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways.

Cell 2014 Oct;159(3):499-513

Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article and Find Full Text PDF
October 2014

Lack of genomic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases.

PLoS One 2014 1;9(8):e103177. Epub 2014 Aug 1.

Division of Molecular Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands; Division of Medical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

View Article and Find Full Text PDF
April 2015

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation.

Int J Cancer 2015 Mar 8;136(6):1434-44. Epub 2014 Aug 8.

Division of Molecular Carcinogenesis, Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
March 2015

Molecular pathways: how can BRCA-mutated tumors become resistant to PARP inhibitors?

Clin Cancer Res 2014 Feb 22;20(3):540-7. Epub 2013 Nov 22.

Authors' Affiliation: Division of Molecular Pathology and Cancer Genomics Centre, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article and Find Full Text PDF
February 2014

A high-throughput functional complementation assay for classification of BRCA1 missense variants.

Cancer Discov 2013 Oct 18;3(10):1142-55. Epub 2013 Jul 18.

1Division of Molecular Pathology and Cancer Genomics Centre and 2Department of Pathology, The Netherlands Cancer Institute Amsterdam, The Netherlands; and 3TaconicArtemis GmbH, Cologne, Germany.

View Article and Find Full Text PDF
October 2013