Jos Jonkers

Jos Jonkers

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Jos Jonkers

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Exogenous ERα Expression in the Mammary Epithelium Decreases Over Time and Does Not Contribute to p53-Deficient Mammary Tumor Formation in Mice.

J Mammary Gland Biol Neoplasia 2019 Dec 15;24(4):305-321. Epub 2019 Nov 15.

Division of Molecular Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10911-019-09437-zDOI Listing
December 2019

TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development.

Genes Dev 2019 Dec 26. Epub 2019 Dec 26.

Division of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

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http://dx.doi.org/10.1101/gad.331371.119DOI Listing
December 2019

GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice.

J Mammary Gland Biol Neoplasia 2019 Sep 19;24(3):271-284. Epub 2019 Jun 19.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10911-019-09432-4DOI Listing
September 2019

Ductal carcinoma in situ: to treat or not to treat, that is the question.

Br J Cancer 2019 Aug 9;121(4):285-292. Epub 2019 Jul 9.

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41416-019-0478-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697179PMC
August 2019

Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin.

Nat Commun 2019 08 23;10(1):3800. Epub 2019 Aug 23.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41467-019-11716-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707221PMC
August 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41586-019-0883-2
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http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
February 2019

BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling.

J Pathol 2018 09 4;246(1):41-53. Epub 2018 Jul 4.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/path.5105
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http://dx.doi.org/10.1002/path.5105DOI Listing
September 2018

Easy quantification of template-directed CRISPR/Cas9 editing.

Nucleic Acids Res 2018 06;46(10):e58

Division of Gene Regulation, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.

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http://dx.doi.org/10.1093/nar/gky164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007333PMC
June 2018

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

Br J Cancer 2018 06 8;118(12):1586-1595. Epub 2018 May 8.

Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands.

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http://dx.doi.org/10.1038/s41416-018-0081-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008333PMC
June 2018

Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer.

Cold Spring Harb Symp Quant Biol 2016 4;81:141-150. Epub 2016 Nov 4.

Division of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1101/sqb.2016.81.030924DOI Listing
February 2018

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance.

Nat Methods 2018 02 11;15(2):134-140. Epub 2017 Dec 11.

Division of Molecular Pathology and Cancer Genomics Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nmeth.4535DOI Listing
February 2018

Selected Alkylating Agents Can Overcome Drug Tolerance of G-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice.

Clin Cancer Res 2017 Nov 18;23(22):7020-7033. Epub 2017 Aug 18.

Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1279DOI Listing
November 2017

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.

Nat Cell Biol 2017 Nov 16;19(11):1371-1378. Epub 2017 Oct 16.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncb3626DOI Listing
November 2017

Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer.

Oncotarget 2017 Aug 29;8(33):54364-54377. Epub 2017 Apr 29.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.18632/oncotarget.17532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589587PMC
August 2017

Identifying transposon insertions and their effects from RNA-sequencing data.

Nucleic Acids Res 2017 Jul;45(12):7064-7077

Division of Molecular Pathology and Cancer Genomics Netherlands, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands.

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http://dx.doi.org/10.1093/nar/gkx461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499543PMC
July 2017

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.

Nat Commun 2017 07 17;8:15981. Epub 2017 Jul 17.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

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http://dx.doi.org/10.1038/ncomms15981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520019PMC
July 2017

Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice.

J Pathol 2017 03 23;241(4):511-521. Epub 2017 Jan 23.

Division of Molecular Pathology and Cancer Genomics Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/path.4857
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http://dx.doi.org/10.1002/path.4857DOI Listing
March 2017

Genetically engineered mouse models in oncology research and cancer medicine.

EMBO Mol Med 2017 02;9(2):137-153

Division of Molecular Pathology and Cancer Genomics Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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http://dx.doi.org/10.15252/emmm.201606857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286388PMC
February 2017

p120-Catenin Is Critical for the Development of Invasive Lobular Carcinoma in Mice.

J Mammary Gland Biol Neoplasia 2016 12 13;21(3-4):81-88. Epub 2016 Jul 13.

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s10911-016-9358-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159444PMC
December 2016

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer.

J Natl Cancer Inst 2016 11 5;108(11). Epub 2016 Jul 5.

Affiliations of authors: Division of Molecular Pathology and Cancer Genomics Centre Netherlands (PtB, PK, EvdB, UB, MdM, EL, LM, JdR, JW, JJ), Division of Molecular Carcinogenesis (IM), Department of Epidemiology and Biostatistics (KJ), and Family Cancer Clinic and Department of Pathology (FH), The Netherlands Cancer Institute, Amsterdam, the Netherlands; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain (CM, ME); The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK (HG, NT); Laboratory of Preclinical Investigation, Translational Research Department, Curie Institute, Paris, France (EM); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (WK, MvR, KD, EC); Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain (ME); Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain (ME).

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http://dx.doi.org/10.1093/jnci/djw148DOI Listing
November 2016

PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma.

Cell Rep 2016 08 11;16(8):2087-2101. Epub 2016 Aug 11.

Division of Molecular Pathology, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Cancer Genomics Netherlands, 3584 CG Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999419PMC
August 2016

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature17676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866PMC
June 2016

Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland.

Genes Dev 2016 06;30(12):1470-80

Division of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; Cancer Genomics Netherlands, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1101/gad.279190.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926868PMC
June 2016

HELB Is a Feedback Inhibitor of DNA End Resection.

Mol Cell 2016 Feb 7;61(3):405-418. Epub 2016 Jan 7.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, ON M5S 1A8, Canada. Electronic address:

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http://www.cell.com/molecular-cell/pdf/S1097-2765(15)00947-8
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http://linkinghub.elsevier.com/retrieve/pii/S109727651500947
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http://dx.doi.org/10.1016/j.molcel.2015.12.013DOI Listing
February 2016

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors.

Clin Cancer Res 2016 Jan 15;22(1):96-106. Epub 2015 Sep 15.

Department of Molecular Cell Biology and Cancer Genomics Centre Netherlands, Leiden University Medical Center, Leiden, the Netherlands. Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0743DOI Listing
January 2016

Using the GEMM-ESC strategy to study gene function in mouse models.

Nat Protoc 2015 Nov 15;10(11):1755-85. Epub 2015 Oct 15.

Division of Molecular Pathology and Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nprot.2015.114DOI Listing
November 2015

Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells.

Radiother Oncol 2015 Sep 13;116(3):358-65. Epub 2015 May 13.

Division of Biological Stress Response, Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2015.03.028DOI Listing
September 2015

Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2⁺ breast cancer.

Pain 2015 Aug;156(8):1424-32

aDivision of Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands bDepartment of Anesthesiology, Academic Medical Center, Amsterdam, the Netherlands cDivision of Molecular Pathology and Cancer Genomics Center, Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/j.pain.0000000000000136DOI Listing
August 2015

Lack of genomic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases.

PLoS One 2014 1;9(8):e103177. Epub 2014 Aug 1.

Division of Molecular Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands; Division of Medical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103177PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118860PMC
April 2015

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation.

Int J Cancer 2015 Mar 8;136(6):1434-44. Epub 2014 Aug 8.

Division of Molecular Carcinogenesis, Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ijc.29113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312923PMC
March 2015

BRCA2-deficient sarcomatoid mammary tumors exhibit multidrug resistance.

Cancer Res 2015 Feb 15;75(4):732-41. Epub 2014 Dec 15.

Division of Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands. Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0839DOI Listing
February 2015

The use of mass spectrometry imaging to predict treatment response of patient-derived xenograft models of triple-negative breast cancer.

J Proteome Res 2015 Feb 20;14(2):1069-75. Epub 2015 Jan 20.

Biomolecular Imaging Mass Spectrometry, FOM Institute AMOLF , Science Park 104, 1098 XG Amsterdam, The Netherlands.

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http://dx.doi.org/10.1021/pr501067zDOI Listing
February 2015

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.

EMBO J 2015 Feb 12;34(3):410-24. Epub 2015 Jan 12.

Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Oxford, UK

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http://dx.doi.org/10.15252/embj.201488947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339125PMC
February 2015

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression.

Cell Rep 2015 Jan 15;10(3):383-397. Epub 2015 Jan 15.

Division of Molecular Genetics, Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.12.028DOI Listing
January 2015

Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and growth inhibition of breast cancer cells and cancer stem-like cells.

Oncotarget 2014 Dec;5(23):11827-46

Laboratory of Genomic Applications, Department of Surgical Oncology, Sheba Medical Center, Ramat-Gan 52621, Israel. Sheba Cancer Research Center, Sheba Medical Center, Ramat-Gan 52621, Israel. Department of Human Science, Georgetown University Medical Center, Washington DC 20057, USA. Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NW Washington DC 20057, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322975PMC
http://dx.doi.org/10.18632/oncotarget.2582DOI Listing
December 2014

Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways.

Cell 2014 Oct;159(3):499-513

Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.09.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283810PMC
October 2014

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets.

Nat Commun 2013 ;4:2697

1] Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Old Campus Road, Oxford OX3 7DQ, UK [2] [3].

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http://dx.doi.org/10.1038/ncomms3697DOI Listing
July 2014

Molecular pathways: how can BRCA-mutated tumors become resistant to PARP inhibitors?

Clin Cancer Res 2014 Feb 22;20(3):540-7. Epub 2013 Nov 22.

Authors' Affiliation: Division of Molecular Pathology and Cancer Genomics Centre, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0225DOI Listing
February 2014

A high-throughput functional complementation assay for classification of BRCA1 missense variants.

Cancer Discov 2013 Oct 18;3(10):1142-55. Epub 2013 Jul 18.

1Division of Molecular Pathology and Cancer Genomics Centre and 2Department of Pathology, The Netherlands Cancer Institute Amsterdam, The Netherlands; and 3TaconicArtemis GmbH, Cologne, Germany.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0094DOI Listing
October 2013

Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool.

Stem Cells 2013 Sep;31(9):1910-20

Division of Molecular Pathology and Cancer Genomics Centre, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/stem.1437DOI Listing
September 2013

Proteomics of genetically engineered mouse mammary tumors identifies fatty acid metabolism members as potential predictive markers for cisplatin resistance.

Mol Cell Proteomics 2013 May 8;12(5):1319-34. Epub 2013 Feb 8.

OncoProteomics Laboratory, Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/mcp.M112.024182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650342PMC
May 2013

Genetically engineered mouse models of PI3K signaling in breast cancer.

Mol Oncol 2013 Apr 11;7(2):146-64. Epub 2013 Feb 11.

Division of Molecular Pathology, Cancer Genomics Centre Netherlands and Cancer Systems Biology Center, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.molonc.2013.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528412PMC
April 2013

BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.

Genes Dev 2013 Jan 27;27(1):39-51. Epub 2012 Dec 27.

Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1101/gad.206573.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553282PMC
January 2013