Jos C S Kleinjans

Jos C S Kleinjans

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Jos C S Kleinjans

Publications by authors named "Jos C S Kleinjans"

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Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches.

Cancer Treat Rev 2019 Jul 27;77:57-66. Epub 2019 Jun 27.

Department of Toxicogenomics, GROW Institute and Developmental Biology, Maastricht University, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.ctrv.2019.06.004DOI Listing
July 2019

Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease.

Clin Transl Sci 2019 Jul 15. Epub 2019 Jul 15.

Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1111/cts.12663DOI Listing
July 2019

DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia.

Environ Int 2019 May 15;126:24-36. Epub 2019 Feb 15.

National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., Athens 11635, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2019.01.068DOI Listing
May 2019

Phosphorylation of eIF2α promotes cell survival in response to benzo[a]pyrene exposure.

Toxicol In Vitro 2019 Feb 29;54:330-337. Epub 2018 Oct 29.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2018.10.015DOI Listing
February 2019

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens.

Front Genet 2018 3;9:558. Epub 2018 Dec 3.

Division of Molecular and Computational Toxicology, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fgene.2018.00558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286959PMC
December 2018

Short-term transcriptome and microRNAs responses to exposure to different air pollutants in two population studies.

Environ Pollut 2018 Nov 20;242(Pt A):182-190. Epub 2018 Jun 20.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.envpol.2018.06.051DOI Listing
November 2018

Translational regulation is a key determinant of the cellular response to benzo[a]pyrene.

Toxicol Lett 2018 Oct 12;295:144-152. Epub 2018 Jun 12.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, 6200MD, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2018.06.009DOI Listing
October 2018

Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes.

Toxicol Lett 2018 Jun 6;289:1-13. Epub 2018 Mar 6.

Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2018.02.026DOI Listing
June 2018

A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases.

Toxicol In Vitro 2018 Apr 9;48:318-328. Epub 2018 Feb 9.

Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.tiv.2018.02.006DOI Listing
April 2018

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction.

Toxicology 2018 01 14;393:160-170. Epub 2017 Nov 14.

Department of Toxicogenomics, Grow School for Oncology and Developmental Biology, Maastricht University, P.o. Box 616, 6200 Md, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.tox.2017.11.013DOI Listing
January 2018

A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure.

Methods Mol Biol 2016 ;1425:339-59

Department of Toxicogenomics, Maastricht University, Universiteitssingel 40, Maastricht, 6229ER, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-3609-0_15DOI Listing
December 2017

Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.

Toxicol In Vitro 2017 Oct 1;44:322-329. Epub 2017 Aug 1.

Department of Toxicogenomics, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands; Netherlands Toxicogenomics Centre, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2017.07.024DOI Listing
October 2017

Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes.

Chem Res Toxicol 2017 10 13;30(10):1847-1854. Epub 2017 Sep 13.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University , P.O. Box 616, Maastricht 6200 MD, The Netherlands.

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http://dx.doi.org/10.1021/acs.chemrestox.7b00171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645762PMC
October 2017

Dose and Time Dependencies in Stress Pathway Responses during Chemical Exposure: Novel Insights from Gene Regulatory Networks.

Front Genet 2017 6;8:142. Epub 2017 Oct 6.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands.

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http://dx.doi.org/10.3389/fgene.2017.00142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649202PMC
October 2017

Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics.

Toxicology 2017 09 4;390:74-82. Epub 2017 Sep 4.

Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2017.09.002DOI Listing
September 2017

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds.

Arch Toxicol 2017 Jun 28;91(6):2343-2352. Epub 2016 Dec 28.

Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s00204-016-1922-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429357PMC
June 2017

Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides.

Epidemiology 2017 05;28(3):320-328

From the aDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands; bMedical Research Council-Health Protection Agency Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; cDepartment of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden; dDepartment of Biobank Research, Umeå University, Umeå, Sweden; eMolecular and Nutritional Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy; fJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; gHuGeF Foundation, Turin, Italy; hDepartment of Toxicogenomics, Maastricht University, Maastricht, The Netherlands; iEpidemiology Unit, Instituto Tumori, Milan, Italy; and jNational Hellenic Research Foundation, Institute of Biology, Pharmaceutical Chemistry and Biotechnology, Athens, Greece.

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http://dx.doi.org/10.1097/EDE.0000000000000628DOI Listing
May 2017

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.

Chem Res Toxicol 2016 12 2;29(12):2164-2174. Epub 2016 Dec 2.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University , P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00337DOI Listing
December 2016

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity.

Mutagenesis 2016 09 23;31(5):603-15. Epub 2016 Jun 23.

Department of Toxicogenomics, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 40, 6229ER Maastricht, Netherlands and Netherlands Toxicogenomics Centre (NTC), Universiteitssingel 40, 6229ER Maastricht, Netherlands.

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https://academic.oup.com/mutage/article-lookup/doi/10.1093/m
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http://dx.doi.org/10.1093/mutage/gew027DOI Listing
September 2016

Dynamic Interplay between the Transcriptome and Methylome in Response to Oxidative and Alkylating Stress.

Chem Res Toxicol 2016 09 24;29(9):1428-38. Epub 2016 Aug 24.

Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University , 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00090DOI Listing
September 2016

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma.

Toxicology 2016 03 3;350-352:31-9. Epub 2016 May 3.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.tox.2016.05.002DOI Listing
March 2016

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis.

Arch Toxicol 2015 Nov 9;89(11):1959-69. Epub 2014 Sep 9.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s00204-014-1351-2DOI Listing
November 2015

The exposome concept in a human nutrigenomics study: evaluating the impact of exposure to a complex mixture of phytochemicals using transcriptomics signatures.

Mutagenesis 2015 Nov 22;30(6):723-31. Epub 2015 Feb 22.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/mutage/gev008DOI Listing
November 2015

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes.

Mutagenesis 2015 Nov 14;30(6):771-84. Epub 2015 May 14.

Department of Toxicogenomics, Maastricht University, PO Box 616, 6200 MD Maastricht, Universiteitssingel 40, 6229 ER Maastricht, Netherlands and Netherlands Toxicogenomics Centre, PO Box 616, 6200 MD Maastricht, Universiteitssingel 40, 6229 ER Maastricht, Netherlands.

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http://dx.doi.org/10.1093/mutage/gev036DOI Listing
November 2015

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

Authors:
Norihiro Kato Marie Loh Fumihiko Takeuchi Niek Verweij Xu Wang Weihua Zhang Tanika N Kelly Danish Saleheen Benjamin Lehne Irene Mateo Leach Alexander W Drong James Abbott Simone Wahl Sian-Tsung Tan William R Scott Gianluca Campanella Marc Chadeau-Hyam Uzma Afzal Tarunveer S Ahluwalia Marc Jan Bonder Peng Chen Abbas Dehghan Todd L Edwards Tõnu Esko Min Jin Go Sarah E Harris Jaana Hartiala Silva Kasela Anuradhani Kasturiratne Chiea-Chuen Khor Marcus E Kleber Huaixing Li Zuan Yu Mok Masahiro Nakatochi Nur Sabrina Sapari Richa Saxena Alexandre F R Stewart Lisette Stolk Yasuharu Tabara Ai Ling Teh Ying Wu Jer-Yuarn Wu Yi Zhang Imke Aits Alexessander Da Silva Couto Alves Shikta Das Rajkumar Dorajoo Jemma C Hopewell Yun Kyoung Kim Robert W Koivula Jian'an Luan Leo-Pekka Lyytikäinen Quang N Nguyen Mark A Pereira Iris Postmus Olli T Raitakari Molly Scannell Bryan Robert A Scott Rossella Sorice Vinicius Tragante Michela Traglia Jon White Ken Yamamoto Yonghong Zhang Linda S Adair Alauddin Ahmed Koichi Akiyama Rasheed Asif Tin Aung Inês Barroso Andrew Bjonnes Timothy R Braun Hui Cai Li-Ching Chang Chien-Hsiun Chen Ching-Yu Cheng Yap-Seng Chong Rory Collins Regina Courtney Gail Davies Graciela Delgado Loi D Do Pieter A Doevendans Ron T Gansevoort Yu-Tang Gao Tanja B Grammer Niels Grarup Jagvir Grewal Dongfeng Gu Gurpreet S Wander Anna-Liisa Hartikainen Stanley L Hazen Jing He Chew-Kiat Heng James E Hixson Albert Hofman Chris Hsu Wei Huang Lise L N Husemoen Joo-Yeon Hwang Sahoko Ichihara Michiya Igase Masato Isono Johanne M Justesen Tomohiro Katsuya Muhammad G Kibriya Young Jin Kim Miyako Kishimoto Woon-Puay Koh Katsuhiko Kohara Meena Kumari Kenneth Kwek Nanette R Lee Jeannette Lee Jiemin Liao Wolfgang Lieb David C M Liewald Tatsuaki Matsubara Yumi Matsushita Thomas Meitinger Evelin Mihailov Lili Milani Rebecca Mills Nina Mononen Martina Müller-Nurasyid Toru Nabika Eitaro Nakashima Hong Kiat Ng Kjell Nikus Teresa Nutile Takayoshi Ohkubo Keizo Ohnaka Sarah Parish Lavinia Paternoster Hao Peng Annette Peters Son T Pham Mohitha J Pinidiyapathirage Mahfuzar Rahman Hiromi Rakugi Olov Rolandsson Michelle Ann Rozario Daniela Ruggiero Cinzia F Sala Ralhan Sarju Kazuro Shimokawa Harold Snieder Thomas Sparsø Wilko Spiering John M Starr David J Stott Daniel O Stram Takao Sugiyama Silke Szymczak W H Wilson Tang Lin Tong Stella Trompet Väinö Turjanmaa Hirotsugu Ueshima André G Uitterlinden Satoshi Umemura Marja Vaarasmaki Rob M van Dam Wiek H van Gilst Dirk J van Veldhuisen Jorma S Viikari Melanie Waldenberger Yiqin Wang Aili Wang Rory Wilson Tien-Yin Wong Yong-Bing Xiang Shuhei Yamaguchi Xingwang Ye Robin D Young Terri L Young Jian-Min Yuan Xueya Zhou Folkert W Asselbergs Marina Ciullo Robert Clarke Panos Deloukas Andre Franke Paul W Franks Steve Franks Yechiel Friedlander Myron D Gross Zhirong Guo Torben Hansen Marjo-Riitta Jarvelin Torben Jørgensen J Wouter Jukema Mika Kähönen Hiroshi Kajio Mika Kivimaki Jong-Young Lee Terho Lehtimäki Allan Linneberg Tetsuro Miki Oluf Pedersen Nilesh J Samani Thorkild I A Sørensen Ryoichi Takayanagi Daniela Toniolo Habibul Ahsan Hooman Allayee Yuan-Tsong Chen John Danesh Ian J Deary Oscar H Franco Lude Franke Bastiaan T Heijman Joanna D Holbrook Aaron Isaacs Bong-Jo Kim Xu Lin Jianjun Liu Winfried März Andres Metspalu Karen L Mohlke Dharambir K Sanghera Xiao-Ou Shu Joyce B J van Meurs Eranga Vithana Ananda R Wickremasinghe Cisca Wijmenga Bruce H W Wolffenbuttel Mitsuhiro Yokota Wei Zheng Dingliang Zhu Paolo Vineis Soterios A Kyrtopoulos Jos C S Kleinjans Mark I McCarthy Richie Soong Christian Gieger James Scott Yik-Ying Teo Jiang He Paul Elliott E Shyong Tai Pim van der Harst Jaspal S Kooner John C Chambers

Nat Genet 2015 11 21;47(11):1282-1293. Epub 2015 Sep 21.

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/ng.3405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719169PMC
November 2015

Bayesian Network Inference Enables Unbiased Phenotypic Anchoring of Transcriptomic Responses to Cigarette Smoke in Humans.

Chem Res Toxicol 2015 Oct 17;28(10):1936-48. Epub 2015 Sep 17.

Department of Toxicogenomics, Maastricht University , Universiteitssingel 40, 6229 ER Maastricht, The Netherlands.

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http://dx.doi.org/10.1021/acs.chemrestox.5b00145DOI Listing
October 2015

Pattern recognition methods to relate time profiles of gene expression with phenotypic data: a comparative study.

Bioinformatics 2015 Jul 19;31(13):2115-22. Epub 2015 Feb 19.

Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/btv108DOI Listing
July 2015

Response to cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.

Toxicol Lett 2015 Jun 17;235(3):218-9. Epub 2015 Apr 17.

Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.toxlet.2015.04.003DOI Listing
June 2015

diXa: a data infrastructure for chemical safety assessment.

Bioinformatics 2015 May 12;31(9):1505-7. Epub 2014 Dec 12.

Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, 02215, MA, USA, European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, Department of Bioinformatics - BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, Genedata AG, CH-4053 Basel, Switzerland, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and European Commission, Joint Research Centre, 21027 Ispra VA, Italy.

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http://dx.doi.org/10.1093/bioinformatics/btu827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410652PMC
May 2015

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro.

Toxicol In Vitro 2015 Apr 3;29(3):489-501. Epub 2015 Jan 3.

Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands; Netherlands Toxicogenomics Centre, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2014.12.016DOI Listing
April 2015

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.

Toxicol Lett 2015 Apr 19;234(2):139-50. Epub 2015 Feb 19.

Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.toxlet.2015.02.012DOI Listing
April 2015

Workshop report: Identifying opportunities for global integration of toxicogenomics databases, 26-27 June 2013, Research Triangle Park, NC, USA.

Arch Toxicol 2014 Dec 19;88(12):2323-32. Epub 2014 Oct 19.

Department of Toxicogenomics, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands,

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http://link.springer.com/10.1007/s00204-014-1387-3
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http://dx.doi.org/10.1007/s00204-014-1387-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247478PMC
December 2014

Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity.

Biomark Med 2014 ;8(2):185-200

Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.

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http://dx.doi.org/10.2217/bmm.13.154DOI Listing
October 2014

Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity.

Toxicology 2014 Oct 15;324:18-26. Epub 2014 Jul 15.

Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands; Netherlands Toxicogenomics Centre, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2014.06.003DOI Listing
October 2014

Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices.

Toxicology 2014 Sep 17;323:61-9. Epub 2014 Jun 17.

Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.tox.2014.06.007DOI Listing
September 2014

Elimination of heparin interference during microarray processing of fresh and biobank-archived blood samples.

Environ Mol Mutagen 2014 Jul 17;55(6):482-91. Epub 2014 Apr 17.

Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.

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http://doi.wiley.com/10.1002/em.21869
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http://dx.doi.org/10.1002/em.21869DOI Listing
July 2014

[Health risks of airborne particulate matter in children].

Ned Tijdschr Geneeskd 2013 ;157(42):A6704

Universiteit Maastricht, MUMC+, vakgroep Toxicogenomics, Maastricht.

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May 2014

Can transcriptomics provide insight into the chemopreventive mechanisms of complex mixtures of phytochemicals in humans?

Antioxid Redox Signal 2014 May 27;20(14):2107-13. Epub 2014 Feb 27.

1 Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University , Maastricht, The Netherlands .

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http://dx.doi.org/10.1089/ars.2013.5528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994912PMC
May 2014

Classification of hepatotoxicants using HepG2 cells: A proof of principle study.

Chem Res Toxicol 2014 Mar 28;27(3):433-42. Epub 2014 Jan 28.

Department of Toxicogenomics, Maastricht University , Maastricht, The Netherlands.

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http://pubs.acs.org/doi/10.1021/tx4004165
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http://dx.doi.org/10.1021/tx4004165DOI Listing
March 2014

Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks.

Mutagenesis 2014 Jan 26;29(1):17-26. Epub 2013 Nov 26.

Netherlands Toxicogenomics Centre (NTC), Maastricht University, PO Box 616, Universiteitssingel 50, 6229ER Maastricht, The Netherlands and.

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http://dx.doi.org/10.1093/mutage/get055DOI Listing
January 2014

Gender-specific transcriptomic response to environmental exposure in Flemish adults.

Environ Mol Mutagen 2013 Aug 8;54(7):574-88. Epub 2013 May 8.

Study Centre for Carcinogenesis and Primary Prevention of Cancer, Ghent University, Ghent, 9000, Belgium.

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http://dx.doi.org/10.1002/em.21774DOI Listing
August 2013

Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests.

Toxicol Sci 2013 Mar 13;132(1):118-30. Epub 2012 Dec 13.

National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfs333DOI Listing
March 2013

Performance of in vitro γH2AX assay in HepG2 cells to predict in vivo genotoxicity.

Mutagenesis 2012 Nov 21;27(6):645-52. Epub 2012 Aug 21.

Department of Toxicogenomics, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/mutage/ges030DOI Listing
November 2012

Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity.

Toxicol In Vitro 2012 Apr 17;26(3):373-85. Epub 2012 Jan 17.

Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.tiv.2012.01.012DOI Listing
April 2012

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans.

Toxicol Appl Pharmacol 2012 Mar 20;259(3):320-8. Epub 2012 Jan 20.

Department of Toxicogenomics, Maastricht University, Universitiessingel 50 6229 ER Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.taap.2012.01.009DOI Listing
March 2012

Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn).

Toxicol Sci 2012 Feb 1;125(2):430-8. Epub 2011 Nov 1.

Laboratory for Health Protection Research, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfr293DOI Listing
February 2012

Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.

Mutagenesis 2011 Nov 1;26(6):753-61. Epub 2011 Jul 1.

Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/mutage/ger043DOI Listing
November 2011

Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene.

Toxicol Sci 2011 Sep 29;123(1):123-32. Epub 2011 Jun 29.

Laboratory for Health Protection Research, National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfr169DOI Listing
September 2011

Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells.

Toxicol Sci 2011 Aug 25;122(2):437-47. Epub 2011 May 25.

Laboratory for Health Protection Research, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.

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http://dx.doi.org/10.1093/toxsci/kfr134DOI Listing
August 2011

Impaired repair of ionizing radiation-induced DNA damage in Cockayne syndrome cells.

Radiat Res 2011 Apr 7;175(4):432-43. Epub 2011 Feb 7.

Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, The Netherlands.

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http://www.bioone.org/doi/10.1667/RR1972.1
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April 2011

Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.

Toxicol Sci 2011 Mar 16;120(1):109-22. Epub 2010 Dec 16.

Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/toxsci/kfq380DOI Listing
March 2011

Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures.

Toxicol Appl Pharmacol 2011 Mar 28;251(2):110-8. Epub 2010 Dec 28.

Laboratory for Health Protection Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

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http://dx.doi.org/10.1016/j.taap.2010.12.008DOI Listing
March 2011

Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test.

Toxicol Lett 2011 Mar 30;201(2):143-51. Epub 2010 Dec 30.

Laboratory for Health Protection Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S037842741001814
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http://dx.doi.org/10.1016/j.toxlet.2010.12.019DOI Listing
March 2011

Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures.

Toxicol Sci 2011 Jan 8;119(1):126-34. Epub 2010 Oct 8.

Laboratory for Health Protection Research, National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands.

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https://academic.oup.com/toxsci/article/1635540/Evaluation
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http://dx.doi.org/10.1093/toxsci/kfq291DOI Listing
January 2011

Time series analysis of benzo[A]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets.

Toxicol Sci 2010 Oct 12;117(2):381-92. Epub 2010 Jul 12.

Department of Health Risk Analysis and Toxicology, Maastricht University, 6229ER Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/toxsci/kfq214DOI Listing
October 2010

Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes.

Drug Discov Today 2010 Oct 11;15(19-20):851-8. Epub 2010 Aug 11.

Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands.

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http://dx.doi.org/10.1016/j.drudis.2010.08.002DOI Listing
October 2010

Radical mechanisms in nitrosamine- and nitrosamide-induced whole-genome gene expression modulations in Caco-2 cells.

Toxicol Sci 2010 Jul 19;116(1):194-205. Epub 2010 Apr 19.

Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/toxsci/kfq121DOI Listing
July 2010

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.

Toxicol Sci 2010 May 27;115(1):66-79. Epub 2010 Jan 27.

Department of Health Risk Analysis and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/toxsci/kfq026DOI Listing
May 2010

Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs.

Environ Int 2010 May 26;36(4):344-351. Epub 2010 Feb 26.

Section of Environmental Health, Department of Public Health, University of Copenhagen, Oester Farimagsgade 5A, 1353 Copenhagen K, Denmark. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S016041201000023
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http://dx.doi.org/10.1016/j.envint.2010.02.002DOI Listing
May 2010

Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells.

Toxicol Sci 2010 Apr 31;114(2):193-203. Epub 2009 Dec 31.

Netherlands Toxicogenomics Centre, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/toxsci/kfp309DOI Listing
April 2010

Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors.

Br J Nutr 2010 Feb 2;103(4):490-501. Epub 2009 Nov 2.

Department of Health Risk Analysis and Toxicology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht 6200 MD, The Netherlands.

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http://dx.doi.org/10.1017/S0007114509992066DOI Listing
February 2010

Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time.

Toxicol Sci 2009 Dec 21;112(2):374-84. Epub 2009 Sep 21.

Department of Health Risk Analysis and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/toxsci/kfp229DOI Listing
December 2009

Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO).

J Immunotoxicol 2009 Sep;6(3):174-83

National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

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http://dx.doi.org/10.3109/15476910903496691DOI Listing
September 2009

Potential role of cytochrome P450-1B1 in the metabolic activation of 4-aminobiphenyl in humans.

Mol Carcinog 2009 Aug;48(8):685-91

Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/mc.20530DOI Listing
August 2009

Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes.

Drug Metab Dispos 2009 Jun 27;37(6):1305-11. Epub 2009 Feb 27.

Department of Health Risk Analyses and Toxicology, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1124/dmd.108.025775DOI Listing
June 2009

Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis.

Toxicol Sci 2009 Apr 16;108(2):290-300. Epub 2009 Feb 16.

Department of Health Risk Analysis and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/toxsci/kfp035DOI Listing
April 2009

In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers.

Nutrition 2008 Jul-Aug;24(7-8):703-10

Department of Pharmacology and Toxicology, Faculty of Medicine, University of Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.nut.2008.03.023DOI Listing
September 2008

Multiplex genotyping as a biomarker for susceptibility to carcinogenic exposure in the FLEHS biomonitoring study.

Cancer Epidemiol Biomarkers Prev 2008 Aug;17(8):1902-12

Department of Health Risk Analysis and Toxicology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-0
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http://dx.doi.org/10.1158/1055-9965.EPI-08-0045DOI Listing
August 2008

Genomic analysis suggests higher susceptibility of children to air pollution.

Carcinogenesis 2008 May 10;29(5):977-83. Epub 2008 Mar 10.

Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/carcin/bgn065DOI Listing
May 2008

Discriminative protection against hydroxyl and superoxide anion radicals by quercetin in human leucocytes in vitro.

Toxicol In Vitro 2008 Mar 14;22(2):301-7. Epub 2007 Sep 14.

Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.tiv.2007.09.002DOI Listing
March 2008

Characterization of the exposure-disease continuum in neonates of mothers exposed to carcinogens during pregnancy.

Basic Clin Pharmacol Toxicol 2008 Feb;102(2):109-17

Nutrition and Toxicology Research Institute Maastricht, Department of Health Risk Analysis and Toxicology, University of Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.1111/j.1742-7843.2007.00174.xDOI Listing
February 2008

GSTM1 and GSTT1 polymorphism influences protection against induced oxidative DNA damage by quercetin and ascorbic acid in human lymphocytes in vitro.

Food Chem Toxicol 2007 Dec 30;45(12):2592-6. Epub 2007 Jun 30.

Department of Health Risk Analysis and Toxicology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.fct.2007.06.031DOI Listing
December 2007

Cigarette smoke-induced differential gene expression in blood cells from monozygotic twin pairs.

Carcinogenesis 2007 Mar 19;28(3):691-7. Epub 2006 Oct 19.

Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/carcin/bgl199DOI Listing
March 2007