Publications by authors named "José-Blas Navarro"

16 Publications

  • Page 1 of 1

Resilience and occupational health of health care workers: a moderator analysis of organizational resilience and sociodemographic attributes.

Int Arch Occup Environ Health 2021 Jun 2. Epub 2021 Jun 2.

Department of Psychobiology and Methodology of the Health Sciences, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

Objectives: Although previous studies have proposed a positive influence of resilience on the mental and physical health of health care workers, empirical evidence on its relationship with occupational health remains scarce. This study aimed to analyze the relationship between individual resilience and several occupational health indicators, as well as exploring the moderating role of organizational resilience and sociodemographic attributes on this relationship.

Methods: A cross-sectional design was used with a questionnaire applied to a sample of 325 workers from the Spanish health care sector.

Results: Individual resilience was significantly associated with the indicators of occupational health. A direct effect of individual resilience on job satisfaction was found. The influence of resilience on the perception of fatigue and suffering from an illness was reverse. Age moderated the impact of resilience on the perception of stress and medical leave. Besides, organizational resilience proved to be an important adjustment variable in job satisfaction and perception of stress.

Conclusions: The findings show the relevance to take both individual and organizational resilience into account when applying intervention programs to improve the occupational health of health care workers.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00420-021-01725-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170862PMC
June 2021

Life Conditions during COVID-19 Lockdown and Mental Health in Spanish Adolescents.

Int J Environ Res Public Health 2020 10 7;17(19). Epub 2020 Oct 7.

Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament, 08193 Bellaterra, Barcelona, Spain.

Spanish children were locked down for 72 days due to COVID-19, causing severe disruption to their normal life. The threat posed by COVID-19 continues and clinicians, administrators, and families need to know the life conditions associated with more psychological problems to modify them and minimize their effect on mental health. The goal was to study the life conditions of adolescents during lockdown and their association with psychological problems. A total of 226 parents of 117 girls and 109 boys (mean age: 13.9; Standard deviation: 0.28) from the community that were participants in a longitudinal study answered an online questionnaire about life conditions during lockdown and the Strengths and Difficulties Questionnaire (SDQ). Stepwise regression analyses controlling by previous reports of SDQ were performed. Conduct, peer, prosocial, and total problems scores increased after lockdown. After adjusting for previous measures of psychopathology, worse adolescents' mental health during COVID-19 lockdown was associated with unhealthy activities, worsening of the relationships with others, and dysfunctional parenting style. It seems important to mitigate psychological stress in a situation of isolation due to a state of emergency by keeping the adolescent active and maintaining their daily habits and routines in a non-conflictive atmosphere and give support to parents.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17197327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579639PMC
October 2020

Warning signs of preschool victimization using the strengths and difficulties questionnaire: Prevalence and individual and family risk factors.

PLoS One 2019 23;14(8):e0221580. Epub 2019 Aug 23.

Unit of Epidemiology and Diagnosis in Developmental Psychopathology, Department of Clinical and Health Psychology, Universitat Autònoma de Barcelona, Bellaterra, Spain.

Introduction: School victimization by peers is an important social problem with serious short- and long-term consequences poorly studied at preschool ages, which can lead to school bullying without timely intervention. Longitudinal data was used to determine the prevalence of warning signs of preschool peer victimization and its individual and family risk factors.

Methods: Data was obtained from 577 community preschoolers. School victimization was measured using the Strengths and Difficulties Questionnaire (SDQ) administered to parents and teachers of children at ages 4 and 5. Risk factors for the child (demographics, conduct and emotional problems, aggressiveness) and the family (maternal problems during pregnancy and early development, parenting styles, adaptive functioning and parents' problems) were previously recorded at 3 years old.

Results: Combined information from parents and teachers showed that 4.2% of preschoolers presented warning signs of victimization at ages 4 and 5. Low socioeconomic status, poor emotional control, early problems making friends and low level of parenting education in social norms at age 3 predicted later victimization at ages 4 and 5 (AUC = .78).

Conclusion: Peer victimization affects a considerable percentage of preschoolers. Early detection may help to reduce the risk of escalation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221580PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707553PMC
March 2020

Theory of Mind (ToM) Performance in High Functioning Autism (HFA) and Schizotypal-Schizoid Personality Disorders (SSPD) Patients.

J Autism Dev Disord 2019 Aug;49(8):3376-3386

Department of Clinical and Health Psychology, Psychopathology and Neuropsychology Research Unit, Universitát Autónoma de Barcelona, Campus de Bellaterra, Edifici B, Cerdanyola de Valles, 08193, Barcelona, Spain.

The similarities between high functioning autism (HFA) and schizotypal-schizoid personality disorder (SSPD) in terms of social cognition and interpersonal deficits may lead to confusion in symptom interpretation, and consequently result in misdiagnosis. Thus, this study aims to investigate differences in mentalizing with particular interest on the socio-cognitive and socio-affective dimensions. Three Advanced Theory of Mind (ToM) tests were applied in 35 patients with HFA, 30 patients with SSPD and 36 healthy controls. Individuals with HFA showed greater impairment and no dissociation between affective and cognitive ToM components. Conversely, SSPD individuals displayed less difficulties but greater impairments on the cognitive component. Beyond the replicability of ToM impairment in HFA individuals, our findings suggest more impaired cognitive ToM in SSPD participants which further support the sequence of mentalizing development build upon different chronological stages.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10803-019-04058-1DOI Listing
August 2019

Prevalence, comorbidity, functioning and long-term effects of subthreshold oppositional defiant disorder in a community sample of preschoolers.

Eur Child Adolesc Psychiatry 2019 Oct 5;28(10):1385-1393. Epub 2019 Mar 5.

Unitat D'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament, Universitat Autònoma de Barcelona, Barcelona, Spain.

To study the prevalence of subthreshold oppositional defiant disorder (ST ODD)-less than 4 symptoms, but nonetheless an impairing form of oppositional defiant disorder (ODD)-its coexistence with other homotypic externalizing and heterotypical internalizing problems in children and associated impairment, as well as the long-term effect of this condition. A population-based sample of 622 preschoolers (5.0% boys) was followed up from preschool to preadolescence. Parents were interviewed when the children were 3, 6 and 9 years old with the Diagnostic Interview for Preschoolers/Children and Adolescents versions following DSM-5 and the children's functioning was assessed by trained clinicians. ST ODD diagnosis is highly prevalent (19.4-25.5%), highly comorbid [homo- (1.9-18.4%) and heterotypical (5.8-23.7%)], resulting in functional impairment across child development in a similar way for both genders. ST is also a risk factor condition that predicts the presence of psychological problems and impairment in childhood and preadolescence from preschool age. A broader clinical assessment and intervention similar to that provided full syndrome cases is needed for children presenting subthreshold forms of ODD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00787-019-01300-0DOI Listing
October 2019

Cognitive impairment following chemotherapy for breast cancer: The impact of practice effect on results.

J Clin Exp Neuropsychol 2019 04 26;41(3):290-299. Epub 2018 Nov 26.

d Department of Oncology , Consorci Sanitari de Terrassa (CST), Terrassa , Barcelona , Spain.

Chemotherapy-Related Cognitive Impairment (CRCI) can be an adverse effect in women treated for breast cancer. Some longitudinal studies reported deficits in attention, memory, and executive function following treatment, but other studies did not find cognitive changes. It is known that practice effects (PE) on repeated assessments with cognitive tests contribute to the discrepancies in these results, but its influence on scores has not been systematically explored. The present study examines the impact of PE on retest scores in a group of women with breast cancer treated with chemotherapy and evaluated longitudinally.

Method: 51 women with breast cancer treated with a combination of 5-fluorouracil, epirubicin, and cyclophosphamide with or without taxanes were assessed after surgery but before chemotherapy (T1), post-chemotherapy (T2), and at one year after T2 (T3). Longitudinal changes on cognitive performance were analyzed twice: when retest scores were not corrected for PE and when correction for PE was applied to T2 and T3 scores.

Results: When PE was not corrected, progressive improvement over time in measures of memory and divided attention at T2 and T3 was observed. In contrast, when PE was corrected, worsening was found in measures of memory, fluency, executive function, and attention at T2 and in attention and executive function at T3. Results after correction for PE are in line with previous longitudinal studies that report cognitive impairment after treatment with chemotherapy for breast cancer.

Conclusion: Accounting for PE is recommended to identify true change on cognition through treatment with chemotherapy for breast cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/13803395.2018.1546381DOI Listing
April 2019

Oppositional Defiant Disorder dimensions and aggression: The moderating role of hostile bias and sex.

Psicothema 2018 08;30(3):264-269

Departament de Psícologia Clínica i de la Salut.

Background: Hostile Attributional Bias (HAB) has been related to conduct problems. The common and unique associations between the different dimensions of Oppositional Defiant Disorder (ODD) symptoms, specific components of HAB, sex and types of aggression (overt and relational) in a community sample of 491 7-year-old children are investigated.

Method: Teachers rated the children's ODD symptoms and aggression and the children self-reported about HAB. Multiple linear regressions showed that ODD dimensions were directly associated with both types of aggression.

Results: Boys were more overtly aggressive and girls more relational. Emotional distress was directly associated with relational aggression. The relational component of HAB uniquely moderated the influence of the oppositional dimension on relational aggressive behaviour.

Conclusions: The assessment of social cognition variables is necessary to approach specific interventions in the presence of ODD symptoms, as this may help to identify a subset of children prone to aggressive reactions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.7334/psicothema2017.363DOI Listing
August 2018

Joint Hypermobility Classes in 9-Year-Old Children from the General Population and Anxiety Symptoms.

J Dev Behav Pediatr 2018 Jul/Aug;39(6):481-488

Departament de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objective: To obtain joint hypermobility classes in children from the general population and to study their characteristics in relation to anxiety measures.

Methods: A total of 336 nine-year-old children from the general population were clinically assessed through 9 items of hypermobility, and their parents reported about the severity of anxiety symptoms. Latent class analysis was estimated to group the children according to the presence of hypermobility symptoms, and the obtained classes were related to anxiety.

Results: A 2-class solution, labeled as high hypermobility and low hypermobility, best fitted the data. Children in the high hypermobility group scored higher in separation anxiety, social phobia, physical injury fears, and total anxiety than did those in the low group. When applying the threshold reference scores to the total anxiety score, 7.4% of children in the high hypermobility group versus 6% in the low group were reported to experience clinical elevations on total anxiety.

Conclusion: High symptoms of hypermobility are associated with higher scores in anxiety symptoms in children from the general population. Children with frequent symptoms of hypermobility may benefit from screening for anxiety symptoms because a subset of them are experiencing clinical elevations and may need comprehensive physical and psychological treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/DBP.0000000000000577DOI Listing
November 2019

Role of taxanes in chemotherapy-related cognitive impairment: A prospective longitudinal study.

Breast Cancer Res Treat 2017 Jul 18;164(1):179-187. Epub 2017 Apr 18.

Department of Oncology, Consorci Sanitari de Terrassa (CST), Terrassa, Spain.

Purpose: The aim of this study is to elucidate the role of taxanes on cognition when they are administered as a part of the treatment with a fluorouracil, epirubicin and cyclophosphamide (FEC) regimen for breast cancer (BC).

Methods: Two groups of women (n = 51) with a novel diagnostic of BC that were treated with a combination of FEC alone (6 cycles of FEC) or with taxanes (4 cycles of FEC plus 8 cycles of taxanes) were compared at three moments: before chemotherapy, after its completion (short-term evaluation) and at a mean of 74.5 weeks from baseline as a long-term evaluation.

Results: Both groups showed worsening in tests of attention and executive functions on the short-term assessment, with the group treated with taxanes showing more number of affected cognitive measures at this time point, including verbal learning and speed measures. At the long-term evaluation, cognitive dysfunction was still found in attention and executive functions in both groups.

Conclusion: Our results suggest that chemotherapy for BC with a FEC regimen can have a negative effect on cognition. Acute deficits seem to be larger when taxanes are added, but treatment seems to affect cognition also at long term.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-017-4240-6DOI Listing
July 2017

The Brief Problem Monitor-Parent form (BPM-P), a short version of the Child Behavior Checklist: Psychometric properties in Spanish 6- to 8-year-old children.

Psychol Assess 2017 Nov 12;29(11):1309-1320. Epub 2017 Jan 12.

Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament, Universitat Autònoma de Barcelona.

We provide the first validation data on the Spanish version of the Brief Problem Monitor-Parent form (BPM-P), a recently developed abbreviated version of the 120-item Child Behavior Checklist for Ages 6 to 18 (CBCL/6-18) in young schoolchildren. Parents of a community sample of 521 children aged 6-8 answered the CBCL/6-18 yearly, and the 19 BPM-P items were examined; parents also provided different measures of psychopathology. Confirmatory factor analysis of the expected 3-factor model (attention, externalizing, and internalizing) showed adequate fit (root mean square error of approximation, RMSEA ≤ .057), and measurement invariance across sex and age was observed. Internal consistency for the derived scores was satisfactory (ω ≥ .83). Concurrent validity with the equivalent scale scores of the original full CBCL/6-18 (r ≥ .84) and convergent validity with parents' ratings of the Strengths and Difficulties Questionnaire scores (r ≥ .52) were good. BPM-P scores at age 7 showed good predictive accuracy for discriminating the use of mental health services (OR ≥ 1.12), functional impairment (B ≤ -1.25), and the presence of the corresponding disorders diagnosed with an independent clinical interview, both cross-sectionally at age 7 and longitudinally at age 8 (OR ≥ 1.24). The BPM-P provides reliable and valid scores as a very brief follow-up and screening tool for assessing behavioral and emotional problems in young schoolchildren. (PsycINFO Database Record
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1037/pas0000428DOI Listing
November 2017

Tracing developmental trajectories of oppositional defiant behaviors in preschool children.

PLoS One 2014 27;9(6):e101089. Epub 2014 Jun 27.

Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament, Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objective: Previous studies on developmental trajectories have used ad hoc definitions of oppositional defiant behaviors (ODB), which makes it difficult to compare results. This article defines developmental trajectories of ODB from ages 3-5 based on five different standard measurements derived from three separate instruments.

Method: A sample of 622 three-year-old preschoolers, followed up at ages 4, 5, and 6, was assessed with the five measures of oppositionality answered by parents and teachers. Growth-Mixture-Modeling (GMM) estimated separate developmental trajectories for each ODB measure for ages 3 to 5.

Results: The number of classes-trajectories obtained in each GMM depended on the ODB measure, but two clear patterns emerged: four trajectories (persistent low, decreasers, increasers/high increasers, persistent moderate/persistent high) or three trajectories (persistent low, decreasers, increasers/high increasers). Persistent high trajectories accounted for 4.4%-9.5% of the children. The trajectories emerging from the different ODB measures at ages 3 to 5 discriminated disruptive disorders, comorbidity, use of services, and impairment at age 6, and globally showed a similar pattern, summarizing longitudinal information on oppositionality in preschool children in a similar way.

Conclusions: Trajectories resulting from standard scales of the questionnaires have predictive validity for identifying relevant clinical outcomes, but are measure-specific. The results contribute to knowledge about the development of ODB in preschool children.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101089PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074167PMC
October 2015

Spanish adaptation of the Markova and Berrios Insight scale.

Actas Esp Psiquiatr 2012 Sep-Oct;40(5):248-56. Epub 2012 Sep 1.

Departament de Psicologia Clínica i de la Salut Unitat de Recerca en Psicopatologia i Neuropsicologia Universitat Autonoma de Barcelona. Bellaterra Barcelona, 08019.

Introduction: The aim of this study was to adapt the Markova and Berrios Insight scale in Spanish and to analyze its psychometric properties and relationships to the severity of the psychotic symptoms.

Methodology: A translation-backtranslation of the original scale was elaborated and a panel of professionals participated to assess conceptual equivalence and naturality. This is a 30-item self-administered scale with response options Yes/No. A total of 170 psychotic patients were assessed according to DSM-IV-TR diagnostic criteria. Confirmatory factor analysis validated the structure originally proposed. Internal consistency was evaluated using Cronbach’s Alpha Coefficient and the Intraclass Correlation Coefficient (ICC). We calculated the association between variables with Spearman’s rank correlation coefficient.

Results: The 4-factors structure originally proposed by Markova and Berrios was verified. Cronbach’s alpha coefficient value for the whole scale was 0.824, indicating good internal consistency. The ICC value was 0.855. There were no statistically significant relationships between severity of psychotic symptoms and the lack of insight.

Conclusions: The Spanish adaptation of the Markova and Berrios Insight Scale has good internal and external reliability. It is simple and easy to perform and very sensitive to change.
View Article and Find Full Text PDF

Download full-text PDF

Source
December 2013

Insight, symptomatic dimensions, and cognition in patients with acute-phase psychosis.

Compr Psychiatry 2012 Jul 27;53(5):502-8. Epub 2011 Oct 27.

Department of Clinical and Health Psychology, Psychopathology and Neuropsychology Research Unit, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.

Aims: This study was designed to evaluate the relationship between insight and the severity of psychotic symptomatology in a sample of patients in an acute phase of psychosis, as well as to analyze the relationship between insight and the symptomatic profile of the patient. In addition, the role of general cognitive abilities in this relationship was explored.

Method: Cross-sectional observational study of 96 acute psychotic adults. To evaluate psychopathology we used the Positive and Negative Syndrome Scale; for insight, the Scale of Unawareness of Mental Disorder; and for general cognitive abilities, the Screen for Cognitive Impairment in Psychiatry.

Results: Insight showed significant and moderate positive correlations with positive and general symptoms but not with negative symptoms. In the subgroup with positive symptomatic profile, awareness of the disorder and of the effects of medication were positively associated with severity of positive and general psychotic symptoms. Awareness of social consequences of the disease was positively associated with positive symptoms. In the subgroup with a negative symptomatic profile, awareness of the disorder and of the effects of medication were positively associated with severity of positive and general psychotic symptoms. In this subgroup, these relationships were significantly affected by general cognitive abilities.

Conclusions: Insight was not related with the severity of negative psychotic symptoms. The symptomatic profile of subjects played an important role in determining the relationship between insight and its dimensions and the severity of psychotic symptoms. Cognitive function moderated these relationships only in the negative symptomatic profile.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.comppsych.2011.08.008DOI Listing
July 2012

'Theory of Mind', psychotic-like experiences and psychometric schizotypy in adolescents from the general population.

Psychiatry Res 2011 Apr 21;186(2-3):225-31. Epub 2010 Aug 21.

Department of Clinical and Health Psychology, Universidad Autónoma de Barcelona, Spain.

This study examined 'Theory of Mind' (ToM) functioning, its association with psychometric schizotypy and with self-reported psychotic-like experiences (PLEs) and depressive symptoms, in a community sample of adolescents. Seventy-two adolescents (mean age 14.51years) from Barcelona, Spain, completed questionnaires assessing PLEs, depressive symptoms, and schizotypy. A verbal ToM task and a vocabulary test were administered. The effect of symptomatology, vocabulary ability, age, and gender on task performance was explored. Neither total score on schizotypy nor PLEs were associated with ToM performance. A significant effect of vocabulary on adolescent's performance of both ToM and control stories was found. ToM showed significant negative associations with positive schizotypy, and with one cluster of positive PLEs: first-rank experiences. Positive significant associations between ToM and persecutory delusions and the impulsive aspects of schizotypy were found. Depressive symptoms did not affect ToM performance. Positive schizotypal traits and first-rank symptoms are associated with ToM deficits in adolescents. Results support the trait-(versus state-) dependent notion of ToM impairments in schizophrenia. ToM may be a developmental impairment associated with positive schizotypy and PLEs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psychres.2010.07.051DOI Listing
April 2011

Exophenotypical profile of adolescents with sustained attention deficit: A 10-year follow-up study.

Psychiatry Res 2007 Oct 26;153(2):119-30. Epub 2007 Jul 26.

Psychopathology and Neuropsychology Research Unit, Department of Health Psychology, Autonomous University of Barcelona, Bellaterra, 08193, Barcelona, Spain.

Unlabelled: We aimed to explore prospectively the relationship between the presence of sustained attention deficit (SAD) in early adolescence and exophenotypical measures of vulnerability to schizophrenia spectrum disorders (personality and psychosocial measures) in early adulthood. Two cohorts of community adolescents were selected in 1993 according to the presence or absence of a CPT-linked SAD. In 2003, both cohorts (Index: n=42, and

Control: n=38) were administered the O-LIFE, the SCID-II, the DOI battery and the COPE scale, among other tests. T-tests were used to compare both cohorts. Index subjects showed a higher level of negative schizotypy, avoidant, depressive and narcissistic personality traits, as well as more asocial behavior and poorer use of coping resources than CONTROL subjects did. A SAD in early adolescence may be associated with coping and social deficits, negative schizotypy, and personality traits indicative of emotional disturbance in adulthood. Our results suggest that SAD in early adolescence might be an indicator of psychopathology in adulthood and give support to dimensional models of psychopathology.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psychres.2006.12.021DOI Listing
October 2007

Plasma osteopontin levels in multiple sclerosis.

J Neuroimmunol 2005 Jan;158(1-2):231-9

Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), Escola d'Infermeria 2a planta, Pg. Vall d'Hebron 119-129, 08035 Barcelona, Spain.

Osteopontin (OPN) is a pleiotropic integrin binding protein with functions in cell-mediated immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN may play an important role in the pathogenesis of experimental autoimmune encephalomyelitis and multiple sclerosis (MS). Here, we investigated the plasma levels of OPN in 221 MS patients and 36 healthy controls using an enzyme-linked immunoassay. The MS group comprised of 71 patients with primary and transitional progressive MS (PP/TP-MS), 35 patients with secondary progressive MS (SPMS), and 115 patients with relapsing-remitting MS (RRMS)[46 patients during clinical remission, 26 patients during relapse, and 43 patients treated with interferon-beta (IFNbeta)]. Levels of OPN in plasma were elevated in SPMS patients compared with healthy controls, RRMS patients in remission, and PP/TP-MS patients. Patients with RRMS during relapse presented higher OPN levels than patients with RRMS during clinical remission. When MS patients were classified based on progression of neurological disability, an inverse relation between levels of OPN and disability progression was observed only in patients with relapsing MS. In RRMS patients receiving therapy with IFNbeta, OPN plasma levels were similar to RRMS patients during remission. These findings suggest that OPN is involved in both acute and chronic disease activity, thus expanding the role of OPN in MS pathogenesis suggested by previous studies. Furthermore, the different profiles of OPN levels found in acute relapses and chronic progression and its apparent lack of influence in primary progressive MS phenotypes raise interesting questions on the actual role of OPN in the pathogenesis of MS.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneuroim.2004.09.004DOI Listing
January 2005
-->