Publications by authors named "José R Vega-Baudrit"

5 Publications

  • Page 1 of 1

Curcumin Loaded and Co-loaded Nanosystems: A Review from a Biological Activity Enhancement Perspective.

Pharm Nanotechnol 2021 ;9(2):85-100

BIODESS, Escuela de Química, Universidad de Costa Rica, San Pedro de Montes de Oca, 2060, San José, Costa Rica.

Background: Curcumin is a natural phenolic compound exhibiting multiple bioactivities that have been evaluated in vitro, in vivo as well as through clinical studies in humans. Some of them include antimicrobial, antioxidant, anti-inflammatory, and central nervous system protective effects. Further, curcumin is generally recognized as a safe substance because of its low toxicity. However, its molecular structure is susceptible to changes in pH, oxidation, photodegradation, low aqueous solubility, and biotransformation compromising its bioavailability; these drawbacks are successfully addressed through nanotechnology.

Objective: The present review systematizes findings on the enhancement of curcumin's beneficial effects when it is loaded and co-loaded into different types of nanosystems covering liposomes, polymeric and solid-lipid nanoparticles, nanostructured lipid carrier, lipid-polymeric hybrids, self- -assembled and protein-based core-shell systems in relation to its antimicrobial, antioxidant, anti-inflammatory and central nervous system protective bioactivities.

Conclusion: Curcumin is a versatile molecule capable of exerting antimicrobial, antioxidant, anti- inflammatory, and central nervous system protective effects in an enhanced manner using the possibilities offered by the nanotechnology-based approach. Its enhanced bioactivities are associated with increments in solubility, stability, bioavailability, as well as in improved intracellular uptake and cell internalization. These advantages, in addition to curcumin's low toxicity, indicate the potential of curcumin to be loaded and co-loaded into nanosystems capable of providing a controlled release and targeted administration.
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http://dx.doi.org/10.2174/2211738508666201228150659DOI Listing
January 2021

Organic amendments exacerbate the effects of silver nanoparticles on microbial biomass and community composition of a semiarid soil.

Sci Total Environ 2020 Nov 15;744:140919. Epub 2020 Jul 15.

CEBAS-CSIC. Department of Soil and Water Conservation. Campus Universitario de Espinardo, 30100 Murcia, Spain.

Increased utilization of silver nanoparticles (AgNPs) can result in an accumulation of these particles in the environment. The potential detrimental effects of AgNPs in soil may be associated with the low fertility of soils in semiarid regions that are usually subjected to restoration through the application of organic amendments. Microbial communities are responsible for fundamental processes related to soil fertility, yet the potential impacts of low and realistic AgNPs concentrations on soil microorganisms are still unknown. We studied the effects of realistic citrate-stabilized AgNPs concentrations (0.015 and 1.5 μg kg) at two exposure times (7 and 30 days) on a sandy clay loam Mediterranean soil unamended (SU) and amended with compost (SA). We assessed soil microbial biomass (microbial fatty acids), soil enzyme activities (urease, β-glucosidase, and alkaline phosphatase), and composition of the microbial community (bacterial 16S rRNA gene and fungal ITS2 sequencing) in a microcosm experiment. In the SA, the two concentrations of AgNPs significantly decreased the bacterial biomass after 7 days of incubation. At 30 days of incubation, only a significant decrease in the Gram+ was observed at the highest AgNPs concentration. In contrast, in the SU, there was a significant increase in bacterial biomass after 30 days of incubation at the lowest AgNPs concentration. Overall, we found that fungal biomass was more resistant to AgNPs than bacterial biomass, in both SA and SU. Further, the AgNPs changed the composition of the soil bacterial community in SA, the relative abundance of some bacterial taxa in SA and SU, and fungal richness in SU at 30 days of incubation. However, AgNPs did not affect the activity of extracellular enzymes. This study demonstrates that the exposure time and organic amendments modulate the effects of realistic concentrations of AgNPs in the biomass and composition of the microbial community of a Mediterranean soil.
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http://dx.doi.org/10.1016/j.scitotenv.2020.140919DOI Listing
November 2020

Environmentally relevant concentrations of silver nanoparticles diminish soil microbial biomass but do not alter enzyme activities or microbial diversity.

J Hazard Mater 2020 06 4;391:122224. Epub 2020 Feb 4.

CEBAS-CSIC. Department of Soil and Water Conservation, Campus Universitario de Espinardo, 30100, Murcia, Spain.

The increasing use of silver nanoparticles (AgNPs) due to their well-known antimicrobial activity, has led to their accumulation in soil ecosystems. However, the impact of environmental realistic concentrations of AgNPs on the soil microbial community has been scarcely studied. In this work, we have assessed the impact of AgNPs, that mimic real concentrations in nature, on tropical soils cultivated with Coffea arabica under conventional and organic management systems. We evaluated the biomass, extracellular enzyme activities, and diversity of the soil microbial community, in a microcosm experiment as a function of time. After seven days of incubation, we found an increase in microbial biomass in an AgNPs-concentration-independent manner. In contrast, after 60-day-incubation, there was a decrease in Gram+ and actinobacterial biomass, in both soils and all AgNPs concentrations. Soil physico-chemical properties and enzyme activities were not affected overall by AgNPs. Regarding the microbial community composition, only some differences in the relative abundance at phylum and genus level in the fungal community were observed. Our results suggest that environmental concentrations of AgNPs affected microbial biomass but had little impact on microbial diversity and may have little effects on the soil biogeochemical cycles mediated by extracellular enzyme activities.
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http://dx.doi.org/10.1016/j.jhazmat.2020.122224DOI Listing
June 2020

Biogenic silica-based microparticles obtained as a sub-product of the nanocellulose extraction process from pineapple peels.

Sci Rep 2018 Jul 10;8(1):10417. Epub 2018 Jul 10.

National Laboratory of Nanotechnology LANOTEC - National Center of High Technology CeNAT, 1.3 km north from the USA embassy, San José, Costa Rica.

Silica in plant tissues has been suggested as a component for enhancing mechanical properties, and as a physical barrier. Pineapples present in their shell and bracts rosette-like microparticles that could be associated to biogenic silica. In this study, we show for the first time that silica-based microparticles are co-purified during the extraction process of nanocellulose from pineapple (Ananas comosus). This shows that vegetable biomass could be an underappreciated source, not only for nanocellulose, but also for a highly valuable sub-product, like 10 µm biogenic rosette-like silica-based microparticles. The recovery yield obtained was 7.2 wt.%; based on the dried initial solid. Due to their size and morphology, the microparticles have potential applications as reinforcement in adhesives, polymer composites, in the biomedical field, and even as a source of silica for fertilizers.
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http://dx.doi.org/10.1038/s41598-018-28444-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039511PMC
July 2018

Silver Nanoparticles: Technological Advances, Societal Impacts, and Metrological Challenges.

Front Chem 2017 21;5. Epub 2017 Feb 21.

National Laboratory of Nanotechnology, National Center of High Technology San Jose, Costa Rica.

Silver nanoparticles (AgNPs) show different physical and chemical properties compared to their macroscale analogs. This is primarily due to their small size and, consequently, the exceptional surface area of these materials. Presently, advances in the synthesis, stabilization, and production of AgNPs have fostered a new generation of commercial products and intensified scientific investigation within the nanotechnology field. The use of AgNPs in commercial products is increasing and impacts on the environment and human health are largely unknown. This article discusses advances in AgNP production and presents an overview of the commercial, societal, and environmental impacts of this emerging nanoparticle (NP), and nanomaterials in general. Finally, we examine the challenges associated with AgNP characterization, discuss the importance of the development of NP reference materials (RMs) and explore their role as a metrological mechanism to improve the quality and comparability of NP measurements.
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http://dx.doi.org/10.3389/fchem.2017.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318410PMC
February 2017