Publications by authors named "José Javier Meana"

2 Publications

  • Page 1 of 1

5-HT receptor-mediated Gα activation in psychiatric disorders: A postmortem study.

World J Biol Psychiatry 2020 Nov 9:1-11. Epub 2020 Nov 9.

Laboratory of Neuropharmacology, IUNICS/IdISPa, University of the Balearic Islands (UIB), Palma de Mallorca, Spain.

Objectives: Serotonin-2A (5-HT) receptors play an important role in the regulation of many brain functions that are disturbed in patients with such psychiatric diseases as mood disorders and schizophrenia. The objective of this study was to evaluate 5-HT receptor-mediated signalling pathway through Gα activation in psychiatric patients by using post-mortem brain samples.

Methods: Functional activation of Gα proteins coupled to 5-HT receptors was determined by means of [S]GTPγS binding/immunoprecipitation assay in post-mortem prefrontal cortex of psychiatric patients diagnosed as bipolar disorder (BP), major depressive disorder (MDD), and schizophrenia, and individually matched controls. The effects of antipsychotic treatment as well as suicide were also analysed.

Results: There was no significant difference in maximum percent increase (%E) or slope factor among the four groups. The negative logarithm of concentration eliciting the half-maximal effect (pEC) was significantly reduced in BP and schizophrenia patients as compared to controls. These alterations were attributable to antipsychotic medication. The pEC values in 'non-suicide' group of schizophrenia, but not in 'suicide' group, were significantly reduced as compared with controls.

Conclusions: Altered 5-HT receptor-mediated signalling pathway through Gα proteins in prefrontal cortex might be apparently involved in pathophysiology and pharmacotherapy of BP and schizophrenia. In schizophrenic patients, these alterations as a result of successful treatment with antipsychotic agents may help in prevention of suicidal behaviour.
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http://dx.doi.org/10.1080/15622975.2020.1839967DOI Listing
November 2020

CIBERSAM: Ten years of collaborative translational research in mental disorders.

Rev Psiquiatr Salud Ment (Engl Ed) 2019 Jan - Mar;12(1):1-8. Epub 2018 Nov 9.

Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, España; Servicio de Psiquiatría y Psicología, Hospital Clínic, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España. Electronic address:

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http://dx.doi.org/10.1016/j.rpsm.2018.10.001DOI Listing
January 2020
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