Publications by authors named "José Edgardo Dipierri"

15 Publications

  • Page 1 of 1

Excess weight and thinness over two decades (1996-2015) and spatial distribution in children from Jujuy, Argentina.

BMC Public Health 2021 01 22;21(1):196. Epub 2021 Jan 22.

Centro de Investigaciones en Nutrición Humana, Escuela de Nutrición, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Boulevard de la Reforma s/n, CP 5000, Córdoba, Argentina.

Background: The increase of excess weight around the world is progressive and sustained in children. This is the most prevalent form of malnutrition in this population and they represent the major public health problem in developed and developing countries. The aim of this study was to analyze the magnitude of change in thinness and excess weight prevalence in 4-7 years-old schoolchildren from Jujuy (Argentina), between 1996 and 2015 and to examine the association according to sex and school location.

Methods: Cross-sectional study. Data was obtained from databases of School Health programs and it is representative of the city school population. For the analysis, 31,014 schoolchildren between 4 and 7 years old were evaluated, 20,224 from the first period (1996-2001) and 10,790 from the second (2010-2015). The city was partitioned in three different areas determined by the rivers that cross it. Nutritional status was determined by BMI for age with the criteria suggested by the International Obesity Task Force. The percentage of malnutrition change between periods was calculated and a binomial regression model was adjusted.

Results: Between periods, a significant (p-value< 0.0001) increase in the prevalence of overweight from 15.1% (CI 14.6-15.6%) to 18.1% (CI 17.4-18.8%) and obesity from 5% (CI 4.7-5.3) to 10.7% (CI 10.1-11.3%), and a decrease of thinness prevalence from 6.3% (CI 6.0-6.7%) to 4.7% (CI 4.3-5.1%) were observed. The percentage of change in the prevalence of obesity was very high in all areas and in both sexes (103.5% girls; 125.6% in boys), being higher in the south for girls (122.4%) and in the north for boys (158.8%). Besides, being a boy was inversely associated with the presence of excess weight and, as the age increases, the presence of obesity does it too. By analyzing the effect of the school location, the south and north zones had an inverse association with the presence of obesity. The period has a direct association with the presence of excess weight.

Conclusion: The study contributes with valuable information on the magnitude of the increase in obesity in schoolchildren and suggests a possible correlation with sex and spatial distribution in the capital city of Jujuy.
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January 2021

Waist circumference percentiles for Hispanic-American children and comparison with other international references.

Am J Hum Biol 2021 May 7;33(3):e23496. Epub 2020 Sep 7.

Institute of Biology of Altitude, National University of Jujuy, San Salvador de Jujuy, Argentina.

Introduction: Waist circumference (WC) constitutes an indirect measurement of central obesity in children and adolescents.

Objective: To provide percentiles of WC for Hispanic-American children and adolescents, and compare them with other international references.

Materials And Methods: The sample comprised 13 289 healthy children between 6 and 18 years coming from public schools of middle and low socioeconomic levels in different parts of Argentina, Cuba, Spain, Mexico, and Venezuela. The LMS method to calculate WC percentiles was applied. Sex and age differences were assessed using Student's t test and ANOVA (SPSS v.21.0). Comparisons were established with references from the United States, Colombia, India, China, Australia, Kuwait, Germany, Tunisia, Greece, and Portugal.

Results: WC increases with age in both sexes. Boys show higher WC in P3, P50, and P97. Comparison of 50th and 90th percentiles among populations from diverse sociocultural and geographical contexts shows high variability, not all justified by the measurement method.

Discussion And Conclusions: Specific WC percentiles for sex and age, and P90 cut-off points are provided; these values are potentially useful to assess central obesity in Hispanic-American adolescent children.
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May 2021

Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina.

PLoS One 2020 16;15(7):e0233808. Epub 2020 Jul 16.

Departamento de Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.

Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to perform population structure analyses at a sub-continental level. Concerning the Native American ancestry, we could identify four Native American components segregating in modern Argentinean populations. Three of them are also found in modern South American populations and are specifically represented in Central Andes, Central Chile/Patagonia, and Subtropical and Tropical Forests geographic areas. The fourth component might be specific to the Central Western region of Argentina, and it is not well represented in any genomic data from the literature. As for the European and African ancestries, we confirmed previous results about origins from Southern Europe, Western and Central Western Africa, and we provide evidences for the presence of Northern European and Eastern African ancestries.
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September 2020

An invincible memory: what surname analysis tells us about history, health and population medical genetics in the Brazilian Northeast.

J Biosoc Sci 2021 Mar 16;53(2):183-198. Epub 2020 Mar 16.

Genetics Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Several studies have shown that the Brazilian Northeast is a region with high rates of inbreeding as well as a high incidence of autosomal recessive diseases. The elaboration of public health policies focused on the epidemiological surveillance of congenital anomalies and rare genetic diseases in this region is urgently needed. However, the vast territory, socio-demographic heterogeneity, economic difficulties and low number of professionals with expertise in medical genetics make strategic planning a challenging task. Surnames can be compared to a genetic system with multiple neutral alleles and allow some approximation of population structure. Here, surname analysis of more than 37 million people was combined with health and socio-demographic indicators covering all 1794 municipalities of the nine states of the region. The data distribution showed a heterogeneous spatial pattern (Global Moran Index, GMI = 0.58; p < 0.001), with higher isonymy rates in the east of the region and the highest rates in the Quilombo dos Palmares region - the largest conglomerate of escaped slaves in Latin America. A positive correlation was found between the isonymy index and the frequency of live births with congenital anomalies (r = 0.268; p < 0.001), and the two indicators were spatially correlated (GMI = 0.50; p < 0.001). With this approach, quantitative information on the genetic structure of the Brazilian Northeast population was obtained, which may represent an economical and useful tool for decision-making in the medical field.
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March 2021

Microcephaly infant mortality in Brazil before zika outbreak.

Rev Fac Cien Med Univ Nac Cordoba 2019 12 3;76(4):217-221. Epub 2019 Dec 3.

Universidade Federal do Rio Grande do Sul. Departamento de Genética. Hospital de Clínicas de Porto Alegre.Serviço de Genética Médica do; Porto Alegre. Brasil.

Introduction: We present temporal and spatial variation of deaths from microcephaly in children under 1 year of age is analyzed at regional, state, and municipal level in the pre-Zika period in Brazil.

Materials And Methods: Data on births and deaths of infants with microcephaly was obtained from DATASUS from 1996 to 2013. Infant mortality rate from microcephaly (IMR-M) was estimated at Region, Federative Unit (UF), and Municipality level. Secular trend (ST) and risk of death variation were estimated using a Poisson regression model. Satscan software was used to obtain a statistic spatial scan for the Poisson model.

Results: IMR-M shows a non-significant negative ST in the Southeast, South and Central West Regions of Brazil. A greater IMR-M risk of death variation is found in the North and Northeast Regions. Most UFs in the Southeast, South and Central West Regions showed a negative ST, in contrast to what occurs in the UFs of the North and Northeast Regions showed a positive ST. Six high risk significant clusters were found: 3 in the North-Northeast and 3 in the South-SouthWest-Center-West.

Conclusions: The North and Northeast Regions showed positive ST for IRM-M and higher death risk, which was not observed in the other regions. Cluster distribution for higher IMR-M and risk resembles the distribution of the microcephaly and Zika cases in the outbreak period.
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December 2019

Dyslipidemia in schoolchildren with excess weight from Jujuy assessed by the program of school health

Rev Fac Cien Med Univ Nac Cordoba 2019 08 29;76(3):159-163. Epub 2019 Aug 29.

Instituto de Ecorregiones Andinas - CONICET-UNJu - Argentina Instituto de Biología de la Altura - Universidad Nacional de Jujuy - Argentina.

Background: Excess weight (EW) and alterations in lipid metabolism constitute risk factors for cardiovascular disease in adults and children. Prevalence of dyslipidemia in schoolchildren from Jujuy with EW is analyzed in this study.

Methods: Cross-sectional descriptive study of 891 schoolchildren 10-14 years old (367 girls; 524 boys) from the province of Jujuy (Northwestern Argentina). Prevalence of dyslipidemia for Overweight (OW) and Obesity (OB) were calculated, according to the International Obesity Task Force cut-off points. Prevalence of lipid alterations were analyzed and 7 dyslipidemic profiles were established. Comparisons and associations between variables were analyzed by Chi-square test. Crude and adjusted odds ratio were estimated from a logistic regressions.

Results: Regardless of sex and nutritional status, 13.7%, 21.8%, and 16.5% of schoolchildren showed high values of total cholesterol, triglycerides, and LDL cholesterol, respectively, and 20.3% had low HDL cholesterol. Significantly higher values of HDL cholesterol were found in OW, and of triglycerides in OB. A significant association was recorded between OB and high triglycerides. Schoolchildren with OB have a 54% more chances of showing at least one lipid alteration.

Conclusion: EW, and especially OB, constitutes an important risk factor in the development of dyslipidemia in schoolchildren from Jujuy.
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August 2019

Comparative study of mid-upper arm circumference, arm muscle area and arm fat area percentiles in Argentinean and US children aged 4-14 years.

Nutr Hosp 2019 Jul;36(3):552-562

Instituto de Ecorregiones Andinas (INECOA). UNJu-CONICET.

Introduction: Background: mid-upper arm circumference (MUAC), subcutaneous fat and muscle measurements are an alternative method to diagnose overweight and evaluate growth as well as protein and energy reserves. Aim: to compare MUAC, arm muscle area (AMA) and arm fat area (AFA) measurements of Argentinean boys and girls (Sa) with reference curves for US boys and girls (R). Subjects and methods: data from 22,736 school-children aged 4-14 years from six Argentinean provinces were collected. MUAC and triceps skinfold thickness were measured and the derived AMA and AFA measures were calculated. Analyses were performed with GAMLSS using the R software. Differences in mean values of Sa and R were compared in percentiles 3, 50 and 97. Results: mean values of MUAC and AMA in boys and girls were higher in R than in Sa at all ages; conversely, AFA values were lower. Conclusions: our results confirm differences in upper arm anthropometry of Argentinean school-children with respect to the US reference. The higher adipose tissue and lower skeletal muscle mass observed in Argentinean children could be partly associated with the different ethnic origin of both populations. However, differences should be interpreted in the context of an obesogenic environment, which has favored a calorie-protein imbalance.
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July 2019

[Spatial and temporal analysis of infant mortality from microcephaly in Argentina (1998-2012)].

Rev Fac Cien Med Univ Nac Cordoba 2017 09 8;74(3):299-304. Epub 2017 Sep 8.

Instituto de Biología de la Altura (UNJu).

Due to the increase in cases of microcephaly caused by Zika virus in Brazil, the Ministry of Health of Argentina recommends increasing surveillance of this malformation. In order to deepen the knowledge of the epidemiological behavior of microcephaly in the country, infant mortality by microcephaly is analyzed between 1998 and 2012. The data come from the Direction of Statistics and Health Information (DEIS). The infant mortality rate by microcephaly (IMR-M) was calculated by provinces and regions and a clustering analysis was performed at the departmental level. The highest rates were observed in the regions and provinces of the north of the country. The spatial distribution of IMR-M is related to the prevalence of microcephaly in newborns. This distribution is related to the greater poverty and consanguinity of the north of Argentina, synergic factors predisposing to the occurrence of congenital malformations in general and microcephaly in particular.
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September 2017

Isonymic Relations in the Bolivia-Argentina Border Region.

Hum Biol 2016 Jul;88(3):191-200

4 Patagonian Institute of Social and Human Sciences (CCT CENPAT-CONICET), Puerto Madryn, Argentina.

When migrating, people carry their cultural and genetic history, changing both the transmitting and the receiving populations. This phenomenon changes the structure of the population of a country. The question is how to analyze the impact on the border region. A demographic and geopolitical analysis of borders requires an interdisciplinary approach. An isonymic analysis can be a useful tool. Surnames are part of cultural history, sociocultural features transmitted from ancestors to their descendants through a vertical mechanism similar to that of genetic inheritance. The analysis of surname distribution can give quantitative information about the genetic structure of populations. The isonymic relations between border communities in southern Bolivia and northern Argentina were analyzed from electoral registers for 89 sections included in four major administrative divisions, two from each country, that include the international frontier. The Euclidean and geographic distance matrices where estimated for all possible pairwise comparisons between sections. The average isonymic distance was lower between Argentine than between Bolivian populations. Argentine sections formed three clusters, of which only one included a Bolivian section. The remaining clusters were exclusively formed by sections from Bolivia. The isonymic distance was greater along the border. Regardless of the intense human mobility in the past as in the present, and the presence of three major transborder conurbations, the Bolivian-Argentine international boundary functions as a geographical and administrative barrier that differentially affects the distribution and frequency of surnames. The observed pattern could possibly be a continuity of pre-Columbian regional organization.
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July 2016


J Biosoc Sci 2017 05 11;49(3):322-333. Epub 2016 Oct 11.

*Instituto de Ecorregiones Andinas (INECOA),Universidad Nacional de Jujuy,San Salvador de Jujuy,Argentina.

In human populations various flexible, labile and interdependent structures (genetic, demographic, socioeconomic) co-exist, each of which can be organized in an hierarchical order corresponding to administrative entities. The relationship between consanguinity, as estimated by random isonymy (F ST), and socioeconomic conditions was analysed at different levels of political and administrative organization in Argentina. From the surnames of 22,666,139 voters from the 2001 electoral roll, F ST was estimated for 510 Argentinian departments. Using a principal component analysis, a Socio-Demographic and Economic Indicator (SDEI), summarizing the effect of 22 socioeconomic and demographic variables at the departmental level, was computed. The relationship between departmental F ST and SDEI values was analysed for the whole nation and within regions using multiple regression analysis. The F ST presented a clinal distribution with the highest values in the north and west of the country, while SDEI expressed the opposite behaviour. A negative and significant correlation was observed between F ST and SDEI, accounting for 46% of the variation in consanguinity in Argentina. The strongest correlations of F ST with SDEI were observed in the Central, Patagonia and Cuyo regions, i.e. those with the highest values of SDEI and lowest values of F ST.
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May 2017

[Infant mortality from congenital malformations in Chile: temporal and spatial analysis, 1997-2011].

Rev Panam Salud Publica 2015 Nov;38(5):380-7

Area de Genética Médica y Poblacional, Hospital General Ramos Mejía, Buenos Aires, Argentina,

Objective: To analyze the spatial and temporal distribution (1997-2011) of infant mortality resulting from congenital malformations (CM) in Chile.

Methods: Data on births and deaths among infants aged less than one year using ICD-10 coding were obtained from the National Statistics Institute. The percentage of deaths from CM (PD-CM) and the infant mortality rate from CM (IMR-CM) during three different periods (1997-2001, 2002-2009, 2007-2011) were estimated for Chile's administrative and natural regions (Norte Grande, Norte Chico, Central, Austral, and Sur), broken down by systems (nervous, cardiovascular, digestive, genitourinary, musculoskeletal, and chromosomal abnormalities) and by 28 specific malformations. The secular trend and the variation in the risk of death were estimated using a Poisson regression model.

Results: For the whole of Chile, the secular trend for the IMR-CM was negative, and the secular trend for the PD-CM was positive (P < 0,01). The IMR-CM and the PD-CM both showed mild spatial heterogeneity in all administrative and natural regions. The Central region was the natural region that came closest to showing the pattern observed nationwide. The IMR-CM involving the nervous and cardiovascular systems and specific types of CM (anencephaly, spina bifida, and atrial and ventricular septal defects) showed a negative secular trend. For Chile as a whole, the pattern of infant mortality from CM is marked by a drop in the IMR-CM and by an increase in the PD-CM over the period from 1997 to 2011.

Conclusion: The findings suggest that Chile is in the latter stages of the epidemiological transition with respect to the causes of infant mortality. However, these indicators show disparities between regions, more pronounced in the south of the country.
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November 2015

Geographical altitude, size, mass and body surface area in children (1-4 years) in the Province of Jujuy (Argentina).

Ann Hum Biol 2015 2;42(5):431-8. Epub 2014 Dec 2.

a Instituto de Biología de la Altura, Universidad Nacional de Jujuy (UNJu), San Salvador de Jujuy , Jujuy , Argentina .

Background: Highland child populations show low growth rates.

Aim: To evaluate the variation of size, mass and body surface area of Jujenean infants (1-4 years) as a function of geographic altitude.

Subjects And Methods: Nutritional status of 8059 healthy infants was determined based on weight and height data; body mass index, ponderal index, body surface area, body surface area/mass and ectomorphy were calculated. Variables were standardized with a provincial mean and WHO references. Data were grouped by age, sex and geographic altitude: Highlands (≥2500 masl) and Lowlands (<2500 masl). Chi-square, correlation and t-tests were applied.

Results: Highlands infants had higher prevalence of stunting, reduced height, weight, body surface area and ectomorphy; also higher body mass index, ponderal index and body surface area/mass. The population average z-score for height, weight and body surface area was positive in Lowlands and negative in Highlands. The opposite happened with body mass index, ponderal index and body surface area/mass. In Highlands and Lowlands the average z-score reference was negative for weight and height and positive for body mass index. Correlations between indices were high and significant, higher in Highlands.

Conclusion: Jujenean children differ in size, mass and body surface area based on the geographical altitude and adverse nutritional and socioeconomic factors.
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August 2016

Composite index of anthropometric failure and geographic altitude in children from Jujuy (1 to 5 years old).

Arch Argent Pediatr 2014 Dec;112(6):526-31

Facultad de Humanidades y Ciencias Sociales, Universidad Nacional de Jujuy.

Introduction: The Composite Index of Anthropometric Failure (CIAF) is made up of typical anthropometric indicators and their combination into seven categories, and proposes an additional measure to study malnutrition as an alternative to the evaluation of stunting, wasting and underweight as separate measures.

Objective: To assess the CIAF in the child population settled at different altitudinal zones in Jujuy.

Population And Methods: Weight and height were obtained from healthy 1 to 5 year-old control children, measured at primary healthcare centers (PHCCs) in Jujuy between 2005 and 2007. Nutritional status indicators such as underweight, stunting and wasting were determined as per the World Health Organization 2007 child growth standards. The CIAF and its seven categories were estimated by grouping data by gender, age and altitudinal zone (highlands: >2500 MASL; lowlands: <2500 MASL). The CIAF percentage differences for height, gender and age were verified using a chi-square test.

Results: A total of 8059 children were included. The CIAF for highland children (6.1%) doubled that for lowland children (3.4%) (p < 0.05), and underweight prevalence (group Y) was significantly higher in the highlands (p < 0.05). The CIAF value and stunting (group F) increased with age, but such increase was more significant in the highlands.

Conclusions: A significantly higher CIAF was observed in highland children, at the expense of stunting. However, the index of anthropometric failure was not more than 10% at both the highlands and the lowlands, and this accounts for a scarcely significant malnutrition health status in the studied child population of Jujuy.
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December 2014

Prevalence of overweight and obesity in students from different altitudinal zones of Jujuy according to three international references (IOTF, CDC and WHO).

Arch Argent Pediatr 2013 Dec;111(6):516-22

INTRODUCTION. Prevalences of overweight and obesity in students from different altitudinal zones of Jujuy are compared using the International Obesity Task Force (IOTF), the Centers for Disease Control (CDC) and the World Health Organization (WHO) references, and the agreement among them. MATERIAL AND METHODS. Weight and height data from 15 541 students were grouped in highlands (HL) (≥2500 MASL) and lowlands (LL) (<2500 MASL) and in two age groups (5-6.99 years old and 11-12.99 years old). Overweight and obesity prevalences were calculated according to the different references. The differences in outcome measures and prevalences were established using the ?2 test and the t test, and agreement among the criteria was calculated using the kappa index. RESULTS. Students from the HL had lower weight, height and body mass index (BMI) values (p< 0.05). Overweight and obesity prevalences compared to the WHO reference were higher, except for overweight in students of both sexes, from 11 to 12.99 years old, from the HL and the LL. Regardless of the references, gender and age, overweight and obesity prevalences were generally higher in the LL. Agreement between the IOTF and the CDC was good-very good, and agreement among them and the WHO was fair-moderate. CONCLUSIONS. Students from the HL had a lower overweight and obesity prevalence. The greatest agreement was observed between the IOTF and the CDC references.
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December 2013

Anthropometric parameters in screening for excess of adiposity in Argentinian and Spanish adolescents: evaluation using receiver operating characteristic (ROC) methodology.

Ann Hum Biol 2013 Sep-Oct;40(5):396-405. Epub 2013 Jun 27.

Department of Zoology and Physical Anthropology, Faculty of Biology and.

Background: Various anthropometric parameters have been proposed for defining overweight in adolescence, but few studies have evaluated their diagnostic accuracy in comparative terms, using samples from different regions.

Aim: To compare the performance of anthropometric parameters in determining the excess of adiposity in Argentinian and Spanish adolescents.

Subjects And Methods: The sample is composed of 1781 Argentinian and 1350 Spanish subjects, aged 12-17 years. Excess adiposity was defined as percentage BF in the 90th percentile or higher. ROC curves established the validity of parameters to define excess adiposity.

Results: Descriptive statistics showed differences between the Argentinian and Spanish samples. ROC curves indicate that all the parameters analysed had, in the Spanish and Argentinian samples, a positive and elevated association with excess of adiposity. The waist-to-height ratio had the highest value of the area under ROC curve (AUC), while conicity index and waist-to-hip ratio had the lowest.

Conclusions: Differences exist with respect to size and body composition between the Argentinian and Spanish samples. ROC curves reflect a general pattern of variation. Waist-to-hip ratio and conicity index are less desirable in the diagnosis of excess adiposity and the most desirable is waist-to-height ratio.
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March 2014