Publications Authored by Jorunn E Eyfjord

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Authors:

Serena Nik-Zainal Helen Davies Johan Staaf Manasa Ramakrishna Dominik Glodzik Xueqing Zou Inigo Martincorena Ludmil B Alexandrov Sancha Martin David C Wedge Peter Van Loo Young Seok Ju Marcel Smid Arie B Brinkman Sandro Morganella Miriam R Aure Ole Christian Lingjærde Anita Langerød Markus Ringnér Sung-Min Ahn Sandrine Boyault Jane E Brock Annegien Broeks Adam Butler Christine Desmedt Luc Dirix Serge Dronov Aquila Fatima John A Foekens Moritz Gerstung Gerrit K J Hooijer Se Jin Jang David R Jones Hyung-Yong Kim Tari A King Savitri Krishnamurthy Hee Jin Lee Jeong-Yeon Lee Yilong Li Stuart McLaren Andrew Menzies Ville Mustonen Sarah O'Meara Iris Pauporté Xavier Pivot Colin A Purdie Keiran Raine Kamna Ramakrishnan F Germán Rodríguez-González Gilles Romieu Anieta M Sieuwerts Peter T Simpson Rebecca Shepherd Lucy Stebbings Olafur A Stefansson Jon Teague Stefania Tommasi Isabelle Treilleux Gert G Van den Eynden Peter Vermeulen Anne Vincent-Salomon Lucy Yates Carlos Caldas Laura Van't Veer Andrew Tutt Stian Knappskog Benita Kiat Tee Tan Jos Jonkers Åke Borg Naoto T Ueno Christos Sotiriou Alain Viari P Andrew Futreal Peter J Campbell Paul N Span Steven Van Laere Sunil R Lakhani Jorunn E Eyfjord Alastair M Thompson Ewan Birney Hendrik G Stunnenberg Marc J van de Vijver John W M Martens Anne-Lise Børresen-Dale Andrea L Richardson Gu Kong Gilles Thomas Michael R Stratton

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41586-019-0883-2	Publisher Site
http://dx.doi.org/10.1038/s41586-019-0883-2	DOI Listing

February 2019

Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency.

Authors:

Helen Davies Sandro Morganella Colin A Purdie Se Jin Jang Elin Borgen Hege Russnes Dominik Glodzik Xueqing Zou Alain Viari Andrea L Richardson Anne-Lise Børresen-Dale Alastair Thompson Jorunn E Eyfjord Gu Kong Michael R Stratton Serena Nik-Zainal

Cancer Res 2017 09;77(18):4755-4762

Wellcome Trust Sanger Institute, Hinxton, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1083	DOI Listing

September 2017

Telomere Length Is Predictive of Breast Cancer Risk in Mutation Carriers.

Authors:

Birna Thorvaldsdottir Margret Aradottir Olafur A Stefansson Sigridur K Bodvarsdottir Jorunn E Eyfjörd

Cancer Epidemiol Biomarkers Prev 2017 08 24;26(8):1248-1254. Epub 2017 Feb 24.

Cancer Research Laboratory, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1158/1055-9965.EPI-16-0946	DOI Listing

August 2017

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.

Nat Med 2017 Apr 13;23(4):517-525. Epub 2017 Mar 13.

Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/nm.4292	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833945	PMC

April 2017

Oestrogen receptor status, treatment and breast cancer prognosis in Icelandic BRCA2 mutation carriers.

Authors:

Jon G Jonasson Olafur A Stefansson Oskar T Johannsson Helgi Sigurdsson Bjarni A Agnarsson Gudridur H Olafsdottir Kristin K Alexiusdottir Hrefna Stefansdottir Rodrigo Munoz Mitev Katrin Olafsdottir Kristrun Olafsdottir Adalgeir Arason Vigdis Stefansdottir Elinborg J Olafsdottir Rosa B Barkardottir Jorunn E Eyfjord Steven A Narod Laufey Tryggvadóttir

Br J Cancer 2016 09 18;115(7):776-83. Epub 2016 Aug 18.

Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/bjc.2016.249	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046206	PMC

September 2016

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Authors:

Serena Nik-Zainal Helen Davies Johan Staaf Manasa Ramakrishna Dominik Glodzik Xueqing Zou Inigo Martincorena Ludmil B Alexandrov Sancha Martin David C Wedge Peter Van Loo Young Seok Ju Marcel Smid Arie B Brinkman Sandro Morganella Miriam R Aure Ole Christian Lingjærde Anita Langerød Markus Ringnér Sung-Min Ahn Sandrine Boyault Jane E Brock Annegien Broeks Adam Butler Christine Desmedt Luc Dirix Serge Dronov Aquila Fatima John A Foekens Moritz Gerstung Gerrit K J Hooijer Se Jin Jang David R Jones Hyung-Yong Kim Tari A King Savitri Krishnamurthy Hee Jin Lee Jeong-Yeon Lee Yilong Li Stuart McLaren Andrew Menzies Ville Mustonen Sarah O'Meara Iris Pauporté Xavier Pivot Colin A Purdie Keiran Raine Kamna Ramakrishnan F Germán Rodríguez-González Gilles Romieu Anieta M Sieuwerts Peter T Simpson Rebecca Shepherd Lucy Stebbings Olafur A Stefansson Jon Teague Stefania Tommasi Isabelle Treilleux Gert G Van den Eynden Peter Vermeulen Anne Vincent-Salomon Lucy Yates Carlos Caldas Laura van't Veer Andrew Tutt Stian Knappskog Benita Kiat Tee Tan Jos Jonkers Åke Borg Naoto T Ueno Christos Sotiriou Alain Viari P Andrew Futreal Peter J Campbell Paul N Span Steven Van Laere Sunil R Lakhani Jorunn E Eyfjord Alastair M Thompson Ewan Birney Hendrik G Stunnenberg Marc J van de Vijver John W M Martens Anne-Lise Børresen-Dale Andrea L Richardson Gu Kong Gilles Thomas Michael R Stratton

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature17676	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866	PMC

June 2016

The topography of mutational processes in breast cancer genomes.

Nat Commun 2016 May 2;7:11383. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/ncomms11383	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001788	PMC

May 2016

Inbreeding and homozygosity in breast cancer survival.

Authors:

Hauke Thomsen Miguel Inacio da Silva Filho Andrea Woltmann Robert Johansson Jorunn E Eyfjörd Ute Hamann Jonas Manjer Kerstin Enquist-Olsson Roger Henriksson Stefan Herms Per Hoffmann Bowang Chen Stefanie Huhn Kari Hemminki Per Lenner Asta Försti

Sci Rep 2015 Nov 12;5:16467. Epub 2015 Nov 12.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/srep16467	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642301	PMC

November 2015

Systematic pathway enrichment analysis of a genome-wide association study on breast cancer survival reveals an influence of genes involved in cell adhesion and calcium signaling on the patients' clinical outcome.

Authors:

Andrea Woltmann Bowang Chen Jesús Lascorz Robert Johansson Jorunn E Eyfjörd Ute Hamann Jonas Manjer Kerstin Enquist-Olsson Roger Henriksson Stefan Herms Per Hoffmann Kari Hemminki Per Lenner Asta Försti

PLoS One 2014 2;9(6):e98229. Epub 2014 Jun 2.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098229	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041745	PMC

January 2015

Aurora A is a prognostic marker for breast cancer arising in BRCA2 mutation carriers.

Authors:

Margret Aradottir Sigridur T Reynisdottir Olafur A Stefansson Jon G Jonasson Asgerdur Sverrisdottir Laufey Tryggvadottir Jorunn E Eyfjord Sigridur K Bodvarsdottir

J Pathol Clin Res 2015 Jan 7;1(1):33-40. Epub 2014 Nov 7.

Cancer Research Laboratory, Biomedical Center, Faculty of Medicine, School of Health Sciences, University of Iceland Reykjavik Iceland.

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http://dx.doi.org/10.1002/cjp2.6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858119	PMC

January 2015

A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition.

Cancer Res 2014 Oct 8;74(19):5608-19. Epub 2014 Aug 8.

Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat; Barcelona, Spain. Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain. Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3659	DOI Listing

October 2014

Linkage of DNA methylation quantitative trait loci to human cancer risk.

Authors:

Holger Heyn Sergi Sayols Catia Moutinho Enrique Vidal Jose V Sanchez-Mut Olafur A Stefansson Ernest Nadal Sebastian Moran Jorunn E Eyfjord Eva Gonzalez-Suarez Miguel Angel Pujana Manel Esteller

Cell Rep 2014 Apr 3;7(2):331-338. Epub 2014 Apr 3.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.016	DOI Listing

April 2014

Tumour diploidy and survival in breast cancer patients with BRCA2 mutations.

Authors:

Laufey Tryggvadottir Elinborg J Olafsdottir Gudridur H Olafsdottir Helgi Sigurdsson Oskar T Johannsson Einar Bjorgvinsson Kristin Alexiusdottir Olafur A Stefansson Bjarni A Agnarsson Steven A Narod Jorunn E Eyfjord Jon G Jonasson

Breast Cancer Res Treat 2013 Jul 16;140(2):375-84. Epub 2013 Jul 16.

Icelandic Cancer Registry, Icelandic Cancer Society, Skogarhlid 8, P.O. Box 5420, 125, Reykjavik, Iceland.

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http://dx.doi.org/10.1007/s10549-013-2637-4	DOI Listing

July 2013

DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker.

Authors:

Holger Heyn F Javier Carmona Antonio Gomez Humberto J Ferreira Jordana T Bell Sergi Sayols Kirsten Ward Olafur A Stefansson Sebastian Moran Juan Sandoval Jorunn E Eyfjord Tim D Spector Manel Esteller

Carcinogenesis 2013 Jan 10;34(1):102-8. Epub 2012 Oct 10.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Catalonia 08907, Spain.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c	Publisher Site
http://dx.doi.org/10.1093/carcin/bgs321	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534196	PMC

January 2013

Tetraploidy in BRCA2 breast tumours.

Authors:

Asta Bjork Jonsdottir Olafur Andri Stefansson Johannes Bjornsson Jon G Jonasson Helga M Ogmundsdottir Jorunn E Eyfjord

Eur J Cancer 2012 Feb 29;48(3):305-10. Epub 2011 Nov 29.

Cancer Research Laboratory, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1016/j.ejca.2011.11.008	DOI Listing

February 2012

Dysfunctional telomeres in human BRCA2 mutated breast tumors and cell lines.

Authors:

Sigridur K Bodvarsdottir Margret Steinarsdottir Hordur Bjarnason Jorunn E Eyfjord

Mutat Res 2012 Jan 12;729(1-2):90-9. Epub 2011 Oct 12.

Cancer Research Laboratory, BioMedical Centre, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1016/j.mrfmmm.2011.10.002	DOI Listing

January 2012

Single nucleotide polymorphisms in the 20q13 amplicon genes in relation to breast cancer risk and clinical outcome.

Breast Cancer Res Treat 2011 Dec 1;130(3):905-16. Epub 2011 Jun 1.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s10549-011-1600-5	DOI Listing

December 2011

Cytogenetic polyclonality of breast carcinomas: association with clinico-pathological characteristics and outcome.

Authors:

Margret Steinarsdottir Ingi Hrafn Gudmundsson Jon Gunnlaugur Jonasson Elinborg J Olafsdottir Jorunn E Eyfjörd Helga M Ogmundsdottir

Genes Chromosomes Cancer 2011 Nov 24;50(11):930-9. Epub 2011 Aug 24.

Chromosome Laboratory, Department of Genetics and Molecular Medicine, Landspitali University Hospital, Reykjavík, Iceland.

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http://dx.doi.org/10.1002/gcc.20915	DOI Listing

November 2011

Genomic and phenotypic analysis of BRCA2 mutated breast cancers reveals co-occurring changes linked to progression.

Authors:

Olafur A Stefansson Jon G Jonasson Kristrun Olafsdottir Hordur Bjarnason Oskar Th Johannsson Sigridur K Bodvarsdottir Sigridur Valgeirsdottir Jorunn E Eyfjord

Breast Cancer Res 2011 Sep 29;13(5):R95. Epub 2011 Sep 29.

Cancer Research Laboratory, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, Reykjavik, Iceland.

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http://dx.doi.org/10.1186/bcr3020	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262207	PMC

September 2011

Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer.

Authors:

Ferdinandos Skoulidis Liam D Cassidy Venkat Pisupati Jon G Jonasson Hordur Bjarnason Jorunn E Eyfjord Florian A Karreth Michael Lim Lorraine M Barber Susan A Clatworthy Susan E Davies Kenneth P Olive David A Tuveson Ashok R Venkitaraman

Cancer Cell 2010 Nov 4;18(5):499-509. Epub 2010 Nov 4.

Department of Oncology and the Medical Research Council Cancer Cell Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1016/j.ccr.2010.10.015	DOI Listing

November 2010

Centriole movements in mammalian epithelial cells during cytokinesis.

Authors:

Asta Björk Jonsdottir Roeland W Dirks Johannes Vrolijk Helga M Ogmundsdottir Hans J Tanke Jorunn E Eyfjörd Karoly Szuhai

BMC Cell Biol 2010 May 21;11:34. Epub 2010 May 21.

Cancer Research Laboratory, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1186/1471-2121-11-34	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893098	PMC

May 2010

BRCA2 heterozygosity delays cytokinesis in primary human fibroblasts.

Authors:

Asta Björk Jonsdottir Maaike P G Vreeswijk Ron Wolterbeek Peter Devilee Hans J Tanke Jorunn E Eyfjörd Karoly Szuhai

Cell Oncol 2009 ;31(3):191-201

Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.3233/CLO-2009-0465	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618909	PMC

July 2009

Positive association between DNA strand breaks in peripheral blood mononuclear cells and polyunsaturated fatty acids in red blood cells from women.

Authors:

Audur Y Thorlaksdottir Jon J Jonsson Laufey Tryggvadottir Gudrun V Skuladottir Anna L Petursdottir Helga M Ogmundsdottir Jorunn E Eyfjord Ingibjorg Hardardottir

Nutr Cancer 2007 ;59(1):21-8

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1080/01635580701365092	DOI Listing

January 2008

AURKA and breast cancer in BRCA1/2 mutation carriers.

Authors:

Sigridur K Bodvarsdottir Linda Vidarsdottir Jorunn E Eyfjord

Cancer Epidemiol Biomarkers Prev 2007 Nov;16(11):2517

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http://dx.doi.org/10.1158/1055-9965.EPI-07-0669	DOI Listing

November 2007

MYC amplification and TERT expression in breast tumor progression.

Authors:

Sigríthur K Bodvarsdóttir Margrét Steinarsdóttir Hólmfríthur Hilmarsdóttir Jón G Jónasson Jorunn E Eyfjörd

Cancer Genet Cytogenet 2007 Jul;176(2):93-9

Department of Medicine, University of Iceland, Vatnsmýrarvegi 16, 101 Reykjavik, Iceland.

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http://dx.doi.org/10.1016/j.cancergencyto.2007.04.002	DOI Listing

July 2007

Breast cancer risk associated with AURKA 91T -->A polymorphism in relation to BRCA mutations.

Authors:

Linda Vidarsdottir Sigridur K Bodvarsdottir Holmfridur Hilmarsdottir Laufey Tryggvadottir Jorunn E Eyfjord

Cancer Lett 2007 Jun 17;250(2):206-12. Epub 2006 Nov 17.

Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, Skogarhlid 8, 105 Reykjavik, Iceland.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350600556	Publisher Site
http://dx.doi.org/10.1016/j.canlet.2006.10.003	DOI Listing

June 2007

Aurora-A amplification associated with BRCA2 mutation in breast tumours.

Authors:

Sigridur K Bodvarsdottir Holmfridur Hilmarsdottir Valgerdur Birgisdottir Margret Steinarsdottir Jon G Jonasson Jorunn E Eyfjord

Cancer Lett 2007 Apr 24;248(1):96-102. Epub 2006 Jul 24.

Icelandic Cancer Society, Skogarhlid 8, 105 Reykjavik, Iceland; University of Iceland, Department of Medicine, Vatnsmyrarvegi 16, 101 Reykjavik, Iceland.

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