Joris J T H Roelofs

Joris J T H Roelofs

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Publications by authors named "Joris J T H Roelofs"

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Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice.

J Pathol 2019 Oct 9. Epub 2019 Oct 9.

Center of Experimental & Molecular Medicine, Amsterdam University Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/path.5354DOI Listing
October 2019

Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis.

Infect Immun 2019 Aug 23;87(8). Epub 2019 Jul 23.

Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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http://dx.doi.org/10.1128/IAI.00409-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652761PMC
August 2019

Pulmonary complement depositions in autopsy of critically ill patients have no relation with ARDS.

Intensive Care Med Exp 2019 Jul 25;7(Suppl 1):35. Epub 2019 Jul 25.

Department of Intensive Care, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s40635-019-0237-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658633PMC
July 2019

Experimental thrombocytopenia does not affect acute kidney injury 24 hours after renal ischemia reperfusion in mice.

Platelets 2019 Jul 31:1-9. Epub 2019 Jul 31.

a Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam UMC, University of Amsterdam , Amsterdam , Netherlands.

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http://dx.doi.org/10.1080/09537104.2019.1646899DOI Listing
July 2019

Melioidosis in travelers: An analysis of Dutch melioidosis registry data 1985-2018.

Travel Med Infect Dis 2019 Jul 29:101461. Epub 2019 Jul 29.

Center for Experimental and Molecular Medicine and Melioidosis Expertise Center, Amsterdam UMC, Location Academic Medical Center (AMC), Amsterdam Infection & Immunity Institute, University of Amsterdam, Amsterdam, the Netherlands; Division of Infectious Diseases, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tmaid.2019.07.017DOI Listing
July 2019

Platelet Btk is Required for Maintaining Lung Vascular Integrity during Murine Pneumococcal Pneumosepsis.

Thromb Haemost 2019 Jun 14;119(6):930-940. Epub 2019 Mar 14.

Center for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1055/s-0039-1681046DOI Listing
June 2019

Airway smooth muscle reduction after bronchial thermoplasty in severe asthma correlates with FEV.

Clin Exp Allergy 2019 Apr 20;49(4):541-544. Epub 2019 Feb 20.

Department of Pulmonology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/cea.13365DOI Listing
April 2019

A multicenter application of the 2018 Banff Classification for BK polyomavirus-associated nephropathy in renal transplantation.

Transplantation 2019 Mar 21. Epub 2019 Mar 21.

Amsterdam UMC, University of Amsterdam, Department of Pathology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam Cardiovascular Sciences (ACS), Meibergdreef 9, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/TP.0000000000002712DOI Listing
March 2019

Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Shock 2019 Feb;51(2):267

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001143DOI Listing
February 2019

The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato.

Sci Rep 2019 Feb 5;9(1):1431. Epub 2019 Feb 5.

Amsterdam UMC, University of Amsterdam, Center for Experimental and Molecular Medicine, Meibergdreef 9, Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/s41598-018-37922-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363739PMC
February 2019

Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite-induced murine asthma model.

Am J Physiol Lung Cell Mol Physiol 2019 Jan 25;316(1):L187-L196. Epub 2018 Oct 25.

Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00162.2018DOI Listing
January 2019

Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion.

Transfusion 2019 01 21;59(1):134-145. Epub 2018 Nov 21.

Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/trf.15039DOI Listing
January 2019

Platelet-Dense Granules Worsen Pre-Infection Thrombocytopenia during Gram-Negative Pneumonia-Derived Sepsis.

J Innate Immun 2019 17;11(2):168-180. Epub 2018 Dec 17.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000494147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738263PMC
December 2018

MRP8/14 does not contribute to dissemination or inflammation in a murine model of Lyme borreliosis.

Immunobiology 2018 11 17;223(11):694-698. Epub 2018 Jul 17.

Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands; Division of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.imbio.2018.07.017DOI Listing
November 2018

Inhibition of the extrinsic or intrinsic coagulation pathway during pneumonia-derived sepsis.

Am J Physiol Lung Cell Mol Physiol 2018 11 23;315(5):L799-L809. Epub 2018 Aug 23.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00014.2018DOI Listing
November 2018

Confocal Laser Endomicroscopy as a Guidance Tool for Transbronchial Lung Cryobiopsies in Interstitial Lung Disorder.

Respiration 2019 14;97(3):259-263. Epub 2018 Nov 14.

Department of Respiratory Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands,

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https://www.karger.com/Article/FullText/493271
Publisher Site
http://dx.doi.org/10.1159/000493271DOI Listing
November 2018

Nbeal2 Deficiency Increases Organ Damage but Does Not Affect Host Defense During Gram-Negative Pneumonia-Derived Sepsis.

Arterioscler Thromb Vasc Biol 2018 08;38(8):1772-1784

From the Center for Experimental and Molecular Medicine (T.A.M.C., S.F.d.S., A.F.d.V., C.v.V., T.v.d.P.).

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http://dx.doi.org/10.1161/ATVBAHA.118.311332DOI Listing
August 2018

The role of platelets in acute kidney injury.

Nat Rev Nephrol 2018 07;14(7):457-471

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/s41581-018-0015-5DOI Listing
July 2018

Aryl hydrocarbon receptor expression by macrophages and lymphocytes within infiltrates in BK polyomavirus associated nephropathy.

Transpl Immunol 2018 04 2;47:18-21. Epub 2018 Jan 2.

Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.trim.2017.12.005DOI Listing
April 2018

Limited role of kininogen in the host response during gram-negative pneumonia-derived sepsis.

Am J Physiol Lung Cell Mol Physiol 2018 03 9;314(3):L397-L405. Epub 2017 Nov 9.

Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00288.2017DOI Listing
March 2018

Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria.

Blood 2018 02 29;131(8):864-876. Epub 2017 Nov 29.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2017-06-788067DOI Listing
February 2018

Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes.

Intensive Care Med Exp 2017 Dec 26;5(1):27. Epub 2017 May 26.

Department of Intensive Care Medicine, Leiden University Medical Center, Post Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s40635-017-0142-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446430PMC
December 2017

Endotoxemia Results in Trapping of Transfused Red Blood Cells in Lungs with Associated Lung Injury.

Shock 2017 10;48(4):484-489

*Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands †Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands ‡Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000000875DOI Listing
October 2017

Optical coherence tomography for identification and quantification of human airway wall layers.

PLoS One 2017 5;12(10):e0184145. Epub 2017 Oct 5.

Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184145PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628810PMC
October 2017

Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy.

Am J Pathol 2017 Sep 29;187(9):1971-1983. Epub 2017 Jun 29.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.05.004DOI Listing
September 2017

Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response.

Cell Mol Gastroenterol Hepatol 2018 5;5(1):67-82.e1. Epub 2017 Sep 5.

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jcmgh.2017.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738458PMC
September 2017

Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation.

Thromb Haemost 2017 07 11;117(8):1601-1614. Epub 2017 May 11.

Ingrid Stroo, Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, G2-1051105 AZ Amsterdam, the Netherlands, Tel.: +31 20 5666034, E-mail:

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http://dx.doi.org/10.1160/TH16-12-0920DOI Listing
July 2017

Composition of the cellular infiltrate in patients with simple and complex appendicitis.

J Surg Res 2017 06 6;214:190-196. Epub 2017 Mar 6.

Department of Paediatric Surgery, Paediatric Surgical Centre of Amsterdam, Emma Children's Hospital AMC and VU University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jss.2017.02.062DOI Listing
June 2017

Differences in Inflammation Patterns Induced by African and Asian Isolates in Mice.

Am J Trop Med Hyg 2017 Jun;96(6):1365-1369

Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4269/ajtmh.16-0121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462573PMC
June 2017

Nebulized Recombinant Human Tissue Factor Pathway Inhibitor Attenuates Coagulation and Exerts Modest Anti-inflammatory Effects in Rat Models of Lung Injury.

J Aerosol Med Pulm Drug Deliv 2017 Apr 15;30(2):91-99. Epub 2016 Dec 15.

1 Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam , Amsterdam, The Netherlands .

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http://dx.doi.org/10.1089/jamp.2016.1317DOI Listing
April 2017

The gut microbiota as a modulator of innate immunity during melioidosis.

PLoS Negl Trop Dis 2017 04 19;11(4):e0005548. Epub 2017 Apr 19.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0005548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411098PMC
April 2017

Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps.

Kidney Int 2017 02 28;91(2):352-364. Epub 2016 Sep 28.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.kint.2016.08.006DOI Listing
February 2017

Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII.

Am J Physiol Lung Cell Mol Physiol 2017 Feb 2;312(2):L163-L171. Epub 2016 Dec 2.

Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1152/ajplung.00320.2016DOI Listing
February 2017

Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer.

BMC Cancer 2017 Feb 7;17(1):113. Epub 2017 Feb 7.

Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands.

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http://dx.doi.org/10.1186/s12885-017-3081-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297223PMC
February 2017

Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats.

Crit Care Med 2016 Dec;44(12):e1226-e1235

1Department of Pediatric Intensive Care, Academic Medical Center, Amsterdam, the Netherlands.2Department of Intensive Care, Academic Medical Center, Amsterdam, the Netherlands.3Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Academic Medical Center, Amsterdam, the Netherlands.4Department of Intensive Care, University Medical Center Leiden, Leiden, the Netherlands.5Department of Pediatrics, Laboratory of Neonatology, University Medical Center Leiden, Leiden, the Netherlands.6Division of Women and Child Health, Departments of Pediatric Surgery and Obstetrics, Center for Fetal Medicine, University of Leipzig, Leipzig, Germany.7Departments of Respiratory Medicine and Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.8Department of Pathology, Academic Medical Center, Amsterdam, the Netherlands.9Department of Neonatology, Academic Medical Center, Amsterdam, the Netherlands.10Department of Pharmacology and Therapeutics, School of Medicine and School of Pharmacy, University College Cork, Cork, Ireland.

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http://dx.doi.org/10.1097/CCM.0000000000002008DOI Listing
December 2016

Nebulized C1-Esterase Inhibitor does not Reduce Pulmonary Complement Activation in Rats with Severe Streptococcus Pneumoniae Pneumonia.

Cell Biochem Biophys 2016 Dec 28;74(4):545-552. Epub 2016 Sep 28.

Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s12013-016-0766-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101262PMC
December 2016

Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis.

Shock 2016 11;46(5):566-574

*Center for Infection and Immunity Amsterdam (CINIMA)/Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands †Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands ‡Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand §Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK ||Novartis Institutes for BioMedical Research, Basel, Switzerland ¶Department of Internal medicine, Division of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000000625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058638PMC
November 2016

Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia.

Am J Physiol Lung Cell Mol Physiol 2016 08 24;311(2):L507-16. Epub 2016 Jun 24.

Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00116.2016DOI Listing
August 2016

Activated protein C protects against renal ischaemia/reperfusion injury, independent of its anticoagulant properties.

Thromb Haemost 2016 07 7;116(1):124-33. Epub 2016 Apr 7.

J. J. T. H. Roelofs, Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room M2-130, 1105 AZ Amsterdam, The Netherlands, Tel.: +31 20 56 65626, Fax: +31 20 56 69523, E-mail:

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http://dx.doi.org/10.1160/TH15-07-0584DOI Listing
July 2016

Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental Melioidosis.

PLoS Negl Trop Dis 2016 06 2;10(6):e0004747. Epub 2016 Jun 2.

Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0004747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890812PMC
June 2016

Feasibility and Safety of Local Treatment with Recombinant Human Tissue Factor Pathway Inhibitor in a Rat Model of Streptococcus pneumoniae Pneumonia.

PLoS One 2015 18;10(5):e0127261. Epub 2015 May 18.

Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127261PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436292PMC
April 2016

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia.

Gut 2016 Apr 28;65(4):575-83. Epub 2015 Oct 28.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2015-309728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819612PMC
April 2016

Case report of cheilitis granulomatosa and joint complaints as presentation of Crohn's disease.

Clin J Gastroenterol 2016 Apr 26;9(2):73-8. Epub 2016 Mar 26.

Department of Pediatric Gastroenterology and Nutrition, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s12328-016-0641-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829618PMC
April 2016

The lectin like domain of thrombomodulin is involved in the defence against pyelonephritis.

Thromb Res 2015 Dec 10;136(6):1325-31. Epub 2015 Nov 10.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.thromres.2015.11.004DOI Listing
December 2015

Mast cell-deficient kit mice develop house dust mite-induced lung inflammation despite impaired eosinophil recruitment.

J Innate Immun 2014 18;6(2):219-26. Epub 2013 Oct 18.

Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000354984DOI Listing
November 2015

The prognostic significance of glomerular infiltrating leukocytes during acute renal allograft rejection.

Transpl Immunol 2015 Nov 20;33(3):168-75. Epub 2015 Oct 20.

Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.trim.2015.10.004DOI Listing
November 2015

Effect of the oral thrombin inhibitor dabigatran on allergic lung inflammation induced by repeated house dust mite administration in mice.

Am J Physiol Lung Cell Mol Physiol 2015 Oct 28;309(8):L768-75. Epub 2015 Aug 28.

Academic Medical Center, University of Amsterdam, Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, the Netherlands. Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, the Netherlands.

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http://dx.doi.org/10.1152/ajplung.00102.2015DOI Listing
October 2015

Endogenous tissue factor pathway inhibitor has a limited effect on host defence in murine pneumococcal pneumonia.

Thromb Haemost 2015 Jul 2;114(1):115-22. Epub 2015 Apr 2.

Floor van den Boogaard, MD, Academic Medical Center, University of Amsterdam, Center for Experimental and Molecular Medicine, G2-130, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands, Tel: +31 20 566 5910, Fax: +31 20 566 7192, E-mail:

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http://dx.doi.org/10.1160/TH14-12-1053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786014PMC
July 2015

Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model.

PLoS Negl Trop Dis 2015 Apr 10;9(4):e0003663. Epub 2015 Apr 10.

Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity Amsterdam (CINIMA), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0003663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393299PMC
April 2015

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.

Bone 2015 Mar 18;72:14-22. Epub 2014 Nov 18.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2014.11.004DOI Listing
March 2015

Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia.

Crit Care Med 2015 Mar;43(3):e75-83

1Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands. 2Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands. 3Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands. 4Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands. 5Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Academic Medical Center, Amsterdam, The Netherlands. 6Division of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000000853DOI Listing
March 2015

Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice.

Blood 2014 Dec 9;124(25):3781-90. Epub 2014 Oct 9.

Center for Infection and Immunity Amsterdam, Center for Experimental and Molecular Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2014-05-573915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263985PMC
December 2014

Mast cells impair host defense during murine Streptococcus pneumoniae pneumonia.

J Infect Dis 2014 Nov 13;210(9):1376-84. Epub 2014 May 13.

Center for Experimental and Molecular Medicine Center for Infection and Immunity Amsterdam Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/infdis/jiu285DOI Listing
November 2014

Accuracy of abdominal ultrasound and MRI for detection of Crohn disease and ulcerative colitis in children.

Pediatr Radiol 2014 Nov 6;44(11):1370-8. Epub 2014 Jun 6.

Academic Medical Center, Department of Radiology, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands,

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http://dx.doi.org/10.1007/s00247-014-3010-4DOI Listing
November 2014

Protease-activated receptor 2 suppresses lymphangiogenesis and subsequent lymph node metastasis in a murine pancreatic cancer model.

J Pathol 2014 Nov 12;234(3):398-409. Epub 2014 Sep 12.

Centre for Experimental and Molecular Medicine, Academic Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/path.4411DOI Listing
November 2014

Protease-activated receptor-2 deficient mice have reduced house dust mite-evoked allergic lung inflammation.

Innate Immun 2014 Aug 18;20(6):618-25. Epub 2013 Sep 18.

Academic Medical Center, University of Amsterdam, Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, Amsterdam, the Netherlands Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1177/1753425913503387DOI Listing
August 2014

Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia.

PLoS One 2013 11;8(11):e80062. Epub 2013 Nov 11.

Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands ; Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080062PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823867PMC
August 2014

Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques.

Arterioscler Thromb Vasc Biol 2014 Aug 19;34(8):1668-73. Epub 2014 Jun 19.

From the Departments of Experimental Vascular Medicine (M.L.v.M., V.L.K., J.C.M.M.) and Pathology (J.J.T.H.R.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands (M.J.E.K., J.W.M.H.); Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc, Carlsbad, CA (S.B., B.P.M.); and Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands (J.C.M.M.).

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http://atvb.ahajournals.org/cgi/doi/10.1161/ATVBAHA.114.3032
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http://dx.doi.org/10.1161/ATVBAHA.114.303209DOI Listing
August 2014

Limited role for ASC and NLRP3 during in vivo Salmonella Typhimurium infection.

BMC Immunol 2014 Aug 13;15:30. Epub 2014 Aug 13.

Department of Internal Medicine, Division of Infectious Diseases and Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Meibergdreef 9, Room G2-132, Amsterdam, 1105, AZ, the Netherlands.

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http://dx.doi.org/10.1186/s12865-014-0030-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243774PMC
August 2014

The endothelial protein C receptor impairs the antibacterial response in murine pneumococcal pneumonia and sepsis.

Thromb Haemost 2014 May 9;111(5):970-80. Epub 2014 Jan 9.

Marcel Schouten, MD, Center for Experimental and Molecular Medicine (CEMM), Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ Amsterdam, The Netherlands, Tel.: +31 20 566 5910, Fax: +31 20 697 7192, E-mail:

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http://www.schattauer.de/index.php?id=1214&doi=10.1160/T
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http://dx.doi.org/10.1160/TH13-10-0859DOI Listing
May 2014

A new murine model to study musculoskeletal tuberculosis (short communication).

Tuberculosis (Edinb) 2014 May 8;94(3):306-10. Epub 2014 Feb 8.

Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Division of Infectious Diseases, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2014.01.002DOI Listing
May 2014

A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

PLoS Negl Trop Dis 2014 Apr 24;8(4):e2819. Epub 2014 Apr 24.

Center for Experimental and Molecular Medicine, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands; Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands; Division of Infectious Diseases, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0002819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998929PMC
April 2014

Evaluation of conventional, dynamic contrast enhanced and diffusion weighted MRI for quantitative Crohn's disease assessment with histopathology of surgical specimens.

Eur Radiol 2014 Mar 15;24(3):619-29. Epub 2013 Sep 15.

Academic Medical Center, Department of Radiology, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands,

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http://dx.doi.org/10.1007/s00330-013-3015-7DOI Listing
March 2014

Mice lacking the lectin-like domain of thrombomodulin are protected against melioidosis.

Crit Care Med 2014 Mar;42(3):e221-30

1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 3Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 4Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 5Department of Immunopathology, Sanquin, Amsterdam, The Netherlands. 6Centre for Blood Research, Life Sciences Institute, Division of Hematology-Oncology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1097/CCM.0000000000000134DOI Listing
March 2014

The thrombomodulin lectin-like domain does not change host responses to tuberculosis.

Thromb Haemost 2014 Feb 17;111(2):345-53. Epub 2013 Oct 17.

Liesbeth M. Kager, MD, Center for Experimental and Molecular Medicine (CEMM), Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ Amsterdam, The Netherlands, Tel.: +31 20 566 5910, Fax: +31 20 697 7192, E-mail:

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http://dx.doi.org/10.1160/TH13-08-0719DOI Listing
February 2014

Deficiency of protease-activated receptor-1 limits bacterial dissemination during severe Gram-negative sepsis (melioidosis).

Microbes Infect 2014 Feb 13;16(2):171-4. Epub 2013 Nov 13.

Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Center for Experimental and Molecular Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Division of Infectious Diseases, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.micinf.2013.11.001DOI Listing
February 2014

Overexpression of activated protein C is detrimental during severe experimental gram-negative sepsis (melioidosis).

Crit Care Med 2013 Oct;41(10):e266-74

1Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands. 2Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, the Netherlands. 3Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands. 4Department of Pathology, Academic Medical Center, Amsterdam, the Netherlands. 5Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands. 6Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands. 7Department of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.1097/CCM.0b013e31828a4316DOI Listing
October 2013

The extent of ventilator-induced lung injury in mice partly depends on duration of mechanical ventilation.

Crit Care Res Pract 2013 17;2013:435236. Epub 2013 Apr 17.

Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1155/2013/435236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652114PMC
May 2013

The lectin-like domain of thrombomodulin hampers host defence in pneumococcal pneumonia.

Eur Respir J 2013 Apr 30;41(4):935-42. Epub 2012 Aug 30.

Center for Experimental and Molecular Medicine,Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1183/09031936.00015212DOI Listing
April 2013

The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis.

Thromb Haemost 2013 Apr 24;109(4):726-37. Epub 2013 Jan 24.

Center for Experimental and Molecular Medicine (CEMM), Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ Amsterdam, The Netherlands.

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http://www.thieme-connect.de/DOI/DOI?10.1160/TH12-11-0859
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http://dx.doi.org/10.1160/TH12-11-0859DOI Listing
April 2013

Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice.

Am J Respir Cell Mol Biol 2013 Mar 13;48(3):382-9. Epub 2012 Dec 13.

Center of Infection and Immunity Amsterdam and Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1165/rcmb.2012-0331OCDOI Listing
March 2013

Management of giant liver hemangiomas: an update.

Expert Rev Gastroenterol Hepatol 2013 Mar;7(3):263-8

Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1586/egh.13.10DOI Listing
March 2013

[Giant haemangioma of the liver: diagnosis and treatment].

Ned Tijdschr Geneeskd 2012 ;156(31):A3820

Academisch Medisch Centrum, Afd. Chirurgie, Amsterdam, the Netherlands.

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October 2012