Joris Hoeks

Joris Hoeks

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Joris Hoeks

Publications by authors named "Joris Hoeks"

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MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells.

J Cell Physiol 2019 May 11;234(5):6601-6610. Epub 2018 Nov 11.

Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, The Netherlands.

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http://dx.doi.org/10.1002/jcp.27401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344277PMC
May 2019

Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox.

Mol Metab 2018 11 18;17:71-81. Epub 2018 Aug 18.

Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197504PMC
November 2018

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.

Proc Natl Acad Sci U S A 2018 07 9;115(30):7789-7794. Epub 2018 Jul 9.

Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1722295115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065021PMC
July 2018

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

J Physiol 2018 03 23;596(5):857-868. Epub 2017 Nov 23.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

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http://doi.wiley.com/10.1113/JP275182
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http://dx.doi.org/10.1113/JP275182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830434PMC
March 2018

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism.

Mol Metab 2017 11 31;6(11):1429-1442. Epub 2017 Aug 31.

Department of Human Biology and Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, 6200MD, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681243PMC
November 2017

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity.

Mol Metab 2016 Aug 1;5(8):635-645. Epub 2016 Jul 1.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021670PMC
August 2016

Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease.

Clin Sci (Lond) 2016 06;130(11):843-52

Department of Human Biology and Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands

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http://clinsci.org/cgi/doi/10.1042/CS20150780
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http://dx.doi.org/10.1042/CS20150780DOI Listing
June 2016

Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans.

Diabetes 2016 05 30;65(5):1179-89. Epub 2015 Dec 30.

Departments of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands

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http://dx.doi.org/10.2337/db15-1372DOI Listing
May 2016

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans.

Diabetologia 2016 May 10;59(5):1040-8. Epub 2016 Feb 10.

Department of Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6200MD, Maastricht, the Netherlands.

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http://link.springer.com/10.1007/s00125-016-3865-z
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http://dx.doi.org/10.1007/s00125-016-3865-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826431PMC
May 2016

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity.

Diabetologia 2016 May 17;59(5):1030-9. Epub 2016 Feb 17.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, P. O. Box 616, 6200MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-016-3885-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826430PMC
May 2016

A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats.

Sci Rep 2016 Mar 14;6:22854. Epub 2016 Mar 14.

Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/srep22854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789602PMC
March 2016

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.

Nat Med 2015 Aug 6;21(8):863-5. Epub 2015 Jul 6.

Department of Human Biology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.

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http://dx.doi.org/10.1038/nm.3891DOI Listing
August 2015

Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance.

Diabetologia 2015 Mar 13;58(3):586-95. Epub 2014 Dec 13.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+ (MUMC+), P.O. Box 616, 6200 MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-014-3465-8DOI Listing
March 2015

Impaired skeletal muscle mitochondrial function in morbidly obese patients is normalized one year after bariatric surgery.

Surg Obes Relat Dis 2013 Nov-Dec;9(6):936-41. Epub 2013 Apr 18.

Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands; Department of Human Biology, School for Nutrition, Toxicology and Metabolism, NUTRIM, Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.soard.2013.03.009DOI Listing
September 2014

High-fat diet-induced mitochondrial biogenesis is regulated by mitochondrial-derived reactive oxygen species activation of CaMKII.

Diabetes 2014 Jun 11;63(6):1907-13. Epub 2014 Feb 11.

Department of Human Health & Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

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http://dx.doi.org/10.2337/db13-0816DOI Listing
June 2014

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis.

J Clin Invest 2013 Aug 15;123(8):3395-403. Epub 2013 Jul 15.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+ (MUMC+), Maastricht, Netherlands.

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http://www.jci.org/articles/view/68993
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http://dx.doi.org/10.1172/JCI68993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726172PMC
August 2013

Increased oxygen consumption in human adipose tissue from the "brown adipose tissue" region.

J Clin Endocrinol Metab 2013 Jul 19;98(7):E1230-4. Epub 2013 Jun 19.

Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands.

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http://dx.doi.org/10.1210/jc.2013-1348DOI Listing
July 2013

High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.

Diabetes 2012 Oct 10;61(10):2472-8. Epub 2012 Jul 10.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.2337/db11-1832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447923PMC
October 2012

Muscle mitochondria and insulin resistance: a human perspective.

Trends Endocrinol Metab 2012 Sep 20;23(9):444-50. Epub 2012 Jun 20.

NUTRIM - School for Nutrition, Toxicology and Metabolism, Department of Human Biology, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S10432760120008
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http://dx.doi.org/10.1016/j.tem.2012.05.007DOI Listing
September 2012

Enhanced lipid-but not carbohydrate-supported mitochondrial respiration in skeletal muscle of PGC-1α overexpressing mice.

J Cell Physiol 2012 Mar;227(3):1026-33

NUTRIM-School for Nutrition, Toxicology and Metabolism, Department of Human Biology, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/jcp.22812DOI Listing
March 2012

Long- and medium-chain fatty acids induce insulin resistance to a similar extent in humans despite marked differences in muscle fat accumulation.

J Clin Endocrinol Metab 2012 Jan 26;97(1):208-16. Epub 2011 Oct 26.

NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of Human Biology, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2011-1884DOI Listing
January 2012

Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure.

FEBS Lett 2011 Dec 21;585(24):4010-7. Epub 2011 Nov 21.

Departments of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2011.11.012DOI Listing
December 2011

Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice.

Biochim Biophys Acta 2011 Sep 1;1807(9):1095-105. Epub 2011 May 1.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S000527281100087
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http://dx.doi.org/10.1016/j.bbabio.2011.04.003DOI Listing
September 2011

Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance.

Diabetes 2010 Sep 23;59(9):2117-25. Epub 2010 Jun 23.

Department of Human Biology, School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands.

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http://dx.doi.org/10.2337/db10-0519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927932PMC
September 2010

Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats.

Obesity (Silver Spring) 2010 Jun 29;18(6):1100-7. Epub 2009 Oct 29.

NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://doi.wiley.com/10.1038/oby.2009.372
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http://dx.doi.org/10.1038/oby.2009.372DOI Listing
June 2010

Mitochondrial dysfunction and lipotoxicity.

Biochim Biophys Acta 2010 Mar 24;1801(3):266-71. Epub 2009 Sep 24.

Maastricht University Medical Centre (MUMC), Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Human Biology, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S138819810900224
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http://dx.doi.org/10.1016/j.bbalip.2009.09.011DOI Listing
March 2010

The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice.

FEBS Lett 2008 Dec 27;582(30):4147-52. Epub 2008 Nov 27.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2008.11.016DOI Listing
December 2008

Mitochondrial uncoupling protein 3 and its role in cardiac- and skeletal muscle metabolism.

Physiol Behav 2008 May 28;94(2):259-69. Epub 2007 Nov 28.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.physbeh.2007.11.039DOI Listing
May 2008

Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding.

FEBS Lett 2008 Feb 28;582(4):510-6. Epub 2008 Jan 28.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2008.01.013DOI Listing
February 2008

Involvement of UCP3 in mild uncoupling and lipotoxicity.

Exp Gerontol 2006 Jul 27;41(7):658-62. Epub 2006 Mar 27.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S053155650600040
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http://dx.doi.org/10.1016/j.exger.2006.02.005DOI Listing
July 2006

UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent.

J Biol Chem 2006 May 16;281(20):13882-93. Epub 2006 Mar 16.

Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE-106 91 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M601387200DOI Listing
May 2006

The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice.

FEBS Lett 2006 Feb 26;580(5):1371-5. Epub 2006 Jan 26.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2006.01.059DOI Listing
February 2006

Putative function and physiological relevance of the mitochondrial uncoupling protein-3: involvement in fatty acid metabolism?

Prog Lipid Res 2006 Jan 9;45(1):17-41. Epub 2005 Dec 9.

Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S016378270500049
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http://dx.doi.org/10.1016/j.plipres.2005.11.001DOI Listing
January 2006

Uncoupling protein 3 as a mitochondrial fatty acid anion exporter.

FASEB J 2003 Dec 2;17(15):2272-4. Epub 2003 Oct 2.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht , Maastricht University, The Netherlands.

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http://dx.doi.org/10.1096/fj.03-0515fjeDOI Listing
December 2003

Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation.

FEBS Lett 2003 Dec;555(3):631-7

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/s0014-5793(03)01343-7DOI Listing
December 2003

Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans.

Am J Physiol Endocrinol Metab 2003 Oct 24;285(4):E775-82. Epub 2003 Jun 24.

NUTRIM, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1152/ajpendo.00175.2003DOI Listing
October 2003