Jordan Tang

Jordan Tang

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Jordan Tang

Publications by authors named "Jordan Tang"

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Cardosin A endocytosis mediated by integrin leads to lysosome leakage and apoptosis of epithelial cells.

Proteins 2019 06 15;87(6):502-511. Epub 2019 Mar 15.

Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.

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http://dx.doi.org/10.1002/prot.25672DOI Listing
June 2019

Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.

Bioorg Med Chem Lett 2018 08 26;28(15):2605-2610. Epub 2018 Jun 26.

Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States.

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http://dx.doi.org/10.1016/j.bmcl.2018.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085084PMC
August 2018

Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.

Bioorg Med Chem Lett 2017 06 8;27(11):2432-2438. Epub 2017 Apr 8.

Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, United States.

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http://dx.doi.org/10.1016/j.bmcl.2017.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479133PMC
June 2017

Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes.

Chem Sci 2016 May 4;7:3117-3122. Epub 2016 Feb 4.

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 (USA); Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907 (USA); Department of Biochemistry, Purdue University, West Lafayette, IN 47907 (USA).

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http://dx.doi.org/10.1039/C5SC03718BDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916918PMC
May 2016

Prospects of β-Secretase Inhibitors for the Treatment of Alzheimer's Disease.

ChemMedChem 2015 Sep 3;10(9):1463-6. Epub 2015 Jul 3.

Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104 (USA).

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http://dx.doi.org/10.1002/cmdc.201500216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029879PMC
September 2015

Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.

Curr Alzheimer Res 2015 ;12(1):13-21

Center for Dementia Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414026PMC
http://dx.doi.org/10.2174/1567205012666141218125042DOI Listing
August 2015

Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.

Bioorg Med Chem Lett 2015 Feb 6;25(3):668-72. Epub 2014 Dec 6.

Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States; Protein Studies Program, Oklahoma Medical Research Foundation, United States; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, United States.

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http://dx.doi.org/10.1016/j.bmcl.2014.11.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297543PMC
February 2015

Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease.

Acta Biochim Biophys Sin (Shanghai) 2013 Aug 15;45(8):613-21. Epub 2013 May 15.

Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China.

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http://dx.doi.org/10.1093/abbs/gmt050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717758PMC
August 2013

Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism.

FASEB J 2013 Jun 19;27(6):2132-44. Epub 2013 Feb 19.

Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1096/fj.12-214353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188231PMC
June 2013

Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP).

Biochim Biophys Acta 2013 Jun 19;1833(6):1562-71. Epub 2013 Mar 19.

Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2013.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753662PMC
June 2013

Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group.

Appl Microbiol Biotechnol 2012 May 25;94(4):1041-9. Epub 2012 Jan 25.

Protein Studies Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1007/s00253-012-3893-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364607PMC
May 2012

Developing β-secretase inhibitors for treatment of Alzheimer's disease.

J Neurochem 2012 Jan 28;120 Suppl 1:71-83. Epub 2011 Nov 28.

Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07476.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276244PMC
January 2012

Subsite specificity of anthrax lethal factor and its implications for inhibitor development.

Biochem Biophys Res Commun 2011 Apr 21;407(2):400-5. Epub 2011 Mar 21.

Protein Studies, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1016/j.bbrc.2011.03.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104405PMC
April 2011

Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice.

FASEB J 2011 Feb 8;25(2):775-84. Epub 2010 Nov 8.

Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1096/fj.10-167213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023390PMC
February 2011

Treating transgenic Alzheimer mice with a β-secretase inhibitor, what have we learned?

Aging (Albany NY) 2011 Jan;3(1):14-6

Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047132PMC
http://dx.doi.org/10.18632/aging.100267DOI Listing
January 2011

Predicting memapsin 2 (β-secretase) hydrolytic activity.

Protein Sci 2010 Nov;19(11):2175-85

Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1002/pro.502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005788PMC
November 2010

gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons.

Brain Res 2009 Mar 18;1262:89-99. Epub 2009 Jan 18.

Laboratory for Neurodegenerative Research, The Conway Institute for Biomolecular and Biomedical Research, School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Republic of Ireland.

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http://linkinghub.elsevier.com/retrieve/pii/S000689930900052
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http://dx.doi.org/10.1016/j.brainres.2009.01.008DOI Listing
March 2009

beta-Secretase as a therapeutic target for Alzheimer's disease.

Neurotherapeutics 2008 Jul;5(3):399-408

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.

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http://dx.doi.org/10.1016/j.nurt.2008.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963069PMC
July 2008

Memapsin 2 (beta-secretase) inhibitors: drug development.

Curr Alzheimer Res 2008 Apr;5(2):121-31

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.

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http://dx.doi.org/10.2174/156720508783954730DOI Listing
April 2008

Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization.

FASEB J 2007 Oct 10;21(12):3184-96. Epub 2007 May 10.

Protein Studies Program, Oklahoma Medical Research Foundation, 825 N.E. 13th St., Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1096/fj.06-7993comDOI Listing
October 2007

Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality.

Curr Alzheimer Res 2007 Sep;4(4):418-22

Department of Chemistry and Medical Chemistry, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.2174/156720507781788864DOI Listing
September 2007

Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease.

Curr Top Med Chem 2005 ;5(16):1609-22

Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.2174/156802605775009711DOI Listing
June 2006

Recent developments on the studies of human memapsin 2 (beta-secretase).

Curr Alzheimer Res 2005 Apr;2(2):261-4

Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma University Health Science Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.2174/1567205053585800DOI Listing
April 2005

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

J Biol Chem 2005 Mar 21;280(12):11696-703. Epub 2004 Dec 21.

Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1074/jbc.M411296200DOI Listing
March 2005

Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).

Bioorg Med Chem Lett 2005 Jan;15(1):15-20

Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL 60607, USA.

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http://dx.doi.org/10.1016/j.bmcl.2004.10.084DOI Listing
January 2005

Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).

Biochemistry 2005 Jan;44(1):105-12

Protein Studies Program, Oklahoma Medical Research Foundation, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi048106k
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http://dx.doi.org/10.1021/bi048106kDOI Listing
January 2005

Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors.

J Leukoc Biol 2004 Dec 2;76(6):1151-61. Epub 2004 Sep 2.

Department of Dermatology, University Medical Centre Mannheim, University of Heidelberg, Theodor-Kutzer Ufer 1-3, 68167 Mannheim, Germany.

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http://dx.doi.org/10.1189/jlb.0504300DOI Listing
December 2004

Structural features of human memapsin 2 (beta-secretase) and their biological and pathological implications.

Acta Biochim Biophys Sin (Shanghai) 2004 Dec;36(12):787-92

Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1093/abbs/36.12.787DOI Listing
December 2004

Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5.

EMBO J 2004 Oct 30;23(20):3909-17. Epub 2004 Sep 30.

Crystallography Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524345PMC
October 2004

Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.

J Biol Chem 2004 Sep 14;279(36):37886-94. Epub 2004 Jun 14.

Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M402130200
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http://dx.doi.org/10.1074/jbc.M402130200DOI Listing
September 2004

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors.

J Neurochem 2004 Jun;89(6):1409-16

Protein Studies Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02452.xDOI Listing
June 2004

Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis.

Biochemistry 2004 Apr;43(16):4689-95

Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi0498252
Publisher Site
http://dx.doi.org/10.1021/bi0498252DOI Listing
April 2004

Memapsin 2, a drug target for Alzheimer's disease.

Biochem Soc Symp 2003 (70):213-20

Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Medical Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1042/bss0700213DOI Listing
February 2004

Study of memapsin 2 (beta-secretase) and strategy of inhibitor design.

J Mol Neurosci 2003 ;20(3):299-304

Protein Studies Program, Oklahoma Medical Research Foundation, Department of Biochemistry and Molecular Biology, Oklahoma University Medical Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1385/JMN:20:3:299DOI Listing
December 2003

The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle.

Biochemistry 2003 Dec;42(47):13901-8

Crystallography Research Program, Oklahoma Medical Research Foundation, 825 NE 13(th) Street, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1021/bi035392bDOI Listing
December 2003

Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.

Biochemistry 2003 Oct;42(42):12174-80

Protein Studies Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1021/bi035199hDOI Listing
October 2003

Crystal structure of the human GGA1 GAT domain.

Biochemistry 2003 Jun;42(21):6392-9

Crystallography Research Program and Protein Studies Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1021/bi034334nDOI Listing
June 2003

Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket.

FEBS Lett 2003 Feb;537(1-3):171-6

Crystallography Research Program of Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City 73104, USA.

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http://dx.doi.org/10.1016/s0014-5793(03)00095-4DOI Listing
February 2003

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.

Biochemistry 2002 Sep;41(36):10963-7

Protein Studies Program, Oklahoma Medical Research Foundation, and Department of Biochemistry and Molecular Biology, University of Oklahoma Medical Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1021/bi026232nDOI Listing
September 2002

Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.

Biochemistry 2002 Jul;41(27):8742-6

Protein Studies Program, Oklahoma Medical Research Foundation and Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1021/bi025926tDOI Listing
July 2002

Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.

FEBS Lett 2002 Jul;524(1-3):183-7

Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1016/s0014-5793(02)03052-1DOI Listing
July 2002

Beta-secretase as a therapeutic target for inhibitor drugs.

Curr Med Chem 2002 Jun;9(11):1135-44

Department of Chemistry, University of Illinois at Chicago, USA.

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http://dx.doi.org/10.2174/0929867023370149DOI Listing
June 2002

Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls.

Exp Neurol 2002 May;175(1):10-22

Department of Anatomy & Neurobiology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1006/exnr.2002.7875DOI Listing
May 2002

Design of Potent Inhibitors for Human Brain Memapsin 2 (-Secretase).

J Am Chem Soc 2000 Apr 23;122(14):3522-3523. Epub 2000 Mar 23.

Protein Studies Program, Oklahoma Medical Research Foundation and Department of Biochemistry and Molecular Biology, UniVersity of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104.

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http://dx.doi.org/10.1021/ja000300gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233310PMC
April 2000