Joost Smolders

Joost Smolders

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Joost Smolders

Publications by authors named "Joost Smolders"

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Randomized trial of daily high-dose vitamin D in patients with RRMS receiving subcutaneous interferon β-1a.

Neurology 2019 Oct 8. Epub 2019 Oct 8.

From the Department of Neurology (R.H., J.S.,), Zuyderland Medical Centre Sittard, Maastricht University Medical Centre; Department of Neurology (J.S.), Canisius Wilhelmina Ziekenhuis, Nijmegen, the Netherlands; Department of Nutritional Sciences (R.V.), University of Toronto, Canada; Akershus University Hospital and University of Oslo (T.H.), Norway; Merck GmbH (K.M.), Vienna, Austria; Service de Neurologie (M.S.), Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Departments of Neurology (J.K.) and Radiology and Nuclear Medicine (F.B.), VU University Medical Centre, Amsterdam, the Netherlands; Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK; Independent Consultant (M.B.), Krailling, Germany; and U.O.C. Neurologia and Multiple Sclerosis Center (L.M.E.G.), Fondazione Istituto G. Giglio di Cefalù, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000008445DOI Listing
October 2019

Post-mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms.

Brain Pathol 2019 Jun 22. Epub 2019 Jun 22.

Department of Neuroimmunology, The Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/bpa.12760DOI Listing
June 2019

Mycoplasma Pneumoniae and Antibodies against Galactocerebroside in a 9-Year-Old Boy with Encephalitis.

Neuropediatrics 2019 02 26;50(1):54-56. Epub 2018 Nov 26.

Department of Pediatric Neurology, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676054
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http://dx.doi.org/10.1055/s-0038-1676054DOI Listing
February 2019

Correlation of different cellular assays to analyze T cell-related cytokine profiles in vitamin D-supplemented patients with multiple sclerosis.

Mol Immunol 2019 01 11;105:198-204. Epub 2018 Dec 11.

Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2018.12.001DOI Listing
January 2019

Tissue-resident memory T cells populate the human brain.

Nat Commun 2018 11 2;9(1):4593. Epub 2018 Nov 2.

Department of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands.

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http://www.nature.com/articles/s41467-018-07053-9
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http://dx.doi.org/10.1038/s41467-018-07053-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214977PMC
November 2018

Exploring the effect of vitamin D supplementation on the anti-EBV antibody response in relapsing-remitting multiple sclerosis.

Mult Scler 2018 09 21;24(10):1280-1287. Epub 2017 Jul 21.

School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands/Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands.

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http://dx.doi.org/10.1177/1352458517722646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108041PMC
September 2018

The Engagement Between Vitamin D and the Immune System: Is Consolidation by a Marriage to Be Expected?

EBioMedicine 2018 05 18;31:9-10. Epub 2018 Apr 18.

Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands; Neuroimmunology research group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ebiom.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013778PMC
May 2018

Stress-Axis Regulation by Vitamin D in Multiple Sclerosis.

Front Neurol 2018 26;9:263. Epub 2018 Apr 26.

School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.

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http://dx.doi.org/10.3389/fneur.2018.00263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933207PMC
April 2018

Vitamin D supplementation and the IL-2/IL-2R pathway in multiple sclerosis: Attenuation of progressive disturbances?

J Neuroimmunol 2018 01 10;314:50-57. Epub 2017 Nov 10.

Canisius Wilhelmina Hospital, Department of Neurology, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2017.11.007DOI Listing
January 2018

On the ethics of not supplementing low 25-hydroxyvitamin D levels in a controlled study in relapsing remitting multiple sclerosis.

J Neurol Sci 2017 08 9;379:331. Epub 2017 Jun 9.

Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands; School for Mental Health and Neurocience, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jns.2017.06.009DOI Listing
August 2017

Vitamin D supplementation in multiple sclerosis: Symptoms and biomarkers of depression.

J Neurol Sci 2017 Jul 19;378:30-35. Epub 2017 Apr 19.

Maastricht University, School for Mental Health and Neuroscience, Universiteitssingel 40, 6229 ER Maastricht, The Netherlands; Zuyderland Medical Center, Academic MS Center Limburg, PO Box 5500, 6130 MB Sittard, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X173023
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http://dx.doi.org/10.1016/j.jns.2017.04.017DOI Listing
July 2017

Vitamin D status is negatively correlated with retinal nerve fiber layer thickness in relapsing-remitting MS patients without acute optic neuritis.

Mult Scler 2017 01 11;23(1):128-129. Epub 2016 Jul 11.

1 Academic MS Center Limburg, Department of Neurology, Zuyderland Medical Center, Sittard, The Netherlands.

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http://dx.doi.org/10.1177/1352458516652950DOI Listing
January 2017

A low vitamin D status at diagnosis is associated with an early conversion to secondary progressive multiple sclerosis.

J Steroid Biochem Mol Biol 2016 11 17;164:254-257. Epub 2015 Nov 17.

Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands; Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jsbmb.2015.11.009DOI Listing
November 2016

Network of nuclear receptor ligands in multiple sclerosis: Common pathways and interactions of sex-steroids, corticosteroids and vitamin D3-derived molecules.

Autoimmun Rev 2016 Sep 6;15(9):900-10. Epub 2016 Jul 6.

Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands; MS Center CWZ, Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2016.07.002DOI Listing
September 2016

Immunomodulation by vitamin D in multiple sclerosis: More than IL-17.

J Neuroimmunol 2016 Mar 27;292:79-80. Epub 2016 Jan 27.

Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jneuroim.2016.01.017DOI Listing
March 2016

Circulating vitamin D binding protein levels are not associated with relapses or with vitamin D status in multiple sclerosis.

Mult Scler 2014 Apr 19;20(4):433-7. Epub 2013 Aug 19.

Neuroimmunology Research Group, Netherlands Institute for Neuroscience, The Netherlands.

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http://dx.doi.org/10.1177/1352458513500552DOI Listing
April 2014

Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed.

Glia 2013 Nov 6;61(11):1848-61. Epub 2013 Sep 6.

Neuroimmunology Group, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/glia.22562
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http://dx.doi.org/10.1002/glia.22562DOI Listing
November 2013

Vitamin D supplementation and antibodies against the Epstein-Barr virus in multiple sclerosis patients.

Mult Scler 2013 Oct 4;19(12):1679-80. Epub 2013 Jul 4.

Department of Physiology, Anatomy and Genetics and Medical Research Council Functional Genomics Unit, University of Oxford, UK.

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http://dx.doi.org/10.1177/1352458513494494DOI Listing
October 2013

Characteristics of differentiated CD8(+) and CD4 (+) T cells present in the human brain.

Acta Neuropathol 2013 Oct 24;126(4):525-35. Epub 2013 Jul 24.

Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00401-013-1155-0DOI Listing
October 2013

Expression of vitamin D receptor and metabolizing enzymes in multiple sclerosis-affected brain tissue.

J Neuropathol Exp Neurol 2013 Feb;72(2):91-105

Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/NEN.0b013e31827f4fccDOI Listing
February 2013

Phenotyping primary human microglia: tight regulation of LPS responsiveness.

Glia 2012 Oct 27;60(10):1506-17. Epub 2012 Jun 27.

Department of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/glia.22370DOI Listing
October 2012

Vitamin D in multiple sclerosis: implications for assessment and treatment.

Expert Rev Neurother 2012 Sep;12(9):1101-12

Department of Neurology, Akershus University Hospital, Lørenskog, Norway.

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http://dx.doi.org/10.1586/ern.12.99DOI Listing
September 2012

Intracellular IL-10 detection in T cells by flowcytometry: the use of protein transport inhibitors revisited.

J Immunol Methods 2012 Jul 29;381(1-2):59-65. Epub 2012 Apr 29.

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jim.2012.04.011DOI Listing
July 2012

Effect of vitamin D(3) supplementation on peripheral B cell differentiation and isotype switching in patients with multiple sclerosis.

Mult Scler 2011 Dec 20;17(12):1418-23. Epub 2011 Jun 20.

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://journals.sagepub.com/doi/10.1177/1352458511412655
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http://dx.doi.org/10.1177/1352458511412655DOI Listing
December 2011

Vitamin D in the healthy and inflamed central nervous system: access and function.

J Neurol Sci 2011 Dec 23;311(1-2):37-43. Epub 2011 Aug 23.

Department of Internal Medicine, Division of Clinical and Experimental Immunology, and School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jns.2011.07.033DOI Listing
December 2011

Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse.

J Neuroimmunol 2011 Dec 26;240-241:97-103. Epub 2011 Oct 26.

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jneuroim.2011.09.013DOI Listing
December 2011

Effects of vitamin D on the peripheral adaptive immune system: a review.

Autoimmun Rev 2011 Oct 18;10(12):733-43. Epub 2011 May 18.

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.autrev.2011.05.002DOI Listing
October 2011

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission.

J Neuroimmunol 2011 Oct 21;239(1-2):80-6. Epub 2011 Sep 21.

School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, Maastricht,The Netherlands.

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http://dx.doi.org/10.1016/j.jneuroim.2011.08.019DOI Listing
October 2011

Vitamin D as a T-cell modulator in multiple sclerosis.

Vitam Horm 2011 ;86:401-28

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/B978-0-12-386960-9.00018-6DOI Listing
July 2011

Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis.

J Neuroimmunol 2011 Jun 20;235(1-2):91-7. Epub 2011 Apr 20.

School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jneuroim.2011.03.012DOI Listing
June 2011

Control of T cell activation by vitamin D.

Nat Immunol 2011 Jan;12(1):3; author reply 3-4

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http://dx.doi.org/10.1038/ni0111-3aDOI Listing
January 2011

Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.

PLoS One 2010 Dec 13;5(12):e15235. Epub 2010 Dec 13.

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015235PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001453PMC
December 2010

Vitamin d and multiple sclerosis: correlation, causality, and controversy.

Authors:
Joost Smolders

Autoimmune Dis 2010 Oct 5;2011:629538. Epub 2010 Oct 5.

Division of Clinical and Experimental Immunology, Department of Internal Medicine and School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.4061/2011/629538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003950PMC
October 2010

Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis.

J Steroid Biochem Mol Biol 2010 Jul 6;121(1-2):243-6. Epub 2010 Mar 6.

School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jsbmb.2010.03.001DOI Listing
July 2010

Complementary and alternative medicine in alopecia areata.

Am J Clin Dermatol 2010 ;11(1):11-20

Alopecia Areata Patient Organization, Utrecht, The Netherlands.

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http://dx.doi.org/10.2165/11530040-000000000-00000DOI Listing
April 2010

Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis.

Ann N Y Acad Sci 2009 Sep;1173:515-20

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1111/j.1749-6632.2009.04656.xDOI Listing
September 2009

The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis.

Autoimmun Rev 2009 Jun 11;8(7):621-6. Epub 2009 Feb 11.

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.autrev.2009.02.009DOI Listing
June 2009

Fok-I vitamin D receptor gene polymorphism (rs10735810) and vitamin D metabolism in multiple sclerosis.

J Neuroimmunol 2009 Feb;207(1-2):117-21

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S016557280900002
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http://dx.doi.org/10.1016/j.jneuroim.2008.12.011DOI Listing
February 2009

Vitamin D as an immune modulator in multiple sclerosis, a review.

J Neuroimmunol 2008 Feb 4;194(1-2):7-17. Epub 2008 Jan 4.

Department of Neurology, University Hospital Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jneuroim.2007.11.014DOI Listing
February 2008