Joost H A Martens

Joost H A Martens

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Joost H A Martens

Joost H A Martens

Publications by authors named "Joost H A Martens"

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BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition.

Cell Death Dis 2019 Apr 18;10(5):338. Epub 2019 Apr 18.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. De Crecchio 7, 80138, Napoli, Italy.

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http://dx.doi.org/10.1038/s41419-019-1570-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472371PMC
April 2019

RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs.

Blood Adv 2019 Feb;3(3):320-332

Department of Hematology, University Medical Centre Groningen, University of Groningen Cancer Research Centre, Groningen, The Netherlands; and.

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http://dx.doi.org/10.1182/bloodadvances.2018024422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373749PMC
February 2019

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells.

PLoS One 2017 14;12(12):e0189102. Epub 2017 Dec 14.

Department of Experimental Hematology, Cancer Research Center Groningen (CRCG), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189102PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730124PMC
January 2018

Time-resolved analysis of DNA-protein interactions in living cells by UV laser pulses.

Sci Rep 2017 09 15;7(1):11725. Epub 2017 Sep 15.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Università degli Studi della Campania "L. Vanvitelli", Vico L. De Crecchio 7, 80138, Napoli, IT, Italy.

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http://dx.doi.org/10.1038/s41598-017-12010-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601431PMC
September 2017

AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis.

Oncotarget 2017 Feb;8(8):12855-12865

Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.14150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355061PMC
February 2017

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs.

Cell Rep 2016 11;17(8):2087-2100

Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, the Netherlands; Dipartimento di Patologia Generale, Seconda Università degli Studi di Napoli, Vico Luigi de Crecchio 7, 80138 Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.082DOI Listing
November 2016

Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems.

Cell Rep 2016 11;17(8):2101-2111

CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, Barcelona 08028, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889099PMC
November 2016

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

Cell 2016 11;167(5):1398-1414.e24

Department of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Strangeways Research Laboratory, University of Cambridge, Wort's Causeway, Cambridge CB1 8RN, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163144
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http://dx.doi.org/10.1016/j.cell.2016.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119954PMC
November 2016

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

Cell 2016 11;167(5):1415-1429.e19

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; Department of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge CB1 8RN, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300907PMC
November 2016

MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML.

Cell Rep 2016 07 23;16(2):498-507. Epub 2016 Jun 23.

Institute of Experimental Cancer Research, CCC and University Hospital of Ulm, 89081 Ulm, Germany; Core Facility Genomics, Medical Faculty Ulm, Ulm University, 89081 Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.094DOI Listing
July 2016

The genome-wide molecular signature of transcription factors in leukemia.

Exp Hematol 2014 Aug 6;42(8):637-50. Epub 2014 May 6.

Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.04.012DOI Listing
August 2014

Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392.

Cancer Res 2014 Apr 24;74(8):2328-39. Epub 2014 Feb 24.

Authors' Affiliations: Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli; Istituto di Genetica e Biofisica, IGB, Adriano Buzzati Traverso, Naples; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy; NCMLS, Radboud University, Nijmegen, the Netherlands; Inserm, CRCM, U1068, TrGET & ISCB, University of Marseille; and Laboratoire U944 and UMR 7212, University Paris-Diderot, Paris, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2568DOI Listing
April 2014

ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia.

Blood 2012 Nov 14;120(19):4038-48. Epub 2012 Sep 14.

Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1182/blood-2012-05-429050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496958PMC
November 2012

Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia.

Blood 2012 Oct 24;120(15):3058-68. Epub 2012 Aug 24.

Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1182/blood-2011-10-386086DOI Listing
October 2012

Acute myeloid leukemia: a central role for the ETS factor ERG.

Int J Biochem Cell Biol 2011 Oct 1;43(10):1413-6. Epub 2011 Jun 1.

Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.biocel.2011.05.014DOI Listing
October 2011

Genome-wide interplay of nuclear receptors with the epigenome.

Biochim Biophys Acta 2011 Aug 20;1812(8):818-23. Epub 2010 Oct 20.

Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.bbadis.2010.10.005DOI Listing
August 2011

The decade of the epigenomes?

Genes Cancer 2011 Jun;2(6):680-7

Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands.

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http://gan.sagepub.com/lookup/doi/10.1177/1947601911417860
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http://dx.doi.org/10.1177/1947601911417860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174262PMC
June 2011

The molecular signature of oncofusion proteins in acute myeloid leukemia.

FEBS Lett 2010 Jun 11;584(12):2662-9. Epub 2010 Apr 11.

Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1016/j.febslet.2010.04.002
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http://dx.doi.org/10.1016/j.febslet.2010.04.002DOI Listing
June 2010

PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.

Cancer Cell 2010 Feb;17(2):173-85

Department of Molecular Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University, the Netherlands.

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http://dx.doi.org/10.1016/j.ccr.2009.12.042DOI Listing
February 2010

Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome.

Mol Cell 2007 Aug;27(3):353-66

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Institute of Genetics, Max F. Perutz Laboratories, Vienna Biocenter, Dr. Bohr-Gasse 9/4, A-1030 Vienna, Austria.

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http://dx.doi.org/10.1016/j.molcel.2007.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847180PMC
August 2007

Histone modification patterns associated with the human X chromosome.

EMBO Rep 2006 Jun 28;7(6):628-34. Epub 2006 Apr 28.

Department of Molecular Biology, Nijmegen Centre for Molecular Life Sciences, NCMLS M850/3.79, Radboud University, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/sj.embor.7400686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479594PMC
June 2006

The profile of repeat-associated histone lysine methylation states in the mouse epigenome.

EMBO J 2005 Feb 27;24(4):800-12. Epub 2005 Jan 27.

Research Institute of Molecular Pathology (IMP), The Vienna Biocenter, Vienna, Austria.

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http://dx.doi.org/10.1038/sj.emboj.7600545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549616PMC
February 2005

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.

Mol Cell 2003 Dec;12(6):1577-89

Research Institute of Molecular Pathology, The Vienna Biocenter, Dr. Bohrgasse 7, A-1030 Vienna, Austria.

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December 2003

Cascade of distinct histone modifications during collagenase gene activation.

Mol Cell Biol 2003 Mar;23(5):1808-16

Molecular Cell Biology, Leiden University Medical Center, 2300 RA Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151710PMC
http://dx.doi.org/10.1128/mcb.23.5.1808-1816.2003DOI Listing
March 2003

Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.

Mol Cell Biol 2002 Apr;22(8):2598-606

Molecular Cell Biology, Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133732PMC
http://dx.doi.org/10.1128/mcb.22.8.2598-2606.2002DOI Listing
April 2002