Joop H Jansen

Joop H Jansen

UNVERIFIED PROFILE

Are you Joop H Jansen?   Register this Author

Register author
Joop H Jansen

Joop H Jansen

Publications by authors named "Joop H Jansen"

Are you Joop H Jansen?   Register this Author

92Publications

2065Reads

6Profile Views

Intraperitoneal infusion of ex vivo-cultured allogeneic NK cells in recurrent ovarian carcinoma patients (a phase I study).

Medicine (Baltimore) 2019 Feb;98(5):e14290

Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380776PMC
February 2019

Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency.

Cell Stem Cell 2019 Jan 21;24(1):123-137.e8. Epub 2018 Nov 21.

Department of Molecular Biology, Faculty of Science, Radboud University, Radboud Institute for Molecular Life Sciences (RIMLS), 6525GA Nijmegen, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2018.10.017DOI Listing
January 2019

Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8 T Cells During Relapse after Allogeneic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2018 04 26;24(4):666-677. Epub 2017 Dec 26.

Department of Laboratory Medicine-Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2017.11.027DOI Listing
April 2018

Apoptosis-Related Gene Expression Profiling in Hematopoietic Cell Fractions of MDS Patients.

PLoS One 2016 30;11(11):e0165582. Epub 2016 Nov 30.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center (Radboudumc), Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165582PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130187PMC
September 2017

Evaluating Variant Calling Tools for Non-Matched Next-Generation Sequencing Data.

Sci Rep 2017 02 24;7:43169. Epub 2017 Feb 24.

Institute of Medical Informatics, University of Münster, Münster, 48149, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep43169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324109PMC
February 2017

The Aryl Hydrocarbon Receptor Antagonist StemRegenin1 Improves In Vitro Generation of Highly Functional Natural Killer Cells from CD34(+) Hematopoietic Stem and Progenitor Cells.

Stem Cells Dev 2015 Dec 28;24(24):2886-98. Epub 2015 Oct 28.

2 Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center , Nijmegen, the Netherlands .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/scd.2014.0597DOI Listing
December 2015

5-Hydroxymethylcytosine: An epigenetic mark frequently deregulated in cancer.

Biochim Biophys Acta 2015 Apr 8;1855(2):144-54. Epub 2015 Jan 8.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbcan.2015.01.001DOI Listing
April 2015

High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions.

Haematologica 2014 Dec 22;99(12):e257-9. Epub 2014 Aug 22.

Department of Laboratory medicine, Laboratory of Hematology, RadboudUMC; and Department of Hematology, RadboudUMC, Nijmegen, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2014.110437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258745PMC
December 2014

Characterization of acute myeloid leukemia based on levels of global hydroxymethylation.

Blood 2014 Aug 1;124(7):1110-8. Epub 2014 Jul 1.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2013-08-518514DOI Listing
August 2014

A dominant-negative GFI1B mutation in the gray platelet syndrome.

N Engl J Med 2014 Jan 10;370(3):245-53. Epub 2013 Dec 10.

From the Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen Center for Molecular Life Sciences (D.M., A.E.M., S.M.B., H.V., G.H., F.P., W.V.H., J.H.J., B.A.V.R.) and the Departments of Pathology (K.M.H., B.W.), Hematology (B.A.P.L.G., M.A.M., G.H.), Cardiology (A.L.D.), and Human Genetics (S.S., M.J.E.K.), Radboud University Medical Center - all in Nijmegen, the Netherlands; the Department of Medical Genetics, Antwerp University Hospital and University of Antwerp (N.A.B., E.F., G.V.C., B.L.L., L.V.L.) and the Statua Center for Statistics, University of Antwerp (E.F.), Antwerp, Belgium; and the Department of Hematology, University Hospital, Essen, Germany (C.K., L.B.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1308130DOI Listing
January 2014

Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells.

Cell Stem Cell 2013 Sep 11;13(3):360-9. Epub 2013 Jul 11.

Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences NCMLS, Radboud University, 6525GA, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2013.06.002DOI Listing
September 2013

High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia.

Blood 2012 Sep 11;120(10):2064-75. Epub 2012 Jul 11.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2011-12-397083DOI Listing
September 2012

Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer.

Breast Cancer Res Treat 2012 Aug 16;135(1):125-33. Epub 2012 Jun 16.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-012-2122-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413819PMC
August 2012

Mutations in epigenetic regulators in myelodysplastic syndromes.

Int J Hematol 2012 Jan 11;95(1):8-16. Epub 2012 Jan 11.

Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein zuid 8, 6525 GA Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12185-011-0996-3
Publisher Site
http://dx.doi.org/10.1007/s12185-011-0996-3DOI Listing
January 2012

High BRE expression predicts favorable outcome in adult acute myeloid leukemia, in particular among MLL-AF9-positive patients.

Blood 2011 Nov 21;118(20):5613-21. Epub 2011 Sep 21.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2011-06-359182DOI Listing
November 2011

Advances in understanding the pulmonary infiltration in acute promyelocytic leukaemia.

Br J Haematol 2010 Nov;151(3):209-20

Radboud University Nijmegen Medical Centre, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2141.2010.08325.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2141.2010.08325.xDOI Listing
November 2010

Hematopoietic stem cells exhibit a specific ABC transporter gene expression profile clearly distinct from other stem cells.

BMC Pharmacol 2010 Sep 13;10:12. Epub 2010 Sep 13.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre/Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 8, 6525GA Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://bmcpharma.biomedcentral.com/articles/10.1186/1471-221
Publisher Site
http://dx.doi.org/10.1186/1471-2210-10-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945345PMC
September 2010

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.

Nat Genet 2010 Aug 4;42(8):665-7. Epub 2010 Jul 4.

Department of Laboratory Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.620DOI Listing
August 2010

MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells.

Stem Cells Dev 2010 Jun;19(6):877-85

Central Hematology Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/scd.2009.0112DOI Listing
June 2010

Functional differences between mesenchymal stem cell populations are reflected by their transcriptome.

Stem Cells Dev 2010 Apr;19(4):481-90

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/scd.2009.0288DOI Listing
April 2010

Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome.

Blood 2009 Dec 14;114(27):5512-21. Epub 2009 Oct 14.

Central Hematology Laboratory and Department of Hematology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-02-204834DOI Listing
December 2009

TET proteins in malignant hematopoiesis.

Cell Cycle 2009 Dec 5;8(24):4044-8. Epub 2009 Dec 5.

Radboud University Nijmegen Medical Centre, Laboratory of Hematology, Nijmegen, Gelderland, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.8.24.10239DOI Listing
December 2009

Acquired mutations in TET2 are common in myelodysplastic syndromes.

Nat Genet 2009 Jul 31;41(7):838-42. Epub 2009 May 31.

Department of Hematology and Central Hematology Laboratory, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.391DOI Listing
July 2009

Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia.

Int J Hematol 2009 May 10;89(4):422-430. Epub 2009 Apr 10.

Institut für Zellbiologie (Tumorforschung), IFZ, Universitätsklinikum Essen, Virchowstrasse 173, 45122, Essen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12185-009-0286-5DOI Listing
May 2009

Expression of P2X5 in lymphoid malignancies results in LRH-1-specific cytotoxic T-cell-mediated lysis.

Br J Haematol 2008 Jun 10;141(6):799-807. Epub 2008 Apr 10.

Central Haematology Laboratory, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2141.2008.07125.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2141.2008.07125.xDOI Listing
June 2008

Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha.

Blood 2008 Feb 19;111(3):1634-43. Epub 2007 Nov 19.

Central Hematology Laboratory and Department of Hematology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2007-04-081125DOI Listing
February 2008

Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1.

Blood 2007 Nov 23;110(9):3128-35. Epub 2007 Jul 23.

Central Hematology Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, the Netherlands.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-11-05
Publisher Site
http://dx.doi.org/10.1182/blood-2006-11-058602DOI Listing
November 2007

Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes.

Blood 2007 Jan 3;109(1):100-8. Epub 2006 Aug 3.

Central Hematology Laboratory, Radboud University Nijmegen Medical Centre for Molecular Life Sciences (NCMLS), PO Box 9101, 6500 HB Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2006-02-003590DOI Listing
January 2007

ABCB1 modulation does not circumvent drug extrusion from primitive leukemic progenitor cells and may preferentially target residual normal cells in acute myelogenous leukemia.

Clin Cancer Res 2006 Jun;12(11 Pt 1):3452-8

Department of Hematology and Central Hematology Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-05-1945DOI Listing
June 2006

Isolation of FRET-positive cells using single 408-nm laser flow cytometry.

Cytometry A 2006 Apr;69(4):291-8

Central Hematology Laboratory of the University Medical Centre, St. Radboud, Geert Grooteplein zuid 8, 6500 HB Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cyto.a.20254DOI Listing
April 2006

Isolation of RNA and DNA from leukocytes and cDNA synthesis.

Methods Mol Med 2006 ;125:1-11

Central Hematology Laboratory, University Medical Center St Raboud, The Netherlands.

View Article

Download full-text PDF

Source
April 2006

Diagnosis and monitoring of CBFB-MYH11-positive acute myeloid leukemia by qualitative and quantitative RT-PCR.

Methods Mol Med 2006 ;125:163-75

Central Hematology Laboratory, University Medical Center St Raboud, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
April 2006

The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells.

Blood 2005 Dec 23;106(13):4114-23. Epub 2005 Aug 23.

Central Hematology Laboratory, University Medical Center Nijmegen, PO BOX 9101, 6500 HB Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2005-04-1450DOI Listing
December 2005

Breast cancer resistance protein in drug resistance of primitive CD34+38- cells in acute myeloid leukemia.

Clin Cancer Res 2005 Mar;11(6):2436-44

Department of Hematology and Central Hematology Laboratory, University Medical Center Nijmegen, St. Radboud, 6500 HB Nijmegen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-04-0212DOI Listing
March 2005

Bcl-2 prevents loss of mitochondria in CCCP-induced apoptosis.

Exp Cell Res 2004 Oct;299(2):533-40

Central Hematology Laboratory, Department of Hematology, University Medical Center Nijmegen, Nijmegen 6500 HB, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2004.06.024DOI Listing
October 2004

Epigenetic regulation of tumor suppressors in t(8:21)-containing AML.

Ann Hematol 2004 Jun 30;83(6):329-30. Epub 2004 Mar 30.

Department of Biochemistry, Vanderbilt University School of Medicine, PRB 512, 23rd and Pierce, Nashville, Tennessee 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-003-0841-8DOI Listing
June 2004

Abnormal WT1 expression in the CD34-negative compartment in myelodysplastic bone marrow.

Br J Haematol 2002 Sep;118(4):1027-33

Central Haematology Laboratory, University Medical Centre, St. Radboud, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1365-2141.2002.03728.xDOI Listing
September 2002

Bcl-2 protects against apoptosis induced by antimycin A and bongkrekic acid without restoring cellular ATP levels.

Biochim Biophys Acta 2002 Apr;1554(1-2):57-65

Central Hematology Laboratory/Department of Hematology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0005-2728(02)00213-xDOI Listing
April 2002