Publications Authored by Joo-Youn Cho

Indoxyl sulfate-induced TNF-α is regulated by crosstalk between the aryl hydrocarbon receptor, NF-κB, and SOCS2 in human macrophages.

Authors:

Hee Young Kim Tae-Hyun Yoo Joo-Youn Cho Hyeon Chang Kim Won-Woo Lee

FASEB J 2019 Oct 5;33(10):10844-10858. Epub 2019 Jul 5.

Department of Microbiology and Immunology.

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http://dx.doi.org/10.1096/fj.201900730R	DOI Listing

October 2019

A Population Pharmacokinetic Model of Intravenous Dexmedetomidine for Mechanically Ventilated Children after Neurosurgery.

Authors:

In-Kyung Song SoJeong Yi Hyeong-Seok Lim Ji-Hyun Lee Eun-Hee Kim Joo-Youn Cho Min-Chang Kim Jin-Tae Kim Hee-Soo Kim

J Clin Med 2019 Oct 1;8(10). Epub 2019 Oct 1.

Department of Anesthesiology and Pain medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.

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http://dx.doi.org/10.3390/jcm8101563	DOI Listing

October 2019

Comprehensive Metabolomic Search for Biomarkers to Differentiate Early Stage Hepatocellular Carcinoma from Cirrhosis.

Authors:

Da Jung Kim Eun Ju Cho Kyung-Sang Yu In-Jin Jang Jung-Hwan Yoon Taesung Park Joo-Youn Cho

Cancers (Basel) 2019 Oct 6;11(10). Epub 2019 Oct 6.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul 03080, Korea.

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http://dx.doi.org/10.3390/cancers11101497	DOI Listing

October 2019

Pharmacokinetics of Ursodeoxycholic Acid in Elderly Volunteers Compared With Younger Adults in a Korean Population.

Authors:

Soyoung Lee Seonghae Yoon Hyewon Chung Sang Chun Ji Seo Hyun Yoon Kyung-Sang Yu Joo-Youn Cho Jae-Yong Chung

J Clin Pharmacol 2019 Aug 18;59(8):1085-1092. Epub 2019 Mar 18.

Clinical Trials Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

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http://dx.doi.org/10.1002/jcph.1409	DOI Listing

August 2019

Quantitative prediction of hepatic CYP3A activity using endogenous markers in healthy subjects after administration of CYP3A inhibitors or inducers.

Authors:

Jieon Lee Seo Hyun Yoon Sojeong Yi Andrew HyoungJin Kim Bora Kim SeungHwan Lee Kyung-Sang Yu In-Jin Jang Joo-Youn Cho

Drug Metab Pharmacokinet 2019 Aug 17;34(4):247-252. Epub 2019 Apr 17.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.dmpk.2019.04.002	DOI Listing

August 2019

Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry.

Authors:

Ji Seong Kim Andrew HyoungJin Kim Cholsoon Jang In Jin Jang Ki Bong Kim Joo Youn Cho Ho Young Hwang

J Korean Med Sci 2019 Apr 8;34(13):e104. Epub 2019 Apr 8.

Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

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https://jkms.org/DOIx.php?id=10.3346/jkms.2019.34.e104	Publisher Site
http://dx.doi.org/10.3346/jkms.2019.34.e104	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449602	PMC

April 2019

Ursodeoxycholic acid exerts hepatoprotective effects by regulating amino acid, flavonoid, and fatty acid metabolic pathways.

Authors:

Da Jung Kim Hyewon Chung Sang Chun Ji SeungHwan Lee Kyung-Sang Yu In-Jin Jang Joo-Youn Cho

Metabolomics 2019 Feb 27;15(3):30. Epub 2019 Feb 27.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

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http://dx.doi.org/10.1007/s11306-019-1494-5	DOI Listing

February 2019

Evaluation of the effects of food on levodropropizine controlled-release tablet and its pharmacokinetic profile in comparison to that of immediate-release tablet.

Authors:

Soyoung Lee Kyu-Yeol Nam Jaeseong Oh SeungHwan Lee Sang-Min Cho Youn-Woong Choi Joo-Youn Cho Beom-Jin Lee Jang Hee Hong

Drug Des Devel Ther 2018 23;12:1413-1420. Epub 2018 May 23.

Department of Pharmacology, Chungnam National University Hospital and College of Medicine, Daejeon, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S146958	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973308	PMC

December 2018

A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers.

Authors:

Soyoung Lee Yun Kim Janice Ji Sung Lee Guangjin Im Joo-Youn Cho Jae-Yong Chung Seonghae Yoon

Eur J Clin Pharmacol 2018 Dec 22;74(12):1605-1613. Epub 2018 Aug 22.

Clinical Trials Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

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http://dx.doi.org/10.1007/s00228-018-2543-0	DOI Listing

December 2018

Assessment of Hepatic Cytochrome P450 3A Activity Using Metabolic Markers in Patients with Renal Impairment.

Authors:

Andrew HyoungJin Kim Sumin Yoon Yujin Lee Jieon Lee Eunjin Bae Hajeong Lee Dong Ki Kim SeungHwan Lee Kyung-Sang Yu In-Jin Jang Joo-Youn Cho

J Korean Med Sci 2018 Dec 31;33(53):e298. Epub 2018 Oct 31.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2018.3	Publisher Site
http://dx.doi.org/10.3346/jkms.2018.33.e298	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306325	PMC

December 2018

Effect of food on the pharmacokinetics of YH4808, a potassium-competitive acid blocker, after single- and multiple-oral dosing in healthy subjects.

Authors:

Eunwoo Kim Anhye Kim Sojeong Yi Yu Kyong Kim Seong Bok Jang Hae Mi Byun Seo Hyun Yoon Joo-Youn Cho In-Jin Jang Kyung-Sang Yu SeungHwan Lee

Eur J Clin Pharmacol 2018 Oct 15;74(10):1261-1272. Epub 2018 Jun 15.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.1007/s00228-018-2502-9	DOI Listing

October 2018

Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice.

Authors:

Eun-Jeong Yang Usman Mahmood Hyunju Kim Moonseok Choi Yunjung Choi Jean-Pyo Lee Joo-Youn Cho Jin Won Hyun Yong Sik Kim Moon-Jeong Chang Hye-Sun Kim

Free Radic Biol Med 2018 10 15;126:221-234. Epub 2018 Aug 15.

Department of Pharmacology, Seoul National University, College of Medicine, 103 Daehakro, Jongro-gu, Seoul 03080, Republic of Korea; Department of Biomedical Sciences, Seoul National University, College of Medicine, 103 Daehakro, Jongro-gu, Seoul 03080, Republic of Korea; Seoul National University Bundang Hospital, Seongnam, Sungnam, Bundang-Gu 13620, Republic of Korea; Neuroscience Research Institute, Seoul National University, College of Medicine, 103 Daehakro, Jongro-gu, Seoul 03080, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849183092	Publisher Site
http://dx.doi.org/10.1016/j.freeradbiomed.2018.08.016	DOI Listing

October 2018

Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity.

Authors:

Jaeseong Oh Sojeong Yi Namyi Gu Dongseong Shin Kyung-Sang Yu Seo Hyun Yoon Joo-Youn Cho In-Jin Jang

Genomics Inform 2018 Sep 30;16(3):52-58. Epub 2018 Sep 30.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, 03080, Korea.

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http://dx.doi.org/10.5808/GI.2018.16.3.52	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187817	PMC

September 2018

Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia patients: An integration of metabolomics and lipidomics.

Authors:

Hyunbeom Lee Jong Min Choi Joo-Youn Cho Tae-Eun Kim Hwa Jeong Lee Byung Hwa Jung

Chem Phys Lipids 2018 08 28;214:69-83. Epub 2018 May 28.

Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.chemphyslip.2018.05.005	DOI Listing

August 2018

Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction.

Authors:

Da Jung Kim Seonghae Yoon Sang Chun Ji Jinho Yang Yoon-Keun Kim SeungHwan Lee Kyung-Sang Yu In-Jin Jang Jae-Yong Chung Joo-Youn Cho

Sci Rep 2018 08 8;8(1):11874. Epub 2018 Aug 8.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1038/s41598-018-30349-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082879	PMC

August 2018

Comparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon and Eprex following a single subcutaneous administration in healthy male volunteers.

Authors:

Sumin Yoon Su-Jin Rhee Sun Ju Heo Tae Young Oh Seo Hyun Yoon Joo-Youn Cho SeungHwan Lee Kyung-Sang Yu

Drug Des Devel Ther 2017 27;11:3127-3135. Epub 2017 Oct 27.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul.

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http://dx.doi.org/10.2147/DDDT.S142673	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667778	PMC

July 2018

Pharmacokinetics and tolerability of MB12066, a beta-lapachone derivative targeting NAD(P)H: quinone oxidoreductase 1: two independent, double-blind, placebo-controlled, combined single and multiple ascending dose first-in-human clinical trials.

Authors:

Seokuee Kim SeungHwan Lee Joo-Youn Cho Seo Hyun Yoon In-Jin Jang Kyung-Sang Yu

Drug Des Devel Ther 2017 7;11:3187-3195. Epub 2017 Nov 7.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine.

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http://dx.doi.org/10.2147/DDDT.S151269	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683780	PMC

July 2018

The Genetic Polymorphism UGT1A4*3 Is Associated with Low Posaconazole Plasma Concentrations in Hematological Malignancy Patients Receiving the Oral Suspension.

Authors:

Hyeon Jeong Suh Seo Hyun Yoon Kyung-Sang Yu Joo-Youn Cho Sang-In Park Eunyoung Lee Jeong-Ok Lee Youngil Koh Kyoung-Ho Song Pyoeng Gyun Choe Eu Suk Kim Soo-Mee Bang Hong Bin Kim Inho Kim Nam Joong Kim Sang Hoon Song Wan Beom Park Myoung-Don Oh

Antimicrob Agents Chemother 2018 07 26;62(7). Epub 2018 Jun 26.

Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, South Korea.

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http://dx.doi.org/10.1128/AAC.02230-17	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021653	PMC

July 2018

Assessment of induced CYP3A activity in pregnant women using 4β-hydroxycholesterol: Cholesterol ratio as an appropriate metabolic marker.

Authors:

Andrew HyoungJin Kim Bora Kim Su-Jin Rhee Yujin Lee Joong Shin Park Seung Mi Lee Sun Min Kim SeungHwan Lee Kyung-Sang Yu In-Jin Jang Joo-Youn Cho

Drug Metab Pharmacokinet 2018 Jun 25;33(3):173-178. Epub 2018 Apr 25.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.dmpk.2018.04.004	DOI Listing

June 2018

Identification of ω- or (ω-1)-Hydroxylated Medium-Chain Acylcarnitines as Novel Urinary Biomarkers for CYP3A Activity.

Authors:

Bora Kim Jieon Lee Kwang-Hee Shin SeungHwan Lee Kyung-Sang Yu In-Jin Jang Joo-Youn Cho

Clin Pharmacol Ther 2018 05 10;103(5):879-887. Epub 2017 Oct 10.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.

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http://doi.wiley.com/10.1002/cpt.856	Publisher Site
http://dx.doi.org/10.1002/cpt.856	DOI Listing

May 2018

A phase 4 study of nilotinib in Korean patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTKorea.

Cancer Med 2018 05 25;7(5):1814-1823. Epub 2018 Mar 25.

Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1002/cam4.1450	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943463	PMC

May 2018

A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers.

Authors:

Jieon Lee Bo-Hyung Kim Kyung-Sang Yu Hee Sun Kim Ji Duck Kim Joo-Youn Cho SeungHwan Lee Namyi Gu

Drug Des Devel Ther 2017 24;11:1301-1313. Epub 2017 Apr 24.

Department of Clinical Pharmacology and Therapeutics, Dongguk University College of Medicine and Ilsan Hospital, Goyang, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S128727	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411174	PMC

February 2018

Early Therapeutic Drug Monitoring of Posaconazole Oral Suspension in Patients With Hematologic Malignancies.

Authors:

Hyeon Jeong Suh Inho Kim Joo-Youn Cho Sang-In Park Seo Hyun Yoon Joo-Hee Hwang Ji Yun Bae Jeong-Ok Lee Youngil Koh Kyoung-Ho Song Pyoeng Gyun Choe Kyung-Sang Yu Eu Suk Kim Hong Bin Kim Soo-Mee Bang Nam Joong Kim Sang Hoon Song Wan Beom Park Myoung-Don Oh

Ther Drug Monit 2018 02;40(1):115-119

Departments of Internal Medicine and.

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http://dx.doi.org/10.1097/FTD.0000000000000469	DOI Listing

February 2018

A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study.

Authors:

Hyewon Chung Jaeseong Oh Seo Hyun Yoon Kyung-Sang Yu Joo-Youn Cho Jae-Yong Chung

PLoS One 2018 17;13(1):e0191258. Epub 2018 Jan 17.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191258	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771593	PMC

February 2018

Active maintenance of endothelial cells prevents kidney fibrosis.

Authors:

Seung Hee Yang Yong Chul Kim Jung Nam An Jin Hyuk Kim Juhoh Lee Hee-Yoon Lee Joo-Youn Cho Jin Ho Paik Yun Kyu Oh Chun Soo Lim Yon Su Kim Jung Pyo Lee

Kidney Res Clin Pract 2017 Dec 31;36(4):329-341. Epub 2017 Dec 31.

Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea.

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http://dx.doi.org/10.23876/j.krcp.2017.36.4.329	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743042	PMC

December 2017

The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans.

Authors:

Jaeseong Oh SeungHwan Lee Howard Lee Joo-Youn Cho Seo Hyun Yoon In-Jin Jang Kyung-Sang Yu Kyoung Soo Lim

PLoS One 2017 24;12(4):e0176320. Epub 2017 Apr 24.

Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, Republic of Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176320	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402961	PMC

September 2017

The Effect of Genetic Polymorphisms in SLCO2B1 on the Lipid-Lowering Efficacy of Rosuvastatin in Healthy Adults with Elevated Low-Density Lipoprotein.

Authors:

Tae-Eun Kim Dongseong Shin Namyi Gu Byung Hwa Jung Jayoun Kim Young Min Cho Kyung-Sang Yu Joo-Youn Cho

Basic Clin Pharmacol Toxicol 2017 Sep 10;121(3):195-201. Epub 2017 Jul 10.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/bcpt.12826	DOI Listing

September 2017

LBEC0101, A Proposed Etanercept Biosimilar: Pharmacokinetics, Immunogenicity, and Tolerability Profiles Compared with a Reference Biologic Product in Healthy Male Subjects.

Authors:

Heechan Lee Hyewon Chung SeungHwan Lee Howard Lee Sung Mo Yang Seo Hyun Yoon Joo-Youn Cho In-Jin Jang Kyung-Sang Yu

BioDrugs 2017 Aug;31(4):349-355

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

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http://dx.doi.org/10.1007/s40259-017-0230-9	DOI Listing

August 2017

Integrative Analysis of Renal Ischemia/Reperfusion Injury and Remote Ischemic Preconditioning in Mice.

Authors:

Kumsun Cho Sang-Il Min Sanghyun Ahn Seung-Kee Min Curie Ahn Kyung-Sang Yu In-Jin Jang Joo-Youn Cho Jongwon Ha

J Proteome Res 2017 08 3;16(8):2877-2886. Epub 2017 Jul 3.

Metabolomics Medical Research Center (MMRC), Seoul National University College of Medicine , Seoul 03080, Republic of Korea.

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http://dx.doi.org/10.1021/acs.jproteome.7b00167	DOI Listing

August 2017

Pantoprazole Does Not Reduce the Antiplatelet Effect of Clopidogrel: A Randomized Controlled Trial in Korea.

Authors:

Yoon Jin Choi Nayoung Kim In-Jin Jang Joo-Youn Cho Ryoung Hee Nam Ji Hyun Park Hyun Jin Jo Hyuk Yoon Cheol Min Shin Young Soo Park Dong Ho Lee Hyun Chae Jung

Gut Liver 2017 Jul;11(4):504-511

Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.5009/gnl16352	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491085	PMC

July 2017

Plasma LTE4/PGF2α Ratio and Blood Eosinophil Count Are Increased in Elderly Asthmatics With Previous Asthma Exacerbation.

Authors:

Ga Young Ban Young Min Ye Sang Ha Kim Gyu Young Hur Joo Hee Kim Jae Jung Shim Kumsun Cho Joo Youn Cho Hae Sim Park

Allergy Asthma Immunol Res 2017 Jul;9(4):378-382

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.4168/aair.2017.9.4.378	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446954	PMC

July 2017

Distribution of Exogenous and Endogenous CYP3A Markers and Related Factors in Healthy Males and Females.

Authors:

Jieon Lee Andrew HyoungJin Kim SoJeong Yi SeungHwan Lee Seo Hyun Yoon Kyung-Sang Yu In-Jin Jang Joo-Youn Cho

AAPS J 2017 07 18;19(4):1196-1204. Epub 2017 May 18.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-799, Republic of Korea.

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http://dx.doi.org/10.1208/s12248-017-0090-8	DOI Listing

July 2017

Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants.

Authors:

Jin A Sohn Han-Suk Kim Jaeseong Oh Joo-Youn Cho Kyung-Sang Yu Juyoung Lee Seung Han Shin Jin A Lee Chang Won Choi Ee-Kyung Kim Beyong Il Kim Eun Ae Park

Br J Clin Pharmacol 2017 06 18;83(6):1279-1286. Epub 2017 Jan 18.

Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, South Korea.

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http://dx.doi.org/10.1111/bcp.13211	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427230	PMC

June 2017

Pharmacokinetics and Tolerance of the Phage Endolysin-Based Candidate Drug SAL200 after a Single Intravenous Administration among Healthy Volunteers.

Authors:

Soo Youn Jun In Jin Jang Seonghae Yoon Kyungho Jang Kyung-Sang Yu Joo Youn Cho Moon-Woo Seong Gi Mo Jung Seong Jun Yoon Sang Hyeon Kang

Antimicrob Agents Chemother 2017 06 24;61(6). Epub 2017 May 24.

iNtRON Biotechnology, Inc., Seongnam-si, Gyeonggi-do, Republic of Korea

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http://dx.doi.org/10.1128/AAC.02629-16	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444177	PMC

June 2017

Pharmacokinetic comparison using two tablets of an evogliptin/metformin XR 2.5/500 mg fixed dose combination vs. 1 tablet each of evogliptin 5 mg and metformin XR 1,000 mg .

Authors:

Sumin Yoon Su-Jin Rhee Sang-In Park Seo Hyun Yoon Joo-Youn Cho In-Jin Jang SeungHwan Lee Kyung-Sang Yu

Int J Clin Pharmacol Ther 2017 Jun;55(6):533-539

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http://dx.doi.org/10.5414/CP202930	DOI Listing

June 2017

Indoxyl sulfate (IS)-mediated immune dysfunction provokes endothelial damage in patients with end-stage renal disease (ESRD).

Authors:

Hee Young Kim Tae-Hyun Yoo Yuri Hwang Ga Hye Lee Bonah Kim Jiyeon Jang Hee Tae Yu Min Chang Kim Joo-Youn Cho Chan Joo Lee Hyeon Chang Kim Sungha Park Won-Woo Lee

Sci Rep 2017 06 8;7(1):3057. Epub 2017 Jun 8.

Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.

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http://dx.doi.org/10.1038/s41598-017-03130-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465082	PMC

June 2017

Comparison of Plasma Concentrations of Posaconazole with the Oral Suspension and Tablet in Korean Patients with Hematologic Malignancies.

Authors:

Hyeon Jeong Suh Inho Kim Joo Youn Cho Sang In Park Seo Hyun Yoon Jeong Ok Lee Youngil Koh Kyoung Ho Song Pyoeng Gyun Choe Kyung Sang Yu Eu Suk Kim Hong Bin Kim Soo Mee Bang Nam Joong Kim Sang Hoon Song Wan Beom Park Myoung Don Oh

Infect Chemother 2017 Jun 9;49(2):135-139. Epub 2017 Jun 9.

Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, Korea.

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http://dx.doi.org/10.3947/ic.2017.49.2.135	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500269	PMC

June 2017

High-Fat Diet and Voluntary Chronic Aerobic Exercise Recover Altered Levels of Aging-Related Tryptophan Metabolites along the Kynurenine Pathway.

Authors:

Keon-Joo Lee Keun-Hwa Jung Joo-Youn Cho Soon-Tae Lee Hwa Suk Kim Jun Hwa Shim Sang Kun Lee Manho Kim Kon Chu

Exp Neurobiol 2017 Jun 26;26(3):132-140. Epub 2017 Jun 26.

Department of Neurology, Seoul National University Hospital, Seoul 03080, Korea.

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http://dx.doi.org/10.5607/en.2017.26.3.132	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491581	PMC

June 2017

A randomized, double-blind, single-dose, two-arm, parallel study comparing pharmacokinetics, immunogenicity and tolerability of branded adalimumab and its biosimilar LBAL in healthy male volunteers.

Authors:

Kyoung Ryun Park Hyewon Chung Sung Mo Yang SeungHwan Lee Seo Hyun Yoon Joo-Youn Cho In-Jin Jang Kyung-Sang Yu

Expert Opin Investig Drugs 2017 May 23;26(5):619-624. Epub 2017 Mar 23.

a Department of Clinical Pharmacology and Therapeutics , Seoul National University College of Medicine and Hospital , Seoul , Republic of Korea.

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http://dx.doi.org/10.1080/13543784.2017.1307339	DOI Listing

May 2017

Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers.

Authors:

Kyungho Jang Min-Kyoung Kim Jaeseong Oh SeungHwan Lee Joo-Youn Cho Kyung-Sang Yu Tai Kiu Choi Sang-Hyuk Lee Kyoung Soo Lim

Drug Des Devel Ther 2017 9;11:705-711. Epub 2017 Mar 9.

Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S124307	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352149	PMC

May 2017

Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects.

Authors:

Dongseong Shin SeungHwan Lee Sojeong Yi Seo Hyun Yoon Joo-Youn Cho Mi Young Bahng In-Jin Jang Kyung-Sang Yu

Drug Des Devel Ther 2017 10;11:713-723. Epub 2017 Mar 10.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital.

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http://dx.doi.org/10.2147/DDDT.S126861	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354528	PMC

May 2017

Pharmacometabolomics for predicting variable busulfan exposure in paediatric haematopoietic stem cell transplantation patients.

Authors:

Bora Kim Ji Won Lee Kyung Taek Hong Kyung-Sang Yu In-Jin Jang Kyung Duk Park Hee Young Shin Hyo Seop Ahn Joo-Youn Cho Hyoung Jin Kang

Sci Rep 2017 05 10;7(1):1711. Epub 2017 May 10.

Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://www.nature.com/articles/s41598-017-01861-7	Publisher Site
http://dx.doi.org/10.1038/s41598-017-01861-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431879	PMC

May 2017

Pharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects.

Authors:

Su-Jin Rhee YoonJung Choi SeungHwan Lee Jaeseong Oh Sung-Jin Kim Seo Hyun Yoon Joo-Youn Cho Kyung-Sang Yu

Drug Des Devel Ther 2016 10;10:2525-34. Epub 2016 Aug 10.

Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S110712	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986685	PMC

April 2017

Correction: GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism.

Authors:

Yi Rang Na Gyo Jeong Gu Daun Jung Young Won Kim Juri Na Jin Sun Woo Joo Youn Cho Hyewon Youn Seung Hyeok Seok

J Immunol 2017 04;198(7):3000

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1700174	Publisher Site
http://dx.doi.org/10.4049/jimmunol.1700174	DOI Listing

April 2017

Effects of renal impairment on the pharmacokinetics and pharmacodynamics of a novel dipeptidyl peptidase-4 inhibitor, evogliptin (DA-1229).

Authors:

Jaeseong Oh Andrew HyoungJin Kim SeungHwan Lee Hyunjeong Cho Yon Su Kim Mi Young Bahng Seo Hyun Yoon Joo-Youn Cho In-Jin Jang Kyung-Sang Yu

Diabetes Obes Metab 2017 02 24;19(2):294-298. Epub 2016 Nov 24.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/dom.12813	DOI Listing

February 2017

Pharmacokinetics and effect on the corrected QT interval of single-dose escitalopram in healthy elderly compared with younger adults.

Authors:

Hyewon Chung Anhye Kim Kyoung Soo Lim Sang-In Park Kyung-Sang Yu Seo Hyun Yoon Joo-Youn Cho Jae-Yong Chung

Int Clin Psychopharmacol 2017 01;32(1):20-26

aDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul bDepartment of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center cDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Korea.

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http://dx.doi.org/10.1097/YIC.0000000000000149	DOI Listing

January 2017

Pharmacokinetics of the evogliptin/metformin extended-release (5/1,000 mg) fixed-dose combination formulation compared to the corresponding loose combination, and food effect in healthy subjects.

Authors:

Su-Jin Rhee SeungHwan Lee Seo Hyun Yoon Joo-Youn Cho In-Jin Jang Kyung-Sang Yu

Drug Des Devel Ther 2016 13;10:1411-8. Epub 2016 Apr 13.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S102459	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835124	PMC

December 2016

The influence of dietary sodium content on the pharmacokinetics and pharmacodynamics of fimasartan.

Authors:

Namyi Gu Joo-Youn Cho Kwang-Hee Shin In-Jin Jang Moo-Yong Rhee

Drug Des Devel Ther 2016 19;10:1525-31. Epub 2016 Apr 19.

Clinical Trial Center, Dongguk University College of Medicine and Ilsan Hospital, Goyang, Republic of Korea; Cardiovascular Center, Dongguk University College of Medicine and Ilsan Hospital, Goyang, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S94694	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844258	PMC

December 2016

GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism.

Authors:

Yi Rang Na Gyo Jeong Gu Daun Jung Young Won Kim Juri Na Jin Sun Woo Joo Youn Cho Hyewon Youn Seung Hyeok Seok

J Immunol 2016 11 14;197(10):4101-4109. Epub 2016 Oct 14.

Macrophage Laboratory, Department of Microbiology and Immunology, Institute of Endemic Disease, Seoul National University College of Medicine, Seoul 110-799, South Korea;

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http://dx.doi.org/10.4049/jimmunol.1600745	DOI Listing

November 2016

Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease.

Authors:

Hoang Kim Tu Trinh Su-Chin Kim Kumsun Cho Su-Jung Kim Ga-Young Ban Hyun-Ju Yoo Joo-Youn Cho Hae-Sim Park Seung-Hyun Kim

Sci Rep 2016 11 10;6:36599. Epub 2016 Nov 10.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

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http://www.nature.com/articles/srep36599	Publisher Site
http://dx.doi.org/10.1038/srep36599	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103193	PMC

November 2016

Urinary 6β-Hydroxycortisol/Cortisol Ratio Most Highly Correlates With Midazolam Clearance Under Hepatic CYP3A Inhibition and Induction in Females: A Pharmacometabolomics Approach.

Authors:

Kwang-Hee Shin Li Young Ahn Man Ho Choi Ju-Yeon Moon Jieon Lee In-Jin Jang Kyung-Sang Yu Joo-Youn Cho

AAPS J 2016 09 17;18(5):1254-1261. Epub 2016 Jun 17.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, South Korea.

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http://dx.doi.org/10.1208/s12248-016-9941-y	DOI Listing

September 2016

Monitoring the Intracellular Tacrolimus Concentration in Kidney Transplant Recipients with Stable Graft Function.

Authors:

Seung Seok Han Seung Hee Yang Min Chang Kim Joo-Youn Cho Sang-Il Min Jung Pyo Lee Dong Ki Kim Jongwon Ha Yon Su Kim

PLoS One 2016 15;11(4):e0153491. Epub 2016 Apr 15.

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153491	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833335	PMC

August 2016

Population pharmacokinetic analysis to recommend the optimal dose of udenafil in patients with mild and moderate hepatic impairment.

Authors:

Anhye Kim Jongtae Lee Donghoon Shin Yong Jin Jung Mi Young Bahng Joo-Youn Cho In-Jin Jang

Br J Clin Pharmacol 2016 08 3;82(2):389-98. Epub 2016 Jun 3.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.

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http://dx.doi.org/10.1111/bcp.12977	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972155	PMC

August 2016

A thorough QT study to evaluate the QTc prolongation potential of two neuropsychiatric drugs, quetiapine and escitalopram, in healthy volunteers.

Authors:

Anhye Kim Kyoung Soo Lim Howard Lee Hyewon Chung Seo Hyun Yoon Kyung-Sang Yu Joo-Youn Cho In-Jin Jang Jae-Yong Chung

Int Clin Psychopharmacol 2016 07;31(4):210-7

aDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital bDepartment of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul cDepartment of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center dDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Korea.

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http://dx.doi.org/10.1097/YIC.0000000000000124	DOI Listing

July 2016

Effectiveness of increasing the frequency of posaconazole syrup administration to achieve optimal plasma concentrations in patients with haematological malignancy.

Authors:

Wan Beom Park Joo-Youn Cho Sang-In Park Eun Jung Kim Seonghae Yoon Seo Hyun Yoon Jeong-Ok Lee Youngil Koh Kyoung-Ho Song Pyoeng Gyun Choe Kyung-Sang Yu Eu Suk Kim Su Mi Bang Nam Joong Kim Inho Kim Myoung-Don Oh Hong Bin Kim Sang Hoon Song

Int J Antimicrob Agents 2016 Jul 12;48(1):106-110. Epub 2016 May 12.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2016.04.013	DOI Listing

July 2016

Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state.

Authors:

Kyungho Jang Seonghae Yoon Sung-Eun Kim Joo-Youn Cho Seo Hyun Yoon Kyoung Soo Lim Kyung-Sang Yu In-Jin Jang Howard Lee

Drug Des Devel Ther 2014 25;8:851-8. Epub 2014 Jun 25.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S62176	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077389	PMC

April 2016

A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles.

Authors:

Hyewon Chung Howard Lee Hye Kyung Han Hyungmi An Kyoung Soo Lim Yong Jin Lee Joo-Youn Cho Seo Hyun Yoon In-Jin Jang Kyung-Sang Yu

Drug Des Devel Ther 2015 13;9:2609-16. Epub 2015 May 13.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S80066	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435089	PMC

February 2016

Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form.

Authors:

Hyo Jung Seo Sang Hwan Nam Hyung-Jun Im Ji-yong Park Ji Youn Lee Byeongjun Yoo Yun-Sang Lee Jae Min Jeong Taeghwan Hyeon Ji Who Kim Jae Sung Lee In-Jin Jang Joo-Youn Cho Do Won Hwang Yung Doug Suh Dong Soo Lee

Sci Rep 2015 10 23;5:15685. Epub 2015 Oct 23.

Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.

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http://dx.doi.org/10.1038/srep15685	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616227	PMC

October 2015

Validated LC-MS/MS Assay for the Quantitative Determination of Fimasartan in Human Plasma: Application to Pharmacokinetic Studies.

Authors:

Seo Hyun Yoon Seul Oh Hwa Suk Kim SoJeong Yi Kyung-Sang Yu In-Jin Jang Joo-Youn Cho

J Chromatogr Sci 2015 Sep 22;53(8):1250-6. Epub 2015 Jan 22.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea

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http://dx.doi.org/10.1093/chromsci/bmu219	DOI Listing

September 2015

Phase I/II Study of Weekly Oraxol for the Second-Line Treatment of Patients With Metastatic or Recurrent Gastric Cancer.

Authors:

Keun-Wook Lee Kyung Hee Lee Dae Young Zang Young Iee Park Dong Bok Shin Jin Won Kim Seock-Ah Im Sung Ae Koh Kyung-Sang Yu Joo-Youn Cho Jin-A Jung Yung-Jue Bang

Oncologist 2015 Aug 25;20(8):896-7. Epub 2015 Jun 25.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea;

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http://dx.doi.org/10.1634/theoncologist.2015-0202	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524762	PMC

August 2015

Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects.

Authors:

Yu-Jung Cha Kyoung Soo Lim Min-Kyu Park Stephen Schneider Brian Bray Myung-Chol Kang Jae-Yong Chung Seo Hyun Yoon Joo-Youn Cho Kyung-Sang Yu

Drug Des Devel Ther 2014 26;8:1613-9. Epub 2014 Sep 26.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.

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http://dx.doi.org/10.2147/DDDT.S65596	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189701	PMC

July 2015

Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers.

Authors:

Namyi Gu Min Kyu Park Tae-Eun Kim Mi Young Bahng Kyoung Soo Lim Sang-Heon Cho Seo Hyun Yoon Joo-Youn Cho In-Jin Jang Kyung-Sang Yu

Drug Des Devel Ther 2014 6;8:1709-21. Epub 2014 Oct 6.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S65678	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199987	PMC

July 2015

Modified titanium implant as a gateway to the human body: the implant mediated drug delivery system.

Authors:

Young-Seok Park Joo-Youn Cho Shin-Jae Lee Chee Il Hwang

Biomed Res Int 2014 22;2014:801358. Epub 2014 Jul 22.

Department of Orthodontics, Seoul National University School of Dentistry and Dental Research Institute, Seoul 110-768, Republic of Korea ; Hwang Chee Il Dental Office, Incheon 402-201, Republic of Korea.

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http://dx.doi.org/10.1155/2014/801358	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129930	PMC

May 2015

Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway.

Authors:

Kumsun Cho Jae Yong Chung Sung Kweon Cho Hyun-Woo Shin In-Jin Jang Jong-Wan Park Kyung-Sang Yu Joo-Youn Cho

Sci Rep 2015 Jan 30;5:8145. Epub 2015 Jan 30.

1] Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea [2] Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.1038/srep08145	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311245	PMC

January 2015

Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers.

Authors:

Seonghae Yoon Howard Lee Tae-Eun Kim SeungHwan Lee Dong-Hyun Chee Joo-Youn Cho Kyung-Sang Yu In-Jin Jang

Drug Des Devel Ther 2014 15;8:123-8. Epub 2014 Jan 15.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://www.dovepress.com/comparative-steady-state-pharmacoki	Publisher Site
http://dx.doi.org/10.2147/DDDT.S53027	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896282	PMC

November 2014

Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters: a DMET Plus microarray assessment.

Authors:

SoJeong Yi Hyungmi An Howard Lee Sangin Lee Ichiro Ieiri Youngjo Lee Joo-Youn Cho Takeshi Hirota Masato Fukae Kenji Yoshida Shinichiro Nagatsuka Miyuki Kimura Shin Irie Yuichi Sugiyama Dong Wan Shin Kyoung Soo Lim Jae-Yong Chung Kyung-Sang Yu In-Jin Jang

Pharmacogenet Genomics 2014 Oct;24(10):477-85

aDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital bDepartment of Statistics, Seoul National University cDepartment of Statistics, Ewha University, Seoul, Korea dDepartment of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University eKyushu Clinical Pharmacology Research Clinic, Fukuoka fADME&Tox Research Institute, Sekisui Medical Co. Ltd, Ibaraki gSugiyama Laboratory, RIKEN Innovation Center RIKEN Research Cluster for Innovation, Yokohama Bio Industry Center, Yokohama, Japan.

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http://dx.doi.org/10.1097/FPC.0000000000000075	DOI Listing

October 2014

Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers.

Authors:

Tae-Eun Kim Howard Lee Kyoung Soo Lim SeungHwan Lee Seo-Hyun Yoon Kyung-Mi Park Hyesun Han Sang-Goo Shin In-Jin Jang Kyung-Sang Yu Joo-Youn Cho

Br J Clin Pharmacol 2014 Sep;78(3):556-64

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/bcp.12368	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243906	PMC

September 2014

A rapid, simple and reliable HPLC-triple quadrupole tandem mass spectrometer method for a simultaneous quantification of irinotecan and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma.

Authors:

Gang Ahn Dong Min Park Jun Won Park Hyo-Young Kim Joo-Youn Cho Su-jin Rhee In-Jin Jang Hark Kyun Kim

Biomed Chromatogr 2014 Jul 23;28(7):919-22. Epub 2014 Jan 23.

Biomolecular Function Research Branch, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea.

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http://dx.doi.org/10.1002/bmc.3134	DOI Listing

July 2014

Effects of proton pump inhibitors on metformin pharmacokinetics and pharmacodynamics.

Authors:

AnHye Kim Inbum Chung Seo Hyun Yoon Kyung-Sang Yu Kyoung Soo Lim Joo-Youn Cho Howard Lee In-Jin Jang Jae Yong Chung

Drug Metab Dispos 2014 Jul 24;42(7):1174-9. Epub 2014 Apr 24.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea (A.H.K., I.C., S.H.Y., K.-S.Y., K.S.L., J.-Y.C., H.L., I.-J.J.); Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Korea (J.Y.C.)

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http://dx.doi.org/10.1124/dmd.113.055616	DOI Listing

July 2014

Tolerability and pharmacokinetics of lobeglitazone, a novel peroxisome proliferator-activated receptor-γ agonist, after a single oral administration in healthy female subjects.

Authors:

Min Kyu Park Tae-Eun Kim JaeWoo Kim Chin Kim Seo Hyun Yoon Joo-Youn Cho In-Jin Jang Kyung-Sang Yu Kyoung Soo Lim

Clin Drug Investig 2014 Jul;34(7):467-74

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

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http://dx.doi.org/10.1007/s40261-014-0197-y	DOI Listing

July 2014

A Phase I Study of Oral Paclitaxel with a Novel P-Glycoprotein Inhibitor, HM30181A, in Patients with Advanced Solid Cancer.

Authors:

Hyun Jung Lee Dae-Seog Heo Joo-Youn Cho Sae-Won Han Hye-Jung Chang Hyeon-Gyu Yi Tae-Eun Kim Se-Hoon Lee Do-Youn Oh Seock-Ah Im In-Jin Jang Yung-Jue Bang

Cancer Res Treat 2014 Jul 15;46(3):234-42. Epub 2014 Jul 15.

Department of Internal Medicine, Dongguk University Ilsan Medical Center, Dogguk University College of Medicine, Goyang, Korea ; Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4143/crt.2014.46.3.234	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132447	PMC

July 2014

Pharmacodynamics, pharmacokinetics, and tolerability of intravenous or subcutaneous GC1113, a novel erythropoiesis-stimulating agent.

Authors:

HyeKyung Han Jongtae Lee Donghoon Shin Kwang-Hee Shin Hyewon Jeon Kyoung Soo Lim Seo Hyun Yoon Sang-Goo Shin In-Jin Jang Joo-Youn Cho Kyung-Sang Yu

Clin Drug Investig 2014 Jun;34(6):373-82

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

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http://dx.doi.org/10.1007/s40261-014-0183-4	DOI Listing

June 2014

Pharmacokinetic and pharmacodynamic interaction between gemigliptin and metformin in healthy subjects.

Authors:

Dongseong Shin Young Min Cho SeungHwan Lee Kyoung Soo Lim Jeong-Ae Kim Ji-Yung Ahn Joo-Youn Cho Howard Lee In-Jin Jang Kyung-Sang Yu

Clin Drug Investig 2014 Jun;34(6):383-93

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

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http://dx.doi.org/10.1007/s40261-014-0184-3	DOI Listing

June 2014

The effects of moxifloxacin on QTc interval in healthy Korean male subjects.

Authors:

Seol Ju Moon Jongtae Lee Hyungmi An Dong-Seok Yim Jae-Yong Chung Kyung-Sang Yu Joo-Youn Cho Kyoung Soo Lim

Drugs R D 2014 Jun;14(2):63-71

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea.

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http://dx.doi.org/10.1007/s40268-014-0040-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070463	PMC

June 2014

Development of lipidomic platform and phosphatidylcholine retention time index for lipid profiling of rosuvastatin treated human plasma.

Authors:

Jong Min Choi Tae-Eun Kim Joo-Youn Cho Hwa Jeong Lee Byung Hwa Jung

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Jan 26;944:157-65. Epub 2013 Oct 26.

Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2013.10.029	DOI Listing

January 2014

Sustained Increase in the Oral Bioavailability of Loperamide after a Single Oral Dose of HM30181, a P-glycoprotein Inhibitor, in Healthy Male Participants.

Authors:

Yu-Jung Cha Howard Lee Namyi Gu Tae-Eun Kim Kyoung S Lim Seo H Yoon Jae-Yong Chung In-Jin Jang Sang-Goo Shin Kyung-Sang Yu Joo-Youn Cho

Basic Clin Pharmacol Toxicol 2013 Dec 7;113(6):419-24. Epub 2013 Aug 7.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/bcpt.12108	DOI Listing

December 2013

Development and validation of a microfluidic chip-based nano-liquid chromatography-triple quadrupole tandem mass spectrometry method for a sensitive and reliable quantification of 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma.

Authors:

Gang Ahn Dong Min Park Jun Won Park Joo-Youn Cho Su-jin Rhee Hyo-Young Kim Dae-Seung Lee In-Jin Jang Hark Kyun Kim

Anal Bioanal Chem 2013 Dec 15;405(30):9817-24. Epub 2013 Oct 15.

Biomolecular Function Research Branch, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea.

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http://dx.doi.org/10.1007/s00216-013-7411-2	DOI Listing

December 2013

Relationship between absolute neutrophil count profiles and pharmacokinetics of DA-3031, a pegylated granulocyte colony-stimulating factor (pegylated-G-CSF): a dose block-randomized, double-blind, dose-escalation study in healthy subjects.

Authors:

Li Young Ahn Kwang-Hee Shin Kyoung Soo Lim Tae-Eun Kim Hyewon Jeon Seo Hyun Yoon Joo-Youn Cho Sang-Goo Shin In-Jin Jang Kyung-Sang Yu

Clin Drug Investig 2013 Nov;33(11):817-24

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http://dx.doi.org/10.1007/s40261-013-0130-9	DOI Listing

November 2013

Usefulness of oral loading of oxcarbazepine suspension in selected patients with epilepsy.

Authors:

Dong Wook Kim Namyi Gu Howard Lee In-Jin Jang Kon Chu Kyung-Sang Yu Joo-Youn Cho Seo Hyun Yoon Hyun Jeong Na Sang Kun Lee

Int J Clin Pharmacol Ther 2013 Oct;51(10):780-6

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http://dx.doi.org/10.5414/CP201896	DOI Listing

October 2013

Comparison of pharmacokinetics between new quinolone antibiotics: the zabofloxacin hydrochloride capsule and the zabofloxacin aspartate tablet.

Authors:

Hyekyung Han Sung Eun Kim Kwang-Hee Shin Cheolhee Lim Kyoung Soo Lim Kyung-Sang Yu Joo-Youn Cho

Curr Med Res Opin 2013 Oct 19;29(10):1349-55. Epub 2013 Aug 19.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital , Seoul , Korea.

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http://dx.doi.org/10.1185/03007995.2013.825591	DOI Listing

October 2013

Pharmacokinetic-pharmacodynamic modelling of biomarker response to sitagliptin in healthy volunteers.

Authors:

Bo-Hyung Kim Sung Eun Kim Dongwoo Kang Kyoung Soo Lim Jung-Ryul Kim In-Jin Jang Sang-Goo Shin Seo Hyun Yoon Joo-Youn Cho Kyung-Sang Yu

Basic Clin Pharmacol Toxicol 2013 Aug 20;113(2):113-25. Epub 2013 May 20.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/bcpt.12068	DOI Listing

August 2013

GC-MS-based quantitative signatures of cytochrome P450-mediated steroid oxidation induced by rifampicin.

Authors:

Ju-Yeon Moon Se Mi Kang Jeongae Lee Joo-Youn Cho Myeong Hee Moon In-Jin Jang Bong Chul Chung Man Ho Choi

Ther Drug Monit 2013 Aug;35(4):473-84

Future Convergence Research Division, Korea Institute of Science and Technology, Yonsei University.

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http://dx.doi.org/10.1097/FTD.0b013e318286ee02	DOI Listing

August 2013

Functional characterization of MATE2-K genetic variants and their effects on metformin pharmacokinetics.

Authors:

Jae-Yong Chung Sung Kweon Cho Tae Hee Kim Kyoung Hee Kim Geun Hye Jang Choon Ok Kim Eun-Mi Park Joo-Youn Cho In-Jin Jang Ji Ha Choi

Pharmacogenet Genomics 2013 Jul;23(7):365-73

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Korea.

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http://dx.doi.org/10.1097/FPC.0b013e3283622037	DOI Listing

July 2013

The effect of udenafil on the hemodynamics of healthy male volunteers administered tamsulosin.

Authors:

Min-Gul Kim Jung-Ryul Kim Bo-Hyung Kim Kyoung Soo Lim Sang-Goo Shin In-Jin Jang Kyung-Sang Yu Joo-Youn Cho

Curr Med Res Opin 2013 Jun 17;29(6):685-93. Epub 2013 Apr 17.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://www.tandfonline.com/doi/full/10.1185/03007995.2013.79	Publisher Site
http://dx.doi.org/10.1185/03007995.2013.792792	DOI Listing

June 2013

Population pharmacokinetics of theophylline in premature Korean infants.

Authors:

Sung Eun Kim Bo-Hyung Kim Seunghwan Lee Jin A Sohn Han-Suk Kim Joo-Youn Cho Seo Hyun Yoon In-Jin Jang Kyung-Sang Yu Kyoung Soo Lim

Ther Drug Monit 2013 Jun;35(3):338-44

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.1097/FTD.0b013e3182866695	DOI Listing

June 2013

Intravenous amantadine for freezing of gait resistant to dopaminergic therapy: a randomized, double-blind, placebo-controlled, cross-over clinical trial.

Authors:

Young Eun Kim Ji Young Yun Hui June Yang Han-Joon Kim Namyi Gu Seo Hyun Yoon Joo-Youn Cho Beom S Jeon

PLoS One 2012 19;7(11):e48890. Epub 2012 Nov 19.

Department of Neurology and Movement Disorder Center, Seoul National University Hospital, Seoul, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048890	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501515	PMC

May 2013

Pharmacokinetic and pharmacodynamic properties of a new long-acting granulocyte colony-stimulating factor (HM10460A) in healthy volunteers.

Authors:

Kwang-Hee Shin Tae-Eun Kim Kyoung Soo Lim Seo-Hyun Yoon Joo-Youn Cho Sei-Eun Kim Kyung-Mi Park Sang-Goo Shin In-Jin Jang Kyung-Sang Yu

BioDrugs 2013 Apr;27(2):149-58

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Seoul 110-744, Korea.

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http://dx.doi.org/10.1007/s40259-013-0010-0	DOI Listing

April 2013

Global metabolomics and targeted steroid profiling reveal that rifampin, a strong human PXR activator, alters endogenous urinary steroid markers.

Authors:

Bora Kim Ju-Yeon Moon Man Ho Choi Hyang Hee Yang Seunghwan Lee Kyoung Soo Lim Seo Hyun Yoon Kyung-Sang Yu In-Jin Jang Joo-Youn Cho

J Proteome Res 2013 Mar 28;12(3):1359-68. Epub 2013 Jan 28.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.1021/pr301021p	DOI Listing

March 2013

Apple juice greatly reduces systemic exposure to atenolol.

Authors:

Hyewon Jeon In-Jin Jang SeungHwan Lee Kyoichi Ohashi Tsutomu Kotegawa Ichiro Ieiri Joo-Youn Cho Seo Hyun Yoon Sang-Goo Shin Kyung-Sang Yu Kyoung Soo Lim

Br J Clin Pharmacol 2013 Jan;75(1):172-9

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/j.1365-2125.2012.04324.x	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555056	PMC

January 2013

Increased systemic exposure of fimasartan, an angiotensin II receptor antagonist, by ketoconazole and rifampicin.

Authors:

Jung Won Kim SoJeong Yi Tae-Eun Kim Kyoung Soo Lim Seo Hyun Yoon Joo-Youn Cho Min Goo Lee Im-Sook Song Sang-Goo Shin In-Jin Jang Kyung-Sang Yu

J Clin Pharmacol 2013 Jan 24;53(1):75-81. Epub 2013 Jan 24.

Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://doi.wiley.com/10.1177/0091270011433328	Publisher Site
http://dx.doi.org/10.1177/0091270011433328	DOI Listing

January 2013

Comparative pharmacokinetics/pharmacodynamics of clopidogrel besylate and clopidogrel bisulfate in healthy Korean subjects.

Authors:

Bo-Hyung Kim Jung-Ryul Kim Kyoung Soo Lim Hyun-Suk Shin Seo Hyun Yoon Joo-Youn Cho In-Jin Jang Sang-Goo Shin Kyung-Sang Yu

Clin Drug Investig 2012 Dec;32(12):817-26

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Jongno-gu, Seoul, Republic of Korea.

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