Joo-Youn Cho

Joo-Youn Cho

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Joo-Youn Cho

Publications by authors named "Joo-Youn Cho"

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Indoxyl sulfate-induced TNF-α is regulated by crosstalk between the aryl hydrocarbon receptor, NF-κB, and SOCS2 in human macrophages.

FASEB J 2019 Oct 5;33(10):10844-10858. Epub 2019 Jul 5.

Department of Microbiology and Immunology.

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http://dx.doi.org/10.1096/fj.201900730RDOI Listing
October 2019

A Population Pharmacokinetic Model of Intravenous Dexmedetomidine for Mechanically Ventilated Children after Neurosurgery.

J Clin Med 2019 Oct 1;8(10). Epub 2019 Oct 1.

Department of Anesthesiology and Pain medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.

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http://dx.doi.org/10.3390/jcm8101563DOI Listing
October 2019

Comprehensive Metabolomic Search for Biomarkers to Differentiate Early Stage Hepatocellular Carcinoma from Cirrhosis.

Cancers (Basel) 2019 Oct 6;11(10). Epub 2019 Oct 6.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul 03080, Korea.

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http://dx.doi.org/10.3390/cancers11101497DOI Listing
October 2019

Pharmacokinetics of Ursodeoxycholic Acid in Elderly Volunteers Compared With Younger Adults in a Korean Population.

J Clin Pharmacol 2019 Aug 18;59(8):1085-1092. Epub 2019 Mar 18.

Clinical Trials Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

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http://dx.doi.org/10.1002/jcph.1409DOI Listing
August 2019

Quantitative prediction of hepatic CYP3A activity using endogenous markers in healthy subjects after administration of CYP3A inhibitors or inducers.

Drug Metab Pharmacokinet 2019 Aug 17;34(4):247-252. Epub 2019 Apr 17.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.dmpk.2019.04.002DOI Listing
August 2019

Ursodeoxycholic acid exerts hepatoprotective effects by regulating amino acid, flavonoid, and fatty acid metabolic pathways.

Metabolomics 2019 Feb 27;15(3):30. Epub 2019 Feb 27.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

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http://dx.doi.org/10.1007/s11306-019-1494-5DOI Listing
February 2019

Evaluation of the effects of food on levodropropizine controlled-release tablet and its pharmacokinetic profile in comparison to that of immediate-release tablet.

Drug Des Devel Ther 2018 23;12:1413-1420. Epub 2018 May 23.

Department of Pharmacology, Chungnam National University Hospital and College of Medicine, Daejeon, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S146958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973308PMC
December 2018

A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers.

Eur J Clin Pharmacol 2018 Dec 22;74(12):1605-1613. Epub 2018 Aug 22.

Clinical Trials Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

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http://dx.doi.org/10.1007/s00228-018-2543-0DOI Listing
December 2018

Assessment of Hepatic Cytochrome P450 3A Activity Using Metabolic Markers in Patients with Renal Impairment.

J Korean Med Sci 2018 Dec 31;33(53):e298. Epub 2018 Oct 31.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2018.3
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http://dx.doi.org/10.3346/jkms.2018.33.e298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306325PMC
December 2018

Effect of food on the pharmacokinetics of YH4808, a potassium-competitive acid blocker, after single- and multiple-oral dosing in healthy subjects.

Eur J Clin Pharmacol 2018 Oct 15;74(10):1261-1272. Epub 2018 Jun 15.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.1007/s00228-018-2502-9DOI Listing
October 2018

Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice.

Free Radic Biol Med 2018 10 15;126:221-234. Epub 2018 Aug 15.

Department of Pharmacology, Seoul National University, College of Medicine, 103 Daehakro, Jongro-gu, Seoul 03080, Republic of Korea; Department of Biomedical Sciences, Seoul National University, College of Medicine, 103 Daehakro, Jongro-gu, Seoul 03080, Republic of Korea; Seoul National University Bundang Hospital, Seongnam, Sungnam, Bundang-Gu 13620, Republic of Korea; Neuroscience Research Institute, Seoul National University, College of Medicine, 103 Daehakro, Jongro-gu, Seoul 03080, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849183092
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http://dx.doi.org/10.1016/j.freeradbiomed.2018.08.016DOI Listing
October 2018

Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity.

Genomics Inform 2018 Sep 30;16(3):52-58. Epub 2018 Sep 30.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, 03080, Korea.

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http://dx.doi.org/10.5808/GI.2018.16.3.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187817PMC
September 2018

Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia patients: An integration of metabolomics and lipidomics.

Chem Phys Lipids 2018 08 28;214:69-83. Epub 2018 May 28.

Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.chemphyslip.2018.05.005DOI Listing
August 2018

Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction.

Sci Rep 2018 08 8;8(1):11874. Epub 2018 Aug 8.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1038/s41598-018-30349-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082879PMC
August 2018

Comparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon and Eprex following a single subcutaneous administration in healthy male volunteers.

Drug Des Devel Ther 2017 27;11:3127-3135. Epub 2017 Oct 27.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul.

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http://dx.doi.org/10.2147/DDDT.S142673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667778PMC
July 2018

Assessment of induced CYP3A activity in pregnant women using 4β-hydroxycholesterol: Cholesterol ratio as an appropriate metabolic marker.

Drug Metab Pharmacokinet 2018 Jun 25;33(3):173-178. Epub 2018 Apr 25.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.dmpk.2018.04.004DOI Listing
June 2018

Identification of ω- or (ω-1)-Hydroxylated Medium-Chain Acylcarnitines as Novel Urinary Biomarkers for CYP3A Activity.

Clin Pharmacol Ther 2018 05 10;103(5):879-887. Epub 2017 Oct 10.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.

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http://doi.wiley.com/10.1002/cpt.856
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http://dx.doi.org/10.1002/cpt.856DOI Listing
May 2018

A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers.

Drug Des Devel Ther 2017 24;11:1301-1313. Epub 2017 Apr 24.

Department of Clinical Pharmacology and Therapeutics, Dongguk University College of Medicine and Ilsan Hospital, Goyang, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S128727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411174PMC
February 2018

Active maintenance of endothelial cells prevents kidney fibrosis.

Kidney Res Clin Pract 2017 Dec 31;36(4):329-341. Epub 2017 Dec 31.

Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea.

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http://dx.doi.org/10.23876/j.krcp.2017.36.4.329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743042PMC
December 2017

The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans.

PLoS One 2017 24;12(4):e0176320. Epub 2017 Apr 24.

Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, Republic of Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176320PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402961PMC
September 2017

The Effect of Genetic Polymorphisms in SLCO2B1 on the Lipid-Lowering Efficacy of Rosuvastatin in Healthy Adults with Elevated Low-Density Lipoprotein.

Basic Clin Pharmacol Toxicol 2017 Sep 10;121(3):195-201. Epub 2017 Jul 10.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/bcpt.12826DOI Listing
September 2017

LBEC0101, A Proposed Etanercept Biosimilar: Pharmacokinetics, Immunogenicity, and Tolerability Profiles Compared with a Reference Biologic Product in Healthy Male Subjects.

BioDrugs 2017 Aug;31(4):349-355

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

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http://dx.doi.org/10.1007/s40259-017-0230-9DOI Listing
August 2017

Integrative Analysis of Renal Ischemia/Reperfusion Injury and Remote Ischemic Preconditioning in Mice.

J Proteome Res 2017 08 3;16(8):2877-2886. Epub 2017 Jul 3.

Metabolomics Medical Research Center (MMRC), Seoul National University College of Medicine , Seoul 03080, Republic of Korea.

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http://dx.doi.org/10.1021/acs.jproteome.7b00167DOI Listing
August 2017

Distribution of Exogenous and Endogenous CYP3A Markers and Related Factors in Healthy Males and Females.

AAPS J 2017 07 18;19(4):1196-1204. Epub 2017 May 18.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-799, Republic of Korea.

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http://dx.doi.org/10.1208/s12248-017-0090-8DOI Listing
July 2017

A randomized, double-blind, single-dose, two-arm, parallel study comparing pharmacokinetics, immunogenicity and tolerability of branded adalimumab and its biosimilar LBAL in healthy male volunteers.

Expert Opin Investig Drugs 2017 May 23;26(5):619-624. Epub 2017 Mar 23.

a Department of Clinical Pharmacology and Therapeutics , Seoul National University College of Medicine and Hospital , Seoul , Republic of Korea.

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http://dx.doi.org/10.1080/13543784.2017.1307339DOI Listing
May 2017

Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers.

Drug Des Devel Ther 2017 9;11:705-711. Epub 2017 Mar 9.

Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S124307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352149PMC
May 2017

Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects.

Drug Des Devel Ther 2017 10;11:713-723. Epub 2017 Mar 10.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital.

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http://dx.doi.org/10.2147/DDDT.S126861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354528PMC
May 2017

Pharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects.

Drug Des Devel Ther 2016 10;10:2525-34. Epub 2016 Aug 10.

Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S110712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986685PMC
April 2017

Effects of renal impairment on the pharmacokinetics and pharmacodynamics of a novel dipeptidyl peptidase-4 inhibitor, evogliptin (DA-1229).

Diabetes Obes Metab 2017 02 24;19(2):294-298. Epub 2016 Nov 24.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/dom.12813DOI Listing
February 2017

Pharmacokinetics and effect on the corrected QT interval of single-dose escitalopram in healthy elderly compared with younger adults.

Int Clin Psychopharmacol 2017 01;32(1):20-26

aDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul bDepartment of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center cDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Korea.

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http://dx.doi.org/10.1097/YIC.0000000000000149DOI Listing
January 2017

Pharmacokinetics of the evogliptin/metformin extended-release (5/1,000 mg) fixed-dose combination formulation compared to the corresponding loose combination, and food effect in healthy subjects.

Drug Des Devel Ther 2016 13;10:1411-8. Epub 2016 Apr 13.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S102459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835124PMC
December 2016

The influence of dietary sodium content on the pharmacokinetics and pharmacodynamics of fimasartan.

Drug Des Devel Ther 2016 19;10:1525-31. Epub 2016 Apr 19.

Clinical Trial Center, Dongguk University College of Medicine and Ilsan Hospital, Goyang, Republic of Korea; Cardiovascular Center, Dongguk University College of Medicine and Ilsan Hospital, Goyang, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S94694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844258PMC
December 2016

GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism.

J Immunol 2016 11 14;197(10):4101-4109. Epub 2016 Oct 14.

Macrophage Laboratory, Department of Microbiology and Immunology, Institute of Endemic Disease, Seoul National University College of Medicine, Seoul 110-799, South Korea;

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http://dx.doi.org/10.4049/jimmunol.1600745DOI Listing
November 2016

Urinary 6β-Hydroxycortisol/Cortisol Ratio Most Highly Correlates With Midazolam Clearance Under Hepatic CYP3A Inhibition and Induction in Females: A Pharmacometabolomics Approach.

AAPS J 2016 09 17;18(5):1254-1261. Epub 2016 Jun 17.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, South Korea.

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http://dx.doi.org/10.1208/s12248-016-9941-yDOI Listing
September 2016

Population pharmacokinetic analysis to recommend the optimal dose of udenafil in patients with mild and moderate hepatic impairment.

Br J Clin Pharmacol 2016 08 3;82(2):389-98. Epub 2016 Jun 3.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.

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http://dx.doi.org/10.1111/bcp.12977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972155PMC
August 2016

A thorough QT study to evaluate the QTc prolongation potential of two neuropsychiatric drugs, quetiapine and escitalopram, in healthy volunteers.

Int Clin Psychopharmacol 2016 07;31(4):210-7

aDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital bDepartment of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul cDepartment of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center dDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Korea.

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http://dx.doi.org/10.1097/YIC.0000000000000124DOI Listing
July 2016

Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state.

Drug Des Devel Ther 2014 25;8:851-8. Epub 2014 Jun 25.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S62176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077389PMC
April 2016

A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles.

Drug Des Devel Ther 2015 13;9:2609-16. Epub 2015 May 13.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S80066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435089PMC
February 2016

Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form.

Sci Rep 2015 10 23;5:15685. Epub 2015 Oct 23.

Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.

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http://dx.doi.org/10.1038/srep15685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616227PMC
October 2015

Validated LC-MS/MS Assay for the Quantitative Determination of Fimasartan in Human Plasma: Application to Pharmacokinetic Studies.

J Chromatogr Sci 2015 Sep 22;53(8):1250-6. Epub 2015 Jan 22.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea

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http://dx.doi.org/10.1093/chromsci/bmu219DOI Listing
September 2015

Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects.

Drug Des Devel Ther 2014 26;8:1613-9. Epub 2014 Sep 26.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.

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http://dx.doi.org/10.2147/DDDT.S65596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189701PMC
July 2015

Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers.

Drug Des Devel Ther 2014 6;8:1709-21. Epub 2014 Oct 6.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.2147/DDDT.S65678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199987PMC
July 2015

Modified titanium implant as a gateway to the human body: the implant mediated drug delivery system.

Biomed Res Int 2014 22;2014:801358. Epub 2014 Jul 22.

Department of Orthodontics, Seoul National University School of Dentistry and Dental Research Institute, Seoul 110-768, Republic of Korea ; Hwang Chee Il Dental Office, Incheon 402-201, Republic of Korea.

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http://dx.doi.org/10.1155/2014/801358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129930PMC
May 2015

Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway.

Sci Rep 2015 Jan 30;5:8145. Epub 2015 Jan 30.

1] Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea [2] Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.1038/srep08145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311245PMC
January 2015

Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers.

Drug Des Devel Ther 2014 15;8:123-8. Epub 2014 Jan 15.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://www.dovepress.com/comparative-steady-state-pharmacoki
Publisher Site
http://dx.doi.org/10.2147/DDDT.S53027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896282PMC
November 2014

Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters: a DMET Plus microarray assessment.

Pharmacogenet Genomics 2014 Oct;24(10):477-85

aDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital bDepartment of Statistics, Seoul National University cDepartment of Statistics, Ewha University, Seoul, Korea dDepartment of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University eKyushu Clinical Pharmacology Research Clinic, Fukuoka fADME&Tox Research Institute, Sekisui Medical Co. Ltd, Ibaraki gSugiyama Laboratory, RIKEN Innovation Center RIKEN Research Cluster for Innovation, Yokohama Bio Industry Center, Yokohama, Japan.

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http://dx.doi.org/10.1097/FPC.0000000000000075DOI Listing
October 2014

Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers.

Br J Clin Pharmacol 2014 Sep;78(3):556-64

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/bcp.12368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243906PMC
September 2014

A rapid, simple and reliable HPLC-triple quadrupole tandem mass spectrometer method for a simultaneous quantification of irinotecan and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma.

Biomed Chromatogr 2014 Jul 23;28(7):919-22. Epub 2014 Jan 23.

Biomolecular Function Research Branch, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea.

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http://dx.doi.org/10.1002/bmc.3134DOI Listing
July 2014

Effects of proton pump inhibitors on metformin pharmacokinetics and pharmacodynamics.

Drug Metab Dispos 2014 Jul 24;42(7):1174-9. Epub 2014 Apr 24.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea (A.H.K., I.C., S.H.Y., K.-S.Y., K.S.L., J.-Y.C., H.L., I.-J.J.); Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Korea (J.Y.C.)

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http://dx.doi.org/10.1124/dmd.113.055616DOI Listing
July 2014

Tolerability and pharmacokinetics of lobeglitazone, a novel peroxisome proliferator-activated receptor-γ agonist, after a single oral administration in healthy female subjects.

Clin Drug Investig 2014 Jul;34(7):467-74

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

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http://dx.doi.org/10.1007/s40261-014-0197-yDOI Listing
July 2014

A Phase I Study of Oral Paclitaxel with a Novel P-Glycoprotein Inhibitor, HM30181A, in Patients with Advanced Solid Cancer.

Cancer Res Treat 2014 Jul 15;46(3):234-42. Epub 2014 Jul 15.

Department of Internal Medicine, Dongguk University Ilsan Medical Center, Dogguk University College of Medicine, Goyang, Korea ; Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4143/crt.2014.46.3.234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132447PMC
July 2014

Pharmacodynamics, pharmacokinetics, and tolerability of intravenous or subcutaneous GC1113, a novel erythropoiesis-stimulating agent.

Clin Drug Investig 2014 Jun;34(6):373-82

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

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http://dx.doi.org/10.1007/s40261-014-0183-4DOI Listing
June 2014

Pharmacokinetic and pharmacodynamic interaction between gemigliptin and metformin in healthy subjects.

Clin Drug Investig 2014 Jun;34(6):383-93

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

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http://dx.doi.org/10.1007/s40261-014-0184-3DOI Listing
June 2014

The effects of moxifloxacin on QTc interval in healthy Korean male subjects.

Drugs R D 2014 Jun;14(2):63-71

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea.

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http://dx.doi.org/10.1007/s40268-014-0040-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070463PMC
June 2014

Development of lipidomic platform and phosphatidylcholine retention time index for lipid profiling of rosuvastatin treated human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Jan 26;944:157-65. Epub 2013 Oct 26.

Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2013.10.029DOI Listing
January 2014

Sustained Increase in the Oral Bioavailability of Loperamide after a Single Oral Dose of HM30181, a P-glycoprotein Inhibitor, in Healthy Male Participants.

Basic Clin Pharmacol Toxicol 2013 Dec 7;113(6):419-24. Epub 2013 Aug 7.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/bcpt.12108DOI Listing
December 2013

Development and validation of a microfluidic chip-based nano-liquid chromatography-triple quadrupole tandem mass spectrometry method for a sensitive and reliable quantification of 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma.

Anal Bioanal Chem 2013 Dec 15;405(30):9817-24. Epub 2013 Oct 15.

Biomolecular Function Research Branch, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea.

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http://dx.doi.org/10.1007/s00216-013-7411-2DOI Listing
December 2013

Comparison of pharmacokinetics between new quinolone antibiotics: the zabofloxacin hydrochloride capsule and the zabofloxacin aspartate tablet.

Curr Med Res Opin 2013 Oct 19;29(10):1349-55. Epub 2013 Aug 19.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital , Seoul , Korea.

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http://dx.doi.org/10.1185/03007995.2013.825591DOI Listing
October 2013

Pharmacokinetic-pharmacodynamic modelling of biomarker response to sitagliptin in healthy volunteers.

Basic Clin Pharmacol Toxicol 2013 Aug 20;113(2):113-25. Epub 2013 May 20.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/bcpt.12068DOI Listing
August 2013

GC-MS-based quantitative signatures of cytochrome P450-mediated steroid oxidation induced by rifampicin.

Ther Drug Monit 2013 Aug;35(4):473-84

Future Convergence Research Division, Korea Institute of Science and Technology, Yonsei University.

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http://dx.doi.org/10.1097/FTD.0b013e318286ee02DOI Listing
August 2013

Functional characterization of MATE2-K genetic variants and their effects on metformin pharmacokinetics.

Pharmacogenet Genomics 2013 Jul;23(7):365-73

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Korea.

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http://dx.doi.org/10.1097/FPC.0b013e3283622037DOI Listing
July 2013

The effect of udenafil on the hemodynamics of healthy male volunteers administered tamsulosin.

Curr Med Res Opin 2013 Jun 17;29(6):685-93. Epub 2013 Apr 17.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://www.tandfonline.com/doi/full/10.1185/03007995.2013.79
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http://dx.doi.org/10.1185/03007995.2013.792792DOI Listing
June 2013

Population pharmacokinetics of theophylline in premature Korean infants.

Ther Drug Monit 2013 Jun;35(3):338-44

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.1097/FTD.0b013e3182866695DOI Listing
June 2013

Pharmacokinetic and pharmacodynamic properties of a new long-acting granulocyte colony-stimulating factor (HM10460A) in healthy volunteers.

BioDrugs 2013 Apr;27(2):149-58

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 101 Daehak-ro, Seoul 110-744, Korea.

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http://dx.doi.org/10.1007/s40259-013-0010-0DOI Listing
April 2013

Global metabolomics and targeted steroid profiling reveal that rifampin, a strong human PXR activator, alters endogenous urinary steroid markers.

J Proteome Res 2013 Mar 28;12(3):1359-68. Epub 2013 Jan 28.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.1021/pr301021pDOI Listing
March 2013

Apple juice greatly reduces systemic exposure to atenolol.

Br J Clin Pharmacol 2013 Jan;75(1):172-9

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/j.1365-2125.2012.04324.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555056PMC
January 2013

Comparative pharmacokinetics/pharmacodynamics of clopidogrel besylate and clopidogrel bisulfate in healthy Korean subjects.

Clin Drug Investig 2012 Dec;32(12):817-26

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Jongno-gu, Seoul, Republic of Korea.

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http://dx.doi.org/10.1007/s40261-012-0007-3DOI Listing
December 2012

Multiple-dose pharmacokinetics of fesoterodine sustained-release in healthy Korean volunteers.

Int J Clin Pharmacol Ther 2012 Oct;50(10):722-8

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.

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http://dx.doi.org/10.5414/CP201708DOI Listing
October 2012

Reduced valproic acid serum concentrations due to drug interactions with carbapenem antibiotics: overview of 6 cases.

Ther Drug Monit 2012 Oct;34(5):599-603

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.

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http://dx.doi.org/10.1097/FTD.0b013e318260f7b3DOI Listing
October 2012

Evaluation of the pharmacokinetics, food effect, pharmacodynamics, and tolerability of DA-1229, a dipeptidyl peptidase IV inhibitor, in healthy volunteers: first-in-human study.

Clin Ther 2012 Sep 1;34(9):1986-98. Epub 2012 Sep 1.

Department of Clinical Pharmacology and Therapeutics, National University College of Medicine and Hospital, Jongno-gu, Seoul, Korea.

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http://dx.doi.org/10.1016/j.clinthera.2012.08.006DOI Listing
September 2012

Assessment of the pharmacokinetics of co-administered metformin and lobeglitazone, a thiazolidinedione antihyperglycemic agent, in healthy subjects.

Curr Med Res Opin 2012 Jul 2;28(7):1213-20. Epub 2012 Jul 2.

Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://www.tandfonline.com/doi/full/10.1185/03007995.2012.70
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http://dx.doi.org/10.1185/03007995.2012.703131DOI Listing
July 2012

The effect of fimasartan, an angiotensin receptor type 1 blocker, on the pharmacokinetics and pharmacodynamics of warfarin in healthy Korean male volunteers: a one-sequence, two-period crossover clinical trial.

Clin Ther 2012 Jul 22;34(7):1592-600. Epub 2012 Jun 22.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.1016/j.clinthera.2012.06.004DOI Listing
July 2012

Tolerability and pharmacokinetics of a new P-glycoprotein inhibitor, HM30181, in healthy Korean male volunteers: single- and multiple-dose randomized, placebo-controlled studies.

Clin Ther 2012 Feb 28;34(2):482-94. Epub 2012 Jan 28.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.1016/j.clinthera.2012.01.003DOI Listing
February 2012