Publications by authors named "Jonathan Seidman"

100Publications

Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles.

PLoS Genet 2020 Nov 20;16(11):e1009189. Epub 2020 Nov 20.

The Mindich Child Health and Development Institute and Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1009189DOI Listing
November 2020

Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2-Mediated COVID-19.

Mayo Clin Proc 2020 07 28;95(7):1354-1368. Epub 2020 Apr 28.

Department of Molecular Pharmacology & Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN; Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mayocp.2020.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186205PMC
July 2020

Congenital Heart Defects Due to Missense Variants.

Circ Genom Precis Med 2020 06 12;13(3):e002843. Epub 2020 May 12.

Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital (S.U.M., P.B.A.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGEN.119.002843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329268PMC
June 2020

The Translational Landscape of the Human Heart.

Cell 2019 06 30;178(1):242-260.e29. Epub 2019 May 30.

Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347 Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany; Charité-Universitätsmedizin, 10117 Berlin, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2019.05.010DOI Listing
June 2019

Novel Therapies for Prevention and Early Treatment of Cardiomyopathies.

Circ Res 2019 05;124(11):1536-1550

From the Department of Genetics, Harvard Medical School, Boston, MA (G.G.R., C.N.T., J.G.S., C.E.S.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.31356
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.119.313569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092753PMC
May 2019

Advances in the Genetic Basis and Pathogenesis of Sarcomere Cardiomyopathies.

Annu Rev Genomics Hum Genet 2019 08 12;20:129-153. Epub 2019 Apr 12.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; email:

View Article

Download full-text PDF

Source
https://www.annualreviews.org/doi/10.1146/annurev-genom-0831
Publisher Site
http://dx.doi.org/10.1146/annurev-genom-083118-015306DOI Listing
August 2019

SarcTrack.

Circ Res 2019 04;124(8):1172-1183

From the Department of Genetics (C.N.T., A.S., A.C.G., M.N., J.A.L.W., R.A., M.S., J.R., O.P., J.G.S., C.E.S.), Harvard Medical School, Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.118.314505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485312PMC
April 2019

Telomere shortening is a hallmark of genetic cardiomyopathies.

Proc Natl Acad Sci U S A 2018 09 27;115(37):9276-9281. Epub 2018 Aug 27.

Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305;

View Article

Download full-text PDF

Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1714538115
Publisher Site
http://dx.doi.org/10.1073/pnas.1714538115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140486PMC
September 2018

The Transcriptional Signature of Growth in Human Fetal Aortic Valve Development.

Ann Thorac Surg 2018 12 30;106(6):1834-1840. Epub 2018 Jul 30.

Department of Genetics, Harvard University, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.athoracsur.2018.06.034DOI Listing
December 2018

A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases.

Cell Rep 2018 07;24(2):515-527

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092947PMC
July 2018

Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy.

Heart Fail Clin 2018 Apr;14(2):139-146

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Department of Genetics, Brigham and Women's Hospital, Harvard Medical School, New Research Building Room 256, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15517136173012
Publisher Site
http://dx.doi.org/10.1016/j.hfc.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851453PMC
April 2018

ViroFind: A novel target-enrichment deep-sequencing platform reveals a complex JC virus population in the brain of PML patients.

PLoS One 2018 23;13(1):e0186945. Epub 2018 Jan 23.

Division of NeuroImmunology, Center for Virology and Vaccine Research, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186945PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779639PMC
February 2018

Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.

Dev Cell 2018 01 8;44(1):87-96.e5. Epub 2018 Jan 8.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2017.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421364PMC
January 2018

Fabry Disease in Families With Hypertrophic Cardiomyopathy: Clinical Manifestations in the Classic and Later-Onset Phenotypes.

Circ Cardiovasc Genet 2017 Aug;10(4)

From the Faculty of Medicine, University of Iceland, Reykjavik, Iceland (B.A., R.P., R.A., G.T.G.); Division of Cardiology (B.A., R.D.), Department of Genetics (R.A.), Division of Nephrology (R.P.), and Department of Radiology (M.G.), Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland; Department of Cardiology, Haukeland University Hospital, Bergen, Norway (B.A.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (R.J.D., B.C., S.P.); Department of Genetics, Harvard Medical School, Boston, MA (P.T., M.A.B., J.G.S., C.E.S.); Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.A., U.N.); Division of Cardiology, Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (M.M., B.J.M.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (M.A.B., C.E.S.); Division of Cardiology, Emory University School of Medicine, Atlanta, GA (M.A.B.); Department of Medical Endocrinology, Rigshospitalet and University of Copenhagen, Denmark (C.V.M., U.F.-R.); Howard Hughes Medical Institute, Boston, MA (C.E.S.); and Department of Medicine, Akureyri Hospital, Iceland (G.T.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.116.001639DOI Listing
August 2017

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.

Cancer Cell 2017 06 18;31(6):820-832.e3. Epub 2017 May 18.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502825PMC
June 2017

Early remodeling of repolarizing K currents in the αMHC mouse model of familial hypertrophic cardiomyopathy.

J Mol Cell Cardiol 2017 02 13;103:93-101. Epub 2017 Jan 13.

Department of Developmental Biology, Washington University Medical School, St. Louis, MO 63110-1093, USA; Department of Medicine, Washington University Medical School, St. Louis, MO 63110-1093, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2017.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398411PMC
February 2017

Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts.

J Vis Exp 2016 12 17(118). Epub 2016 Dec 17.

Department of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/54787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226409PMC
December 2016

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.

Cell Rep 2016 12;17(12):3292-3304

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.11.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193246PMC
December 2016

Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy.

J Am Coll Cardiol 2016 Dec;68(25):2871-2886

Department of Genetics, Harvard Medical School, Boston, Massachusetts; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Howard Hughes Medical Institute, Chevy Chase, Maryland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2016.08.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843375PMC
December 2016

Fulminant Myocarditis with Combination Immune Checkpoint Blockade.

N Engl J Med 2016 Nov;375(18):1749-1755

From the Departments of Medicine (D.B.J., J.M.B., M.H., I.P., M.R.A., T.L.B., J.R.B., D.A.S., E.J.P., M.A.P., D.M.R., J.A.S., J.J.M.), Cancer Biology (J.M.B., J.J.M.), Pathology, Microbiology, and Immunology (M.L.C., L.C.-O., R.D.H.), Biostatistics (Y.X.), Pharmacology (D.M.R.), and Biomedical Informatics (Y.X., D.M.R.), the Cardio-oncology Program (D.A.S., J.J.M.), the Breast Cancer Research Program (J.M.B.), and the Center for Quantitative Sciences (Y.X.), Vanderbilt University Medical Center, Nashville; the Department of Medicine (S.C.) and the Division of Neuroimmunology (S.C., I.J.K.), Beth Israel Deaconess Medical Center, the Departments of Medicine (B.A.O., C.E.S., J.G.S.) and Pathology (A.H.L.), Brigham and Women's Hospital, the Department of Genetics, Harvard Medical School (J.G., C.E.S., J.G.S.) - all in Boston; Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.); Bristol-Myers Squibb, New York (N.K., G.P., D.S.R., J.S.D.); Neon Therapeutics, Cambridge, MA (R.P.D.); and the Departments of Pathology (J.M.T., R.A.A.), Dermatology (J.M.T.), and Oncology (L.A.D.), Johns Hopkins University, Baltimore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1609214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247797PMC
November 2016

RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing.

Physiol Genomics 2016 10 5;48(10):749-761. Epub 2016 Aug 5.

Centre de recherche Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec, Canada; Department of Molecular Medicine, Laval University, Quebec, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00041.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195654PMC
October 2016

Detection of Cell Proliferation Markers by Immunofluorescence Staining and Microscopy Imaging in Paraffin-Embedded Tissue Sections.

Curr Protoc Mol Biol 2016 07 1;115:14.25.1-14.25.14. Epub 2016 Jul 1.

Department of Genetics, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpmb.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349766PMC
July 2016

Molecular profiling of dilated cardiomyopathy that progresses to heart failure.

JCI Insight 2016 May;1(6)

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.86898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882118PMC
May 2016

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.

Cell 2016 May 21;165(5):1147-1159. Epub 2016 Apr 21.

Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati 45247, OH, USA; Cincinnati Children's Hospital Medical Center, Howard Hughes Medical Institute, Cincinnati 45247, OH, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874838PMC
May 2016

The Muscle-Bound Heart.

Card Electrophysiol Clin 2016 Mar;8(1):223-31

Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccep.2015.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599619PMC
March 2016

Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies.

N Engl J Med 2016 Jan 6;374(3):233-41. Epub 2016 Jan 6.

From the Department of Genetics, Harvard Medical School (J.S.W., E.M., C.M.Y., C.E.S., J.G.S.), the Howard Hughes Medical Institute (C.E.S.), and the Cardiovascular Division, Brigham and Women's Hospital (J.S.W., E.M., C.E.S., J.G.S.) - all in Boston; the Cardiovascular Institute and the Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (J.L., T.D., T.P.C., Z.A.), the Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh (I.H., J.P., K.H.-Y., J.G., D.M.M.), and Penn State Hershey Medical Center, Hershey (J.B.) - all in Pennsylvania; the National Institute for Health Research Royal Brompton Cardiovascular Biomedical Research Unit (J.S.W., F.M., S.K.P.) and the National Heart and Lung Institute (J.S.W., F.M., S.A.C., S.K.P.), Imperial College London, London; the Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York (E.J.T.), and the University of Rochester, Rochester (J.A.) - both in New York; the Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany (D.H.-K.); the Department of Perinatology and Gynecology, the National Cerebral and Cardiovascular Center, Osaka, Japan (C.A.K.); the National Heart Center and Duke-National University of Singapore, Singapore (S.A.C.); the Intermountain Medical Center, Murray, Utah (R.A.); Vanderbilt University, Nashville (J.D.); Cleveland Clinic, Cleveland (E.H.); University of Southern California, Los Angeles (U.E.); McGill University and Jewish General Hospital, Montreal (R.S.), University of Calgary, Calgary, AB (A.K.), and University of Toronto, Toronto (P.L.) - all in Canada; University of Maryland, College Park (G.R.), and Johns Hopkins Hospital, Baltimore (I.S.W.) - both in Maryland; Morristown Hospital, Morristown (J.S.), and Newark Beth Israel Medical Center, Newark (M.J.Z.) - both in New Jersey; Truman Medical Center, University of Missouri, Kansas City (D.F.P.); and Wa

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1505517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797319PMC
January 2016

Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.

Circ Cardiovasc Genet 2015 Dec 9;8(6):812-22. Epub 2015 Nov 9.

From the Centre de recherche Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, Canada (S.G.-O., M.L., J.T.-M., E.L.-C., N.G., P.M., P.P., Y.B.); Departments of Molecular Medicine (A.D., Y.B.), Surgery (P.M.), and Medicine (P.P.), Laval University, Quebec, Canada; Cardiology Department, AP-HP, Bichat Hospital, Paris, France (D.M.-Z.); INSERM U698, Paris, France (D.M.-Z.); Département de Génétique, Hôpital Bichat, 75018 Paris, France (C.B.); Centre de Recherche du CHUQ, Quebec, Canada (A.D.); Montreal Heart Institute, Department of Medicine (M.-P.D., J.-C.T.), Université de Montréal, Montreal, Canada (B.J.A.); Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (S.C.B.); and Department of Genetics, Harvard Medical School, Boston, MA (J.G.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.115.001145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934886PMC
December 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Phenotype and prognostic correlations of the converter region mutations affecting the β myosin heavy chain.

Heart 2015 Jul 2;101(13):1047-53. Epub 2015 May 2.

Health in Code, A Coruña, Spain Inherited Cardiovascular Disease Unit, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas Universidade da Coruña (UDC), A Coruña, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/heartjnl-2014-307205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484257PMC
July 2015

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.

J Mol Cell Cardiol 2015 Feb 25;79:234-43. Epub 2014 Nov 25.

Department of Cell and Molecular Physiology, Health Sciences Division, Loyola University Chicago, Maywood, IL, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2014.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642280PMC
February 2015

Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells.

Nat Commun 2014 Nov 26;5:5507. Epub 2014 Nov 26.

1] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms6507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352754PMC
November 2014

Nationwide study on hypertrophic cardiomyopathy in Iceland: evidence of a MYBPC3 founder mutation.

Circulation 2014 Sep 30;130(14):1158-67. Epub 2014 Jul 30.

From Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland (B.A., R.D.); Faculty of Medicine (B.A., K.S., G.T.G.) and School of Engineering and Natural Sciences (D.F.G.), University of Iceland, Reykjavik, Iceland; Department of Genetics, Harvard Medical School, Boston, MA (P.T., M.A.B., S.R.D., E.M., B.M., J.G.S., C.E.S.); Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (M.A.B., C.E.S.); deCODE Genetics, Reykjavik, Iceland (D.F.G., H.H., K.S.); Howard Hughes Medical Institute, Boston, MA (C.E.S.); and Akureyri Hospital, Akureyri, Iceland (G.T.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.114.011207DOI Listing
September 2014

Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model.

Circ Res 2014 Jul 15;115(3):354-63. Epub 2014 May 15.

From the Departments of Cardiology, Boston Children's Hospital (Z.L., A.v.G., P.Z., F.G., Q.M., A.L.Y., J.N.B., K.A.G., P.R.R.v.G., B.Z., J.C., D.-Z.W., W.T.P.) and Genetics (J.J., J.G.S.), Harvard Medical School, Boston, MA; Department of Pediatric Cardiology and Intensive Care, MHH-Hannover Medical School, Hannover, Germany (A.v.G.); Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands (P.R.R.v.G.); Harvard Stem Cell Institute, Harvard University, Cambridge, MA (D.-Z.W., W.T.P.); and Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China (B.Z.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.115.303632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104149PMC
July 2014

Alpha blockade potentiates CPVT therapy in calsequestrin-mutant mice.

Heart Rhythm 2014 Aug 21;11(8):1471-9. Epub 2014 Apr 21.

Leviev Heart Center, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2014.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108570PMC
August 2014

Genetics and disease of ventricular muscle.

Cold Spring Harb Perspect Med 2014 Jan 1;4(1):a021063. Epub 2014 Jan 1.

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a021063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869277PMC
January 2014

The role of mutant protein level in autosomal recessive catecholamine dependent polymorphic ventricular tachycardia (CPVT2).

Biochem Pharmacol 2013 Dec 23;86(11):1576-83. Epub 2013 Sep 23.

Leviev Heart Center, Sheba Medical Center, Tel Hashomer and Sackler School of, Medicine, Tel Aviv University, Tel Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2013.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103182PMC
December 2013

HOXA2 haploinsufficiency in dominant bilateral microtia and hearing loss.

Hum Mutat 2013 Oct 11;34(10):1347-51. Epub 2013 Jul 11.

Department of Genetics, Harvard Medical School, Boston, Massachusetts; Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.22367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883620PMC
October 2013

Exercise training improves cardiac function and attenuates arrhythmia in CPVT mice.

J Appl Physiol (1985) 2012 Dec 4;113(11):1677-83. Epub 2012 Oct 4.

Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/japplphysiol.00818.201
Publisher Site
http://dx.doi.org/10.1152/japplphysiol.00818.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774075PMC
December 2012

Stable gene targeting in human cells using single-strand oligonucleotides with modified bases.

PLoS One 2012 14;7(5):e36697. Epub 2012 May 14.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036697PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351460PMC
September 2012

Barcoding bias in high-throughput multiplex sequencing of miRNA.

Genome Res 2011 Sep 12;21(9):1506-11. Epub 2011 Jul 12.

Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.121715.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166835PMC
September 2011

Optimizing catecholaminergic polymorphic ventricular tachycardia therapy in calsequestrin-mutant mice.

Heart Rhythm 2010 Nov 8;7(11):1676-82. Epub 2010 Jul 8.

Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2010.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103178PMC
November 2010

Genetics of hypertrophic cardiomyopathy.

Curr Opin Cardiol 2010 May;25(3):205-9

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/HCO.0b013e3283375698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932754PMC
May 2010

Locus for familial migrainous vertigo disease maps to chromosome 5q35.

Ann Otol Rhinol Laryngol 2009 Sep;118(9):670-6

Department of Genetics, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767209PMC
http://dx.doi.org/10.1177/000348940911800912DOI Listing
September 2009