Jonathan R Chubb

Jonathan R Chubb

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Jonathan R Chubb

Jonathan R Chubb

Publications by authors named "Jonathan R Chubb"

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Live imaging of ERK signalling dynamics in differentiating mouse embryonic stem cells.

Development 2019 Jun 3;146(12). Epub 2019 Jun 3.

MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK

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http://dev.biologists.org/lookup/doi/10.1242/dev.172940
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http://dx.doi.org/10.1242/dev.172940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602347PMC
June 2019

The fate of cells undergoing spontaneous DNA damage during development.

Development 2019 May 2;146(12). Epub 2019 May 2.

MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, London, UK

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http://dx.doi.org/10.1242/dev.174268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602350PMC
May 2019

Transition state dynamics during a stochastic fate choice.

Development 2019 Apr 8;146(12). Epub 2019 Apr 8.

Laboratory for Molecular Cell Biology and Division of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK

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http://dx.doi.org/10.1242/dev.173740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602359PMC
April 2019

The Atypical MAP Kinase ErkB Transmits Distinct Chemotactic Signals through a Core Signaling Module.

Dev Cell 2019 02 3;48(4):491-505.e9. Epub 2019 Jan 3.

Cell Biology Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807183103
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http://dx.doi.org/10.1016/j.devcel.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397043PMC
February 2019

Promoter-mediated diversification of transcriptional bursting dynamics following gene duplication.

Proc Natl Acad Sci U S A 2018 08 30;115(33):8364-8369. Epub 2018 Jul 30.

Medical Research Council Laboratory for Molecular Cell Biology, University College London, WC1E 6BT London, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1800943115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099902PMC
August 2018

Symmetry breaking in development and stochastic gene expression.

Authors:
Jonathan R Chubb

Wiley Interdiscip Rev Dev Biol 2017 11 18;6(6). Epub 2017 Jul 18.

MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, London, UK.

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http://dx.doi.org/10.1002/wdev.284DOI Listing
November 2017

Generation of Single-Cell Transcript Variability by Repression.

Curr Biol 2017 Jun 8;27(12):1811-1817.e3. Epub 2017 Jun 8.

Laboratory for Molecular Cell Biology and Division of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2017.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483230PMC
June 2017

A continuum model of transcriptional bursting.

Elife 2016 Feb 20;5. Epub 2016 Feb 20.

Division of Cell and Developmental Biology, University College London, London, United Kingdom.

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https://elifesciences.org/content/5/e13051v1-download.pdf
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http://elifesciences.org/lookup/doi/10.7554/eLife.13051
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http://dx.doi.org/10.7554/eLife.13051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850746PMC
February 2016

Gene Regulation: Stable Noise.

Authors:
Jonathan R Chubb

Curr Biol 2016 Jan;26(2):R61-R64

MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2015.12.002DOI Listing
January 2016

Quantitative measurement of transcription dynamics in living cells.

Methods Cell Biol 2015 8;125:29-41. Epub 2015 Jan 8.

MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1016/bs.mcb.2014.11.001DOI Listing
September 2015

Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity.

Development 2015 Aug 24;142(16):2840-9. Epub 2015 Jul 24.

Medical Research Council Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK

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http://dx.doi.org/10.1242/dev.120741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550964PMC
August 2015

Imaging nascent RNA dynamics in Dictyostelium.

Methods Mol Biol 2013 ;1042:101-13

MRC Laboratory for Molecular Cell Biology, Department of Cell and Developmental Biology, University College London, London, UK.

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http://dx.doi.org/10.1007/978-1-62703-526-2_8DOI Listing
March 2014

Regulation of transcriptional bursting by a naturally oscillating signal.

Curr Biol 2014 Jan 2;24(2):205-11. Epub 2014 Jan 2.

MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2013.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928820PMC
January 2014

Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote.

Nucleic Acids Res 2012 Aug 16;40(15):7247-56. Epub 2012 May 16.

Nuclear Signalling Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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http://dx.doi.org/10.1093/nar/gks367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424546PMC
August 2012

Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation.

Proc Natl Acad Sci U S A 2012 May 23;109(19):7350-5. Epub 2012 Apr 23.

Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1117603109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358836PMC
May 2012

Pol II caught speeding by single gene imaging.

EMBO Rep 2011 Dec 1;12(12):1208-10. Epub 2011 Dec 1.

Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/embor.2011.217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245703PMC
December 2011

Nuclear organization and transcriptional dynamics in Dictyostelium.

Dev Growth Differ 2011 May;53(4):576-86

Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://doi.wiley.com/10.1111/j.1440-169X.2011.01271.x
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http://dx.doi.org/10.1111/j.1440-169X.2011.01271.xDOI Listing
May 2011

Bursts and pulses: insights from single cell studies into transcriptional mechanisms.

Curr Opin Genet Dev 2010 Oct 16;20(5):478-84. Epub 2010 Jul 16.

Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1016/j.gde.2010.06.009DOI Listing
October 2010

Stable morphology, but dynamic internal reorganisation, of interphase human chromosomes in living cells.

PLoS One 2010 Jul 13;5(7):e11560. Epub 2010 Jul 13.

Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, UK.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011560PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903487PMC
July 2010

Methylation of H3K4 Is required for inheritance of active transcriptional states.

Curr Biol 2010 Mar 25;20(5):397-406. Epub 2010 Feb 25.

Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S09609822100005
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http://dx.doi.org/10.1016/j.cub.2010.01.017DOI Listing
March 2010

Digital nature of the immediate-early transcriptional response.

Development 2010 Feb;137(4):579-84

Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1242/dev.043836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827614PMC
February 2010

Gene activation at the edge of the nucleus.

Authors:
Jonathan R Chubb

EMBO J 2009 Aug;28(15):2145-6

Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2009.148
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http://dx.doi.org/10.1038/emboj.2009.148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726702PMC
August 2009

Live imaging of the Dictyostelium cell cycle reveals widespread S phase during development, a G2 bias in spore differentiation and a premitotic checkpoint.

Development 2008 May 26;135(9):1647-57. Epub 2008 Mar 26.

Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1242/dev.020115DOI Listing
May 2008

Recruitment to the nuclear periphery can alter expression of genes in human cells.

PLoS Genet 2008 Mar 21;4(3):e1000039. Epub 2008 Mar 21.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1000039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265557PMC
March 2008

The spatial order of transcription in mammalian cells.

J Cell Biochem 2007 Oct;102(3):609-17

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1002/jcb.21495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956920PMC
October 2007

Epigenetics in Dictyostelium.

Methods Mol Biol 2006 ;346:491-505

Abt. Genetik, Kassel University, Germany.

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http://dx.doi.org/10.1385/1-59745-144-4:491DOI Listing
October 2006

Transcriptional pulsing of a developmental gene.

Curr Biol 2006 May;16(10):1018-25

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, The Bronx, New York 10461, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096098220601426
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http://dx.doi.org/10.1016/j.cub.2006.03.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764056PMC
May 2006

Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase.

Dev Biol 2006 Apr 15;292(2):519-32. Epub 2006 Feb 15.

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.ydbio.2005.12.054DOI Listing
April 2006

The radial positioning of chromatin is not inherited through mitosis but is established de novo in early G1.

Curr Biol 2004 Jan;14(2):166-72

Medical Research Council, Human Genetics Unit, Edinburgh EH4 2XU, United Kingdom.

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http://dx.doi.org/10.1016/j.cub.2003.12.024DOI Listing
January 2004

Dispatch. Chromosome position: now, where was I?

Curr Biol 2003 Apr;13(9):R357-9

MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1016/s0960-9822(03)00276-8DOI Listing
April 2003

Considering nuclear compartmentalization in the light of nuclear dynamics.

Cell 2003 Feb;112(4):403-6

MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, United Kingdom.

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http://dx.doi.org/10.1016/s0092-8674(03)00078-3DOI Listing
February 2003

Pseudopodium dynamics and rapid cell movement in Dictyostelium Ras pathway mutants.

Cell Motil Cytoskeleton 2002 Oct;53(2):150-62

School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1002/cm.10064DOI Listing
October 2002

Chromatin motion is constrained by association with nuclear compartments in human cells.

Curr Biol 2002 Mar;12(6):439-45

MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/s0960-9822(02)00695-4DOI Listing
March 2002