Jonathan R Chekan

Jonathan R Chekan

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Jonathan R Chekan

Jonathan R Chekan

Publications by authors named "Jonathan R Chekan"

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18Publications

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Biosynthesis of l-4-Chlorokynurenine, an Antidepressant Prodrug and a Non-Proteinogenic Amino Acid Found in Lipopeptide Antibiotics.

Angew Chem Int Ed Engl 2019 Jun 13;58(25):8394-8399. Epub 2019 May 13.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1002/anie.201901571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555645PMC
June 2019

Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid.

Angew Chem Int Ed Engl 2019 Jun 10;58(25):8454-8457. Epub 2019 May 10.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093, USA.

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http://doi.wiley.com/10.1002/anie.201902910
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http://dx.doi.org/10.1002/anie.201902910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574125PMC
June 2019

Preparation and Characterization of Tetrabromopyrrole Debrominase From Marine Proteobacteria.

Methods Enzymol 2018 16;605:253-265. Epub 2018 Mar 16.

Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2018.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211843PMC
May 2019

Bacterial Tetrabromopyrrole Debrominase Shares a Reductive Dehalogenation Strategy with Human Thyroid Deiodinase.

Biochemistry 2019 May 22. Epub 2019 May 22.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography , University of California San Diego , La Jolla , California 92093 , United States.

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http://dx.doi.org/10.1021/acs.biochem.9b00318DOI Listing
May 2019

Biosynthesis of the Antibiotic Bicyclomycin in Soil and Pathogenic Bacteria.

Biochemistry 2018 02 9;57(6):897-898. Epub 2018 Jan 9.

Scripps Institution of Oceanography and ‡Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego , La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b01204DOI Listing
February 2018

Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.

Proc Natl Acad Sci U S A 2017 06 5;114(25):6551-6556. Epub 2017 Jun 5.

Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801;

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http://dx.doi.org/10.1073/pnas.1620499114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488928PMC
June 2017

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes.

Chem Rev 2017 Apr 30;117(8):5457-5520. Epub 2017 Jan 30.

Howard Hughes Medical Institute and Department of Chemistry, ‡Department of Biochemistry, and §Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.

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http://dx.doi.org/10.1021/acs.chemrev.6b00591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408752PMC
April 2017

Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.

ACS Chem Biol 2017 02 27;12(2):456-463. Epub 2016 Dec 27.

Department of Biochemistry, ‡Department of Chemistry, §Carl R. Woese Institute for Genomic Biology, ∥Howard Hughes Medical Institute, and ⊥Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.

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http://dx.doi.org/10.1021/acschembio.6b00939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315633PMC
February 2017

Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates.

J Am Chem Soc 2016 12 7;138(50):16452-16458. Epub 2016 Dec 7.

Department of Biochemistry, ‡Institute for Genomic Biology and §Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States and.

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http://dx.doi.org/10.1021/jacs.6b10389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245167PMC
December 2016

Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides.

Medchemcomm 2016 Jan 12;7(1):28-36. Epub 2015 Oct 12.

Department of Biochemistry, University of Illinois at Urbana Champaign, USA; Center for Biophysics and Computational Biology, University of Illinois at Urbana Champaign, USA; Institute for Genomic Biology, University of Illinois at Urbana Champaign, USA.

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http://dx.doi.org/10.1039/C5MD00351BDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723106PMC
January 2016

A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase.

J Am Chem Soc 2015 Mar 26;137(9):3217-20. Epub 2015 Feb 26.

Howard Hughes Medical Institute and Department of Chemistry, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.

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http://pubs.acs.org/doi/10.1021/jacs.5b00282
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http://dx.doi.org/10.1021/jacs.5b00282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487810PMC
March 2015

Structural and biochemical basis for mannan utilization by Caldanaerobius polysaccharolyticus strain ATCC BAA-17.

J Biol Chem 2014 Dec 23;289(50):34965-77. Epub 2014 Oct 23.

From the Departments of Biochemistry, Institute for Genomic Biology, Center for Biophysics and Computational Biology, and

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http://dx.doi.org/10.1074/jbc.M114.579904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263893PMC
December 2014

Chemical rescue and inhibition studies to determine the role of Arg301 in phosphite dehydrogenase.

PLoS One 2014 31;9(1):e87134. Epub 2014 Jan 31.

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America ; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America ; Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087134PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909101PMC
October 2014

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis.

Nat Chem Biol 2014 Oct 17;10(10):823-9. Epub 2014 Aug 17.

1] Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. [2] Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. [3] Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

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http://dx.doi.org/10.1038/nchembio.1608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167974PMC
October 2014

Xylan utilization in human gut commensal bacteria is orchestrated by unique modular organization of polysaccharide-degrading enzymes.

Proc Natl Acad Sci U S A 2014 Sep 18;111(35):E3708-17. Epub 2014 Aug 18.

Energy Biosciences Institute, Institute for Genomic Biology, and Departments of Animal Sciences, Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801

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http://dx.doi.org/10.1073/pnas.1406156111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156774PMC
September 2014

Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation.

Chem Biol 2014 Jan 19;21(1):125-35. Epub 2013 Dec 19.

Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10745521130041
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http://dx.doi.org/10.1016/j.chembiol.2013.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313731PMC
January 2014