Jonathan R Brody

Jonathan R Brody

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Jonathan R Brody

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Abemaciclib Is Effective Against Pancreatic Cancer Cells and Synergizes with HuR and YAP1 Inhibition.

Mol Cancer Res 2019 Oct 5;17(10):2029-2041. Epub 2019 Aug 5.

Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-19-0589DOI Listing
October 2019

Evaluation of Post-transcriptional Gene Regulation in Pancreatic Cancer Cells: Studying RNA Binding Proteins and Their mRNA Targets.

Methods Mol Biol 2019 ;1882:239-252

Division of Surgical Research, Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

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http://link.springer.com/10.1007/978-1-4939-8879-2_22
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http://dx.doi.org/10.1007/978-1-4939-8879-2_22DOI Listing
June 2019

RNA-Binding Protein HuR Regulates Both Mutant and Wild-Type IDH1 in IDH1-Mutated Cancer.

Mol Cancer Res 2019 02 28;17(2):508-520. Epub 2018 Sep 28.

Department of Surgery, University Hospitals; Case Western University, School of Medicine, Cleveland, Ohio.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-18-0557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359963PMC
February 2019

Corrigendum: Metabolic Dependencies in Pancreatic Cancer.

Front Oncol 2018 31;8:672. Epub 2019 Jan 31.

School of Medicine, Case Western Reserve University, Cleveland, OH, United States.

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http://dx.doi.org/10.3389/fonc.2018.00672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371022PMC
January 2019

Metabolic Dependencies in Pancreatic Cancer.

Front Oncol 2018 12;8:617. Epub 2018 Dec 12.

School of Medicine, Case Western Reserve University, Cleveland, OH, United States.

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http://dx.doi.org/10.3389/fonc.2018.00617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315177PMC
December 2018

Genetic Drivers of Pancreatic Cancer Are Identical Between the Primary Tumor and a Secondary Lesion in a Long-Term (>5 Years) Survivor After a Whipple Procedure.

J Pancreat Cancer 2018 1;4(1):81-87. Epub 2018 Nov 1.

Department of Surgery, The Jefferson Pancreas, Biliary, and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/pancan.2018.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371588PMC
November 2018

Prevalence of Homologous Recombination-Related Gene Mutations Across Multiple Cancer Types.

JCO Precis Oncol 2018 23;2018. Epub 2018 Jul 23.

Arielle L. Heeke, Michael J. Pishvaian, Filipa Lynce, John L. Marshall, Claudine Isaacs, Georgetown University, Washington, DC, Joanne Xiu, Wang-Juh Chen, Tabari M. Baker, Caris Life Sciences, Inc., Phoenix, AZ; and Jonathan R. Brody, Thomas Jefferson University, Philadelphia, PA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139373PMC
http://dx.doi.org/10.1200/PO.17.00286DOI Listing
July 2018

Precious Data: Interim Report from the Jefferson Pancreas Tumor Registry.

J Pancreat Cancer 2018 1;4(1):17-24. Epub 2018 Jun 1.

Department of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.

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http://www.liebertpub.com/doi/10.1089/pancan.2018.0004
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http://dx.doi.org/10.1089/pancan.2018.0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145534PMC
June 2018

Complex HuR function in pancreatic cancer cells.

Wiley Interdiscip Rev RNA 2018 05 16;9(3):e1469. Epub 2018 Feb 16.

Department of Cancer Biology and University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas.

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http://dx.doi.org/10.1002/wrna.1469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040811PMC
May 2018

A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2.

J Am Coll Surg 2018 04 7;226(4):596-603. Epub 2018 Feb 7.

Jefferson Pancreas, Biliary and Related Cancer Center and Department of Surgery, Thomas Jefferson University, Philadelphia, PA; Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10727515183006
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http://dx.doi.org/10.1016/j.jamcollsurg.2017.12.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047862PMC
April 2018

STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair.

Clin Cancer Res 2018 04 26;24(8):1917-1931. Epub 2018 Feb 26.

Department of Pathology, Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036914PMC
April 2018

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype.

Mol Cancer Res 2017 06 27;15(6):696-707. Epub 2017 Feb 27.

Division of Surgical Research, Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466444PMC
June 2017

Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer.

Oncology (Williston Park) 2017 Mar;31(3):159-66, 168

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March 2017

The Landscape of Pancreatic Cancer Therapeutic Resistance Mechanisms.

Int J Biol Sci 2016 27;12(3):273-82. Epub 2016 Jan 27.

1. Department of Surgery, The Jefferson Pancreas, Biliary, and Related Cancer Center;

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http://dx.doi.org/10.7150/ijbs.14951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753156PMC
December 2016

WEE1 inhibition in pancreatic cancer cells is dependent on DNA repair status in a context dependent manner.

Sci Rep 2016 09 12;6:33323. Epub 2016 Sep 12.

Department of Surgery, Division of Surgical Research; Jefferson Pancreas, Biliary and Related Cancer Center; Jefferson Medical College; Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/srep33323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018859PMC
September 2016

HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells.

Mol Cancer Res 2016 07 6;14(7):599-611. Epub 2016 Apr 6.

Division of Surgical Research, Department of Surgery, Jefferson Pancreas, Biliary, and Related Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312260PMC
July 2016

Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth.

Cancer Res 2016 Mar 26;76(6):1549-59. Epub 2016 Feb 26.

Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania. Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-15-2073DOI Listing
March 2016

Personalized therapy for pancreatic cancer: Do we need better targets, arrows, or both?

Discov Med 2016 Feb;21(114):117-23

Department of Surgery and the Jefferson Pancreatic, Biliary, and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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February 2016

Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine.

Gastroenterology 2016 Jan 15;150(1):48-63. Epub 2015 Sep 15.

Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.08.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010785PMC
January 2016

Upgrading gemcitabine with recycled kinase inhibitors.

Cell Cycle 2014 ;13(18):2810-1

a Department of Surgery ; Thomas Jefferson University ; Philadelphia , PA USA.

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http://dx.doi.org/10.4161/15384101.2014.954211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613457PMC
December 2015

Current Standards and Novel Treatment Options for Metastatic Pancreatic Adenocarcinoma.

Oncology (Williston Park) 2015 Nov;29(11):809-20, 886

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November 2015

Studying RNA-binding protein interactions with target mRNAs in eukaryotic cells: native ribonucleoprotein immunoprecipitation (RIP) assays.

Methods Mol Biol 2015 ;1262:239-46

Department of Surgery, The Jefferson Pancreas, Biliary, and Related Cancer Center, Thomas Jefferson University, 623 College Building, 1015 Walnut St., Philadelphia, PA, 19107, USA.

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http://dx.doi.org/10.1007/978-1-4939-2253-6_14DOI Listing
September 2015

MUC1 Promoter-Driven DTA as a Targeted Therapeutic Strategy against Pancreatic Cancer.

Mol Cancer Res 2015 Mar 21;13(3):439-48. Epub 2014 Oct 21.

Department of Surgery and the Jefferson Pancreas, Biliary, and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0199DOI Listing
March 2015

Novel targets in pancreatic cancer research.

Semin Oncol 2015 Feb 10;42(1):177-87. Epub 2014 Dec 10.

Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1053/j.seminoncol.2014.12.015DOI Listing
February 2015

PARP inhibitors for chemoprevention--letter.

Cancer Prev Res (Phila) 2014 Nov;7(11):1170-1

Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0220DOI Listing
November 2014

Fusing transcriptomics to progressive prostate cancer.

Am J Pathol 2014 Oct 14;184(10):2608-10. Epub 2014 Aug 14.

Division of Surgical Research, Department of Surgery, The Jefferson Pancreas, Biliary, and Related Cancer Center, Sidney Kimmel Medical College, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.08.001DOI Listing
October 2014

HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells.

Cancer Res 2014 Feb;74(4):1128-40

Authors' Affiliations: Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Jefferson Medical College; Computational Medicine Center; Kimmel Cancer Center, Thomas Jefferson University; Fox Chase Cancer Center, Philadelphia; and Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353573PMC
February 2014

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

Cancer Res 2014 Jan 4;74(1):31-7. Epub 2013 Nov 4.

Authors' Affiliations: Departments of Biochemistry and Molecular Biology and Surgery, Division of Surgical Research, The Jefferson Pancreas, Biliary, and Related Cancer Center; and Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-1701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903668PMC
January 2014

Structural Implications for Selective Targeting of PARPs.

Front Oncol 2013 Dec 20;3:301. Epub 2013 Dec 20.

Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University , Philadelphia, PA , USA.

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http://journal.frontiersin.org/article/10.3389/fonc.2013.003
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http://dx.doi.org/10.3389/fonc.2013.00301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868897PMC
December 2013

Molecular-based and alternative therapies for pancreatic cancer: looking "out of the box".

Cancer J 2012 Nov-Dec;18(6):665-73

Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/PPO.0b013e3182793ff6DOI Listing
August 2013

Diagnostic, prognostic, and predictive biomarkers in pancreatic cancer.

J Surg Oncol 2013 Jan 21;107(1):15-22. Epub 2012 Jun 21.

Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/jso.23192DOI Listing
January 2013

Molecular profiling of synchronous and metachronous cancers of the pancreas reveal molecular mimicry between samples from the same patient.

J Surg Res 2012 Jul 12;176(1):154-8. Epub 2011 Oct 12.

Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1016/j.jss.2011.09.043DOI Listing
July 2012

HuR's role in gemcitabine efficacy: an exception or opportunity?

Wiley Interdiscip Rev RNA 2011 May-Jun;2(3):435-44. Epub 2010 Nov 30.

Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/wrna.62DOI Listing
March 2012

Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival.

Cell Cycle 2011 Dec 15;10(24):4250-5. Epub 2011 Dec 15.

Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.10.24.18551DOI Listing
December 2011

The past, present, and future of biomarkers: a need for molecular beacons for the clinical management of pancreatic cancer.

Adv Surg 2011 ;45:301-21

Department of Surgery, Jefferson Pancreas Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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October 2011

Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma.

Hum Pathol 2010 Sep 22;41(9):1205-9. Epub 2010 Jun 22.

Department of Pathology, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00468177100010
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http://dx.doi.org/10.1016/j.humpath.2010.03.004DOI Listing
September 2010

CXCR4 signaling identifies a role for IFT2 in ER-negative breast cancers.

Cancer Biol Ther 2010 Sep 7;10(6):615-6. Epub 2010 Sep 7.

Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cbt.10.6.12906
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http://dx.doi.org/10.4161/cbt.10.6.12906DOI Listing
September 2010

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers.

Cancer Biol Ther 2010 Jul 7;10(2):135-43. Epub 2010 Jul 7.

Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040896PMC
http://dx.doi.org/10.4161/cbt.10.2.11983DOI Listing
July 2010

Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway.

J Gastroenterol Hepatol 2010 Apr 19;25(4):738-44. Epub 2009 Nov 19.

Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://doi.wiley.com/10.1111/j.1440-1746.2009.06085.x
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http://dx.doi.org/10.1111/j.1440-1746.2009.06085.xDOI Listing
April 2010

Identifying pancreatic cancer patients for targeted treatment: the challenges and limitations of the current selection process and vision for the future.

Expert Opin Drug Deliv 2010 Mar;7(3):273-84

Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Jefferson Pancreatic Tumor Registry, Department of Surgery, Suite 611A Curtis Building, Philadelphia, PA 19107, USA.

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http://www.tandfonline.com/doi/full/10.1517/1742524090354446
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http://dx.doi.org/10.1517/17425240903544462DOI Listing
March 2010

The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase.

Cancer Res 2009 Jun;69(11):4567-72

Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Departments of Pathology and Pharmacology and Experimental Therapeutics, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744447PMC
June 2009

Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome.

Cell Cycle 2008 Oct 23;7(19):3021-5. Epub 2008 Oct 23.

Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.7.19.6719
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http://dx.doi.org/10.4161/cc.7.19.6719DOI Listing
October 2008

Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells.

Cancer Biol Ther 2008 Oct 3;7(10):1584-90. Epub 2008 Oct 3.

Department of Surgery, Thomas Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218426PMC
http://dx.doi.org/10.4161/cbt.7.10.6562DOI Listing
October 2008

Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells.

Cancer Biol Ther 2008 Sep 23;7(9):1496-506. Epub 2008 Sep 23.

Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey 08106, USA.

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http://dx.doi.org/10.4161/cbt.7.9.6490DOI Listing
September 2008

Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?

Cancer Biol Ther 2008 Jul 21;7(7):986-94. Epub 2008 Apr 21.

Department of Surgery, Thomas Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University Philadelphia, Pennsylvania 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081718PMC
http://dx.doi.org/10.4161/cbt.7.7.6181DOI Listing
July 2008

A syngeneic variance library for functional annotation of human variation: application to BRCA2.

Cancer Res 2008 Jul;68(13):5023-30

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536704PMC
July 2008

Expression of indoleamine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection.

J Am Coll Surg 2008 May 4;206(5):849-54; discussion 854-6. Epub 2008 Mar 4.

Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.jamcollsurg.2007.12.014DOI Listing
May 2008

High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif.

Cancer Res 2007 Oct;67(19):9055-65

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0474DOI Listing
October 2007

No K01 offered from the NCI What's the message?

Cancer Biol Ther 2007 Jul;6(7):1002; discussion 1003-4

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http://dx.doi.org/10.4161/cbt.6.7.4619DOI Listing
July 2007

Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer.

Cancer Biol Ther 2007 May 7;6(5):654-60. Epub 2007 Feb 7.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.4161/cbt.6.5.3978DOI Listing
May 2007

High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells.

Cancer Res 2007 Mar;67(5):2169-77

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2711DOI Listing
March 2007

Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy.

Cancer Res 2006 Oct;66(19):9369-73

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2165DOI Listing
October 2006

A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes.

Cancer Biol Ther 2006 Aug 2;5(8):923-7. Epub 2006 Aug 2.

Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center and The Sidney Kimmel Comprehensive Cancer Center at The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.4161/cbt.5.8.2976DOI Listing
August 2006