Jonathan R Brody

Jonathan R Brody

UNVERIFIED PROFILE

Are you Jonathan R Brody?   Register this Author

Register author
Jonathan R Brody

Jonathan R Brody

Publications by authors named "Jonathan R Brody"

Are you Jonathan R Brody?   Register this Author

100Publications

1844Reads

12Profile Views

Abemaciclib Is Effective Against Pancreatic Cancer Cells and Synergizes with HuR and YAP1 Inhibition.

Authors:
Teena Dhir Christopher W Schultz Aditi Jain Samantha Z Brown Alex Haber Austin Goetz Chunhua Xi Gloria H Su Liang Xu James Posey Wei Jiang Charles J Yeo Talia Golan Michael J Pishvaian Jonathan R Brody

Mol Cancer Res 2019 Oct 5;17(10):2029-2041. Epub 2019 Aug 5.

Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1541-7786.MCR-19-0589DOI Listing
October 2019

The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells.

Authors:
Erika Parasido George S Avetian Aisha Naeem Garrett Graham Michael Pishvaian Eric Glasgow Shaila Mudambi Yichien Lee Chukwuemeka Ihemelandu Muhammad Choudhry Ivana Peran Partha P Banerjee Maria Laura Avantaggiati Kirsten Bryant Elisa Baldelli Mariaelena Pierobon Lance Liotta Emanuel Petricoin Stanley T Fricke Aimy Sebastian Joseph Cozzitorto Gabriela G Loots Deepak Kumar Stephen Byers Eric Londin Analisa DiFeo Goutham Narla Jordan Winter Jonathan R Brody Olga Rodriguez Chris Albanese

Mol Cancer Res 2019 Sep 4;17(9):1815-1827. Epub 2019 Jun 4.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1541-7786.MCR-19-0191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726538PMC
September 2019

Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer.

Authors:
Aditi Jain Lebaron C Agostini Grace A McCarthy Saswati N Chand AnnJosette Ramirez Avinoam Nevler Joseph Cozzitorto Christopher W Schultz Cinthya Yabar Lowder Kate M Smith Ian D Waddell Maria Raitses-Gurevich Chani Stossel Yulia Glick Gorman Dikla Atias Charles J Yeo Jordan M Winter Kenneth P Olive Talia Golan Michael J Pishvaian Donald Ogilvie Dominic I James Allan M Jordan Jonathan R Brody

Cancer Res 2019 Sep 4;79(17):4491-4502. Epub 2019 Jul 4.

The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-18-3645DOI Listing
September 2019

Multi-omic molecular comparison of primary versus metastatic pancreatic tumours.

Authors:
Gagandeep Brar Edik M Blais R Joseph Bender Jonathan R Brody Davendra Sohal Subha Madhavan Vincent J Picozzi Andrew E Hendifar Vincent M Chung David Halverson Sameh Mikhail Lynn M Matrisian Lola Rahib Emanuel Petricoin Michael J Pishvaian

Br J Cancer 2019 Jul 11;121(3):264-270. Epub 2019 Jul 11.

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41416-019-0507-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738081PMC
July 2019

Evaluation of Post-transcriptional Gene Regulation in Pancreatic Cancer Cells: Studying RNA Binding Proteins and Their mRNA Targets.

Authors:
Aditi Jain Samantha Z Brown Henry L Thomsett Eric Londin Jonathan R Brody

Methods Mol Biol 2019 ;1882:239-252

Division of Surgical Research, Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/978-1-4939-8879-2_22
Publisher Site
http://dx.doi.org/10.1007/978-1-4939-8879-2_22DOI Listing
June 2019

A Pilot Trial of Molecularly Tailored Therapy for Patients with Metastatic Pancreatic Ductal Adenocarcinoma.

Authors:
Anteneh A Tesfaye Hongkun Wang Marion L Hartley Aiwu Ruth He Louis Weiner Nina Gabelia Lana Kapanadze Muhammad Shezad Jonathan R Brody John L Marshall Michael J Pishvaian

J Pancreat Cancer 2019 2;5(1):12-21. Epub 2019 May 2.

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1089/pancan.2019.0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503449PMC
May 2019

RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells.

Authors:
Hehai Pan Adam Strickland Vedavathi Madhu Zariel I Johnson Saswati N Chand Jonathan R Brody Andrzej Fertala Zhaomin Zheng Irving M Shapiro Makarand V Risbud

Matrix Biol 2019 04 7;77:23-40. Epub 2018 Aug 7.

Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.matbio.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367062PMC
April 2019

RNA-Binding Protein HuR Regulates Both Mutant and Wild-Type IDH1 in IDH1-Mutated Cancer.

Authors:
Mahsa Zarei Shruti Lal Ali Vaziri-Gohar Kevin O'Hayer Venugopal Gunda Pankaj K Singh Jonathan R Brody Jordan M Winter

Mol Cancer Res 2019 02 28;17(2):508-520. Epub 2018 Sep 28.

Department of Surgery, University Hospitals; Case Western University, School of Medicine, Cleveland, Ohio.

View Article

Download full-text PDF

 Source
http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
Publisher Site
http://dx.doi.org/10.1158/1541-7786.MCR-18-0557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359963PMC
February 2019

Host Gene Status Influences Tumor Progression and Radiotherapy Response in -Driven Sporadic Pancreatic Cancers.

Authors:
Avinoam Nevler Alexander J Muller Erika Sutanto-Ward James B DuHadaway Kei Nagatomo Eric Londin Kevin O'Hayer Joseph A Cozzitorto Harish Lavu Theresa P Yeo Mark Curtis Tatiana Villatoro Benjamin E Leiby Laura Mandik-Nayak Jordan M Winter Charles J Yeo George C Prendergast Jonathan R Brody

Clin Cancer Res 2019 Jan 28;25(2):724-734. Epub 2018 Sep 28.

Departments of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-18-0814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335160PMC
January 2019

Corrigendum: Metabolic Dependencies in Pancreatic Cancer.

Authors:
Ali Vaziri-Gohar Mahsa Zarei Jonathan R Brody Jordan M Winter

Front Oncol 2018 31;8:672. Epub 2019 Jan 31.

School of Medicine, Case Western Reserve University, Cleveland, OH, United States.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3389/fonc.2018.00672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371022PMC
January 2019

Metabolic Dependencies in Pancreatic Cancer.

Authors:
Ali Vaziri-Gohar Mahsa Zarei Jonathan R Brody Jordan M Winter

Front Oncol 2018 12;8:617. Epub 2018 Dec 12.

School of Medicine, Case Western Reserve University, Cleveland, OH, United States.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3389/fonc.2018.00617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315177PMC
December 2018

Genetic Drivers of Pancreatic Cancer Are Identical Between the Primary Tumor and a Secondary Lesion in a Long-Term (>5 Years) Survivor After a Whipple Procedure.

Authors:
Tyler M Bauer Teena Dhir Adam Strickland Henry Thomsett Austin B Goetz Shawnna Cannaday Jonathan R Brody Michael J Pishvaian Charles J Yeo

J Pancreat Cancer 2018 1;4(1):81-87. Epub 2018 Nov 1.

Department of Surgery, The Jefferson Pancreas, Biliary, and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1089/pancan.2018.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371588PMC
November 2018

Molecular Profiling of Patients with Pancreatic Cancer: Initial Results from the Know Your Tumor Initiative.

Authors:
Michael J Pishvaian Robert J Bender David Halverson Lola Rahib Andrew E Hendifar Sameh Mikhail Vincent Chung Vincent J Picozzi Davendra Sohal Edik M Blais Kimberly Mason Emily E Lyons Lynn M Matrisian Jonathan R Brody Subha Madhavan Emanuel F Petricoin

Clin Cancer Res 2018 10 28;24(20):5018-5027. Epub 2018 Jun 28.

Perthera, Inc, McLean, Virginia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1078-0432.CCR-18-0531DOI Listing
October 2018

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.

Authors:
Hervé Tiriac Pascal Belleau Dannielle D Engle Dennis Plenker Astrid Deschênes Tim D D Somerville Fieke E M Froeling Richard A Burkhart Robert E Denroche Gun-Ho Jang Koji Miyabayashi C Megan Young Hardik Patel Michelle Ma Joseph F LaComb Randze Lerie D Palmaira Ammar A Javed Jasmine C Huynh Molly Johnson Kanika Arora Nicolas Robine Minita Shah Rashesh Sanghvi Austin B Goetz Cinthya Y Lowder Laura Martello Else Driehuis Nicolas LeComte Gokce Askan Christine A Iacobuzio-Donahue Hans Clevers Laura D Wood Ralph H Hruban Elizabeth Thompson Andrew J Aguirre Brian M Wolpin Aaron Sasson Joseph Kim Maoxin Wu Juan Carlos Bucobo Peter Allen Divyesh V Sejpal William Nealon James D Sullivan Jordan M Winter Phyllis A Gimotty Jean L Grem Dominick J DiMaio Jonathan M Buscaglia Paul M Grandgenett Jonathan R Brody Michael A Hollingsworth Grainne M O'Kane Faiyaz Notta Edward Kim James M Crawford Craig Devoe Allyson Ocean Christopher L Wolfgang Kenneth H Yu Ellen Li Christopher R Vakoc Benjamin Hubert Sandra E Fischer Julie M Wilson Richard Moffitt Jennifer Knox Alexander Krasnitz Steven Gallinger David A Tuveson

Cancer Discov 2018 09 31;8(9):1112-1129. Epub 2018 May 31.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/2159-8290.CD-18-0349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125219PMC
September 2018

Prevalence of Homologous Recombination-Related Gene Mutations Across Multiple Cancer Types.

Authors:
Arielle L Heeke Michael J Pishvaian Filipa Lynce Joanne Xiu Jonathan R Brody Wang-Juh Chen Tabari M Baker John L Marshall Claudine Isaacs

JCO Precis Oncol 2018 23;2018. Epub 2018 Jul 23.

Arielle L. Heeke, Michael J. Pishvaian, Filipa Lynce, John L. Marshall, Claudine Isaacs, Georgetown University, Washington, DC, Joanne Xiu, Wang-Juh Chen, Tabari M. Baker, Caris Life Sciences, Inc., Phoenix, AZ; and Jonathan R. Brody, Thomas Jefferson University, Philadelphia, PA.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139373PMC
http://dx.doi.org/10.1200/PO.17.00286DOI Listing
July 2018

A phase 2 study of the PARP inhibitor veliparib plus temozolomide in patients with heavily pretreated metastatic colorectal cancer.

Authors:
Michael J Pishvaian Rebecca S Slack Wei Jiang A Ruth He Jimmy J Hwang Amy Hankin Karen Dorsch-Vogel Divyesh Kukadiya Louis M Weiner John L Marshall Jonathan R Brody

Cancer 2018 06 26;124(11):2337-2346. Epub 2018 Mar 26.

Jefferson Pancreas, Biliary, and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/cncr.31309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992024PMC
June 2018

Precious Data: Interim Report from the Jefferson Pancreas Tumor Registry.

Authors:
Theresa P Yeo Harish Lavu Avinoam Nevler Jennifer Brumbaugh Dominique Vicchairelli Jordan M Winter Jonathan R Brody Charles J Yeo

J Pancreat Cancer 2018 1;4(1):17-24. Epub 2018 Jun 1.

Department of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://www.liebertpub.com/doi/10.1089/pancan.2018.0004
Publisher Site
http://dx.doi.org/10.1089/pancan.2018.0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145534PMC
June 2018

Complex HuR function in pancreatic cancer cells.

Authors:
Jonathan R Brody Dan A Dixon

Wiley Interdiscip Rev RNA 2018 05 16;9(3):e1469. Epub 2018 Feb 16.

Department of Cancer Biology and University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/wrna.1469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040811PMC
May 2018

Identification of a novel metabolic-related mutation (IDH1) in metastatic pancreatic cancer.

Authors:
Jonathan R Brody Cinthya S Yabar Mahsa Zarei Joseph Bender Lynn M Matrisian Lola Rahib Craig Heartwell Kimberly Mason Charles J Yeo Stephen C Peiper Wei Jiang Katelyn Varieur Subha Madhavan Emanuel Petricoin Danielle Fortuna Mark Curtis Zi-Xuan Wang Michael J Pishvaian Jordan M Winter

Cancer Biol Ther 2018 04 6;19(4):249-253. Epub 2018 Mar 6.

a Department of Surgery , Jefferson Pancreas, Biliary and Related Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University , Philadelphia , PA , USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1080/15384047.2016.1210743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902240PMC
April 2018

A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2.

Authors:
Avinoam Nevler Alexander J Muller Joseph A Cozzitorto Austin Goetz Jordan M Winter Theresa P Yeo Harish Lavu Charles J Yeo George C Prendergast Jonathan R Brody

J Am Coll Surg 2018 04 7;226(4):596-603. Epub 2018 Feb 7.

Jefferson Pancreas, Biliary and Related Cancer Center and Department of Surgery, Thomas Jefferson University, Philadelphia, PA; Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S10727515183006
Publisher Site
http://dx.doi.org/10.1016/j.jamcollsurg.2017.12.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047862PMC
April 2018

STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair.

Authors:
Cristina Maranto Vindhya Udhane David T Hoang Lei Gu Vitali Alexeev Kareem Malas Karmel Cardenas Jonathan R Brody Ulrich Rodeck Carmen Bergom Ken A Iczkowski Ken Jacobsohn William See Sara M Schmitt Marja T Nevalainen

Clin Cancer Res 2018 04 26;24(8):1917-1931. Epub 2018 Feb 26.

Department of Pathology, Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1078-0432.CCR-17-2768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036914PMC
April 2018

Cytoplasmic HuR Status Predicts Disease-free Survival in Resected Pancreatic Cancer: A Post-hoc Analysis From the International Phase III ESPAC-3 Clinical Trial.

Authors:
Talar Tatarian Wei Jiang Benjamin E Leiby Amanda Grigoli Masaya Jimbo Nooreen Dabbish John P Neoptolemos William Greenhalf Eithne Costello Paula Ghaneh Christopher Halloran Daniel Palmer Markus Buchler Charles J Yeo Jordan M Winter Jonathan R Brody

Ann Surg 2018 02;267(2):364-369

Jefferson Pancreas, Biliary, and Related Cancer Center, Department of Surgery, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/SLA.0000000000002088DOI Listing
February 2018

Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development.

Authors:
Weidan Peng Narumi Furuuchi Ludmila Aslanukova Yu-Hung Huang Samantha Z Brown Wei Jiang Sankar Addya Vikalp Vishwakarma Erika Peters Jonathan R Brody Dan A Dixon Janet A Sawicki

Mol Cell Biol 2018 02 16;38(3). Epub 2018 Jan 16.

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, USA

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1128/MCB.00427-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770537PMC
February 2018

A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative.

Authors:
Michael J Pishvaian R Joseph Bender Lynn M Matrisian Lola Rahib Andrew Hendifar William A Hoos Sam Mikhail Vincent Chung Vincent Picozzi Craig Heartwell Kimberly Mason Katelyn Varieur Metasebia Aberra Subha Madhavan Emanuel Petricoin Jonathan R Brody

Oncotarget 2017 Oct 8;8(48):83446-83456. Epub 2016 Nov 8.

Perthera, Inc, McLean, VA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.13225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663527PMC
October 2017

Posttranscriptional Regulation of mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors.

Authors:
Saswati N Chand Mahsa Zarei Matthew J Schiewer Akshay R Kamath Carmella Romeo Shruti Lal Joseph A Cozzitorto Avinoam Nevler Laura Scolaro Eric Londin Wei Jiang Nicole Meisner-Kober Michael J Pishvaian Karen E Knudsen Charles J Yeo John M Pascal Jordan M Winter Jonathan R Brody

Cancer Res 2017 09 7;77(18):5011-5025. Epub 2017 Jul 7.

Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-2704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663502PMC
September 2017

Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells.

Authors:
Mahsa Zarei Shruti Lal Seth J Parker Avinoam Nevler Ali Vaziri-Gohar Katerina Dukleska Nicole C Mambelli-Lisboa Cynthia Moffat Fernando F Blanco Saswati N Chand Masaya Jimbo Joseph A Cozzitorto Wei Jiang Charles J Yeo Eric R Londin Erin L Seifert Christian M Metallo Jonathan R Brody Jordan M Winter

Cancer Res 2017 08 26;77(16):4460-4471. Epub 2017 Jun 26.

Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-17-0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922269PMC
August 2017

Quantification and expert evaluation of evidence for chemopredictive biomarkers to personalize cancer treatment.

Authors:
Shruti Rao Robert A Beckman Shahla Riazi Cinthya S Yabar Simina M Boca John L Marshall Michael J Pishvaian Jonathan R Brody Subha Madhavan

Oncotarget 2017 Jun;8(23):37923-37934

Innovation Center for Biomedical Informatics, Georgetown University, Washington, DC, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.13544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514962PMC
June 2017

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype.

Authors:
Shruti Lal Edwin C Cheung Mahsa Zarei Ranjan Preet Saswati N Chand Nicole C Mambelli-Lisboa Carmella Romeo Matthew C Stout Eric Londin Austin Goetz Cinthya Y Lowder Avinoam Nevler Charles J Yeo Paul M Campbell Jordan M Winter Dan A Dixon Jonathan R Brody

Mol Cancer Res 2017 06 27;15(6):696-707. Epub 2017 Feb 27.

Division of Surgical Research, Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1541-7786.MCR-16-0361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466444PMC
June 2017

Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas.

Authors:
Natini Jinawath Meng-Shin Shiao Alexis Norris Kathleen Murphy Alison P Klein Raluca Yonescu Christine Iacobuzio-Donahue Alan Meeker Artit Jinawath Charles J Yeo James R Eshleman Ralph H Hruban Jonathan R Brody Constance A Griffin Shuko Harada

Genes Chromosomes Cancer 2017 05 7;56(5):427-435. Epub 2017 Mar 7.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/gcc.22447DOI Listing
May 2017

BRCA2 secondary mutation-mediated resistance to platinum and PARP inhibitor-based therapy in pancreatic cancer.

Authors:
Michael J Pishvaian Andrew V Biankin Peter Bailey David K Chang Daniel Laheru Christopher L Wolfgang Jonathan R Brody

Br J Cancer 2017 Apr 14;116(8):1021-1026. Epub 2017 Mar 14.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/bjc.2017.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396101PMC
April 2017

Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer.

Authors:
Michael J Pishvaian Jonathan R Brody

Oncology (Williston Park) 2017 Mar;31(3):159-66, 168

View Article

Download full-text PDF

 Source
March 2017

The Landscape of Pancreatic Cancer Therapeutic Resistance Mechanisms.

Authors:
Saswati Chand Kevin O'Hayer Fernando F Blanco Jordan M Winter Jonathan R Brody

Int J Biol Sci 2016 27;12(3):273-82. Epub 2016 Jan 27.

1. Department of Surgery, The Jefferson Pancreas, Biliary, and Related Cancer Center;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.7150/ijbs.14951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753156PMC
December 2016

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis.

Authors:
Fernando F Blanco Ranjan Preet Andrea Aguado Vikalp Vishwakarma Laura E Stevens Alok Vyas Subhash Padhye Liang Xu Scott J Weir Shrikant Anant Nicole Meisner-Kober Jonathan R Brody Dan A Dixon

Oncotarget 2016 Nov;7(45):74043-74058

Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.12189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342034PMC
November 2016

WEE1 inhibition in pancreatic cancer cells is dependent on DNA repair status in a context dependent manner.

Authors:
Shruti Lal Mahsa Zarei Saswati N Chand Emanuela Dylgjeri Nicole C Mambelli-Lisboa Michael J Pishvaian Charles J Yeo Jordan M Winter Jonathan R Brody

Sci Rep 2016 09 12;6:33323. Epub 2016 Sep 12.

Department of Surgery, Division of Surgical Research; Jefferson Pancreas, Biliary and Related Cancer Center; Jefferson Medical College; Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep33323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018859PMC
September 2016

HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells.

Authors:
Carmella Romeo Matthew C Weber Mahsa Zarei Danielle DeCicco Saswati N Chand Angie D Lobo Jordan M Winter Janet A Sawicki Jonathan N Sachs Nicole Meisner-Kober Charles J Yeo Rajanikanth Vadigepalli Mark L Tykocinski Jonathan R Brody

Mol Cancer Res 2016 07 6;14(7):599-611. Epub 2016 Apr 6.

Division of Surgical Research, Department of Surgery, Jefferson Pancreas, Biliary, and Related Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1541-7786.MCR-15-0448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312260PMC
July 2016

Insights from HuR biology point to potential improvement for second-line ovarian cancer therapy.

Authors:
Yu-Hung Huang Weidan Peng Narumi Furuuchi James B DuHadaway Masaya Jimbo Andrea Pirritano Charles J Dunton Gary S Daum Benjamin E Leiby Jonathan R Brody Janet A Sawicki

Oncotarget 2016 Apr;7(16):21812-24

Lankenau Institute for Medical Research, Wynnewood, PA 19086, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.7840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008325PMC
April 2016

Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth.

Authors:
Yu-Hung Huang Weidan Peng Narumi Furuuchi Jacquelyn Gerhart Kelly Rhodes Neelanjan Mukherjee Masaya Jimbo Gregory E Gonye Jonathan R Brody Robert C Getts Janet A Sawicki

Cancer Res 2016 Mar 26;76(6):1549-59. Epub 2016 Feb 26.

Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania. Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-15-2073DOI Listing
March 2016

Personalized therapy for pancreatic cancer: Do we need better targets, arrows, or both?

Authors:
Kevin M O'Hayer Jonathan R Brody

Discov Med 2016 Feb;21(114):117-23

Department of Surgery and the Jefferson Pancreatic, Biliary, and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
February 2016

Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine.

Authors:
Erik S Knudsen Eileen M O'Reilly Jonathan R Brody Agnieszka K Witkiewicz

Gastroenterology 2016 Jan 15;150(1):48-63. Epub 2015 Sep 15.

Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1053/j.gastro.2015.08.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010785PMC
January 2016

Upgrading gemcitabine with recycled kinase inhibitors.

Authors:
Fernando F Blanco Michael J Pishvaian Jonathan R Brody

Cell Cycle 2014 ;13(18):2810-1

a Department of Surgery ; Thomas Jefferson University ; Philadelphia , PA USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4161/15384101.2014.954211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613457PMC
December 2015

Current Standards and Novel Treatment Options for Metastatic Pancreatic Adenocarcinoma.

Authors:
Benjamin A Weinberg Cinthya S Yabar Jonathan R Brody Michael J Pishvaian

Oncology (Williston Park) 2015 Nov;29(11):809-20, 886

View Article

Download full-text PDF

 Source
November 2015

Studying RNA-binding protein interactions with target mRNAs in eukaryotic cells: native ribonucleoprotein immunoprecipitation (RIP) assays.

Authors:
Joseph A Cozzitorto Masaya Jimbo Saswati Chand Fernando Blanco Shruti Lal Melissa Gilbert Jordan M Winter Myriam Gorospe Jonathan R Brody

Methods Mol Biol 2015 ;1262:239-46

Department of Surgery, The Jefferson Pancreas, Biliary, and Related Cancer Center, Thomas Jefferson University, 623 College Building, 1015 Walnut St., Philadelphia, PA, 19107, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/978-1-4939-2253-6_14DOI Listing
September 2015

Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells.

Authors:
Masaya Jimbo Fernando F Blanco Yu-Hung Huang Aristeidis G Telonis Brad A Screnci Gabriela L Cosma Vitali Alexeev Gregory E Gonye Charles J Yeo Janet A Sawicki Jordan M Winter Jonathan R Brody

Oncotarget 2015 Sep;6(29):27312-31

Department of Surgery and The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.4743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694992PMC
September 2015

Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer.

Authors:
Agnieszka K Witkiewicz Nicholas A Borja Jorge Franco Jonathan R Brody Charles J Yeo John Mansour Michael A Choti Peter McCue Erik S Knudsen

Oncotarget 2015 Jun;6(18):15788-801

Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599237PMC
http://dx.doi.org/10.18632/oncotarget.3819DOI Listing
June 2015

MUC1 Promoter-Driven DTA as a Targeted Therapeutic Strategy against Pancreatic Cancer.

Authors:
Renee M Tholey Shruti Lal Masaya Jimbo Richard A Burkhart Fernando F Blanco Joseph A Cozzitorto Josh D Eisenberg Wei Jiang Christine A Iacobuzio-Donahue Agnieszka K Witkiewicz Melissa Glbert Charles J Yeo Jonathan R Brody Janet A Sawicki Jordan M Winter

Mol Cancer Res 2015 Mar 21;13(3):439-48. Epub 2014 Oct 21.

Department of Surgery and the Jefferson Pancreas, Biliary, and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1541-7786.MCR-14-0199DOI Listing
March 2015

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs.

Authors:
Eric Londin Phillipe Loher Aristeidis G Telonis Kevin Quann Peter Clark Yi Jing Eleftheria Hatzimichael Yohei Kirino Shozo Honda Michelle Lally Bharat Ramratnam Clay E S Comstock Karen E Knudsen Leonard Gomella George L Spaeth Lisa Hark L Jay Katz Agnieszka Witkiewicz Abdolmohamad Rostami Sergio A Jimenez Michael A Hollingsworth Jen Jen Yeh Chad A Shaw Steven E McKenzie Paul Bray Peter T Nelson Simona Zupo Katrien Van Roosbroeck Michael J Keating George A Calin Charles Yeo Masaya Jimbo Joseph Cozzitorto Jonathan R Brody Kathleen Delgrosso John S Mattick Paolo Fortina Isidore Rigoutsos

Proc Natl Acad Sci U S A 2015 Mar 23;112(10):E1106-15. Epub 2015 Feb 23.

Computational Medicine Center, Sidney Kimmel Medical School at Thomas Jefferson University, Philadelphia, PA 19107;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1073/pnas.1420955112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364231PMC
March 2015

Novel targets in pancreatic cancer research.

Authors:
Geoffrey Kozak Fernando F Blanco Jonathan R Brody

Semin Oncol 2015 Feb 10;42(1):177-87. Epub 2014 Dec 10.

Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, PA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1053/j.seminoncol.2014.12.015DOI Listing
February 2015

PARP inhibitors for chemoprevention--letter.

Authors:
Saswati N Chand Fernando F Blanco Masaya Jimbo Theodore N Tsangaris Massimo Cristofanilli Charles J Yeo Jordan M Winter Michael J Pishvaian Jonathan R Brody

Cancer Prev Res (Phila) 2014 Nov;7(11):1170-1

Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1940-6207.CAPR-14-0220DOI Listing
November 2014

Fusing transcriptomics to progressive prostate cancer.

Authors:
Masaya Jimbo Karen E Knudsen Jonathan R Brody

Am J Pathol 2014 Oct 14;184(10):2608-10. Epub 2014 Aug 14.

Division of Surgical Research, Department of Surgery, The Jefferson Pancreas, Biliary, and Related Cancer Center, Sidney Kimmel Medical College, Philadelphia, Pennsylvania. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ajpath.2014.08.001DOI Listing
October 2014

dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: a dual-institutional follow-up with the RTOG 9704 trial.

Authors:
Florencia McAllister Danielle M Pineda Masaya Jimbo Shruti Lal Richard A Burkhart Jennifer Moughan Kathryn A Winter Kotb Abdelmohsen Myriam Gorospe Ana de Jesus Acosta Rachana H Lankapalli Jordan M Winter Charles J Yeo Agnieska K Witkiewicz Christine A Iacobuzio-Donahue Daniel Laheru Jonathan R Brody

Cancer Biol Ther 2014 Jun 11;15(6):688-98. Epub 2014 Mar 11.

Department of Surgery; Division of Surgical Research; The Jefferson Pancreas, Biliary, and Related Cancer Center; Jefferson Medical College; Thomas Jefferson University; Philadelphia, PA USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4161/cbt.28413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049785PMC
June 2014

HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells.

Authors:
Shruti Lal Richard A Burkhart Neil Beeharry Vikram Bhattacharjee Eric R Londin Joseph A Cozzitorto Carmella Romeo Masaya Jimbo Zoë A Norris Charles J Yeo Janet A Sawicki Jordan M Winter Isidore Rigoutsos Timothy J Yen Jonathan R Brody

Cancer Res 2014 Feb;74(4):1128-40

Authors' Affiliations: Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Jefferson Medical College; Computational Medicine Center; Kimmel Cancer Center, Thomas Jefferson University; Fox Chase Cancer Center, Philadelphia; and Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-1915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353573PMC
February 2014

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

Authors:
Jamin D Steffen Renee M Tholey Marie-France Langelier Jamie L Planck Matthew J Schiewer Shruti Lal Nikolai A Bildzukewicz Charles J Yeo Karen E Knudsen Jonathan R Brody John M Pascal

Cancer Res 2014 Jan 4;74(1):31-7. Epub 2013 Nov 4.

Authors' Affiliations: Departments of Biochemistry and Molecular Biology and Surgery, Division of Surgical Research, The Jefferson Pancreas, Biliary, and Related Cancer Center; and Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

 Source
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-13-1701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903668PMC
January 2014

Structural Implications for Selective Targeting of PARPs.

Authors:
Jamin D Steffen Jonathan R Brody Roger S Armen John M Pascal

Front Oncol 2013 Dec 20;3:301. Epub 2013 Dec 20.

Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University , Philadelphia, PA , USA.

View Article

Download full-text PDF

 Source
http://journal.frontiersin.org/article/10.3389/fonc.2013.003
Publisher Site
http://dx.doi.org/10.3389/fonc.2013.00301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868897PMC
December 2013

Molecular-based and alternative therapies for pancreatic cancer: looking "out of the box".

Authors:
Renee Tholey Janet A Sawicki Jonathan R Brody

Cancer J 2012 Nov-Dec;18(6):665-73

Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/PPO.0b013e3182793ff6DOI Listing
August 2013

Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival.

Authors:
Richard A Burkhart Yu Peng Zoë A Norris Renée M Tholey Vanessa A Talbott Qin Liang Yongxing Ai Kathy Miller Shruti Lal Joseph A Cozzitorto Agnieska K Witkiewicz Charles J Yeo Matthew Gehrmann Andrew Napper Jordan M Winter Janet A Sawicki Zhihao Zhuang Jonathan R Brody

Mol Cancer Res 2013 Aug 21;11(8):901-11. Epub 2013 May 21.

Thomas Jefferson University, 1015 Walnut Street, Curtis 611A, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1541-7786.MCR-12-0699DOI Listing
August 2013

HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer.

Authors:
Richard A Burkhart Danielle M Pineda Saswati N Chand Carmella Romeo Eric R Londin Edward D Karoly Joseph A Cozzitorto Isidore Rigoutsos Charles J Yeo Jonathan R Brody Jordan M Winter

RNA Biol 2013 Aug 13;10(8):1312-23. Epub 2013 Jun 13.

Department of Surgery; Jefferson Pancreas, Biliary and Related Cancer Center; Philadelphia, PA USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4161/rna.25274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817153PMC
August 2013

A novel survival-based tissue microarray of pancreatic cancer validates MUC1 and mesothelin as biomarkers.

Authors:
Jordan M Winter Laura H Tang David S Klimstra Murray F Brennan Jonathan R Brody Flavio G Rocha Xiaoyu Jia Li-Xuan Qin Michael I D'Angelica Ronald P DeMatteo Yuman Fong William R Jarnagin Eileen M O'Reilly Peter J Allen

PLoS One 2012 6;7(7):e40157. Epub 2012 Jul 6.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America [corrected].

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040157PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391218PMC
March 2013

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

Authors:
Wan-chi Lin Nirakar Rajbhandari Chengbao Liu Kazuhito Sakamoto Qian Zhang Aleata A Triplett Surinder K Batra Rene Opavsky Dean W Felsher Dominick J DiMaio Michael A Hollingsworth John P Morris Matthias Hebrok Agnieszka K Witkiewicz Jonathan R Brody Hallgeir Rui Kay-Uwe Wagner

Cancer Res 2013 Mar 6;73(6):1821-30. Epub 2013 Mar 6.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198-5950, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-12-2067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602120PMC
March 2013

Diagnostic, prognostic, and predictive biomarkers in pancreatic cancer.

Authors:
Jordan M Winter Charles J Yeo Jonathan R Brody

J Surg Oncol 2013 Jan 21;107(1):15-22. Epub 2012 Jun 21.

Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/jso.23192DOI Listing
January 2013

Dual roles of PARP-1 promote cancer growth and progression.

Authors:
Matthew J Schiewer Jonathan F Goodwin Sumin Han J Chad Brenner Michael A Augello Jeffry L Dean Fengzhi Liu Jamie L Planck Preethi Ravindranathan Arul M Chinnaiyan Peter McCue Leonard G Gomella Ganesh V Raj Adam P Dicker Jonathan R Brody John M Pascal Margaret M Centenera Lisa M Butler Wayne D Tilley Felix Y Feng Karen E Knudsen

Cancer Discov 2012 Dec 19;2(12):1134-49. Epub 2012 Sep 19.

Departments of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/2159-8290.CD-12-0120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519969PMC
December 2012

HuR's post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells.

Authors:
Danielle M Pineda David W Rittenhouse Christopher C Valley Joseph A Cozzitorto Richard A Burkhart Benjamin Leiby Jordan M Winter Matthew C Weber Eric R Londin Isidore Rigoutsos Charles J Yeo Myriam Gorospe Agnieska K Witkiewicz Jonathan N Sachs Jonathan R Brody

Cancer Biol Ther 2012 Aug 1;13(10):946-55. Epub 2012 Aug 1.

Department of Surgery, Division of Surgical Research, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4161/cbt.20952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414415PMC
August 2012

Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma.

Authors:
Matias E Valsecchi Mary McDonald Jonathan R Brody Terry Hyslop Boris Freydin Charles J Yeo Charalambos Solomides Stephen C Peiper Agnieszka K Witkiewicz

Cancer 2012 Jul 15;118(14):3484-93. Epub 2011 Nov 15.

Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/cncr.26661DOI Listing
July 2012

Molecular profiling of synchronous and metachronous cancers of the pancreas reveal molecular mimicry between samples from the same patient.

Authors:
Vanessa A Talbott Charles J Yeo Jonathan R Brody Agnieszka K Witkiewicz

J Surg Res 2012 Jul 12;176(1):154-8. Epub 2011 Oct 12.

Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jss.2011.09.043DOI Listing
July 2012

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized.

Authors:
Christopher C Valley Andrew K Lewis Deepti J Mudaliar Jason D Perlmutter Anthony R Braun Christine B Karim David D Thomas Jonathan R Brody Jonathan N Sachs

J Biol Chem 2012 Jun 10;287(25):21265-78. Epub 2012 Apr 10.

Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.

View Article

Download full-text PDF

 Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M111.306480
Publisher Site
http://dx.doi.org/10.1074/jbc.M111.306480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375548PMC
June 2012

HuR's role in gemcitabine efficacy: an exception or opportunity?

Authors:
Jonathan R Brody Gregory E Gonye

Wiley Interdiscip Rev RNA 2011 May-Jun;2(3):435-44. Epub 2010 Nov 30.

Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/wrna.62DOI Listing
March 2012

Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?

Authors:
Matias E Valsecchi Thomas Holdbrook Benjamin E Leiby Edward Pequignot Susan J Littman Charles J Yeo Jonathan R Brody Agnieszka K Witkiewicz

BMC Cancer 2012 Mar 22;12:104. Epub 2012 Mar 22.

Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1471-2407-12-104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364898PMC
March 2012

Subject review: pancreatic ductal adenocarcinoma in the setting of mutations in the cystic fibrosis transmembrane conductance regulator gene: case report and review of the literature.

Authors:
David W Rittenhouse Vanessa A Talbott Zafia Anklesaria Jonathan R Brody Agneszkia K Witkiewicz Charles J Yeo

J Gastrointest Surg 2011 Dec 2;15(12):2284-90. Epub 2011 Aug 2.

Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/s11605-011-1639-y
Publisher Site
http://dx.doi.org/10.1007/s11605-011-1639-yDOI Listing
December 2011

Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival.

Authors:
Karen N Wu Maria Queenan Jonathan R Brody Magdalena Potoczek Federica Sotgia Michael P Lisanti Agnieszka K Witkiewicz

Cell Cycle 2011 Dec 15;10(24):4250-5. Epub 2011 Dec 15.

Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4161/cc.10.24.18551DOI Listing
December 2011

The past, present, and future of biomarkers: a need for molecular beacons for the clinical management of pancreatic cancer.

Authors:
Jonathan R Brody Agnieszka K Witkiewicz Charles J Yeo

Adv Surg 2011 ;45:301-21

Department of Surgery, Jefferson Pancreas Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
October 2011

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers.

Authors:
Agnieszka K Witkiewicz Jessica Kline Maria Queenan Jonathan R Brody Aristotelis Tsirigos Erhan Bilal Stephanos Pavlides Adam Ertel Federica Sotgia Michael P Lisanti

Cell Cycle 2011 Jun 1;10(11):1794-809. Epub 2011 Jun 1.

Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142463PMC
http://dx.doi.org/10.4161/cc.10.11.15675DOI Listing
June 2011

CanScript, an 18-Base pair DNA sequence, boosts tumor cell-specific promoter activity: implications for targeted gene therapy.

Authors:
Yu-Hung Huang Joseph A Cozzitorto Nathan G Richards Ahmed A Eltoukhy Charles J Yeo Robert Langer Daniel G Anderson Jonathan R Brody Janet A Sawicki

Cancer Biol Ther 2010 Nov 1;10(9):878-84. Epub 2010 Nov 1.

Lankenau Institute for Medical Research, Wynnewood, PA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4161/cbt.10.9.13234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040857PMC
November 2010

pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs.

Authors:
Timothy K Williams Christina L Costantino Nikolai A Bildzukewicz Nathan G Richards David W Rittenhouse Lisa Einstein Joseph A Cozzitorto Judith C Keen Abhijit Dasgupta Myriam Gorospe Gregory E Gonye Charles J Yeo Agnieszka K Witkiewicz Jonathan R Brody

PLoS One 2010 Nov 29;5(11):e15455. Epub 2010 Nov 29.

Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015455PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994932PMC
November 2010

Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma.

Authors:
Adam D Toll Abhijit Dasgupta Magdalena Potoczek Charles J Yeo Celina G Kleer Jonathan R Brody Agnieszka K Witkiewicz

Hum Pathol 2010 Sep 22;41(9):1205-9. Epub 2010 Jun 22.

Department of Pathology, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S00468177100010
Publisher Site
http://dx.doi.org/10.1016/j.humpath.2010.03.004DOI Listing
September 2010

CXCR4 signaling identifies a role for IFT2 in ER-negative breast cancers.

Authors:
Jonathan R Brody Agnieszka K Witkiewicz

Cancer Biol Ther 2010 Sep 7;10(6):615-6. Epub 2010 Sep 7.

Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://www.tandfonline.com/doi/abs/10.4161/cbt.10.6.12906
Publisher Site
http://dx.doi.org/10.4161/cbt.10.6.12906DOI Listing
September 2010

HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients.

Authors:
Nathan G Richards David W Rittenhouse Boris Freydin Joseph A Cozzitorto Dane Grenda Hallgeir Rui Greg Gonye Eugene P Kennedy Charles J Yeo Jonathan R Brody Agnieszka K Witkiewicz

Ann Surg 2010 Sep;252(3):499-505; discussion 505-6

Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/SLA.0b013e3181f1fd44DOI Listing
September 2010

Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrence.

Authors:
Agnieszka K Witkiewicz Boris Freydin Inna Chervoneva Magdalena Potoczek Wendy Rizzo Hallgeir Rui Jonathan R Brody Gordon F Schwartz Michael P Lisanti

Cancer Biol Ther 2010 Aug 21;10(4):391-6. Epub 2010 Aug 21.

Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040854PMC
http://dx.doi.org/10.4161/cbt.10.4.12449DOI Listing
August 2010

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers.

Authors:
Agnieszka K Witkiewicz Abhijit Dasgupta Sara Sammons Ozlem Er Magdalena B Potoczek Fran Guiles Federica Sotgia Jonathan R Brody Edith P Mitchell Michael P Lisanti

Cancer Biol Ther 2010 Jul 7;10(2):135-43. Epub 2010 Jul 7.

Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040896PMC
http://dx.doi.org/10.4161/cbt.10.2.11983DOI Listing
July 2010

Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway.

Authors:
Shayna L Showalter Ziqiu Wang Christina L Costantino Agnieszka K Witkiewicz Charles J Yeo Jonathan R Brody Brian I Carr

J Gastroenterol Hepatol 2010 Apr 19;25(4):738-44. Epub 2009 Nov 19.

Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

 Source
http://doi.wiley.com/10.1111/j.1440-1746.2009.06085.x
Publisher Site
http://dx.doi.org/10.1111/j.1440-1746.2009.06085.xDOI Listing
April 2010

Identifying pancreatic cancer patients for targeted treatment: the challenges and limitations of the current selection process and vision for the future.

Authors:
Shayna L Showalter Sarah Charles Justin Belin Joseph Cozzitorto Peter Einstein Nathan G Richards Patricia K Sauter Eugene P Kennedy Agnes Witkiewicz Jonathan R Brody Charles J Yeo

Expert Opin Drug Deliv 2010 Mar;7(3):273-84

Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Jefferson Pancreatic Tumor Registry, Department of Surgery, Suite 611A Curtis Building, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
http://www.tandfonline.com/doi/full/10.1517/1742524090354446
Publisher Site
http://dx.doi.org/10.1517/17425240903544462DOI Listing
March 2010

The 'RNA-binding ome': future implications for chemotherapeutic efficacy.

Authors:
Jonathan R Brody Agnieszka K Witkiewicz Charles J Yeo Myriam Gorospe Judith C Keen

Future Oncol 2009 Nov;5(9):1317-9

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.2217/fon.09.114DOI Listing
November 2009

Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma.

Authors:
Ronald T Cotton Donghui Li Steven E Scherer Donna M Muzny Sally E Hodges Robbi L Catania Agnieszka K Witkiewicz Jonathan R Brody Eugene P Kennedy Charles J Yeo F Charles Brunicardi Richard A Gibbs Marie-Claude Gingras William E Fisher

HPB (Oxford) 2009 Aug;11(5):435-44

Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1111/j.1477-2574.2009.00089.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742614PMC
August 2009

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers.

Authors:
Agnieszka K Witkiewicz Abhijit Dasgupta Federica Sotgia Isabelle Mercier Richard G Pestell Michael Sabel Celina G Kleer Jonathan R Brody Michael P Lisanti

Am J Pathol 2009 Jun 1;174(6):2023-34. Epub 2009 May 1.

Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, 233 South 10 Street, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
http://linkinghub.elsevier.com/retrieve/pii/S000294401061062
Publisher Site
http://dx.doi.org/10.2353/ajpath.2009.080873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684168PMC
June 2009

Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival.

Authors:
Jonathan R Brody Christina L Costantino Adam C Berger Takami Sato Michael P Lisanti Charles J Yeo Robert V Emmons Agnieszka K Witkiewicz

Cell Cycle 2009 Jun 15;8(12):1930-4. Epub 2009 Jun 15.

Department of Surgery, Thomas Jefferson University Philadelphia, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4161/cc.8.12.8745DOI Listing
June 2009

The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase.

Authors:
Christina L Costantino Agnieszka K Witkiewicz Yuki Kuwano Joseph A Cozzitorto Eugene P Kennedy Abhijit Dasgupta Judith C Keen Charles J Yeo Myriam Gorospe Jonathan R Brody

Cancer Res 2009 Jun;69(11):4567-72

Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Departments of Pathology and Pharmacology and Experimental Therapeutics, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-09-0371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744447PMC
June 2009

Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma.

Authors:
Jonathan R Brody Christina L Costantino Magdalena Potoczek Joseph Cozzitorto Peter McCue Charles J Yeo Ralph H Hruban Agnieszka K Witkiewicz

Mod Pathol 2009 May 6;22(5):651-9. Epub 2009 Mar 6.

Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/modpathol.2009.15DOI Listing
May 2009

Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target.

Authors:
Agnieszka K Witkiewicz Christina L Costantino Richard Metz Alexander J Muller George C Prendergast Charles J Yeo Jonathan R Brody

J Am Coll Surg 2009 May;208(5):781-7; discussion 787-9

Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jamcollsurg.2008.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176891PMC
May 2009

Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence.

Authors:
Jonathan R Brody Tomas Hucl Christina L Costantino James R Eshleman Eike Gallmeier Heng Zhu Michiel S van der Heijden Jordan M Winter Agnieszka K Wikiewicz Charles J Yeo Scott E Kern

Cancer Res 2009 Feb 20;69(3):984-91. Epub 2009 Jan 20.

Department of Surgery and Pathology, Jefferson Pancreas, Biliary, and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-08-3610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887094PMC
February 2009

Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome.

Authors:
Agnieszka K Witkiewicz Katherine H Nguyen Abhijit Dasgupta Eugene P Kennedy Charles J Yeo Michael P Lisanti Jonathan R Brody

Cell Cycle 2008 Oct 23;7(19):3021-5. Epub 2008 Oct 23.

Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

View Article

Download full-text PDF

 Source
http://www.tandfonline.com/doi/abs/10.4161/cc.7.19.6719
Publisher Site
http://dx.doi.org/10.4161/cc.7.19.6719DOI Listing
October 2008

Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells.

Authors:
Shayna L Showalter Yu-Hung Huang Agneszka Witkiewicz Christina L Costantino Charles J Yeo Jordan J Green Robert Langer Daniel G Anderson Janet A Sawicki Jonathan R Brody

Cancer Biol Ther 2008 Oct 3;7(10):1584-90. Epub 2008 Oct 3.

Department of Surgery, Thomas Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218426PMC
http://dx.doi.org/10.4161/cbt.7.10.6562DOI Listing
October 2008

Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells.

Authors:
Christine Hostetter Lauren A Licata Agnieszka Witkiewicz Christina L Costantino Charles J Yeo Jonathan R Brody Judith Clancy Keen

Cancer Biol Ther 2008 Sep 23;7(9):1496-506. Epub 2008 Sep 23.

Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey 08106, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4161/cbt.7.9.6490DOI Listing
September 2008

Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?

Authors:
Shayna L Showalter Timothy N Showalter Agnes Witkiewicz Robert Havens Eugene P Kennedy Tomas Hucl Scott E Kern Charles J Yeo Jonathan R Brody

Cancer Biol Ther 2008 Jul 21;7(7):986-94. Epub 2008 Apr 21.

Department of Surgery, Thomas Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University Philadelphia, Pennsylvania 19107, USA.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081718PMC
http://dx.doi.org/10.4161/cbt.7.7.6181DOI Listing
July 2008

A syngeneic variance library for functional annotation of human variation: application to BRCA2.

Authors:
Tomas Hucl Carlo Rago Eike Gallmeier Jonathan R Brody Myriam Gorospe Scott E Kern

Cancer Res 2008 Jul;68(13):5023-30

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-07-6189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536704PMC
July 2008

Expression of indoleamine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection.

Authors:
Agnes Witkiewicz Timothy K Williams Joseph Cozzitorto Brandice Durkan Shayna L Showalter Charles J Yeo Jonathan R Brody

J Am Coll Surg 2008 May 4;206(5):849-54; discussion 854-6. Epub 2008 Mar 4.

Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jamcollsurg.2007.12.014DOI Listing
May 2008

Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia.

Authors:
Jonathan R Brody Agnes Witkiewicz Timothy K Williams Shrihari S Kadkol Joseph Cozzitorto Brandice Durkan Gary R Pasternack Charles J Yeo

Mod Pathol 2007 Dec 28;20(12):1238-44. Epub 2007 Sep 28.

Department of Surgery, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA.

View Article

Download full-text PDF

 Source
http://www.nature.com/articles/3800974
Publisher Site
http://dx.doi.org/10.1038/modpathol.3800974DOI Listing
December 2007

High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif.

Authors:
Tomas Hucl Jonathan R Brody Eike Gallmeier Christine A Iacobuzio-Donahue Iain K Farrance Scott E Kern

Cancer Res 2007 Oct;67(19):9055-65

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-07-0474DOI Listing
October 2007

No K01 offered from the NCI What's the message?

Authors:
Jonathan R Brody Thomas N Tulenko

Cancer Biol Ther 2007 Jul;6(7):1002; discussion 1003-4

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4161/cbt.6.7.4619DOI Listing
July 2007

Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer.

Authors:
Eike Gallmeier Tomas Hucl Eric S Calhoun Steven C Cunningham Fred Bunz Jonathan R Brody Scott E Kern

Cancer Biol Ther 2007 May 7;6(5):654-60. Epub 2007 Feb 7.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4161/cbt.6.5.3978DOI Listing
May 2007

High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells.

Authors:
Eike Gallmeier Tomas Hucl Jonathan R Brody David A Dezentje Khola Tahir Jana Kasparkova Viktor Brabec Kurtis E Bachman Scott E Kern

Cancer Res 2007 Mar;67(5):2169-77

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-06-2711DOI Listing
March 2007

Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy.

Authors:
Jonathan R Brody Tomas Hucl Eike Gallmeier Jordan M Winter Scott E Kern Kathleen M Murphy

Cancer Res 2006 Oct;66(19):9369-73

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-06-2165DOI Listing
October 2006

A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes.

Authors:
Jonathan R Brody Eike Gallmeier Kiyoshi Yoshimura Tomas Hucl Peter Kulesza Marcia I Canto Ralph H Hruban Richard D Schulick Scott E Kern

Cancer Biol Ther 2006 Aug 2;5(8):923-7. Epub 2006 Aug 2.

Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center and The Sidney Kimmel Comprehensive Cancer Center at The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.4161/cbt.5.8.2976DOI Listing
August 2006