Jonathan P T Corcoran

Recent advances in the design of RAR α and RAR β agonists as orally bioavailable drugs. A review.

Authors:

Alan D Borthwick Maria B Goncalves Jonathan P T Corcoran

Bioorg Med Chem 2020 10 29;28(20):115664. Epub 2020 Jul 29.

Neuroscience Drug Discovery Unit, Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College, London SE1 1UL, UK. Electronic address:

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October 2020

RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms.

Authors:

Maria B Goncalves Julien Moehlin Earl Clarke John Grist Carl Hobbs Antony M Carr Julian Jack Marco Antonio Mendoza-Parra Jonathan P T Corcoran

iScience 2019 Nov 11;21:562-563. Epub 2019 Nov 11.

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November 2019

RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms.

Authors:

Maria B Goncalves Julien Moehlin Earl Clarke John Grist Carl Hobbs Antony M Carr Julian Jack Marco Antonio Mendoza-Parra Jonathan P T Corcoran

iScience 2019 Oct 17;20:554-566. Epub 2019 Sep 17.

The Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London SE1 1UL, UK. Electronic address:

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October 2019

Corrigendum to "Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury" [Bioorg. Med. Chem. Lett. 29(8) (2019) 995-1000].

Authors:

Maria B Goncalves Earl Clarke Christopher I Jarvis S Barret Kalindjian Thomas Pitcher John Grist Carl Hobbs Thomas Carlstedt Julian Jack Jane T Brown Mark Mills Peter Mumford Alan D Borthwick Jonathan P T Corcoran

Bioorg Med Chem Lett 2019 Aug 14;29(16):2440-2441. Epub 2019 Jun 14.

Neuroscience Drug Discovery Unit, Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College, London SE1 1UL, UK. Electronic address:

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August 2019

The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor β signaling.

Authors:

Diogo Trigo Maria B Goncalves Jonathan P T Corcoran

FASEB J 2019 06 11;33(6):7225-7235. Epub 2019 Mar 11.

The Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom.

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June 2019

Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury.

Authors:

Maria B Goncalves Earl Clarke Christopher I Jarvis S Barret Kalindjian Thomas Pitcher John Grist Carl Hobbs Thomas Carlstedt Julian Jack Jane T Brown Mark Mills Peter Mumford Alan D Borthwick Jonathan P T Corcoran

Bioorg Med Chem Lett 2019 04 11;29(8):995-1000. Epub 2019 Feb 11.

Neuroscience Drug Discovery Unit, Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College, London SE1 1UL, UK. Electronic address:

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April 2019

Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells.

Authors:

Maria B Goncalves Yue Wu Earl Clarke John Grist Carl Hobbs Diogo Trigo Julian Jack Jonathan P T Corcoran

J Neurosci 2019 04 13;39(16):3013-3027. Epub 2019 Feb 13.

The Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London SE1 1UL, United Kingdom

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April 2019

Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.

Authors:

Earl Clarke Christopher I Jarvis Maria B Goncalves S Barret Kalindjian David R Adams Jane T Brown Jason J Shiers David M A Taddei Elodie Ravier Stephanie Barlow Iain Miller Vanessa Smith Alan D Borthwick Jonathan P T Corcoran

Bioorg Med Chem 2018 02 9;26(4):798-814. Epub 2017 Dec 9.

Neuroscience Drug Discovery Unit, Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College, London SE1 1UL, UK.

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February 2018

Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth.

Authors:

Maria B Goncalves Yue Wu Diogo Trigo Earl Clarke Tony Malmqvist John Grist Carl Hobbs Thomas P Carlstedt Jonathan P T Corcoran

Neurobiol Dis 2018 03 20;111:70-79. Epub 2017 Dec 20.

The Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London SE1 1UL, United Kingdom. Electronic address:

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March 2018

Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration.

Authors:

Maria B Goncalves Tony Malmqvist Earl Clarke Chantal J Hubens John Grist Carl Hobbs Diogo Trigo Mårten Risling Maria Angeria Peter Damberg Thomas P Carlstedt Jonathan P T Corcoran

J Neurosci 2015 Nov;35(47):15731-45

The Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London SE1 1UL, United Kingdom,

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November 2015

Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist.

Authors:

Maria B Goncalves Earl Clarke Carl Hobbs Tony Malmqvist Robert Deacon Julian Jack Jonathan P T Corcoran

Eur J Neurosci 2013 Apr 4;37(7):1182-92. Epub 2013 Feb 4.

The Wolfson Centre For Age-Related Diseases, King's College London, Guy's Campus, London, SE11UL, UK.

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April 2013

A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord.

Authors:

Marta Agudo Ping Yip Meirion Davies Elizabeth Bradbury Patrick Doherty Stephen McMahon Malcolm Maden Jonathan P T Corcoran

Neurobiol Dis 2010 Jan 2;37(1):147-55. Epub 2009 Oct 2.

The Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London SE1 1UL, UK.

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January 2010

Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways.

Authors:

Maria Beatriz C V Goncalves Marta Agudo Siobhán Connor Stephen McMahon Stephen L Minger Malcolm Maden Jonathan P T Corcoran

Dev Biol 2009 Feb 7;326(2):305-13. Epub 2008 Dec 7.

The Wolfson Centre For Age-Related Diseases, King's College London, Guy's Campus, London, UK.

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February 2009

Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth.

Authors:

Po-Lin So Ping K Yip Stephen Bunting Liang-Fong Wong Nicholas D Mazarakis Susan Hall Stephen McMahon Malcolm Maden Jonathan P T Corcoran

Dev Biol 2006 Oct 17;298(1):167-75. Epub 2006 Jun 17.

The MRC Centre for Developmental Neurobiology, King's College London, Guy's Campus, London SE1 1UL, UK.

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October 2006

Timing of the retinoid-signalling pathway determines the expression of neuronal markers in neural progenitor cells.

Authors:

Maria Beatriz C V Goncalves Julia Boyle Daniel J Webber Sara Hall Stephen L Minger Jonathan P T Corcoran

Dev Biol 2005 Feb;278(1):60-70

Stem Cell Laboratory, The Wolfson Centre for Age Related Diseases, London SE1 1UL, UK.

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February 2005

Disruption of the retinoid signalling pathway causes a deposition of amyloid beta in the adult rat brain.

Authors:

Jonathan P T Corcoran Po Lin So Malcolm Maden

Eur J Neurosci 2004 Aug;20(4):896-902

MRC Centre for Developmental Neurobiology, New Hunt's House, King's College London, Guy's Campus, London SE1 1UL, UK.

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August 2004

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