Jonathan M Locke

Jonathan M Locke

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Jonathan M Locke

Jonathan M Locke

Publications by authors named "Jonathan M Locke"

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The Common Variant I27L Is a Modifier of Age at Diabetes Diagnosis in Individuals With HNF1A-MODY.

Diabetes 2018 09 12;67(9):1903-1907. Epub 2018 Jun 12.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Exeter, U.K.

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http://dx.doi.org/10.2337/db18-0133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109380PMC
September 2018

Functional characterisation of ADIPOQ variants using individuals recruited by genotype.

Mol Cell Endocrinol 2016 06 17;428:49-57. Epub 2016 Mar 17.

Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, Devon, EX2 5DW, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2016.03.020DOI Listing
June 2016

Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets.

Diabetologia 2016 Jan;59(1):161-169

Department of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, CH-1005, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00125-015-3783-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670458PMC
January 2016

Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies.

Diabetes 2015 Apr 12;64(4):1484-91. Epub 2014 Nov 12.

Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, U.K.

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http://dx.doi.org/10.2337/db14-0957DOI Listing
April 2015

A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1.

Diabetologia 2015 Apr 30;58(4):745-8. Epub 2015 Jan 30.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1007/s00125-015-3508-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351432PMC
April 2015

A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells.

Acta Diabetol 2014 Apr 5;51(2):325-9. Epub 2013 Jul 5.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Barrack Road, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1007/s00592-013-0499-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969511PMC
April 2014

The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts.

BMC Genomics 2013 Sep 17;14:627. Epub 2013 Sep 17.

RNA mediated mechanisms of disease group, University of Exeter Medical School, EX2 5DW Exeter, UK.

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http://dx.doi.org/10.1186/1471-2164-14-627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848490PMC
September 2013

MicroRNA expression profiling of human islets from individuals with and without type 2 diabetes: promises and pitfalls.

Biochem Soc Trans 2012 Aug;40(4):800-3

Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.1042/BST20120049DOI Listing
August 2012

RNA processing and mRNA surveillance in monogenic diabetes.

Gene Regul Syst Bio 2008 May 21;2:203-12. Epub 2008 May 21.

Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733086PMC
May 2008