Jonathan L Schmid-Burgk

Jonathan L Schmid-Burgk

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Jonathan L Schmid-Burgk

Jonathan L Schmid-Burgk

Publications by authors named "Jonathan L Schmid-Burgk"

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24Publications

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Optical Pooled Screens in Human Cells.

Cell 2019 Oct;179(3):787-799.e17

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biological Engineering, MIT, Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886477PMC
October 2019

RNA-guided DNA insertion with CRISPR-associated transposases.

Science 2019 07 6;365(6448):48-53. Epub 2019 Jun 6.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/science.aax9181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659118PMC
July 2019

Disruptive non-disruptive applications of CRISPR/Cas9.

Curr Opin Biotechnol 2017 12 19;48:203-209. Epub 2017 Jun 19.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2017.06.001DOI Listing
December 2017

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

Cell 2017 Nov 12;171(5):1110-1124.e18. Epub 2017 Oct 12.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 Munich, Germany; Center for Integrated Protein Science (CIPSM), Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901709PMC
November 2017

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia.

Clin Cancer Res 2017 May 25;23(10):2528-2541. Epub 2016 Oct 25.

KU Leuven Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1580DOI Listing
May 2017

Designer Nuclease-Mediated Generation of Knockout THP1 Cells.

Methods Mol Biol 2016 ;1338:261-72

Institute of Molecular Medicine, University Hospital, University of Bonn, Sigmund-Freud-Straße 25, Bonn, Germany.

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http://dx.doi.org/10.1007/978-1-4939-2932-0_19DOI Listing
July 2016

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism.

Nat Commun 2016 07 28;7:12338. Epub 2016 Jul 28.

Institute of Molecular Medicine, University Hospital, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.

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http://dx.doi.org/10.1038/ncomms12338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974478PMC
July 2016

Human Monocytes Engage an Alternative Inflammasome Pathway.

Immunity 2016 Apr 29;44(4):833-46. Epub 2016 Mar 29.

Institute of Molecular Medicine, University Hospital Bonn, 53127 Bonn, Germany; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 München, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.01.012DOI Listing
April 2016

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation.

J Biol Chem 2016 Jan 9;291(1):103-9. Epub 2015 Nov 9.

From the Institute of Molecular Medicine and the Gene Center and Department of Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, Germany

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http://dx.doi.org/10.1074/jbc.C115.700492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697147PMC
January 2016

BrowserGenome.org: web-based RNA-seq data analysis and visualization.

Nat Methods 2015 Nov;12(11):1001

Institute of Molecular Medicine, University Hospital, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/nmeth.3615DOI Listing
November 2015

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.

Eur J Immunol 2015 Oct 6;45(10):2911-7. Epub 2015 Aug 6.

Institute of Molecular Medicine, University Hospital, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/eji.201545523DOI Listing
October 2015

Synthesis of an arrayed sgRNA library targeting the human genome.

Sci Rep 2015 Oct 8;5:14987. Epub 2015 Oct 8.

Institute of Molecular Medicine, University Hospital, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.

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http://dx.doi.org/10.1038/srep14987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597219PMC
October 2015

Ligation-independent cloning (LIC) assembly of TALEN genes.

Methods Mol Biol 2015 ;1239:161-9

Institute of Molecular Medicine, University Hospital, University of Bonn, 53127, Bonn, Germany.

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http://dx.doi.org/10.1007/978-1-4939-1862-1_8DOI Listing
July 2015

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.

Cell Host Microbe 2015 Jun 2;17(6):799-810. Epub 2015 Jun 2.

Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.05.003DOI Listing
June 2015

OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines.

Genome Res 2014 Oct 3;24(10):1719-23. Epub 2014 Sep 3.

Institute of Molecular Medicine, University Hospital, University of Bonn, 53127 Bonn, Germany;

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http://dx.doi.org/10.1101/gr.176701.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199374PMC
October 2014

Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.

J Immunol 2014 Oct 3;193(7):3257-61. Epub 2014 Sep 3.

Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany; Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655; and German Center for Neurodegenerative Diseases, 53175 Bonn, Germany

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http://dx.doi.org/10.4049/jimmunol.1301886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170058PMC
October 2014

Hierarchical ligation-independent assembly of PCR fragments.

Methods Mol Biol 2014 ;1116:49-58

Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1007/978-1-62703-764-8_4DOI Listing
September 2014

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

J Immunol 2014 Jun 9;192(12):5993-7. Epub 2014 May 9.

Institute of Molecular Medicine, University Hospital, University of Bonn, 53127 Bonn, Germany; and

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http://dx.doi.org/10.4049/jimmunol.1400737DOI Listing
June 2014

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

Nature 2013 Nov 29;503(7477):530-4. Epub 2013 Sep 29.

Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany.

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http://dx.doi.org/10.1038/nature12640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142317PMC
November 2013

A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes.

Nat Biotechnol 2013 Jan;31(1):76-81

Institute for Clinical Chemistry and Clinical Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/nbt.2460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142318PMC
January 2013

NLRP3 inflammasome activity is negatively controlled by miR-223.

J Immunol 2012 Oct 14;189(8):4175-81. Epub 2012 Sep 14.

Unit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany.

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http://dx.doi.org/10.4049/jimmunol.1201516DOI Listing
October 2012