Jonathan H Sheehan

Jonathan H Sheehan

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Jonathan H Sheehan

Jonathan H Sheehan

Publications by authors named "Jonathan H Sheehan"

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26Publications

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Inhibitors of the HIV-1 capsid, a target of opportunity.

Curr Opin HIV AIDS 2018 07;13(4):359-365

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center.

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http://dx.doi.org/10.1097/COH.0000000000000472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075716PMC
July 2018

Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia.

BMC Bioinformatics 2018 01 23;19(1):18. Epub 2018 Jan 23.

Department of Biological Sciences, Vanderbilt Genetics Institute, and Center for Structural Biology, Vanderbilt University, Nashville, USA.

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http://dx.doi.org/10.1186/s12859-018-2010-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5781290PMC
January 2018

Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590.

Mol Pharmacol 2017 09 15;92(3):338-346. Epub 2017 Jun 15.

Department of Anesthesiology (S.V.K., E.E.F., J.S.D.), Department of Pharmacology (E.E.F., J.S.D.), Department of Biochemistry (J.H.S., J.M.), Center for Structural Biology (J.H.S., J.M.), Department of Chemistry (J.M.), Institute of Chemical Biology (J.S.D.), Vanderbilt University, Nashville, Tennessee

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.117
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http://dx.doi.org/10.1124/mol.117.108472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553192PMC
September 2017

The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.

Expert Rev Clin Immunol 2016 Jul 4;12(7):763-73. Epub 2016 Mar 4.

b Department of Pathology, Microbiology & Immunology , Vanderbilt University , Nashville , TN , USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070917PMC
http://dx.doi.org/10.1586/1744666X.2016.1152888DOI Listing
July 2016

EGFR Fusions as Novel Therapeutic Targets in Lung Cancer.

Cancer Discov 2016 06 21;6(6):601-11. Epub 2016 Apr 21.

Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee. Addario Lung Cancer Medical Institute, Cambridge, Massachusetts. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893907PMC
June 2016

EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib.

Cancer Discov 2015 Nov 18;5(11):1155-63. Epub 2015 Aug 18.

Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee. Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631701PMC
November 2015

Computational and functional analyses of a small-molecule binding site in ROMK.

Biophys J 2015 Mar;108(5):1094-103

Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee; Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee; Institute for Global Health, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375722PMC
March 2015

Genetic analysis of the localization of APOBEC3F to human immunodeficiency virus type 1 virion cores.

J Virol 2015 Feb 10;89(4):2415-24. Epub 2014 Dec 10.

Division of Infectious Diseases and Northwestern HIV Translational Research Center, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/JVI.01981-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338907PMC
February 2015

Tailoring peptidomimetics for targeting protein-protein interactions.

Mol Cancer Res 2014 Jul 18;12(7):967-78. Epub 2014 Mar 18.

Authors' Affiliations: Department of Urology, University of Texas Southwestern Medical Center, Dallas;

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-13-0611DOI Listing
July 2014

NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression.

Mol Endocrinol 2014 Jun 6;28(6):949-64. Epub 2014 May 6.

Department of Urologic Surgery (M.M.G., G.A. H.Y., Q.S., X.Y., R.J.M.), Department of Molecular Physiology and Biophysics (A.D.E., D.W.P.), and Vanderbilt-Ingram Cancer Center (R.J.M.), Vanderbilt University Medical Center, Nashville, Tennessee 37232; Department of Pathology (D.J.D.), Penn State University College of Medicine, Hershey, Pennsylvania 17033; Department of Biological Sciences (P.D.A.), Salisbury University, Salisbury, Maryland 21801; Mass Spectrometry Research Center (D.B.F., D.L.H.), Department of Biochemistry, Department of Biochemistry and Center for Structural Biology (J.H.S.), and Department of Cell and Developmental Biology (R.J.M.), Vanderbilt University, Nashville, Tennessee 37232; Department of Chemistry (J.-M.A.), University of Texas Dallas, Dallas, Texas 75080; Department of Urology (G.V.R.), University of Texas Southwestern, Dallas, Texas 75390; and Department of Biochemistry (R.M.G.), Developmental Genomics Group, NY State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, New York 14203.

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http://dx.doi.org/10.1210/me.2013-1213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042066PMC
June 2014

Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock.

Biochemistry 2013 Feb 7;52(7):1208-20. Epub 2013 Feb 7.

Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1021/bi301691aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587310PMC
February 2013

Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects.

Retrovirology 2012 Apr 19;9:30. Epub 2012 Apr 19.

Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1186/1742-4690-9-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351742PMC
April 2012

Unique gating properties of C. elegans ClC anion channel splice variants are determined by altered CBS domain conformation and the R-helix linker.

Channels (Austin) 2010 Jul-Aug;4(4):289-301. Epub 2010 Jul 21.

Boylan Center for Cellular and Molecular Physiology, Mount Desert Island Biological Laboratory, Salisbury Cove, ME, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230521PMC
http://dx.doi.org/10.4161/chan.4.4.12445DOI Listing
March 2011

Glycosylation of {beta}2 subunits regulates GABAA receptor biogenesis and channel gating.

J Biol Chem 2010 Oct 16;285(41):31348-61. Epub 2010 Jul 16.

Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1074/jbc.M110.151449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951209PMC
October 2010

Practically useful: what the Rosetta protein modeling suite can do for you.

Biochemistry 2010 Apr;49(14):2987-98

Department of Chemistry, Vanderbilt University, 7330 Stevenson Center, Station B 351822, Nashville, Tennessee 37235, USA.

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http://dx.doi.org/10.1021/bi902153gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850155PMC
April 2010

Structure of the N-terminal calcium sensor domain of centrin reveals the biochemical basis for domain-specific function.

J Biol Chem 2006 Feb 29;281(5):2876-81. Epub 2005 Nov 29.

Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232-8725, USA.

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http://dx.doi.org/10.1074/jbc.M509886200DOI Listing
February 2006

The mode of action of centrin. Binding of Ca2+ and a peptide fragment of Kar1p to the C-terminal domain.

J Biol Chem 2004 Dec 27;279(49):50895-903. Epub 2004 Sep 27.

Departments of Biochemistry and Physics and the Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232-8725, USA.

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http://dx.doi.org/10.1074/jbc.M404233200DOI Listing
December 2004

Designing sequence to control protein function in an EF-hand protein.

J Am Chem Soc 2004 May;126(19):5990-8

Department of Biochemistry, Center for Structural Biology, Vanderbilt University, 5140 BIOSCI/MRB III, Nashville, Tennessee 37232-8725, USA.

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http://dx.doi.org/10.1021/ja0397456DOI Listing
May 2004