Publications by authors named "Jonathan H Fox"

17Publications

Novel proteomic changes in brain mitochondria provide insights into mitochondrial dysfunction in mouse models of Huntington's disease.

Authors:
Sonal Agrawal Jonathan H Fox

Mitochondrion 2019 07 20;47:318-329. Epub 2019 Mar 20.

Department of Veterinary Sciences, University of Wyoming, Laramie, WY 82070, USA. Electronic address:

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July 2019

Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochondrial dysfunction, and can be removed pharmacologically.

Authors:
Sonal Agrawal Julia Fox Baskaran Thyagarajan Jonathan H Fox

Free Radic Biol Med 2018 05 4;120:317-329. Epub 2018 Apr 4.

Department of Veterinary Sciences, University of Wyoming, Laramie, WY 82070, United States. Electronic address:

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May 2018

Acute hepatic steatosis: a helpful diagnostic feature in metallic phosphide-poisoned horses.

Authors:
Jonathan H Fox Brian F Porter Leslie Easterwood Justin R V Hildenbrand Pierre Hélie James Smylie Donal O'Toole

J Vet Diagn Invest 2018 Mar 4;30(2):280-285. Epub 2017 Dec 4.

Wyoming State Veterinary Laboratory, University of Wyoming, Laramie WY (Fox, Hildenbrand, O'Toole).

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March 2018

Amyloid Precursor Protein Haploinsufficiency Preferentially Mediates Brain Iron Accumulation in Mice Transgenic for The Huntington's Disease Mutation.

Authors:
Kiersten Berggren Sonal Agrawal Julia A Fox Justin Hildenbrand Ryan Nelson Ashley I Bush Jonathan H Fox

J Huntingtons Dis 2017 ;6(2):115-125

Department of Veterinary Sciences, University of Wyoming, Laramie, WY, USA.

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March 2018

Impact of high iron intake on cognition and neurodegeneration in humans and in animal models: a systematic review.

Authors:
Sonal Agrawal Kiersten L Berggren Eileen Marks Jonathan H Fox

Nutr Rev 2017 06;75(6):456-470

Department of Veterinary Sciences, University of Wyoming, Laramie, Wyoming, USA.

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June 2017

Huntingtons Disease Mice Infected with Toxoplasma gondii Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality.

Authors:
David W Donley Andrew R Olson Merl F Raisbeck Jonathan H Fox Jason P Gigley

PLoS One 2016 9;11(9):e0162404. Epub 2016 Sep 9.

Department of Molecular Biology, University of Wyoming, Laramie, WY, 82071, United States of America.

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August 2017

Neonatal Iron Supplementation Induces Striatal Atrophy in Female YAC128 Huntington's Disease Mice.

Authors:
Kiersten L Berggren Zhen Lu Julia A Fox Megan Dudenhoeffer Sonal Agrawal Jonathan H Fox

J Huntingtons Dis 2016 ;5(1):53-63

Department of Veterinary Sciences, University of Wyoming, Laramie, WY, USA.

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December 2016

Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease.

Authors:
Kiersten L Berggren Jianfang Chen Julia Fox Jonathan Miller Lindsay Dodds Bryan Dugas Liset Vargas Amber Lothian Erin McAllum Irene Volitakis Blaine Roberts Ashley I Bush Jonathan H Fox

Redox Biol 2015 11;4:363-74. Epub 2015 Feb 11.

Department of Veterinary Sciences, University of Wyoming, 1174 Snowy Range Road, Laramie, WY 82070, USA; Neuroscience Graduate Program, University of Wyoming, 1174 Snowy Range Road, Laramie, WY 82070, USA. Electronic address:

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June 2016

Altered selenium status in Huntington's disease: neuroprotection by selenite in the N171-82Q mouse model.

Authors:
Zhen Lu Eileen Marks Jianfang Chen Jenna Moline Lorraine Barrows Merl Raisbeck Irene Volitakis Robert A Cherny Vanita Chopra Ashley I Bush Steven Hersch Jonathan H Fox

Neurobiol Dis 2014 Nov 8;71:34-42. Epub 2014 Jul 8.

Department of Veterinary Sciences, University of Wyoming, Laramie, WY 82070, USA; Neuroscience Graduate Program, University of Wyoming, Laramie, WY 82070, USA. Electronic address:

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November 2014

Iron accumulates in Huntington's disease neurons: protection by deferoxamine.

Authors:
Jianfang Chen Eileen Marks Barry Lai Zhaojie Zhang James A Duce Linh Q Lam Irene Volitakis Ashley I Bush Steven Hersch Jonathan H Fox

PLoS One 2013 11;8(10):e77023. Epub 2013 Oct 11.

Department of Veterinary Sciences and Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming, United States of America.

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August 2014

Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein.

Authors:
Jonathan H Fox Teal Connor Megan Stiles Jibrin Kama Zhen Lu Kathryn Dorsey Gregory Lieberman Gregory Liebermann Ellen Sapp Robert A Cherny Mary Banks Irene Volitakis Marian DiFiglia Oksana Berezovska Ashley I Bush Steven M Hersch

J Biol Chem 2011 May 30;286(20):18320-30. Epub 2011 Mar 30.

Department of Veterinary Science and Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming 82070, USA.

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May 2011

The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease.

Authors:
Jonathan H Fox Teal Connor Vanita Chopra Kate Dorsey Jibrin A Kama Dorothee Bleckmann Claudia Betschart Daniel Hoyer Stefan Frentzel Marian Difiglia Paolo Paganetti Steven M Hersch

Mol Neurodegener 2010 Jun 22;5:26. Epub 2010 Jun 22.

MassGeneral Institute for Neurodegenerative Disease and Harvard Medical School, Charlestown, MA, USA.

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June 2010

A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.

Authors:
Vanita Chopra Jonathan H Fox Greg Lieberman Kathryn Dorsey Wayne Matson Peter Waldmeier David E Housman Aleksey Kazantsev Anne B Young Steven Hersch

Proc Natl Acad Sci U S A 2007 Oct 9;104(42):16685-9. Epub 2007 Oct 9.

Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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October 2007

Mechanisms of copper ion mediated Huntington's disease progression.

Authors:
Jonathan H Fox Jibrin A Kama Gregory Lieberman Raman Chopra Kate Dorsey Vanita Chopra Irene Volitakis Robert A Cherny Ashley I Bush Steven Hersch

PLoS One 2007 Mar 28;2(3):e334. Epub 2007 Mar 28.

Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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March 2007

Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1.

Authors:
Birgit Zucker Ruth Luthi-Carter Jibrin A Kama Anthone W Dunah Edward A Stern Jonathan H Fox David G Standaert Anne B Young Sarah J Augood

Hum Mol Genet 2005 Jan 17;14(2):179-89. Epub 2004 Nov 17.

Department of Neurology, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA.

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January 2005

Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation.

Authors:
Jonathan H Fox David S Barber Bhupinder Singh Birgit Zucker Mary K Swindell Fran Norflus Rodica Buzescu Raman Chopra Robert J Ferrante Aleksey Kazantsev Steven M Hersch

J Neurochem 2004 Oct;91(2):413-22

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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October 2004

Altered expression of transcripts for alpha-tubulin and an unidentified gene in the spinal cord of phenyl saligenin phosphate treated hens (Gallus gallus).

Authors:
Jonathan H Fox Bernard S Jortner David Barber Marion F Ehrich

J Biochem Mol Toxicol 2003 ;17(5):263-71

Laboratory for Neurotoxicity Studies, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA.

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June 2004