Jonathan Godbout

Jonathan Godbout

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Jonathan Godbout

Jonathan Godbout

Publications by authors named "Jonathan Godbout"

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68Publications

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Bone Marrow-derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic SCI.

J Neurotrauma 2018 Jul 17. Epub 2018 Jul 17.

The Ohio State University, School of Health and Rehabilitation Sciences, Columbus, Ohio, United States.

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July 2018

Prenatal stress disrupts social behavior, cortical neurobiology and commensal microbes in adult male offspring.

Behav Brain Res 2018 Jun 24. Epub 2018 Jun 24.

Institute for Behavioral Medicine Research, Wexner Medical Center at The Ohio State University, United States; Center for Microbial Pathogenesis, The Research Institute, Nationwide Children's Hospital, United States; Biosciences Division, College of Dentistry, The Ohio State University, United States; Department of Pediatrics, Wexner Medical Center at The Ohio State University, United States.

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June 2018

The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer's Disease.

Front Immunol 2018 9;9:672. Epub 2018 Apr 9.

Department of Neuroscience, Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, OH, United States.

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April 2018

Ropivacaine and Bupivacaine prevent increased pain sensitivity without altering neuroimmune activation following repeated social defeat stress.

Brain Behav Immun 2018 Mar 8;69:113-123. Epub 2017 Nov 8.

Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, USA; Department of Anesthesiology, The Ohio State University Wexner Medical Center, USA. Electronic address:

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March 2018

Effects of dermal wounding on distal primary tumor immunobiology in mice.

J Surg Res 2018 Jan 17;221:328-335. Epub 2017 Oct 17.

Center for Wound Healing and Tissue Regeneration, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois.

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January 2018

MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment.

Sci Rep 2017 Oct 30;7(1):14336. Epub 2017 Oct 30.

Havener Eye Institute, Department of Ophthalmology and Visual Science, The Ohio State University Wexner Medical Center, Columbus, OH, 43212, USA.

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October 2017

Tumors Alter Inflammation and Impair Dermal Wound Healing in Female Mice.

PLoS One 2016 22;11(8):e0161537. Epub 2016 Aug 22.

Center for Wound Healing and Tissue Regeneration, College of Dentistry, University of Illinois at Chicago, Chicago, IL, United States of America.

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August 2017

Aging with a traumatic brain injury: Could behavioral morbidities and endocrine symptoms be influenced by microglial priming?

Brain Behav Immun 2017 Jan 11;59:1-7. Epub 2016 Mar 11.

Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA; Department of Child Health, University of Arizona College of Medicine - Phoenix, Phoenix, AZ, USA; Neuroscience Graduate Program, Arizona State University, Tempe, AZ, USA; VA Healthcare System, Phoenix, AZ, USA.

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January 2017

Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal.

Neuropsychopharmacology 2017 01 20;42(1):46-61. Epub 2016 Jun 20.

Division of Biosciences, The Ohio State University, Columbus, OH, USA.

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January 2017

Microglia Priming with Aging and Stress.

Neuropsychopharmacology 2017 01 8;42(1):318-333. Epub 2016 Sep 8.

Department of Neuroscience, The Ohio State University, Columbus, OH, USA.

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January 2017

Can Sustained Glia-Mediated Brain Inflammation After Repeated Concussive Brain Injury Be Detected In Vivo?

JAMA Neurol 2017 Jan;74(1):23-25

Department of Neuroscience, Center for Brain and Spinal Cord Repair, Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus.

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January 2017

Neuroinflammation: the devil is in the details.

J Neurochem 2016 10 4;139 Suppl 2:136-153. Epub 2016 May 4.

Department of Neuroscience, The Ohio State University, Columbus, Ohio, USA.

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October 2016

Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury.

Exp Neurol 2016 08 16;282:86-98. Epub 2016 May 16.

Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, OH 43210, USA; School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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August 2016

Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain.

Neurobiol Aging 2016 08 27;44:22-41. Epub 2016 Apr 27.

Department of Neuroscience, The Ohio State University, Columbus, OH, USA; Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA. Electronic address:

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August 2016

The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming.

J Neurosci 2016 07;36(30):7946-56

Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado 80309, and.

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July 2016

Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat.

Biol Psychiatry 2016 05 26;79(10):803-813. Epub 2015 Jul 26.

Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio; Institute for Behavioral Medicine Research, The Ohio State University, Columbus, Ohio; Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, Ohio. Electronic address:

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May 2016

Cognitive deficits develop 1month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge.

Brain Behav Immun 2016 May 14;54:95-109. Epub 2016 Jan 14.

Department of Neuroscience, The Ohio State University, 333 W. 10th Ave, Columbus, OH, United States; Center for Brain and Spinal Cord Repair, The Ohio State University, 460 W. 12th Ave, Columbus, OH, United States; Institute for Behavioral Medicine Research, The Ohio State University, 460 Medical Center Dr., Columbus, OH, United States. Electronic address:

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May 2016

Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat.

J Neurosci 2016 Mar;36(9):2590-604

Department of Neuroscience, Center for Brain and Spinal Cord Repair, and Institute for Behavioral Medicine Research, Ohio State University, Columbus, Ohio 43210

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March 2016

Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice.

Life Sci 2015 Dec 20;143:65-70. Epub 2015 Oct 20.

College of Nursing, The Ohio State University, United States; Department of Physiology and Cell Biology, The Ohio State University, United States. Electronic address:

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December 2015

Priming the inflammatory pump of the CNS after traumatic brain injury.

Trends Neurosci 2015 Oct;38(10):609-620

Department of Neuroscience, The Ohio State University, 333 West 10th Avenue, Columbus, OH, USA; Center for Brain and Spinal Cord Repair, The Ohio State University, 460 West 12th Avenue, Columbus, OH, USA; Institute for Behavioral Medicine Research, The Ohio State University, 460 Medical Center Drive, Columbus, OH, USA. Electronic address:

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October 2015

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease.

Neuropharmacology 2015 Sep 13;96(Pt A):29-41. Epub 2014 Nov 13.

Department of Neuroscience, The Ohio State University, 333 W. 10th Ave, Columbus, OH 43210, USA; Institute for Behavioral Medicine Research, The Ohio State University, 460 Medical Center Dr., Columbus, OH 43210, USA; Center for Brain and Spinal Cord Repair, The Ohio State University, 460 W. 12th Ave, Columbus, OH 43210, USA. Electronic address:

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September 2015

The Impact of Macrophage- and Microglia-Secreted TNFα on Oncolytic HSV-1 Therapy in the Glioblastoma Tumor Microenvironment.

Clin Cancer Res 2015 Jul 31;21(14):3274-85. Epub 2015 Mar 31.

Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio.

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July 2015

Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue.

Physiol Behav 2015 Mar 30;140:230-5. Epub 2014 Dec 30.

College of Nursing, Marquette University Milwaukee, WI, United States. Electronic address:

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March 2015

Combining time-frequency and spatial information for the detection of sleep spindles.

Front Hum Neurosci 2015 19;9:70. Epub 2015 Feb 19.

Laboratoire PhysNum, École de Technologie Supérieure, Centre de Recherches Mathématiques Montreal, QC, Canada.

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March 2015

Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior.

Front Neurosci 2014 21;8:447. Epub 2015 Jan 21.

Department of Neuroscience, The Ohio State University College of Medicine Columbus, OH, USA ; Institute for Behavioral Medicine Research, The Ohio State University College of Medicine Columbus, OH, USA ; Center for Brain and Spinal Cord Repair, The Ohio State University College of Medicine Columbus, OH, USA.

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February 2015

Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types.

J Neurosci 2015 Feb;35(7):2860-70

Division of Biosciences, The Ohio State University, Columbus, Ohio 43210, Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210,

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February 2015

Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function.

Brain Behav Immun 2015 Jan 4;43:76-85. Epub 2014 Aug 4.

College of Nursing, The Ohio State University, 1585 Neil Ave., Columbus, OH, United States. Electronic address:

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January 2015

Basic aspects of the immunology of neuroinflammation.

Mod Trends Pharmacopsychiatry 2013 27;28:1-19. Epub 2013 Feb 27.

Department of Neuroscience, Institute for Behavioral Medicine Research, Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, Ohio, USA.

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December 2014

A time-frequency analysis of the dynamics of cortical networks of sleep spindles from MEG-EEG recordings.

Front Neurosci 2014 28;8:310. Epub 2014 Oct 28.

Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur Montreal, QC, Canada ; Department of Psychology, Université de Montréal Montreal, QC, Canada.

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November 2014

Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia.

Biol Psychiatry 2014 Oct 25;76(7):575-84. Epub 2013 Oct 25.

Department of Neuroscience, Ohio State University, Columbus, Ohio; Center for Brain and Spinal Cord Repair, Ohio State University, Columbus, Ohio; Institute for Behavioral Medicine Research, Ohio State University, Columbus, Ohio. Electronic address:

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October 2014

The role of inflammatory mediators in immune-to-brain communication during health and disease.

Mediators Inflamm 2013 10;2013:429231. Epub 2013 Sep 10.

Centre for Biological Sciences, University of Southampton, Southampton SO16 6YD, UK.

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June 2014

Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain.

Biol Psychiatry 2014 Jun 10;75(12):970-81. Epub 2013 Dec 10.

Department of Neuroscience; Institute for Behavioral Medicine Research; Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, Ohio. Electronic address:

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June 2014

TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation.

Glia 2014 Jun 25;62(6):881-95. Epub 2014 Feb 25.

Department of Neuroscience, The Ohio State University, Columbus, Ohio.

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June 2014

IL-4 signaling drives a unique arginase+/IL-1β+ microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal cord injury.

J Neurosci 2014 Jun;34(26):8904-17

Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, Center for Brain and Spinal Cord Repair and Institute for Behavioral Medicine Research, The Ohio State University, Columbus, Ohio 43210

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June 2014

Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.

Neuron 2014 Mar;81(5):1009-1023

Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA; Biomedical Sciences Graduate Program, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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March 2014

Knockdown of interleukin-1 receptor type-1 on endothelial cells attenuated stress-induced neuroinflammation and prevented anxiety-like behavior.

J Neurosci 2014 Feb;34(7):2583-91

Oral Biology Division, Department of Neuroscience, Institute for Behavioral Medicine Research, and Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, Ohio 43210.

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February 2014

Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamate transporters and spatial memory.

J Neuroimmune Pharmacol 2013 Dec 25;8(5):1098-105. Epub 2013 May 25.

Department of Psychology, Ohio State University, 1835 Neil Avenue, Columbus, OH, 43210, USA.

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December 2013

Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand.

Neurobiol Aging 2013 Dec 21;34(12):2748-58. Epub 2013 Jul 21.

Department of Neuroscience, The Ohio State University, Columbus, OH, USA.

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December 2013

Neonatal E. coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron.

J Neurosci 2013 Oct;33(41):16334-45

Department of Neuroscience, Division of Oral Biology, Institute for Behavioral Medicine Research, and Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, Ohio 43210, Abbott Nutrition, Columbus, Ohio 43219, and Department of Psychology and Neuroscience, Duke University, Durham, North Carolina 27708.

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October 2013

Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10.

PLoS One 2013 8;8(3):e58488. Epub 2013 Mar 8.

The Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio, United States of America.

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September 2013

Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior.

J Neurosci 2013 Aug;33(34):13820-33

Department of Neuroscience, The Ohio State University, Columbus, OH, USA.

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August 2013

Topography of age-related changes in sleep spindles.

Neurobiol Aging 2013 Feb 17;34(2):468-76. Epub 2012 Jul 17.

Department of Psychology, University of Montréal, Montreal, Quebec, Canada.

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February 2013

Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice.

Psychoneuroendocrinology 2012 Sep 2;37(9):1491-505. Epub 2012 Mar 2.

Division of Oral Biology, The Ohio State University, 305 W. 12th Ave, Columbus, OH 43210, USA.

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September 2012

Cognitive and behavioral consequences of impaired immunoregulation in aging.

J Neuroimmune Pharmacol 2012 Mar 20;7(1):7-23. Epub 2011 Sep 20.

Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA.

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March 2012

β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat.

J Neurosci 2011 Apr;31(17):6277-88

Division of Oral Biology, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA.

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April 2011

Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide.

J Neuroinflammation 2010 Dec 17;7:93. Epub 2010 Dec 17.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 333 W. 10th Ave., Columbus, OH 43210, USA.

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December 2010

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge.

Brain Behav Immun 2010 Oct 4;24(7):1190-201. Epub 2010 Jun 4.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 333 W. 10th Avenue, Columbus, OH 43210, USA.

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October 2010

Immune and behavioral consequences of microglial reactivity in the aged brain.

Integr Comp Biol 2009 Sep 23;49(3):254-66. Epub 2009 Apr 23.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.

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September 2009

Age and neuroinflammation: a lifetime of psychoneuroimmune consequences.

Immunol Allergy Clin North Am 2009 May;29(2):321-37

Institute for Behavioral Medicine Research, the Ohio State University, Columbus, OH 43210, USA.

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May 2009

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines.

Brain Behav Immun 2009 Mar 12;23(3):309-17. Epub 2008 Sep 12.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Room 2166B Graves Hall, 333 W. 10th Avenue, Columbus, OH 43210, USA.

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March 2009

Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system.

Neuropsychopharmacology 2008 Sep 12;33(10):2341-51. Epub 2007 Dec 12.

Department of Molecular Virology, Immunology and Medical Genetics, Institute for Behavioral Medicine, The Ohio State University, Columbus, OH, USA.

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September 2008

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia.

J Neuroinflammation 2008 May 13;5:15. Epub 2008 May 13.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 333 W, 10th Ave, Columbus, OH 43210, USA.

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May 2008

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system.

Brain Behav Immun 2008 Mar 24;22(3):301-11. Epub 2007 Oct 24.

Integrative Immunology and Behavior Program, University of Illinois, Urbana, IL 61801, USA.

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March 2008

Enhanced neuronal activation in central autonomic network nuclei in aged mice following acute peripheral immune challenge.

Auton Neurosci 2007 Jan 14;131(1-2):137-42. Epub 2006 Aug 14.

Program in Sensory and Systems Neuroscience, Department of Psychology, University of Virginia, Charlottesville, VA 22904, USA.

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January 2007

Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer.

J Neuroimmune Pharmacol 2006 Dec 10;1(4):421-7. Epub 2006 Aug 10.

Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA.

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December 2006

Age and neuroinflammation: a lifetime of psychoneuroimmune consequences.

Neurol Clin 2006 Aug;24(3):521-38

Institute for Behavioral Medicine Research, the Ohio State University, Columbus, OH 43210, USA.

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August 2006

alpha-Tocopherol and selenium facilitate recovery from lipopolysaccharide-induced sickness in aged mice.

J Nutr 2005 May;135(5):1157-63

Division of Nutritional Sciences, University of Illinois, Urbana 61801, USA.

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May 2005

Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus.

J Biol Chem 2004 Jul 27;279(27):28045-50. Epub 2004 Apr 27.

Department of Animal Sciences, University of Illinois at Urbana-Champaign, 506 South Mathews, Urbana, IL 61801, USA.

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July 2004

alpha-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain.

J Neuroimmunol 2004 Apr;149(1-2):101-9

Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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April 2004

Alpha-tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice.

Brain Behav Immun 2004 Mar;18(2):149-57

Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA.

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March 2004

Methylglyoxal enhances cisplatin-induced cytotoxicity by activating protein kinase Cdelta.

J Biol Chem 2002 Jan 13;277(4):2554-61. Epub 2001 Nov 13.

Department of Pathology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

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January 2002