Jonathan G Seidman

Jonathan G Seidman

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Jonathan G Seidman

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Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of and .

Circ Res 2019 Oct 9;125(9):834-846. Epub 2019 Sep 9.

From the Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (C.Y.T., J.X.W., P.S.C., H.T., D.L., W.C., J.J.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314794DOI Listing
October 2019

Advances in the Genetic Basis and Pathogenesis of Sarcomere Cardiomyopathies.

Annu Rev Genomics Hum Genet 2019 Aug 12;20:129-153. Epub 2019 Apr 12.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; email:

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https://www.annualreviews.org/doi/10.1146/annurev-genom-0831
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http://dx.doi.org/10.1146/annurev-genom-083118-015306DOI Listing
August 2019

The Translational Landscape of the Human Heart.

Cell 2019 Jun 30;178(1):242-260.e29. Epub 2019 May 30.

Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347 Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany; Charité-Universitätsmedizin, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.05.010DOI Listing
June 2019

Novel Therapies for Prevention and Early Treatment of Cardiomyopathies.

Circ Res 2019 May;124(11):1536-1550

From the Department of Genetics, Harvard Medical School, Boston, MA (G.G.R., C.N.T., J.G.S., C.E.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.31356
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http://dx.doi.org/10.1161/CIRCRESAHA.119.313569DOI Listing
May 2019

SarcTrack.

Circ Res 2019 Apr;124(8):1172-1183

From the Department of Genetics (C.N.T., A.S., A.C.G., M.N., J.A.L.W., R.A., M.S., J.R., O.P., J.G.S., C.E.S.), Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485312PMC
April 2019

The Transcriptional Signature of Growth in Human Fetal Aortic Valve Development.

Ann Thorac Surg 2018 12 30;106(6):1834-1840. Epub 2018 Jul 30.

Department of Genetics, Harvard University, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.athoracsur.2018.06.034DOI Listing
December 2018

Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy.

Heart Fail Clin 2018 Apr;14(2):139-146

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Department of Genetics, Brigham and Women's Hospital, Harvard Medical School, New Research Building Room 256, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15517136173012
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http://dx.doi.org/10.1016/j.hfc.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851453PMC
April 2018

ViroFind: A novel target-enrichment deep-sequencing platform reveals a complex JC virus population in the brain of PML patients.

PLoS One 2018 23;13(1):e0186945. Epub 2018 Jan 23.

Division of NeuroImmunology, Center for Virology and Vaccine Research, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186945PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779639PMC
February 2018

Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.

Dev Cell 2018 01 8;44(1):87-96.e5. Epub 2018 Jan 8.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421364PMC
January 2018

Fabry Disease in Families With Hypertrophic Cardiomyopathy: Clinical Manifestations in the Classic and Later-Onset Phenotypes.

Circ Cardiovasc Genet 2017 Aug;10(4)

From the Faculty of Medicine, University of Iceland, Reykjavik, Iceland (B.A., R.P., R.A., G.T.G.); Division of Cardiology (B.A., R.D.), Department of Genetics (R.A.), Division of Nephrology (R.P.), and Department of Radiology (M.G.), Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland; Department of Cardiology, Haukeland University Hospital, Bergen, Norway (B.A.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (R.J.D., B.C., S.P.); Department of Genetics, Harvard Medical School, Boston, MA (P.T., M.A.B., J.G.S., C.E.S.); Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.A., U.N.); Division of Cardiology, Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (M.M., B.J.M.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (M.A.B., C.E.S.); Division of Cardiology, Emory University School of Medicine, Atlanta, GA (M.A.B.); Department of Medical Endocrinology, Rigshospitalet and University of Copenhagen, Denmark (C.V.M., U.F.-R.); Howard Hughes Medical Institute, Boston, MA (C.E.S.); and Department of Medicine, Akureyri Hospital, Iceland (G.T.G.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001639DOI Listing
August 2017

Early remodeling of repolarizing K currents in the αMHC mouse model of familial hypertrophic cardiomyopathy.

J Mol Cell Cardiol 2017 02 13;103:93-101. Epub 2017 Jan 13.

Department of Developmental Biology, Washington University Medical School, St. Louis, MO 63110-1093, USA; Department of Medicine, Washington University Medical School, St. Louis, MO 63110-1093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2017.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398411PMC
February 2017

Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy.

J Am Coll Cardiol 2016 Dec;68(25):2871-2886

Department of Genetics, Harvard Medical School, Boston, Massachusetts; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Howard Hughes Medical Institute, Chevy Chase, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.08.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843375PMC
December 2016

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.

Cell Rep 2016 12;17(12):3292-3304

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193246PMC
December 2016

Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts.

J Vis Exp 2016 12 17(118). Epub 2016 Dec 17.

Department of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School;

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http://dx.doi.org/10.3791/54787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226409PMC
December 2016

Fulminant Myocarditis with Combination Immune Checkpoint Blockade.

N Engl J Med 2016 Nov;375(18):1749-1755

From the Departments of Medicine (D.B.J., J.M.B., M.H., I.P., M.R.A., T.L.B., J.R.B., D.A.S., E.J.P., M.A.P., D.M.R., J.A.S., J.J.M.), Cancer Biology (J.M.B., J.J.M.), Pathology, Microbiology, and Immunology (M.L.C., L.C.-O., R.D.H.), Biostatistics (Y.X.), Pharmacology (D.M.R.), and Biomedical Informatics (Y.X., D.M.R.), the Cardio-oncology Program (D.A.S., J.J.M.), the Breast Cancer Research Program (J.M.B.), and the Center for Quantitative Sciences (Y.X.), Vanderbilt University Medical Center, Nashville; the Department of Medicine (S.C.) and the Division of Neuroimmunology (S.C., I.J.K.), Beth Israel Deaconess Medical Center, the Departments of Medicine (B.A.O., C.E.S., J.G.S.) and Pathology (A.H.L.), Brigham and Women's Hospital, the Department of Genetics, Harvard Medical School (J.G., C.E.S., J.G.S.) - all in Boston; Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.); Bristol-Myers Squibb, New York (N.K., G.P., D.S.R., J.S.D.); Neon Therapeutics, Cambridge, MA (R.P.D.); and the Departments of Pathology (J.M.T., R.A.A.), Dermatology (J.M.T.), and Oncology (L.A.D.), Johns Hopkins University, Baltimore.

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http://dx.doi.org/10.1056/NEJMoa1609214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247797PMC
November 2016

RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing.

Physiol Genomics 2016 10 5;48(10):749-761. Epub 2016 Aug 5.

Centre de recherche Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec, Canada; Department of Molecular Medicine, Laval University, Quebec, Canada

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http://dx.doi.org/10.1152/physiolgenomics.00041.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195654PMC
October 2016

Detection of Cell Proliferation Markers by Immunofluorescence Staining and Microscopy Imaging in Paraffin-Embedded Tissue Sections.

Curr Protoc Mol Biol 2016 07 1;115:14.25.1-14.25.14. Epub 2016 Jul 1.

Department of Genetics, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cpmb.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349766PMC
July 2016

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.

Cell 2016 May 21;165(5):1147-1159. Epub 2016 Apr 21.

Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati 45247, OH, USA; Cincinnati Children's Hospital Medical Center, Howard Hughes Medical Institute, Cincinnati 45247, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874838PMC
May 2016

Molecular profiling of dilated cardiomyopathy that progresses to heart failure.

JCI Insight 2016 May;1(6)

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.86898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882118PMC
May 2016

The Muscle-Bound Heart.

Card Electrophysiol Clin 2016 Mar;8(1):223-31

Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.1016/j.ccep.2015.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599619PMC
March 2016

Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies.

N Engl J Med 2016 Jan 6;374(3):233-41. Epub 2016 Jan 6.

From the Department of Genetics, Harvard Medical School (J.S.W., E.M., C.M.Y., C.E.S., J.G.S.), the Howard Hughes Medical Institute (C.E.S.), and the Cardiovascular Division, Brigham and Women's Hospital (J.S.W., E.M., C.E.S., J.G.S.) - all in Boston; the Cardiovascular Institute and the Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (J.L., T.D., T.P.C., Z.A.), the Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh (I.H., J.P., K.H.-Y., J.G., D.M.M.), and Penn State Hershey Medical Center, Hershey (J.B.) - all in Pennsylvania; the National Institute for Health Research Royal Brompton Cardiovascular Biomedical Research Unit (J.S.W., F.M., S.K.P.) and the National Heart and Lung Institute (J.S.W., F.M., S.A.C., S.K.P.), Imperial College London, London; the Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York (E.J.T.), and the University of Rochester, Rochester (J.A.) - both in New York; the Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany (D.H.-K.); the Department of Perinatology and Gynecology, the National Cerebral and Cardiovascular Center, Osaka, Japan (C.A.K.); the National Heart Center and Duke-National University of Singapore, Singapore (S.A.C.); the Intermountain Medical Center, Murray, Utah (R.A.); Vanderbilt University, Nashville (J.D.); Cleveland Clinic, Cleveland (E.H.); University of Southern California, Los Angeles (U.E.); McGill University and Jewish General Hospital, Montreal (R.S.), University of Calgary, Calgary, AB (A.K.), and University of Toronto, Toronto (P.L.) - all in Canada; University of Maryland, College Park (G.R.), and Johns Hopkins Hospital, Baltimore (I.S.W.) - both in Maryland; Morristown Hospital, Morristown (J.S.), and Newark Beth Israel Medical Center, Newark (M.J.Z.) - both in New Jersey; Truman Medical Center, University of Missouri, Kansas City (D.F.P.); and Wa

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http://dx.doi.org/10.1056/NEJMoa1505517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797319PMC
January 2016

Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.

Circ Cardiovasc Genet 2015 Dec 9;8(6):812-22. Epub 2015 Nov 9.

From the Centre de recherche Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, Canada (S.G.-O., M.L., J.T.-M., E.L.-C., N.G., P.M., P.P., Y.B.); Departments of Molecular Medicine (A.D., Y.B.), Surgery (P.M.), and Medicine (P.P.), Laval University, Quebec, Canada; Cardiology Department, AP-HP, Bichat Hospital, Paris, France (D.M.-Z.); INSERM U698, Paris, France (D.M.-Z.); Département de Génétique, Hôpital Bichat, 75018 Paris, France (C.B.); Centre de Recherche du CHUQ, Quebec, Canada (A.D.); Montreal Heart Institute, Department of Medicine (M.-P.D., J.-C.T.), Université de Montréal, Montreal, Canada (B.J.A.); Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (S.C.B.); and Department of Genetics, Harvard Medical School, Boston, MA (J.G.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934886PMC
December 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.

J Mol Cell Cardiol 2015 Feb 25;79:234-43. Epub 2014 Nov 25.

Department of Cell and Molecular Physiology, Health Sciences Division, Loyola University Chicago, Maywood, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642280PMC
February 2015

Nationwide study on hypertrophic cardiomyopathy in Iceland: evidence of a MYBPC3 founder mutation.

Circulation 2014 Sep 30;130(14):1158-67. Epub 2014 Jul 30.

From Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland (B.A., R.D.); Faculty of Medicine (B.A., K.S., G.T.G.) and School of Engineering and Natural Sciences (D.F.G.), University of Iceland, Reykjavik, Iceland; Department of Genetics, Harvard Medical School, Boston, MA (P.T., M.A.B., S.R.D., E.M., B.M., J.G.S., C.E.S.); Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (M.A.B., C.E.S.); deCODE Genetics, Reykjavik, Iceland (D.F.G., H.H., K.S.); Howard Hughes Medical Institute, Boston, MA (C.E.S.); and Akureyri Hospital, Akureyri, Iceland (G.T.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.011207DOI Listing
September 2014

Alpha blockade potentiates CPVT therapy in calsequestrin-mutant mice.

Heart Rhythm 2014 Aug 21;11(8):1471-9. Epub 2014 Apr 21.

Leviev Heart Center, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2014.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108570PMC
August 2014

Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model.

Circ Res 2014 Jul 15;115(3):354-63. Epub 2014 May 15.

From the Departments of Cardiology, Boston Children's Hospital (Z.L., A.v.G., P.Z., F.G., Q.M., A.L.Y., J.N.B., K.A.G., P.R.R.v.G., B.Z., J.C., D.-Z.W., W.T.P.) and Genetics (J.J., J.G.S.), Harvard Medical School, Boston, MA; Department of Pediatric Cardiology and Intensive Care, MHH-Hannover Medical School, Hannover, Germany (A.v.G.); Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands (P.R.R.v.G.); Harvard Stem Cell Institute, Harvard University, Cambridge, MA (D.-Z.W., W.T.P.); and Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China (B.Z.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.303632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104149PMC
July 2014

Genetics and disease of ventricular muscle.

Cold Spring Harb Perspect Med 2014 Jan 1;4(1):a021063. Epub 2014 Jan 1.

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia.

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http://dx.doi.org/10.1101/cshperspect.a021063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869277PMC
January 2014

The role of mutant protein level in autosomal recessive catecholamine dependent polymorphic ventricular tachycardia (CPVT2).

Biochem Pharmacol 2013 Dec 23;86(11):1576-83. Epub 2013 Sep 23.

Leviev Heart Center, Sheba Medical Center, Tel Hashomer and Sackler School of, Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1016/j.bcp.2013.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103182PMC
December 2013

HOXA2 haploinsufficiency in dominant bilateral microtia and hearing loss.

Hum Mutat 2013 Oct 11;34(10):1347-51. Epub 2013 Jul 11.

Department of Genetics, Harvard Medical School, Boston, Massachusetts; Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/humu.22367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883620PMC
October 2013

Exercise training improves cardiac function and attenuates arrhythmia in CPVT mice.

J Appl Physiol (1985) 2012 Dec 4;113(11):1677-83. Epub 2012 Oct 4.

Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://www.physiology.org/doi/10.1152/japplphysiol.00818.201
Publisher Site
http://dx.doi.org/10.1152/japplphysiol.00818.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774075PMC
December 2012

Stable gene targeting in human cells using single-strand oligonucleotides with modified bases.

PLoS One 2012 14;7(5):e36697. Epub 2012 May 14.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036697PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351460PMC
September 2012

Barcoding bias in high-throughput multiplex sequencing of miRNA.

Genome Res 2011 Sep 12;21(9):1506-11. Epub 2011 Jul 12.

Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.

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http://dx.doi.org/10.1101/gr.121715.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166835PMC
September 2011

Optimizing catecholaminergic polymorphic ventricular tachycardia therapy in calsequestrin-mutant mice.

Heart Rhythm 2010 Nov 8;7(11):1676-82. Epub 2010 Jul 8.

Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Israel.

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http://dx.doi.org/10.1016/j.hrthm.2010.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103178PMC
November 2010

Genetics of hypertrophic cardiomyopathy.

Curr Opin Cardiol 2010 May;25(3):205-9

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1097/HCO.0b013e3283375698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932754PMC
May 2010

Locus for familial migrainous vertigo disease maps to chromosome 5q35.

Ann Otol Rhinol Laryngol 2009 Sep;118(9):670-6

Department of Genetics, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767209PMC
http://dx.doi.org/10.1177/000348940911800912DOI Listing
September 2009

E2F3 plays an essential role in cardiac development and function.

Cell Cycle 2008 Dec 22;7(23):3775-80. Epub 2008 Dec 22.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.7.23.7240
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723769PMC
http://dx.doi.org/10.4161/cc.7.23.7240DOI Listing
December 2008

Increased glycogen stores due to gamma-AMPK overexpression protects against ischemia and reperfusion damage.

Biochem Pharmacol 2008 Apr 5;75(7):1482-91. Epub 2008 Jan 5.

The Cardiac Research Laboratory, Felsenstein Medical Research Center, Rabin Medical Center, Tel Aviv University, Petah Tikva 49100, Israel.

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http://dx.doi.org/10.1016/j.bcp.2007.12.011DOI Listing
April 2008

Genetic basis of hypertrophic cardiomyopathy: from bench to the clinics.

J Cardiovasc Electrophysiol 2008 Jan 4;19(1):104-10. Epub 2007 Oct 4.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1111/j.1540-8167.2007.00965.xDOI Listing
January 2008

Cardiac myosin binding protein C phosphorylation is cardioprotective.

Proc Natl Acad Sci U S A 2006 Nov 30;103(45):16918-23. Epub 2006 Oct 30.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1073/pnas.0607069103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636554PMC
November 2006

Cardiovascular genomics.

Circulation 2006 Mar;113(11):e450-5

Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.105.5
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March 2006

Cardiac myosin-binding protein-C phosphorylation and cardiac function.

Circ Res 2005 Nov 13;97(11):1156-63. Epub 2005 Oct 13.

Division of Molecular Cardiovascular Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, OH, USA.

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http://dx.doi.org/10.1161/01.RES.0000190605.79013.4dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1343494PMC
November 2005

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.

Development 2004 Aug;131(16):4107-16

Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1242/dev.01265DOI Listing
August 2004

A novel missense mutation in the paired domain of PAX9 causes non-syndromic oligodontia.

Hum Genet 2004 Feb 19;114(3):242-9. Epub 2003 Dec 19.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s00439-003-1066-6DOI Listing
February 2004

IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis.

J Clin Invest 2003 Mar;111(5):671-80

Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI16867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151896PMC
March 2003

Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome.

Structure 2002 Mar;10(3):343-56

European Molecular Biology Laboratory, Grenoble Outstation, France.

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http://dx.doi.org/10.1016/s0969-2126(02)00722-0DOI Listing
March 2002