Publications by authors named "Jonathan G L Mullins"

34Publications

In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate.

J Pharmacol Exp Ther 2020 Aug 11;374(2):295-307. Epub 2020 May 11.

Department of Pharmacy, Faculty of Science (W.K.T., A.R.Y.T., P.S., E.J.H.G., Z.P.Y., N.F.S., A.J.L.) and Department of Pharmacology, Yong Loo Lin School of Medicine (A.J.L.), National University of Singapore, Singapore, Singapore; and Institute of Life Science, Swansea University Medical School, Swansea, United Kingdom (K.A.-M., J.G.L.M.)

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http://dx.doi.org/10.1124/jpet.120.265249DOI Listing
August 2020

In Vitro and In Silico Analyses of the Inhibition of Human Aldehyde Oxidase by Bazedoxifene, Lasofoxifene, and Structural Analogues.

J Pharmacol Exp Ther 2019 10 9;371(1):75-86. Epub 2019 Jul 9.

Department of Pharmacy, Faculty of Science (S.C., A.J.L.), and Department of Pharmacology, Yong Loo Lin School of Medicine (A.J.L.), National University of Singapore, Singapore; Institute of Life Science, Swansea University Medical School, Swansea, United Kingdom (K.A.-M., J.G.L.M.); and NanoBioTec, Whippany, New Jersey (L.H.Z.)

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http://dx.doi.org/10.1124/jpet.119.259267DOI Listing
October 2019

Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes.

Hum Mol Genet 2015 Sep 30;24(18):5313-25. Epub 2015 Jun 30.

Department of Pediatrics, Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA,

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http://dx.doi.org/10.1093/hmg/ddv250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550818PMC
September 2015

Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase.

Appl Environ Microbiol 2015 May 6;81(10):3379-86. Epub 2015 Mar 6.

Centre for Cytochrome P450 Biodiversity, Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom

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http://aem.asm.org/lookup/doi/10.1128/AEM.03965-14
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http://dx.doi.org/10.1128/AEM.03965-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407231PMC
May 2015

Resistance to antifungals that target CYP51.

J Chem Biol 2014 Oct 27;7(4):143-61. Epub 2014 Aug 27.

Centre for Cytochrome P450 Biodiversity, Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales SA2 8PP UK.

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http://dx.doi.org/10.1007/s12154-014-0121-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182338PMC
October 2014

De novo mutations in the beta-tubulin gene TUBB2A cause simplified gyral patterning and infantile-onset epilepsy.

Am J Hum Genet 2014 Apr;94(4):634-41

Center for Integrative Brain Research, Seattle Children's Hospital, Seattle, WA 98101, USA; Departments of Pediatrics and Neurology, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980418PMC
April 2014

A novel GABRG2 mutation, p.R136*, in a family with GEFS+ and extended phenotypes.

Neurobiol Dis 2014 Apr 7;64:131-141. Epub 2014 Jan 7.

Wales Epilepsy Research Network, Institute of Life Sciences, College of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, UK.

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http://dx.doi.org/10.1016/j.nbd.2013.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222744PMC
April 2014

Genotype-phenotype correlations in hyperekplexia: apnoeas, learning difficulties and speech delay.

Brain 2013 Oct 11;136(Pt 10):3085-95. Epub 2013 Sep 11.

1 Institute of Life Science, College of Medicine, Swansea University, SA2 8PP, UK.

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http://dx.doi.org/10.1093/brain/awt207DOI Listing
October 2013

Overlapping cortical malformations and mutations in TUBB2B and TUBA1A.

Brain 2013 Feb 29;136(Pt 2):536-48. Epub 2013 Jan 29.

Institute of Life Science, College of Medicine, Swansea University, Swansea SA2 8PP, UK.

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http://dx.doi.org/10.1093/brain/aws338DOI Listing
February 2013

Structural modelling pipelines in next generation sequencing projects.

Adv Protein Chem Struct Biol 2012 ;89:117-67

Genome and Structural Bioinformatics, Institute of Life Science, College of Medicine, Swansea University, Singleton Park, Swansea, Wales, UK.

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http://dx.doi.org/10.1016/B978-0-12-394287-6.00005-7DOI Listing
November 2013

In silico directed mutagenesis identifies the CD81/claudin-1 hepatitis C virus receptor interface.

Cell Microbiol 2012 Dec 25;14(12):1892-903. Epub 2012 Sep 25.

School of Immunity and Infection, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1111/cmi.12008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549482PMC
December 2012

S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.

Antimicrob Agents Chemother 2012 Apr 17;56(4):2099-107. Epub 2012 Jan 17.

Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom.

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http://aac.asm.org/lookup/doi/10.1128/AAC.05389-11
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http://dx.doi.org/10.1128/AAC.05389-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318376PMC
April 2012

Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes.

FEBS J 2012 May 27;279(9):1640-9. Epub 2012 Jan 27.

Institute of Life Science, Medical School, Swansea University, Swansea, UK.

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http://dx.doi.org/10.1111/j.1742-4658.2011.08447.xDOI Listing
May 2012

Impact of recently emerged sterol 14{alpha}-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity.

Appl Environ Microbiol 2011 Jun 8;77(11):3830-7. Epub 2011 Apr 8.

Department of Plant Pathology and Microbiology, Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, United Kingdom.

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http://dx.doi.org/10.1128/AEM.00027-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127603PMC
June 2011

Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling.

Adv Protein Chem Struct Biol 2010 ;80:117-52

Institute of Life Science, Swansea University, Singleton Park, Swansea, United Kingdom.

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http://dx.doi.org/10.1016/B978-0-12-381264-3.00004-7DOI Listing
April 2011

Claudin association with CD81 defines hepatitis C virus entry.

J Biol Chem 2010 Jul 7;285(27):21092-102. Epub 2010 Apr 7.

Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.104836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898367PMC
July 2010

PAH-domain-specific interactions of the Arabidopsis transcription coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS EARLY2 Myb-DNA binding factors.

J Mol Biol 2010 Feb 4;395(5):937-49. Epub 2009 Dec 4.

Institute of Life Science, School of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, UK.

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http://dx.doi.org/10.1016/j.jmb.2009.11.065DOI Listing
February 2010

Biophysical properties of 9 KCNQ1 mutations associated with long-QT syndrome.

Circ Arrhythm Electrophysiol 2009 Aug 22;2(4):417-26. Epub 2009 May 22.

Department of Medicine and Pharmacology, Oates Institute for Experimental Therapeutics, Vanderbilt University School of Medicine, Nashville, Tenn, USA.

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http://dx.doi.org/10.1161/CIRCEP.109.850149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748886PMC
August 2009

The first virally encoded cytochrome p450.

J Virol 2009 Aug 10;83(16):8266-9. Epub 2009 Jun 10.

Institute of Life Science, Swansea University, United Kingdom.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.00289-09
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http://dx.doi.org/10.1128/JVI.00289-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715754PMC
August 2009

A combinatorial pattern discovery approach for the prediction of membrane dipping (re-entrant) loops.

Bioinformatics 2006 Jul;22(14):e290-7

Membrane Proteins Structural Bioinformatics Group, School of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, Wales, UK.

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http://dx.doi.org/10.1093/bioinformatics/btl209DOI Listing
July 2006

Influence of CrgA on assembly of the cell division protein FtsZ during development of Streptomyces coelicolor.

J Bacteriol 2006 Feb;188(4):1540-50

Institute of Life Science, School of Medicine, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, United Kingdom.

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http://dx.doi.org/10.1128/JB.188.4.1540-1550.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367258PMC
February 2006

Identification of residues controlling transport through the yeast aquaglyceroporin Fps1 using a genetic screen.

Eur J Biochem 2004 Feb;271(4):771-9

Department of Cell and Molecular Biology/Microbiology, Göteborg University, Sweden.

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http://dx.doi.org/10.1111/j.1432-1033.2004.03980.xDOI Listing
February 2004

A regulatory domain in the C-terminal extension of the yeast glycerol channel Fps1p.

J Biol Chem 2004 Apr 28;279(15):14954-60. Epub 2004 Jan 28.

Department of Cell and Molecular Biology/Microbiology, Götegorg University, Götegorg, Sweden.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M313126200
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http://dx.doi.org/10.1074/jbc.M313126200DOI Listing
April 2004

A short regulatory domain restricts glycerol transport through yeast Fps1p.

J Biol Chem 2003 Feb 16;278(8):6337-45. Epub 2002 Dec 16.

Department of Cell and Molecular Biology/Microbiology, Göteborg University, Box 462, 40530 Göteborg, Sweden.

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http://dx.doi.org/10.1074/jbc.M209792200DOI Listing
February 2003