Jonathan Flint

Jonathan Flint

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Jonathan Flint

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The great hairball gambit.

PLoS Genet 2019 Nov 26;15(11):e1008519. Epub 2019 Nov 26.

Division of Genetics, Department of Medicine, University of California San Diego, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008519DOI Listing
November 2019

Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE.

Psychol Med 2019 Apr 2:1-6. Epub 2019 Apr 2.

Department of Psychiatry,Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, School of Medicine,Richmond, VA,USA.

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http://dx.doi.org/10.1017/S0033291719000618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774907PMC
April 2019

Reverse GWAS: Using genetics to identify and model phenotypic subtypes.

PLoS Genet 2019 04 5;15(4):e1008009. Epub 2019 Apr 5.

Department of Medicine, UCSF, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469799PMC
April 2019

Systematic benchmarking of omics computational tools.

Nat Commun 2019 03 27;10(1):1393. Epub 2019 Mar 27.

Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1038/s41467-019-09406-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437167PMC
March 2019

Outside in.

Authors:
Jonathan Flint

PLoS Genet 2019 02 28;15(2):e1008014. Epub 2019 Feb 28.

Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394895PMC
February 2019

Estimating SNP-Based Heritability and Genetic Correlation in Case-Control Studies Directly and with Summary Statistics.

Am J Hum Genet 2018 07;103(1):89-99

Statistics Department, Tel Aviv University, Ramat Aviv 6997801, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035374PMC
July 2018

Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.

Am J Psychiatry 2018 06 2;175(6):545-554. Epub 2018 Mar 2.

From the Virginia Institute for Psychiatric and Behavioral Genetics and the Department of Psychiatry, Virginia Commonwealth University, Richmond, Va.; the Wellcome Trust Sanger Institute, Cambridge, U.K.; the European Bioinformatics Institute (EMBL-EBI), Cambridge, U.K.; the Department of Medicine, University of California, San Francisco; the State University of New York Downstate Medical Center, Brooklyn, N.Y.; and the Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles.

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http://dx.doi.org/10.1176/appi.ajp.2017.17060621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988935PMC
June 2018

Why does the magnitude of genotype-by-environment interaction vary?

Ecol Evol 2018 Jun 8;8(12):6342-6353. Epub 2018 May 8.

University of Illinois at Urbana-Champaign Urbana Illinois.

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http://dx.doi.org/10.1002/ece3.4128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024136PMC
June 2018

The centrality of DSM and non-DSM depressive symptoms in Han Chinese women with major depression.

J Affect Disord 2018 02 10;227:739-744. Epub 2017 Nov 10.

Department of Psychological Methods, University of Amsterdam, USA.

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http://dx.doi.org/10.1016/j.jad.2017.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815309PMC
February 2018

Deep Reads: How I learnt to love population genetics.

Authors:
Jonathan Flint

PLoS Genet 2017 12 21;13(12):e1007140. Epub 2017 Dec 21.

Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739349PMC
December 2017

Age of onset and family history as indicators of polygenic risk for major depression.

Depress Anxiety 2017 05 2;34(5):446-452. Epub 2017 Feb 2.

Virginia Institute for Psychiatric & Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.

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http://doi.wiley.com/10.1002/da.22607
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http://dx.doi.org/10.1002/da.22607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501985PMC
May 2017

Identifying genes for neurobehavioural traits in rodents: progress and pitfalls.

Dis Model Mech 2017 04;10(4):373-383

Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095-1761, USA

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http://dx.doi.org/10.1242/dmm.027789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399566PMC
April 2017

The Genetic Architecture of Major Depressive Disorder in Han Chinese Women.

JAMA Psychiatry 2017 02;74(2):162-168

Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond.

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http://dx.doi.org/10.1001/jamapsychiatry.2016.3578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319866PMC
February 2017

CHRONICITY OF DEPRESSION AND MOLECULAR MARKERS IN A LARGE SAMPLE OF HAN CHINESE WOMEN.

Depress Anxiety 2016 Nov 25;33(11):1048-1054. Epub 2016 Apr 25.

Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079854PMC
http://dx.doi.org/10.1002/da.22517DOI Listing
November 2016

The Amount of Mitochondrial DNA in Blood Reflects the Course of a Depressive Episode.

Biol Psychiatry 2016 09 30;80(6):e41-e42. Epub 2015 Dec 30.

Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2015.12.019DOI Listing
September 2016

Rapid genotype imputation from sequence without reference panels.

Nat Genet 2016 08 4;48(8):965-969. Epub 2016 Jul 4.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966640PMC
August 2016

Rare genetic variants and schizophrenia.

Authors:
Jonathan Flint

Nat Neurosci 2016 Apr;19(4):525-7

Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nn.4271DOI Listing
April 2016

CLASSIFICATION OF ANXIETY DISORDERS COMORBID WITH MAJOR DEPRESSION: COMMON OR DISTINCT INFLUENCES ON RISK?

Depress Anxiety 2016 Feb 29;33(2):120-7. Epub 2015 Sep 29.

Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.

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http://dx.doi.org/10.1002/da.22432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729582PMC
February 2016

G = E: What GWAS Can Tell Us about the Environment.

PLoS Genet 2016 Feb 11;12(2):e1005765. Epub 2016 Feb 11.

MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1005765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750859PMC
February 2016

Genetic Control over mtDNA and Its Relationship to Major Depressive Disorder.

Curr Biol 2015 Dec 10;25(24):3170-7. Epub 2015 Dec 10.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, Oxfordshire OX3 7BN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2015.10.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691240PMC
December 2015

Genomes and phenomes of a population of outbred rats and its progenitors.

Sci Data 2014 10;1:140011. Epub 2014 Jun 10.

Wellcome Trust Centre for Human Genetics, Roosevelt Drive , Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/sdata.2014.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381735PMC
October 2015

Genetics and genomics of psychiatric disease.

Science 2015 Sep 24;349(6255):1489-94. Epub 2015 Sep 24.

Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1126/science.aaa8954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694563PMC
September 2015

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Authors:
Jenny C Taylor Hilary C Martin Stefano Lise John Broxholme Jean-Baptiste Cazier Andy Rimmer Alexander Kanapin Gerton Lunter Simon Fiddy Chris Allan A Radu Aricescu Moustafa Attar Christian Babbs Jennifer Becq David Beeson Celeste Bento Patricia Bignell Edward Blair Veronica J Buckle Katherine Bull Ondrej Cais Holger Cario Helen Chapel Richard R Copley Richard Cornall Jude Craft Karin Dahan Emma E Davenport Calliope Dendrou Olivier Devuyst Aimée L Fenwick Jonathan Flint Lars Fugger Rodney D Gilbert Anne Goriely Angie Green Ingo H Greger Russell Grocock Anja V Gruszczyk Robert Hastings Edouard Hatton Doug Higgs Adrian Hill Chris Holmes Malcolm Howard Linda Hughes Peter Humburg David Johnson Fredrik Karpe Zoya Kingsbury Usha Kini Julian C Knight Jonathan Krohn Sarah Lamble Craig Langman Lorne Lonie Joshua Luck Davis McCarthy Simon J McGowan Mary Frances McMullin Kerry A Miller Lisa Murray Andrea H Németh M Andrew Nesbit David Nutt Elizabeth Ormondroyd Annette Bang Oturai Alistair Pagnamenta Smita Y Patel Melanie Percy Nayia Petousi Paolo Piazza Sian E Piret Guadalupe Polanco-Echeverry Niko Popitsch Fiona Powrie Chris Pugh Lynn Quek Peter A Robbins Kathryn Robson Alexandra Russo Natasha Sahgal Pauline A van Schouwenburg Anna Schuh Earl Silverman Alison Simmons Per Soelberg Sørensen Elizabeth Sweeney John Taylor Rajesh V Thakker Ian Tomlinson Amy Trebes Stephen Rf Twigg Holm H Uhlig Paresh Vyas Tim Vyse Steven A Wall Hugh Watkins Michael P Whyte Lorna Witty Ben Wright Chris Yau David Buck Sean Humphray Peter J Ratcliffe John I Bell Andrew Om Wilkie David Bentley Peter Donnelly Gilean McVean

Nat Genet 2015 Jul 18;47(7):717-726. Epub 2015 May 18.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601524PMC
July 2015

Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease.

Trends Neurosci 2014 Dec 9;37(12):733-41. Epub 2014 Sep 9.

MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK; UK Centre for Tobacco and Alcohol Studies and School of Experimental Psychology, University of Bristol, Bristol BS8 1TU, UK.

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http://dx.doi.org/10.1016/j.tins.2014.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961231PMC
December 2014

The genetic architecture of psychophysiological phenotypes.

Psychophysiology 2014 Dec;51(12):1331-2

MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK; UK Centre for Tobacco and Alcohol Studies and School of Experimental Psychology, University of Bristol, Bristol, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/psyp.12355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278452PMC
December 2014

Practitioner review: A critical perspective on gene-environment interaction models--what impact should they have on clinical perceptions and practice?

J Child Psychol Psychiatry 2014 Oct 15;55(10):1092-101. Epub 2014 May 15.

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; UK Centre for Tobacco and Alcohol Studies, University of Bristol, Bristol, UK; School of Experimental Psychology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/jcpp.12261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961234PMC
October 2014

Commentary: Response to commentary by Rutter on Munafo et al. (2014).

J Child Psychol Psychiatry 2014 Oct 6;55(10):1105-6. Epub 2014 Aug 6.

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; UK Centre for Tobacco and Alcohol Studies, University of Bristol, Bristol, UK; School of Experimental Psychology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/jcpp.12308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961248PMC
October 2014

Genomes and phenomes of a population of outbred rats and its progenitors.

Sci Data 2014 10;1:140011. Epub 2014 Jun 10.

Wellcome Trust Centre for Human Genetics, Roosevelt Drive , Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/sdata.2014.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381735PMC
October 2015

Genetics: finding genes for schizophrenia.

Curr Biol 2014 Aug;24(16):R755-7

MRC Integrative Epidemiology Unit, UK Centre for Tobacco and Alcohol Studies, and School of Experimental Psychology, University of Bristol, BS8 1TU, UK.

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http://dx.doi.org/10.1016/j.cub.2014.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959571PMC
August 2014

Schizophrenia: genesis of a complex disease.

Nature 2014 Jul 22;511(7510):412-3. Epub 2014 Jul 22.

School of Experimental Psychology, University of Bristol, Bristol BS8 1TU, UK.

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http://dx.doi.org/10.1038/nature13645DOI Listing
July 2014

Identification of structural variation in mouse genomes.

Front Genet 2014 2;5:192. Epub 2014 Jul 2.

Center for Integrative Genomics, University of Lausanne Lausanne, Switzerland ; Institute of Genetics and Molecular and Cellular Biology Illkirch, France.

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http://journal.frontiersin.org/article/10.3389/fgene.2014.00
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http://dx.doi.org/10.3389/fgene.2014.00192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079067PMC
July 2014

Common or rare variants for complex traits?

Biol Psychiatry 2014 May;75(10):752-3

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2014.03.010DOI Listing
May 2014

The Genetics of Major Depression.

Neuron 2014 Mar 5;81(5):1214. Epub 2014 Mar 5.

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http://dx.doi.org/10.1016/j.neuron.2014.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629020PMC
March 2014

The genetics of major depression.

Neuron 2014 Feb;81(3):484-503

Virginia Commonwealth University, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA 23298-0126, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08966273140005
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http://dx.doi.org/10.1016/j.neuron.2014.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919201PMC
February 2014

The architecture of parent-of-origin effects in mice.

Cell 2014 Jan;156(1-2):332-42

Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1016/j.cell.2013.11.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898482PMC
January 2014

Dissecting quantitative traits in mice.

Annu Rev Genomics Hum Genet 2013 3;14:421-39. Epub 2013 Jul 3.

Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom; email: ,

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http://dx.doi.org/10.1146/annurev-genom-091212-153419DOI Listing
December 2013

Empirical evidence for low reproducibility indicates low pre-study odds.

Nat Rev Neurosci 2013 Dec 23;14(12):877. Epub 2013 Oct 23.

1] School of Experimental Psychology, University of Bristol, BS8 1TU, UK. [2] School of Social and Community Medicine, University of Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1038/nrn3475-c6DOI Listing
December 2013

[Genome sequencing and genetic mapping to dissect the genetic basis of complex traits].

Med Sci (Paris) 2013 Jun-Jul;29(6-7):671-4. Epub 2013 Jul 12.

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://dx.doi.org/10.1051/medsci/2013296024DOI Listing
September 2013

Genetics. Herit-ability.

Science 2013 Jun;340(6139):1416-7

University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1126/science.1240684DOI Listing
June 2013

Power failure: why small sample size undermines the reliability of neuroscience.

Nat Rev Neurosci 2013 05 10;14(5):365-76. Epub 2013 Apr 10.

School of Experimental Psychology, University of Bristol, UK.

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http://dx.doi.org/10.1038/nrn3475DOI Listing
May 2013

GWAS.

Authors:
Jonathan Flint

Curr Biol 2013 Apr;23(7):R265-6

Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1016/j.cub.2013.01.040DOI Listing
April 2013

Cofilin-1: a modulator of anxiety in mice.

PLoS Genet 2012 4;8(10):e1002970. Epub 2012 Oct 4.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1002970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464202PMC
March 2013

Candidate and non-candidate genes in behavior genetics.

Curr Opin Neurobiol 2013 Feb 8;23(1):57-61. Epub 2012 Aug 8.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.conb.2012.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752971PMC
February 2013

Genome-wide association studies in mice.

Nat Rev Genet 2012 Nov 9;13(11):807-17. Epub 2012 Oct 9.

The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://www.nature.com/articles/nrg3335
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http://dx.doi.org/10.1038/nrg3335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625632PMC
November 2012

Next-generation sequencing of experimental mouse strains.

Mamm Genome 2012 Oct 7;23(9-10):490-8. Epub 2012 Jul 7.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00335-012-9402-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463794PMC
October 2012

Association studies in outbred mice in a new era of full-genome sequencing.

Mamm Genome 2012 Oct 31;23(9-10):719-26. Epub 2012 Jul 31.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00335-012-9409-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463788PMC
October 2012

Epilogue: Lessons from the CONVERGE study of major depressive disorder in China.

J Affect Disord 2012 Sep 28;140(1):1-5. Epub 2011 Sep 28.

Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S016503271100532
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http://dx.doi.org/10.1016/j.jad.2011.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387371PMC
September 2012

Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice.

PLoS One 2012 25;7(4):e35901. Epub 2012 Apr 25.

Department and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035901PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338479PMC
September 2012

Anxious, hypoactive phenotype combined with motor deficits in Gtf2ird1 null mouse model relevant to Williams syndrome.

Behav Brain Res 2012 Aug 28;233(2):458-73. Epub 2012 May 28.

Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK.

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http://dx.doi.org/10.1016/j.bbr.2012.05.014DOI Listing
August 2012

The genomic landscape shaped by selection on transposable elements across 18 mouse strains.

Genome Biol 2012 Jun 15;13(6):R45. Epub 2012 Jun 15.

MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/gb-2012-13-6-r45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446317PMC
June 2012

Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders.

Biol Psychiatry 2011 Nov 25;70(9):888-96. Epub 2011 Aug 25.

Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298-0126, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000632231100725
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http://dx.doi.org/10.1016/j.biopsych.2011.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191234PMC
November 2011

Dissecting the genetic architecture of human personality.

Trends Cogn Sci 2011 Sep 9;15(9):395-400. Epub 2011 Aug 9.

School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, United Kingdom.

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http://dx.doi.org/10.1016/j.tics.2011.07.007DOI Listing
September 2011