Publications by authors named "Jonathan Downar"

94Publications

Predicting treatment response to 1Hz rTMS using early self-rated clinical changes in major depression.

Brain Stimul 2020 Oct 13. Epub 2020 Oct 13.

Centre Hospitalier Le Vinatier, F69500, Bron, France; INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, PSYR2 Team, F-69000 Lyon, France; Lyon University, Université Lyon 1, F-69100, Villeurbanne, France. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2020.10.004DOI Listing
October 2020

Successful treatment of depression with psychotic features using accelerated intermittent theta burst stimulation.

J Affect Disord 2020 Sep 30;279:17-19. Epub 2020 Sep 30.

Department of Psychiatry, University of Toronto; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2020.09.114DOI Listing
September 2020

Interventional Psychiatry: An Idea Whose Time Has Come?

Can J Psychiatry 2020 Oct 5:706743720963887. Epub 2020 Oct 5.

Department of Psychiatry, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1177/0706743720963887DOI Listing
October 2020

A pilot study of magnetic seizure therapy for treatment-resistant obsessive-compulsive disorder.

Depress Anxiety 2020 Sep 19. Epub 2020 Sep 19.

Department of Psychiatry, Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Campbell Family Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/da.23097DOI Listing
September 2020

Vagally Mediated Heart Rate Variability Is Associated With Executive Function Changes in Patients With Treatment-Resistant Depression Following Magnetic Seizure Therapy.

Neuromodulation 2020 Sep 1. Epub 2020 Sep 1.

Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/ner.13262DOI Listing
September 2020

Vagally Mediated Heart Rate Variability Is Associated With Executive Function Changes in Patients With Treatment-Resistant Depression Following Magnetic Seizure Therapy.

Neuromodulation 2020 Sep 1. Epub 2020 Sep 1.

Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/ner.13262DOI Listing
September 2020

Using Brain Imaging to Improve Spatial Targeting of Transcranial Magnetic Stimulation for Depression.

Biol Psychiatry 2020 Jun 7. Epub 2020 Jun 7.

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts; Departments of Neurology and Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts; Departments of Neurology, Psychiatry, and Radiology, Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2020.05.033DOI Listing
June 2020

Accelerated Intermittent Theta Burst Stimulation in Late-Life Depression: A Possible Option for Older Depressed Adults in Need of ECT During the COVID-19 Pandemic.

Am J Geriatr Psychiatry 2020 10 15;28(10):1025-1029. Epub 2020 Jul 15.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2020.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362844PMC
October 2020

Predictors of cognitive impairment in treatment-resistant depression.

J Affect Disord 2020 Sep 27;274:593-601. Epub 2020 May 27.

Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2020.05.101DOI Listing
September 2020

The role of low-frequency repetitive transcranial magnetic stimulation in major depression: A call to increase the evidence base.

Brain Stimul 2020 Sep - Oct;13(5):1296-1297. Epub 2020 Jun 21.

Krembil Research Institute, University Health Network, Toronto, ON, Canada; Poul Hansen Family Centre for Depression, University Health Network, Toronto, ON, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.brs.2020.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306196PMC
June 2020

Predictors of remission after repetitive transcranial magnetic stimulation for the treatment of major depressive disorder: An analysis from the randomised non-inferiority THREE-D trial.

EClinicalMedicine 2020 May 30;22:100349. Epub 2020 Apr 30.

Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, 1001 Queen St. W., Unit 4-115, Toronto, ON M6J1H4, Canada.

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http://dx.doi.org/10.1016/j.eclinm.2020.100349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200243PMC
May 2020

Treatment-emergent mania with psychosis in bipolar depression with left intermittent theta-burst rTMS.

Brain Stimul 2020 May - Jun;13(3):705-706. Epub 2020 Feb 19.

Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2020.02.018DOI Listing
February 2020

Evaluation of the effects of rTMS on self-reported quality of life and disability in treatment-resistant depression: A THREE-D study.

J Affect Disord 2020 May 3;268:127-133. Epub 2020 Mar 3.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.jad.2020.03.002DOI Listing
May 2020

Caution When Continuing Benzodiazepines During rTMS: Response to Hunter and Leuchter.

Am J Psychiatry 2020 02;177(2):172-173

Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto (Kaster, Daskalakis, Blumberger); Department of Psychiatry (Kaster, Downar, Daskalakis, Blumberger), and Institute of Medical Science (Downar, Daskalakis, Blumberger), University of Toronto, Toronto; MRI-Guided rTMS Clinic, Toronto Western Hospital, Toronto (Downar); Krembil Research Institute, University Health Network, Toronto (Downar); Department of Psychiatry and Non-Invasive Neurostimulation Therapies Laboratory, University of British Columbia, Vancouver (Vila-Rodriguez).

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http://dx.doi.org/10.1176/appi.ajp.2019.19060603rDOI Listing
February 2020

Magnetic seizure therapy is efficacious and well tolerated for treatment-resistant bipolar depression: an open-label clinical trial

J Psychiatry Neurosci 2020 09;45(5):313-321

From the Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont., Canada (Tang, Blumberger, Dimitrova, Throop, Voineskos, Knyahnytska, Mulsant, Daskalakis); the Neurocognitive Research Laboratory, Department of Psychiatry, University of Texas Southwestern Medical Center, and Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC (McClintock); the Centre for Mental Health and Krembil Research Institute, University Health Network, Department of Psychiatry, University of Toronto, Toronto, Ont., Canada (Downar); and the Epworth Centre for Innovation in Mental Health, Epworth Healthcare and Monash Alfred Psychiatry Research Centre, the Alfred and Monash University Central Clinical School, Melbourne, Australia (Fitzgerald).

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http://dx.doi.org/10.1503/jpn.190098DOI Listing
September 2020

Retinal tear and posterior vitreous detachment following repetitive transcranial magnetic stimulation for major depression: A case report.

Brain Stimul 2020 Mar - Apr;13(2):467-469. Epub 2019 Dec 19.

Department of Ophthalmology, St. Michael's Hospital/Unity Health Toronto, Toronto, ON, Canada; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada; Kensington Vision and Research Centre, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.12.017DOI Listing
December 2019

Mixing Apples and Oranges in Assessing Outcomes of Repetitive Transcranial Stimulation Meta-Analyses.

Psychother Psychosom 2020 3;89(2):106-107. Epub 2019 Dec 3.

Department of Psychiatry and Psychotherapy, University Hospital LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1159/000504653DOI Listing
June 2020

Escitalopram ameliorates differences in neural activity between healthy comparison and major depressive disorder groups on an fMRI Emotional conflict task: A CAN-BIND-1 study.

J Affect Disord 2020 Mar 13;264:414-424. Epub 2019 Nov 13.

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Department of Psychology Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.11.068DOI Listing
March 2020

A case series of a novel 1 Hz right-sided dorsolateral prefrontal cortex rTMS protocol in major depression.

Brain Stimul 2020 Mar - Apr;13(2):372-374. Epub 2019 Nov 9.

Krembil Research Institute, University Health Network, Toronto, ON, Canada; Poul Hansen Family Centre for Depression, University Health Network, Toronto, ON, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.brs.2019.11.006DOI Listing
November 2019

Considerable evidence supports rTMS for treatment-resistant depression.

J Affect Disord 2020 Feb 6;263:549-551. Epub 2019 Nov 6.

Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.11.017DOI Listing
February 2020

Functional electrical stimulation of the facial muscles to improve symptoms in individuals with major depressive disorder: pilot feasibility study.

Biomed Eng Online 2019 Nov 14;18(1):109. Epub 2019 Nov 14.

Rehabilitation Engineering Laboratory, Lyndhurst Centre, KITE, Toronto Rehabilitation Institute-University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/s12938-019-0730-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857333PMC
November 2019

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation for treatment-refractory major depressive disorder: A three-arm, blinded, randomized controlled trial.

Brain Stimul 2020 Mar - Apr;13(2):337-340. Epub 2019 Oct 31.

Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Department of Psychiatry, University Health Network, Toronto, Canada; Krembil Research Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1016/j.brs.2019.10.020DOI Listing
August 2020

Functional connectivity of the anterior cingulate cortex predicts treatment outcome for rTMS in treatment-resistant depression at 3-month follow-up.

Brain Stimul 2020 Jan - Feb;13(1):206-214. Epub 2019 Oct 18.

Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of Psychiatry, University of British Columbia, 2255, Wesbrook Mall, Vancouver, BC V6T 2A1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.10.012DOI Listing
June 2020

Cardiovascular differences between sham and active iTBS related to treatment response in MDD.

Brain Stimul 2020 Jan - Feb;13(1):167-174. Epub 2019 Oct 9.

Non-Invasive Neurostimulation Therapies (NINET) Laboratory, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.09.016DOI Listing
June 2020

Deep Brain Stimulation in Depression: Even if Successful, Will It Ever Be Scalable?

Authors:
Jonathan Downar

Clin Pharmacol Ther 2019 10;106(4):709-711

MRI-Guided rTMS Clinic, Centre for Mental Health and Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cpt.1572DOI Listing
October 2019

Magnetic seizure therapy (MST) for major depressive disorder.

Neuropsychopharmacology 2020 01 5;45(2):276-282. Epub 2019 Sep 5.

Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41386-019-0515-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901571PMC
January 2020

Reduced accuracy accompanied by reduced neural activity during the performance of an emotional conflict task by unmedicated patients with major depression: A CAN-BIND fMRI study.

J Affect Disord 2019 10 6;257:765-773. Epub 2019 Jul 6.

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Department of Psychology Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.07.037DOI Listing
October 2019

Impact of prior treatment on remission with intermittent theta burst versus high-frequency repetitive transcranial magnetic stimulation in treatment resistant depression.

Brain Stimul 2019 Nov - Dec;12(6):1553-1555. Epub 2019 Jul 17.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.07.011DOI Listing
February 2020

Safety, tolerability and effectiveness of a novel 20 Hz rTMS protocol targeting dorsomedial prefrontal cortex in major depression: An open-label case series.

Brain Stimul 2019 Sep - Oct;12(5):1319-1321. Epub 2019 Jun 20.

MRI-Guided rTMS Clinic and Krembil Research Institute, University Health Network, Toronto, Canada; Department of Psychiatry and Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.brs.2019.06.020DOI Listing
June 2019

Functional and Optogenetic Approaches to Discovering Stable Subtype-Specific Circuit Mechanisms in Depression.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 06 10;4(6):554-566. Epub 2019 May 10.

Feil Family Brain and Mind Research Institute and Department of Psychiatry, Weill Cornell Medicine, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2019.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788795PMC
June 2019

Functional disconnectivity of the hippocampal network and neural correlates of memory impairment in treatment-resistant depression.

J Affect Disord 2019 06 29;253:248-256. Epub 2019 Apr 29.

Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.04.096DOI Listing
June 2019

The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols

J Psychiatry Neurosci 2019 07;44(4):223-236

From the Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alta., Canada (MacQueen, Hassel, Addington, Sharma); the Rotman Research Institute, Baycrest, and Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada (Arnott, Zamyadi, Strother); the Department of Psychology, Queen’s University, Kingston, Ont., Canada (Bowie, Harkness, Milev); the Department of Radiology, University of Calgary, Calgary, Alta., Canada (Bray, Lebel); the Alberta Children’s Hospital Research Institute, Calgary, Alta., Canada (Bray, Lebel); the Child and Adolescent Imaging Research (CAIR) Program, Calgary, Alta., Canada (Bray, Lebel); the Department of Psychology, Neuroscience and Behaviour, McMaster University, and St. Joseph’s Healthcare Hamilton, Hamilton, Ont., Canada (Hall); the Krembil Research Institute and Centre for Mental Health, University Health Network, Toronto, Ont., Canada (Downar); the Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Downar); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Downar, Müller, Rizvi, Rotzinger, Kennedy); the Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, Ont., Canada (Foster, Rotzinger, Kennedy); the Department of Psychiatry and Behavioural Neurosciences, McMaster University, and St. Joseph’s Healthcare Hamilton, Hamilton, Ont., Canada (Foster, Frey); the Centre for Youth Bipolar Disorder, Sunnybrook Health Sciences Centre, Toronto, Ont., Canada (Goldstein); the Departments of Psychiatry and Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Goldstein); the Department of Computer Science, University of Alberta, Edmonton, Alta., Canada (Harris); the University of British Columbia and Vancouver Coastal Health Authority, Vancouver, B.C., Canada (Lam, Vila-Rodriguez); the Department of Psychiatry, Queen’s University and Providence Care Hospital, Kingston, Ont., Canada (Milev, Soares); the Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Müller); the Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA (Parikh); the Arthur Sommer Rotenberg Suicide and Depression Studies Program, Li Ka Shing Knowledge Institute and St. Michael’s Hospital, Toronto, Ont., Canada (Rizvi); the Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Rizvi); the Department of Psychiatry, St. Michael’s Hospital, University of Toronto, Toronto, Ont., Canada (Rotzinger, Soares, Yu); McGill University, Montréal, Que., Canada (Turecki); the Douglas Mental Health University Institute, Frank B. Common, Montréal, Que., Canada (Turecki); and the Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ont., Canada (Kennedy).

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http://dx.doi.org/10.1503/jpn.180036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606427PMC
July 2019

Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study.

Am J Psychiatry 2019 05 15;176(5):367-375. Epub 2019 Feb 15.

The Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto (Kaster, Knyahnytska, Daskalakis, Blumberger); the Department of Psychiatry (Kaster, Downar, Giacobbe, Kennedy, Daskalakis, Blumberger), the Institute of Medical Science (Downar, Giacobbe, Kennedy, Daskalakis, Blumberger), and the Dalla Lana School of Public Health (Thorpe), University of Toronto, Toronto; the MRI-Guided rTMS Clinic, Toronto Western Hospital, Toronto (Downar); the Krembil Research Institute, University Health Network, Toronto (Downar, Kennedy); the Department of Psychiatry, University of British Columbia, Vancouver (Vila-Rodriguez, Lam); the Non-Invasive Neurostimulation Therapies Laboratory, University of British Columbia, Vancouver (Vila-Rodriguez); the Shalvata Mental Health Center, Hod-Hasharon, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv (Feffer); the Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo (Noda); the Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto (Giacobbe); and the Li Ka Shing Knowledge Institute, Saint Michael's Hospital, Toronto (Kennedy).

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18
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http://dx.doi.org/10.1176/appi.ajp.2018.18091096DOI Listing
May 2019

Repetitive transcranial magnetic stimulation for depression - Authors' reply.

Lancet 2019 02;393(10170):403-404

Department of Psychiatry and Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; MRI-Guided rTMS Clinic and Krembil Research Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1016/S0140-6736(18)32837-XDOI Listing
February 2019

Structural network integrity of the central executive network is associated with the therapeutic effect of rTMS in treatment resistant depression.

Prog Neuropsychopharmacol Biol Psychiatry 2019 06 25;92:217-225. Epub 2019 Jan 25.

Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2019.01.012DOI Listing
June 2019

Orbitofrontal Cortex: A 'Non-rewarding' New Treatment Target in Depression?

Authors:
Jonathan Downar

Curr Biol 2019 01;29(2):R59-R62

Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada; Krembil Research Institute, University Health Network, Toronto, Canada; Centre for Mental Health, University Health Network, Toronto, Canada; MRI-Guided rTMS Clinic, Poul Hansen Centre for Depression, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2018.11.057DOI Listing
January 2019

Intermittent theta burst stimulation for major depression during pregnancy.

Brain Stimul 2019 May - Jun;12(3):772-774. Epub 2019 Jan 12.

Department of Psychiatry, University of Toronto, Canada; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1935861X193003
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http://dx.doi.org/10.1016/j.brs.2019.01.003DOI Listing
January 2019

A Real-Time Phase-Locking System for Non-invasive Brain Stimulation.

Front Neurosci 2018 3;12:877. Epub 2018 Dec 3.

Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fnins.2018.00877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287008PMC
December 2018

A Real-Time Phase-Locking System for Non-invasive Brain Stimulation.

Front Neurosci 2018 3;12:877. Epub 2018 Dec 3.

Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fnins.2018.00877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287008PMC
December 2018

A Comprehensive Review of Dorsomedial Prefrontal Cortex rTMS Utilizing a Double Cone Coil.

Neuromodulation 2019 Dec 8;22(8):851-866. Epub 2018 Nov 8.

Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.

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http://doi.wiley.com/10.1111/ner.12874
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http://dx.doi.org/10.1111/ner.12874DOI Listing
December 2019

Resting state functional connectivity in patients with remitted psychotic depression: A multi-centre STOP-PD study.

EBioMedicine 2018 Oct 1;36:446-453. Epub 2018 Oct 1.

Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, 250 College Street, Toronto, ON M5T 1R8, Canada; Campbell Family Mental Health Research Institute, 250 College Street, Toronto, ON M5T 1R8, Canada; Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada; Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON M5T 1R8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183038
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http://dx.doi.org/10.1016/j.ebiom.2018.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197617PMC
October 2018

Spread of activity following TMS is related to intrinsic resting connectivity to the salience network: A concurrent TMS-fMRI study.

Cortex 2018 11 30;108:160-172. Epub 2018 Jul 30.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.cortex.2018.07.010DOI Listing
November 2018

A Case for the Frontal Pole as an Empirically Derived Neuromodulation Treatment Target.

Biol Psychiatry 2019 02 17;85(3):e13-e14. Epub 2018 Aug 17.

Department of Psychiatry, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2018.07.002DOI Listing
February 2019

Development and validation of a 3D-printed neuronavigation headset for therapeutic brain stimulation.

J Neural Eng 2018 08 11;15(4):046034. Epub 2018 Jun 11.

Institute of Biomaterial and Biomedical Engineering, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1088/1741-2552/aacb96DOI Listing
August 2018

Characteristics of ictal EEG in Magnetic Seizure Therapy at various stimulation frequencies.

Clin Neurophysiol 2018 08 22;129(8):1770-1779. Epub 2018 Apr 22.

Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Geriatric Division, Department of Psychiatry, University of Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2018.03.025DOI Listing
August 2018

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial.

Lancet 2018 04 26;391(10131):1683-1692. Epub 2018 Apr 26.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Centre for Mental Health, University Health Network, Toronto, ON, Canada; MRI-Guided rTMS Clinic, University Health Network, Toronto, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183029
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http://dx.doi.org/10.1016/S0140-6736(18)30295-2DOI Listing
April 2018

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial.

Lancet 2018 04 26;391(10131):1683-1692. Epub 2018 Apr 26.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Centre for Mental Health, University Health Network, Toronto, ON, Canada; MRI-Guided rTMS Clinic, University Health Network, Toronto, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S0140-6736(18)30295-2DOI Listing
April 2018

Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation.

Depress Anxiety 2018 05 10;35(5):448-456. Epub 2018 Apr 10.

Centre for Addiction and Mental Health, Temerty Centre for Therapeutic Brain Intervention, Toronto, Canada.

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http://dx.doi.org/10.1002/da.22738DOI Listing
May 2018

Abnormal Functional Connectivity of Frontopolar Subregions in Treatment-Nonresponsive Major Depressive Disorder.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 04 27;3(4):337-347. Epub 2017 Dec 27.

Krembil Research Institute, University Health Network, Toronto, Canada; MRI-Guided rTMS Clinic, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2017.12.003DOI Listing
April 2018

Identifying Prefrontal Networks for Disease Vulnerability Versus Acute Illness in Major Depression.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 04;3(4):308-310

Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2018.02.004DOI Listing
April 2018

Using Mismatch Negativity to Investigate the Pathophysiology of Substance Use Disorders and Comorbid Psychosis.

Clin EEG Neurosci 2018 Jul 4;49(4):226-237. Epub 2018 Mar 4.

1 Temerty Centre for Therapeutic Brain Intervention, Division of Mood and Anxiety, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/1550059418760077DOI Listing
July 2018

1Hz rTMS of the right orbitofrontal cortex for major depression: Safety, tolerability and clinical outcomes.

Eur Neuropsychopharmacol 2018 01 17;28(1):109-117. Epub 2017 Nov 17.

MRI-Guided rTMS Clinic, University Health Network, Toronto, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada; Krembil Research Institute, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2017.11.011DOI Listing
January 2018

Number of pulses or number of sessions? An open-label study of trajectories of improvement for once-vs. twice-daily dorsomedial prefrontal rTMS in major depression.

Brain Stimul 2018 Mar - Apr;11(2):327-336. Epub 2017 Nov 7.

MRI-Guided rTMS Clinic, Department of Psychiatry, University Health Network, Canada; Institute of Medical Science, University of Toronto, Canada; Department of Psychiatry, University of Toronto, Canada; Krembil Research Institute, University Health Network, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2017.11.002DOI Listing
January 2019

Early symptom improvement at 10 sessions as a predictor of rTMS treatment outcome in major depression.

Brain Stimul 2018 Jan - Feb;11(1):181-189. Epub 2017 Oct 19.

MRI-Guided rTMS Clinic, University Health Network, Toronto, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada; Krembil Research Institute, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2017.10.010DOI Listing
July 2018

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation treatment of posttraumatic stress disorder in eating disorders: An open-label case series.

Int J Eat Disord 2017 10 16;50(10):1231-1234. Epub 2017 Aug 16.

Centre for Mental Health, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1002/eat.22764DOI Listing
October 2017

A Fast EEG Forecasting Algorithm for Phase-Locked Transcranial Electrical Stimulation of the Human Brain.

Front Neurosci 2017 20;11:401. Epub 2017 Jul 20.

Institute of Biomaterial and Biomedical Engineering, University of TorontoToronto, ON, Canada.

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http://dx.doi.org/10.3389/fnins.2017.00401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517498PMC
July 2017

A sparse representation-based method for parcellation of the resting brain and its application to treatment-resistant major depressive disorder.

J Neurosci Methods 2017 Oct 22;290:57-68. Epub 2017 Jul 22.

Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada.

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http://dx.doi.org/10.1016/j.jneumeth.2017.07.017DOI Listing
October 2017

Modulation of cognitive cerebello-cerebral functional connectivity by lateral cerebellar continuous theta burst stimulation.

Neuroimage 2017 09 29;158:48-57. Epub 2017 Jun 29.

Division of Neurology, Department of Medicine, University of Toronto, Division of Brain, Imaging and Behavior - Systems Neuroscience, Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2017.06.048DOI Listing
September 2017

Bilateral DMPFC-rTMS Leads to Sustained Remission in Geriatric Treatment-Resistant Depression: A Case Report.

Psychiatr Danub 2017 Jun;29(2):218-220

Laboratory of Panic & Respiration (LABPR), Institute of Psychiatry (IPUB), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

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http://dx.doi.org/10.24869/psyd.2017.218DOI Listing
June 2017

Oral Ketamine in Treatment-Resistant Depression: A Clinical Effectiveness Case Series.

J Clin Psychopharmacol 2017 Aug;37(4):464-467

From the *Department of Psychiatry, University Health Network; †Department of Psychiatry, ‡Institute of Medical Science, Faculty of Medicine, University of Toronto; §Krembil Research Institute, Toronto Western Hospital; ∥Li Ka Shing Knowledge Institute, St. Michael's Hospital; ¶Ontario Brain Institute; and #MRI-Guided repetitive transcranial magnetic stimulation Clinic, Centre for Mental Health, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1097/JCP.0000000000000717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491240PMC
August 2017

Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness.

Front Syst Neurosci 2017 27;11:25. Epub 2017 Apr 27.

Institute of Medical Science, University of TorontoToronto, ON, Canada.

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http://dx.doi.org/10.3389/fnsys.2017.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406748PMC
April 2017

Abnormal functional connectivity within resting-state networks is related to rTMS-based therapy effects of treatment resistant depression: A pilot study.

J Affect Disord 2017 08 26;218:75-81. Epub 2017 Apr 26.

Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2017.04.060DOI Listing
August 2017

Influence of inter-train interval on the plastic effects of rTMS.

Brain Stimul 2017 May - Jun;10(3):630-636. Epub 2017 Mar 2.

Toronto Western Research Institute, University Health Network, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2017.02.012DOI Listing
December 2017

Ensuring that novel resting-state fMRI metrics are physiologically grounded, interpretable and meaningful (A commentary on Canna et al., 2017).

Eur J Neurosci 2017 05 28;45(9):1127-1128. Epub 2017 Mar 28.

Institute of Medical Science, University of Toronto, Medical Sciences Building, 1 King's College Circle, Room 2374, Toronto, ON, M5S 1A8, Canada.

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http://dx.doi.org/10.1111/ejn.13560DOI Listing
May 2017

Successful dorsomedial prefrontal rTMS for major depression in borderline personality disorder: Three cases.

Brain Stimul 2017 May - Jun;10(3):716-717. Epub 2017 Feb 2.

MRI-Guided rTMS Clinic, Centre for Mental Health, University Health Network, Toronto, Canada; Department of Psychiatry, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2017.01.583DOI Listing
February 2017

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment.

Front Syst Neurosci 2016 27;10:104. Epub 2016 Dec 27.

Institute of Medical Science, University of TorontoToronto, ON, Canada; Krembil Research Institute, University Health NetworkToronto, ON, Canada; Department of Psychiatry, University of TorontoToronto, ON, Canada; MRI-Guided rTMS Clinic, University Health NetworkToronto, ON, Canada.

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http://dx.doi.org/10.3389/fnsys.2016.00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187454PMC
December 2016

Neural correlates of successful orbitofrontal 1 Hz rTMS following unsuccessful dorsolateral and dorsomedial prefrontal rTMS in major depression: A case report.

Brain Stimul 2017 Jan - Feb;10(1):165-167. Epub 2016 Nov 16.

Institute of Medical Science, University of Toronto, Canada; Department of Psychiatry, University of Toronto, Canada; MRI-Guided rTMS Clinic, Centre for Mental Health, University Health Network, Toronto, Canada; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2016.11.008DOI Listing
November 2016

Effect of antipsychotic pharmacotherapy on clinical outcomes of intermittent theta-burst stimulation for refractory depression.

J Psychopharmacol 2017 03 11;31(3):312-319. Epub 2016 Nov 11.

1 MRI-Guided rTMS Clinic, Department of Psychiatry, University Health Network, Canada.

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http://dx.doi.org/10.1177/0269881116675516DOI Listing
March 2017

Repetitive transcranial magnetic stimulation: an emerging treatment for medication-resistant depression.

CMAJ 2016 Nov 22;188(16):1175-1177. Epub 2016 Aug 22.

Department of Psychiatry (Downar, Blumberger, Daskalakis); Institute of Medical Science (Downar, Blumberger, Daskalakis), University of Toronto, Toronto, Ont.; Krembil Research Institute (Downar); MRI-Guided Repetitive Transcranial Magnetic Stimulation Clinic (Downar), University Health Network, Toronto, Ont.; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Mental Health Research Institute (Blumberger, Daskalakis), Centre for Addiction and Mental Health, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.151316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088079PMC
November 2016

Repetitive transcranial magnetic stimulation: an emerging treatment for medication-resistant depression.

CMAJ 2016 Nov 22;188(16):1175-1177. Epub 2016 Aug 22.

Department of Psychiatry (Downar, Blumberger, Daskalakis); Institute of Medical Science (Downar, Blumberger, Daskalakis), University of Toronto, Toronto, Ont.; Krembil Research Institute (Downar); MRI-Guided Repetitive Transcranial Magnetic Stimulation Clinic (Downar), University Health Network, Toronto, Ont.; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Mental Health Research Institute (Blumberger, Daskalakis), Centre for Addiction and Mental Health, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.151316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088079PMC
November 2016

Validation of a 25% Nasion-Inion Heuristic for Locating the Dorsomedial Prefrontal Cortex for Repetitive Transcranial Magnetic Stimulation.

Brain Stimul 2016 Sep-Oct;9(5):793-795. Epub 2016 May 24.

Department of Psychiatry, University of Toronto, Canada; MRI-Guided rTMS Clinic, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2016.05.010DOI Listing
May 2016

Unilateral and bilateral MRI-targeted repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled study.

J Psychiatry Neurosci 2016 06;41(4):E58-66

From the Temerty Centre for Therapeutic Brain Intervention, and Campbell Family Research Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont., Canada (Blumberger, Thomson, Mulsant, Rajji, Maher, Daskalakis); the Monash Alfred Psychiatry research centre, The Alfred and Monash University Central Clinical School, Melbourne, Australia (Maller, Fitzgerald); Cancer Care Ontario and the Dalla Lana School of Public Health, University of Toronto, Toronto, Ont., Canada (Brown); the Toronto Western Hospital, University Health Network, Department of Psychiatry, University of Toronto, Toronto, Ont., Canada (Downar); and the Non-Invasive Neurostimulation Therapies laboratory, Department of Psychiatry, University of British Columbia, Vancouver, B.C., Canada (Vila-Rodriguez).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915938PMC
http://dx.doi.org/10.1503/jpn.150265DOI Listing
June 2016

Cognitive safety of dorsomedial prefrontal repetitive transcranial magnetic stimulation in major depression.

Eur Neuropsychopharmacol 2016 07 3;26(7):1213-26. Epub 2016 May 3.

MRI-Guided rTMS Clinic, Department of Psychiatry, University Health Network, 399 Bathurst Street, Room 7M-415, Toronto, Ontario, Canada M5T 2S8; Department of Psychiatry, University of Toronto, 250 College Street, Floor 8, Toronto, Ontario, Canada M5T 1R8; Institute of Medical Science, University of Toronto, Faculty of Medicine, Medical Sciences Building, 1 King׳s College Circle, Room 2374, Toronto, Ontario, Canada M5S 1A8; Toronto Western Research Institute, University Health Network, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2016.04.004DOI Listing
July 2016

Targeting Neural Endophenotypes of Eating Disorders with Non-invasive Brain Stimulation.

Front Neurosci 2016 16;10:30. Epub 2016 Feb 16.

Institute of Medical Sciences, University of TorontoToronto, ON, Canada; MRI-Guided rTMS Clinic, University Health NetworkToronto, ON, Canada; Department of Psychiatry, University Health NetworkToronto, ON, Canada; Department of Psychiatry, University of TorontoToronto, ON, Canada; Toronto Western Research Institute, University Health NetworkToronto, ON, Canada.

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http://dx.doi.org/10.3389/fnins.2016.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754427PMC
February 2016

Association of ventral striatum monoamine oxidase-A binding and functional connectivity in antisocial personality disorder with high impulsivity: A positron emission tomography and functional magnetic resonance imaging study.

Eur Neuropsychopharmacol 2016 Apr 21;26(4):777-86. Epub 2015 Dec 21.

CAMH Research Imaging Centre, Canada; Campbell Family Mental Health Research Institute, CAMH, Canada; Department of Psychiatry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.euroneuro.2015.12.030DOI Listing
April 2016

Noninvasive brain stimulation treatments for addiction and major depression.

Ann N Y Acad Sci 2017 04 5;1394(1):31-54. Epub 2016 Feb 5.

MRI-Guided rTMS Clinic, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/nyas.12985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434820PMC
April 2017

Sinus Tachycardia Induced by Methocarbamol and Repetitive Transcranial Magnetic Stimulation (rTMS).

Brain Stimul 2016 Jan-Feb;9(1):156-8. Epub 2015 Nov 24.

Non-Invasive Neurostimulation Therapies Lab at UBC, Department of Psychiatry, University of British Columbia, Vancouver, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2015.10.012DOI Listing
May 2016

Risk of seizures in transcranial magnetic stimulation: a clinical review to inform consent process focused on bupropion.

Neuropsychiatr Dis Treat 2015 30;11:2975-87. Epub 2015 Nov 30.

Department of Psychiatry, Faculty of Medicine, Non-Invasive Neurostimulation Therapies (NINET) Laboratory, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.2147/NDT.S91126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670017PMC
December 2015

The Neural Crossroads of Psychiatric Illness: An Emerging Target for Brain Stimulation.

Trends Cogn Sci 2016 Feb 3;20(2):107-120. Epub 2015 Dec 3.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.tics.2015.10.007DOI Listing
February 2016