Publications by authors named "Jonathan D Smith"

100Publications

Soat1 mediates the mouse strain effects on cholesterol loading-induced endoplasmic reticulum stress and CHOP expression in macrophages.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Oct 6;1866(1):158825. Epub 2020 Oct 6.

Department of Cardiovascular & Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine -Case Western Reserve University, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2020.158825DOI Listing
October 2020

3D fault architecture controls the dynamism of earthquake swarms.

Science 2020 06;368(6497):1357-1361

Seismological Laboratory, California Institute of Technology, Pasadena, CA, USA.

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http://dx.doi.org/10.1126/science.abb0779DOI Listing
June 2020

MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma.

Mol Metab 2020 04 3;34:136-145. Epub 2020 Feb 3.

Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA; Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA; Center for Microbiome and Human Health, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033598PMC
April 2020

Miltefosine increases macrophage cholesterol release and inhibits NLRP3-inflammasome assembly and IL-1β release.

Sci Rep 2019 07 31;9(1):11128. Epub 2019 Jul 31.

Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, 44195, USA.

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http://dx.doi.org/10.1038/s41598-019-47610-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668382PMC
July 2019

CD13 deficiency leads to increased oxidative stress and larger atherosclerotic lesions.

Atherosclerosis 2019 08 13;287:70-80. Epub 2019 Jun 13.

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT, 06030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.06.901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746312PMC
August 2019

Confirmation of Ath26 locus on chromosome 17 and identification of Cyp4f13 as an atherosclerosis modifying gene.

Atherosclerosis 2019 07 9;286:71-78. Epub 2019 May 9.

Department of Cellular & Molecular Medicine, Cleveland Clinic, Cleveland, OH, 44122, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599485PMC
July 2019

V-ATPase (Vacuolar ATPase) Activity Required for ABCA1 (ATP-Binding Cassette Protein A1)-Mediated Cholesterol Efflux.

Arterioscler Thromb Vasc Biol 2018 11;38(11):2615-2625

From the Department of Cellular and Molecular Medicine (S.W.L., G.B., K.G., J.D.S.), Cleveland Clinic, OH.

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http://dx.doi.org/10.1161/ATVBAHA.118.311814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209108PMC
November 2018

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

Authors:
Jessica van Setten Jennifer A Brody Yalda Jamshidi Brenton R Swenson Anne M Butler Harry Campbell Fabiola M Del Greco Daniel S Evans Quince Gibson Daniel F Gudbjartsson Kathleen F Kerr Bouwe P Krijthe Leo-Pekka Lyytikäinen Christian Müller Martina Müller-Nurasyid Ilja M Nolte Sandosh Padmanabhan Marylyn D Ritchie Antonietta Robino Albert V Smith Maristella Steri Toshiko Tanaka Alexander Teumer Stella Trompet Sheila Ulivi Niek Verweij Xiaoyan Yin David O Arnar Folkert W Asselbergs Joel S Bader John Barnard Josh Bis Stefan Blankenberg Eric Boerwinkle Yuki Bradford Brendan M Buckley Mina K Chung Dana Crawford Marcel den Hoed Josh C Denny Anna F Dominiczak Georg B Ehret Mark Eijgelsheim Patrick T Ellinor Stephan B Felix Oscar H Franco Lude Franke Tamara B Harris Hilma Holm Gandin Ilaria Annamaria Iorio Mika Kähönen Ivana Kolcic Jan A Kors Edward G Lakatta Lenore J Launer Honghuang Lin Henry J Lin Ruth J F Loos Steven A Lubitz Peter W Macfarlane Jared W Magnani Irene Mateo Leach Thomas Meitinger Braxton D Mitchell Thomas Munzel George J Papanicolaou Annette Peters Arne Pfeufer Peter P Pramstaller Olli T Raitakari Jerome I Rotter Igor Rudan Nilesh J Samani David Schlessinger Claudia T Silva Aldana Moritz F Sinner Jonathan D Smith Harold Snieder Elsayed Z Soliman Timothy D Spector David J Stott Konstantin Strauch Kirill V Tarasov Unnur Thorsteinsdottir Andre G Uitterlinden David R Van Wagoner Uwe Völker Henry Völzke Melanie Waldenberger Harm Jan Westra Philipp S Wild Tanja Zeller Alvaro Alonso Christy L Avery Stefania Bandinelli Emelia J Benjamin Francesco Cucca Marcus Dörr Luigi Ferrucci Paolo Gasparini Vilmundur Gudnason Caroline Hayward Susan R Heckbert Andrew A Hicks J Wouter Jukema Stefan Kääb Terho Lehtimäki Yongmei Liu Patricia B Munroe Afshin Parsa Ozren Polasek Bruce M Psaty Dan M Roden Renate B Schnabel Gianfranco Sinagra Kari Stefansson Bruno H Stricker Pim van der Harst Cornelia M van Duijn James F Wilson Sina A Gharib Paul I W de Bakker Aaron Isaacs Dan E Arking Nona Sotoodehnia

Nat Commun 2018 07 25;9(1):2904. Epub 2018 Jul 25.

Departments of Medicine and Epidemiology, Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, 98101, WA, USA.

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http://dx.doi.org/10.1038/s41467-018-04766-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060178PMC
July 2018

Between international donors and local faith communities: Intermediaries in humanitarian assistance to Syrian refugees in Jordan and Lebanon.

Disasters 2019 Jan 12;43(1):24-45. Epub 2018 Jun 12.

PhD Researcher in Theology and Religious Studies, University of Leeds, United Kingdom.

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http://dx.doi.org/10.1111/disa.12301DOI Listing
January 2019

Multi-ethnic genome-wide association study for atrial fibrillation.

Authors:
Carolina Roselli Mark D Chaffin Lu-Chen Weng Stefanie Aeschbacher Gustav Ahlberg Christine M Albert Peter Almgren Alvaro Alonso Christopher D Anderson Krishna G Aragam Dan E Arking John Barnard Traci M Bartz Emelia J Benjamin Nathan A Bihlmeyer Joshua C Bis Heather L Bloom Eric Boerwinkle Erwin B Bottinger Jennifer A Brody Hugh Calkins Archie Campbell Thomas P Cappola John Carlquist Daniel I Chasman Lin Y Chen Yii-Der Ida Chen Eue-Keun Choi Seung Hoan Choi Ingrid E Christophersen Mina K Chung John W Cole David Conen James Cook Harry J Crijns Michael J Cutler Scott M Damrauer Brian R Daniels Dawood Darbar Graciela Delgado Joshua C Denny Martin Dichgans Marcus Dörr Elton A Dudink Samuel C Dudley Nada Esa Tonu Esko Markku Eskola Diane Fatkin Stephan B Felix Ian Ford Oscar H Franco Bastiaan Geelhoed Raji P Grewal Vilmundur Gudnason Xiuqing Guo Namrata Gupta Stefan Gustafsson Rebecca Gutmann Anders Hamsten Tamara B Harris Caroline Hayward Susan R Heckbert Jussi Hernesniemi Lynne J Hocking Albert Hofman Andrea R V R Horimoto Jie Huang Paul L Huang Jennifer Huffman Erik Ingelsson Esra Gucuk Ipek Kaoru Ito Jordi Jimenez-Conde Renee Johnson J Wouter Jukema Stefan Kääb Mika Kähönen Yoichiro Kamatani John P Kane Adnan Kastrati Sekar Kathiresan Petra Katschnig-Winter Maryam Kavousi Thorsten Kessler Bas L Kietselaer Paulus Kirchhof Marcus E Kleber Stacey Knight Jose E Krieger Michiaki Kubo Lenore J Launer Jari Laurikka Terho Lehtimäki Kirsten Leineweber Rozenn N Lemaitre Man Li Hong Euy Lim Henry J Lin Honghuang Lin Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Barry London Ruth J F Loos Siew-Kee Low Yingchang Lu Leo-Pekka Lyytikäinen Peter W Macfarlane Patrik K Magnusson Anubha Mahajan Rainer Malik Alfredo J Mansur Gregory M Marcus Lauren Margolin Kenneth B Margulies Winfried März David D McManus Olle Melander Sanghamitra Mohanty Jay A Montgomery Michael P Morley Andrew P Morris Martina Müller-Nurasyid Andrea Natale Saman Nazarian Benjamin Neumann Christopher Newton-Cheh Maartje N Niemeijer Kjell Nikus Peter Nilsson Raymond Noordam Heidi Oellers Morten S Olesen Marju Orho-Melander Sandosh Padmanabhan Hui-Nam Pak Guillaume Paré Nancy L Pedersen Joanna Pera Alexandre Pereira David Porteous Bruce M Psaty Sara L Pulit Clive R Pullinger Daniel J Rader Lena Refsgaard Marta Ribasés Paul M Ridker Michiel Rienstra Lorenz Risch Dan M Roden Jonathan Rosand Michael A Rosenberg Natalia Rost Jerome I Rotter Samir Saba Roopinder K Sandhu Renate B Schnabel Katharina Schramm Heribert Schunkert Claudia Schurman Stuart A Scott Ilkka Seppälä Christian Shaffer Svati Shah Alaa A Shalaby Jaemin Shim M Benjamin Shoemaker Joylene E Siland Juha Sinisalo Moritz F Sinner Agnieszka Slowik Albert V Smith Blair H Smith J Gustav Smith Jonathan D Smith Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Bruno H Stricker Albert Sun Han Sun Jesper H Svendsen Toshihiro Tanaka Kahraman Tanriverdi Kent D Taylor Maris Teder-Laving Alexander Teumer Sébastien Thériault Stella Trompet Nathan R Tucker Arnljot Tveit Andre G Uitterlinden Pim Van Der Harst Isabelle C Van Gelder David R Van Wagoner Niek Verweij Efthymia Vlachopoulou Uwe Völker Biqi Wang Peter E Weeke Bob Weijs Raul Weiss Stefan Weiss Quinn S Wells Kerri L Wiggins Jorge A Wong Daniel Woo Bradford B Worrall Pil-Sung Yang Jie Yao Zachary T Yoneda Tanja Zeller Lingyao Zeng Steven A Lubitz Kathryn L Lunetta Patrick T Ellinor

Nat Genet 2018 06 11;50(9):1225-1233. Epub 2018 Jun 11.

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41588-018-0133-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136836PMC
June 2018

CD6 expression has no effect on atherosclerosis in apolipoprotein E-deficient mice.

BMC Res Notes 2018 Apr 3;11(1):229. Epub 2018 Apr 3.

Department of Cellular & Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA.

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http://dx.doi.org/10.1186/s13104-018-3327-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883413PMC
April 2018

Genetic Control of Left Atrial Gene Expression Yields Insights into the Genetic Susceptibility for Atrial Fibrillation.

Circ Genom Precis Med 2018 03;11(3):e002107

From the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.

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http://dx.doi.org/10.1161/CIRCGEN.118.002107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858469PMC
March 2018

Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies-Statement From ATVB Council.

Arterioscler Thromb Vasc Biol 2018 02 4;38(2):292-303. Epub 2018 Jan 4.

From the Department of Cellular and Molecular Medicine, Cleveland Clinic, OH (P.R., J.D.S.); Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (D.M.M.); Department of Pharmacology and Nutritional Sciences (L.A.C.) and Saha Cardiovascular Research Center and Department of Physiology (H.S.L.), University of Kentucky, Lexington; and Division of Vascular Surgery, Department of Surgery, Stanford University, CA (N.J.L.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.117.309524
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http://dx.doi.org/10.1161/ATVBAHA.117.309524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785439PMC
February 2018

Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant.

Arterioscler Thromb Vasc Biol 2018 01 2;38(1):83-91. Epub 2017 Nov 2.

From the Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Henan, China (Q.H., J.Z.); Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, OH (Q.H., B.R., P.R., A.M.A., G.B., J.D.S); and Department of Chemistry, Cleveland State University, OH (B.R.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.117.310173
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http://dx.doi.org/10.1161/ATVBAHA.117.310173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746475PMC
January 2018

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium.

Sci Rep 2017 09 12;7(1):11303. Epub 2017 Sep 12.

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41598-017-09396-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595875PMC
September 2017

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

Authors:
Ingrid E Christophersen Michiel Rienstra Carolina Roselli Xiaoyan Yin Bastiaan Geelhoed John Barnard Honghuang Lin Dan E Arking Albert V Smith Christine M Albert Mark Chaffin Nathan R Tucker Molong Li Derek Klarin Nathan A Bihlmeyer Siew-Kee Low Peter E Weeke Martina Müller-Nurasyid J Gustav Smith Jennifer A Brody Maartje N Niemeijer Marcus Dörr Stella Trompet Jennifer Huffman Stefan Gustafsson Claudia Schurmann Marcus E Kleber Leo-Pekka Lyytikäinen Ilkka Seppälä Rainer Malik Andrea R V R Horimoto Marco Perez Juha Sinisalo Stefanie Aeschbacher Sébastien Thériault Jie Yao Farid Radmanesh Stefan Weiss Alexander Teumer Seung Hoan Choi Lu-Chen Weng Sebastian Clauss Rajat Deo Daniel J Rader Svati H Shah Albert Sun Jemma C Hopewell Stephanie Debette Ganesh Chauhan Qiong Yang Bradford B Worrall Guillaume Paré Yoichiro Kamatani Yanick P Hagemeijer Niek Verweij Joylene E Siland Michiaki Kubo Jonathan D Smith David R Van Wagoner Joshua C Bis Siegfried Perz Bruce M Psaty Paul M Ridker Jared W Magnani Tamara B Harris Lenore J Launer M Benjamin Shoemaker Sandosh Padmanabhan Jeffrey Haessler Traci M Bartz Melanie Waldenberger Peter Lichtner Marina Arendt Jose E Krieger Mika Kähönen Lorenz Risch Alfredo J Mansur Annette Peters Blair H Smith Lars Lind Stuart A Scott Yingchang Lu Erwin B Bottinger Jussi Hernesniemi Cecilia M Lindgren Jorge A Wong Jie Huang Markku Eskola Andrew P Morris Ian Ford Alex P Reiner Graciela Delgado Lin Y Chen Yii-Der Ida Chen Roopinder K Sandhu Man Li Eric Boerwinkle Lewin Eisele Lars Lannfelt Natalia Rost Christopher D Anderson Kent D Taylor Archie Campbell Patrik K Magnusson David Porteous Lynne J Hocking Efthymia Vlachopoulou Nancy L Pedersen Kjell Nikus Marju Orho-Melander Anders Hamsten Jan Heeringa Joshua C Denny Jennifer Kriebel Dawood Darbar Christopher Newton-Cheh Christian Shaffer Peter W Macfarlane Stefanie Heilmann-Heimbach Peter Almgren Paul L Huang Nona Sotoodehnia Elsayed Z Soliman Andre G Uitterlinden Albert Hofman Oscar H Franco Uwe Völker Karl-Heinz Jöckel Moritz F Sinner Henry J Lin Xiuqing Guo Martin Dichgans Erik Ingelsson Charles Kooperberg Olle Melander Ruth J F Loos Jari Laurikka David Conen Jonathan Rosand Pim van der Harst Marja-Liisa Lokki Sekar Kathiresan Alexandre Pereira J Wouter Jukema Caroline Hayward Jerome I Rotter Winfried März Terho Lehtimäki Bruno H Stricker Mina K Chung Stephan B Felix Vilmundur Gudnason Alvaro Alonso Dan M Roden Stefan Kääb Daniel I Chasman Susan R Heckbert Emelia J Benjamin Toshihiro Tanaka Kathryn L Lunetta Steven A Lubitz Patrick T Ellinor

Nat Genet 2017 07;49(8):1286

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http://dx.doi.org/10.1038/ng0817-1286cDOI Listing
July 2017

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

Authors:
Ingrid E Christophersen Michiel Rienstra Carolina Roselli Xiaoyan Yin Bastiaan Geelhoed John Barnard Honghuang Lin Dan E Arking Albert V Smith Christine M Albert Mark Chaffin Nathan R Tucker Molong Li Derek Klarin Nathan A Bihlmeyer Siew-Kee Low Peter E Weeke Martina Müller-Nurasyid J Gustav Smith Jennifer A Brody Maartje N Niemeijer Marcus Dörr Stella Trompet Jennifer Huffman Stefan Gustafsson Claudia Schurmann Marcus E Kleber Leo-Pekka Lyytikäinen Ilkka Seppälä Rainer Malik Andrea R V R Horimoto Marco Perez Juha Sinisalo Stefanie Aeschbacher Sébastien Thériault Jie Yao Farid Radmanesh Stefan Weiss Alexander Teumer Seung Hoan Choi Lu-Chen Weng Sebastian Clauss Rajat Deo Daniel J Rader Svati H Shah Albert Sun Jemma C Hopewell Stephanie Debette Ganesh Chauhan Qiong Yang Bradford B Worrall Guillaume Paré Yoichiro Kamatani Yanick P Hagemeijer Niek Verweij Joylene E Siland Michiaki Kubo Jonathan D Smith David R Van Wagoner Joshua C Bis Siegfried Perz Bruce M Psaty Paul M Ridker Jared W Magnani Tamara B Harris Lenore J Launer M Benjamin Shoemaker Sandosh Padmanabhan Jeffrey Haessler Traci M Bartz Melanie Waldenberger Peter Lichtner Marina Arendt Jose E Krieger Mika Kähönen Lorenz Risch Alfredo J Mansur Annette Peters Blair H Smith Lars Lind Stuart A Scott Yingchang Lu Erwin B Bottinger Jussi Hernesniemi Cecilia M Lindgren Jorge A Wong Jie Huang Markku Eskola Andrew P Morris Ian Ford Alex P Reiner Graciela Delgado Lin Y Chen Yii-Der Ida Chen Roopinder K Sandhu Man Li Eric Boerwinkle Lewin Eisele Lars Lannfelt Natalia Rost Christopher D Anderson Kent D Taylor Archie Campbell Patrik K Magnusson David Porteous Lynne J Hocking Efthymia Vlachopoulou Nancy L Pedersen Kjell Nikus Marju Orho-Melander Anders Hamsten Jan Heeringa Joshua C Denny Jennifer Kriebel Dawood Darbar Christopher Newton-Cheh Christian Shaffer Peter W Macfarlane Stefanie Heilmann-Heimbach Peter Almgren Paul L Huang Nona Sotoodehnia Elsayed Z Soliman Andre G Uitterlinden Albert Hofman Oscar H Franco Uwe Völker Karl-Heinz Jöckel Moritz F Sinner Henry J Lin Xiuqing Guo Martin Dichgans Erik Ingelsson Charles Kooperberg Olle Melander Ruth J F Loos Jari Laurikka David Conen Jonathan Rosand Pim van der Harst Marja-Liisa Lokki Sekar Kathiresan Alexandre Pereira J Wouter Jukema Caroline Hayward Jerome I Rotter Winfried März Terho Lehtimäki Bruno H Stricker Mina K Chung Stephan B Felix Vilmundur Gudnason Alvaro Alonso Dan M Roden Stefan Kääb Daniel I Chasman Susan R Heckbert Emelia J Benjamin Toshihiro Tanaka Kathryn L Lunetta Steven A Lubitz Patrick T Ellinor

Nat Genet 2017 Jun 17;49(6):946-952. Epub 2017 Apr 17.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585859PMC
June 2017

PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly.

Circ Res 2016 Sep 11;119(7):827-38. Epub 2016 Aug 11.

From the Department of Cellular and Molecular Medicine (K.G., G.B., H.C., S.W., R.Z., S.L.H., J.D.S.) and Department of Cardiovascular Medicine (S.L.H., J.D.S.), Cleveland Clinic, OH.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026623PMC
September 2016

PANCR, the PITX2 Adjacent Noncoding RNA, Is Expressed in Human Left Atria and Regulates PITX2c Expression.

Circ Arrhythm Electrophysiol 2016 Jan;9(1):e003197

From the Department of Molecular Cardiology, Lerner Research Institute (S.R.G.-P., C.S.M., D.R.V.W., M.K.C.), Department of Cellular & Molecular Medicine, Lerner Research Institute (S.R.G.-P., J.H., J.D.S.), Department of Quantitative Health Sciences (J.B.), and Department of Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), Cleveland Clinic, OH.

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http://dx.doi.org/10.1161/CIRCEP.115.003197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719779PMC
January 2016

Human Macrophage Genetic Engineering.

Authors:
Jonathan D Smith

Arterioscler Thromb Vasc Biol 2016 Jan;36(1):2-3

From the Department of Cellular & Molecular Medicine, Cleveland Clinic, OH.

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http://dx.doi.org/10.1161/ATVBAHA.115.306796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692174PMC
January 2016

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.

Sci Signal 2015 Aug 11;8(389):ra79. Epub 2015 Aug 11.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scisignal.aaa2581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768813PMC
August 2015

Free-cholesterol-mediated autophagy of ORMDL1 stimulates sphingomyelin biosynthesis.

Autophagy 2015 ;11(7):1207-8

a Department of Cellular and Molecular Medicine; Cleveland Clinic ; Cleveland , OH , USA.

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http://dx.doi.org/10.1080/15548627.2015.1052209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590593PMC
April 2016

Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis.

PLoS One 2015 20;10(5):e0126910. Epub 2015 May 20.

Department of Gastroenterology& Hepatology, Cleveland Clinic, Cleveland, OH, United States of America; Department of Pathobiology, Cleveland Clinic, Cleveland, OH, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126910PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439060PMC
April 2016

ORMDL orosomucoid-like proteins are degraded by free-cholesterol-loading-induced autophagy.

Proc Natl Acad Sci U S A 2015 Mar 9;112(12):3728-33. Epub 2015 Mar 9.

Departments of Cellular and Molecular Medicine and

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http://www.pnas.org/lookup/doi/10.1073/pnas.1422455112
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http://dx.doi.org/10.1073/pnas.1422455112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378419PMC
March 2015

Effect of Public Reporting on MR Imaging Use for Low Back Pain.

Radiology 2015 Jul 9;276(1):175-83. Epub 2015 Mar 9.

From the Department of Management, Policy and Community Health, University of Texas School of Public Health, 1200 Pressler St, Houston, TX 77030 (C.M.G., L.F.); The Commonwealth Fund, New York, NY (M.Z.); Centers for Medicare & Medicaid Services, Baltimore, Md (J.D.S.); and Department of Radiology, University of Texas School of Medicine, Houston, Tex (S.D.J.).

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http://dx.doi.org/10.1148/radiol.15141145DOI Listing
July 2015

HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function.

J Lipid Res 2015 Mar 5;56(3):653-64. Epub 2015 Jan 5.

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195 Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195.

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http://dx.doi.org/10.1194/jlr.M056754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340312PMC
March 2015

Left atrial transcriptional changes associated with atrial fibrillation susceptibility and persistence.

Circ Arrhythm Electrophysiol 2015 Feb 18;8(1):32-41. Epub 2014 Dec 18.

From the Department of Medicine, University of Chicago, IL (A.D.); Department of Quantitative Health Sciences (J.B; H.S.), Department of Molecular Cardiology (L.C., D.R.V.W., M.K.C.), and Department of Cellular and Molecular Medicine, Cleveland Clinic (J.D.S.), Lerner Research Institute, OH; Department of Cardiovascular Medicine (D.N., C.M., J.D.S., M.K.C.) and Department of Cardiovascular Medicine and Thoracic and Cardiovascular Surgery (G.P., D.J., E.R., A.M.G., K.M.), Heart and Vascular Institute, Cleveland, OH; and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, OH (C.M., J.D.S., D.R.V.W., M.K.C.).

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http://dx.doi.org/10.1161/CIRCEP.114.001632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334691PMC
February 2015

γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO.

Cell Metab 2014 Nov 4;20(5):799-812. Epub 2014 Nov 4.

Department of Cellular & Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255476PMC
November 2014

ABCA1 and nascent HDL biogenesis.

Biofactors 2014 Nov-Dec;40(6):547-54. Epub 2014 Oct 30.

Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH.

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http://dx.doi.org/10.1002/biof.1187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294467PMC
September 2015

New role for histone deacetylase 9 in atherosclerosis and inflammation.

Authors:
Jonathan D Smith

Arterioscler Thromb Vasc Biol 2014 Sep;34(9):1798-9

From the Department of Cellular and Molecular Medicine, The Cleveland Clinic, OH.

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http://dx.doi.org/10.1161/ATVBAHA.114.304295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143375PMC
September 2014

A₁ adenosine receptor deficiency or inhibition reduces atherosclerotic lesions in apolipoprotein E deficient mice.

Cardiovasc Res 2014 Apr 12;102(1):157-65. Epub 2014 Feb 12.

Department of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences, West Virginia University, 1 Medical Center Drive, Morgantown, WV, USA.

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http://dx.doi.org/10.1093/cvr/cvu033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958624PMC
April 2014

Atrial Fibrillation associated chromosome 4q25 variants are not associated with PITX2c expression in human adult left atrial appendages.

PLoS One 2014 22;9(1):e86245. Epub 2014 Jan 22.

Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America ; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, United States of America ; Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086245PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899225PMC
November 2014

Ribosomal protein L13a deficiency in macrophages promotes atherosclerosis by limiting translation control-dependent retardation of inflammation.

Arterioscler Thromb Vasc Biol 2014 Mar 16;34(3):533-42. Epub 2014 Jan 16.

From the Department of Biology, Geology, and Environmental Sciences, Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH (A.B., D.P., B.M.); Department of Cellular and Molecular Medicine (P.R., J.D.S.), Department of Immunology (W.M.B.), and Department of Molecular Cardiology (M.F), Cleveland Clinic Lerner College of Medicine, Cleveland, OH.

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http://dx.doi.org/10.1161/ATVBAHA.113.302573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954853PMC
March 2014

Effects of native and myeloperoxidase-modified apolipoprotein a-I on reverse cholesterol transport and atherosclerosis in mice.

Arterioscler Thromb Vasc Biol 2014 Apr 9;34(4):779-89. Epub 2014 Jan 9.

From the Department of Medicine, Division of Cardiology and the Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine (B.H., S.P., T.B., W.K.K.C., Y.M.A., T.H., B.R., E.A.F.); Medizinische Klinik für Kardiologie und Angiologie, Charité-Universitaetsmedizin Berlin, Berlin, Germany (B.H.); and Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, OH (T.C.T., M.S.S.Y., J.A.D., Y.H., J.B., S.Z.B., J.D.S., S.L.H.).

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http://dx.doi.org/10.1161/ATVBAHA.113.303044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966977PMC
April 2014

High-density lipoprotein and atherosclerosis regression: evidence from preclinical and clinical studies.

Circ Res 2014 Jan;114(1):205-13

From the Departments of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Vascular Biology Program, New York University School of Medicine, New York, NY (J.E.F., B.H., E.A.F.); and Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH (J.D.S., S.L.H.). J.E.F. is currently affiliated with Department of Medicine (Cardiology), Mount Sinai School of Medicine, New York, NY. B.H. is currently affiliated with Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.114.300760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918097PMC
January 2014

Function and distribution of apolipoprotein A1 in the artery wall are markedly distinct from those in plasma.

Circulation 2013 Oct 22;128(15):1644-55. Epub 2013 Aug 22.

Departments of Cellular and Molecular Medicine, Lerner Research Institute (J.A.D., Y.H., K.A., G.G., V.G., P.L.F., W.H.W.T., J.D.S., S.L.H.), Cardiovascular Medicine, Heart, and Vascular Institute (W.H.W.T., J.D.S., S.L.H.), and Molecular Cardiology, Lerner Research Institute (E.F.P.), Cleveland Clinic, Cleveland, OH; Department of Medicine, New York University, New York, NY (O.E.-O., E.A.F.); and Departments of Chemistry (G.G., V.G., S.L.H.) and Mathematics (Y.W.), Cleveland State University, Cleveland, OH.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882895PMC
October 2013

2H2O-based high-density lipoprotein turnover method for the assessment of dynamic high-density lipoprotein function in mice.

Arterioscler Thromb Vasc Biol 2013 Aug 13;33(8):1994-2003. Epub 2013 Jun 13.

Department of Gastroenterology and Hepatology, Case Western Reserve University School of Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1161/ATVBAHA.113.301700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958961PMC
August 2013

ABCA1 mediates unfolding of apolipoprotein AI N terminus on the cell surface before lipidation and release of nascent high-density lipoprotein.

Arterioscler Thromb Vasc Biol 2013 Jun 4;33(6):1197-205. Epub 2013 Apr 4.

Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.301195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701943PMC
June 2013

Genetic-genomic replication to identify candidate mouse atherosclerosis modifier genes.

J Am Heart Assoc 2013 Jan 23;2(1):e005421. Epub 2013 Jan 23.

Department of Molecular Medicine, Cleveland Clinic, Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1161/JAHA.112.005421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603265PMC
January 2013

Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks.

Arterioscler Thromb Vasc Biol 2013 Jul 21;33(7):1696-705. Epub 2013 Mar 21.

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1161/ATVBAHA.113.301373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743250PMC
July 2013

Physiological difference in autophagic flux in macrophages from 2 mouse strains regulates cholesterol ester metabolism.

Arterioscler Thromb Vasc Biol 2013 May 14;33(5):903-10. Epub 2013 Mar 14.

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.301041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646371PMC
May 2013

High-density lipoprotein function, dysfunction, and reverse cholesterol transport.

Arterioscler Thromb Vasc Biol 2012 Dec;32(12):2813-20

Department of Cardiovascular Medicine, New York University School of Medicine, New York, NY 444195, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.300133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501261PMC
December 2012

Diabetic HDL is dysfunctional in stimulating endothelial cell migration and proliferation due to down regulation of SR-BI expression.

PLoS One 2012 2;7(11):e48530. Epub 2012 Nov 2.

The Institute of Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487724PMC
May 2013

Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation.

Mol Cell 2012 Aug 5;47(4):656-63. Epub 2012 Jul 5.

Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765120049
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http://dx.doi.org/10.1016/j.molcel.2012.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635105PMC
August 2012

Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.

Cell Metab 2012 Jun 24;15(6):861-72. Epub 2012 May 24.

Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372639PMC
June 2012

Meta-analysis identifies six new susceptibility loci for atrial fibrillation.

Nat Genet 2012 Apr 29;44(6):670-5. Epub 2012 Apr 29.

Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.2261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366038PMC
April 2012

Red blood cells play a role in reverse cholesterol transport.

Arterioscler Thromb Vasc Biol 2012 Jun 12;32(6):1460-5. Epub 2012 Apr 12.

Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.112.248971
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http://dx.doi.org/10.1161/ATVBAHA.112.248971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360517PMC
June 2012

Genome-wide studies of gene expression relevant to coronary artery disease.

Curr Opin Cardiol 2012 May;27(3):210-3

Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1097/HCO.0b013e3283522198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332306PMC
May 2012

Whole genome expression differences in human left and right atria ascertained by RNA sequencing.

Circ Cardiovasc Genet 2012 Jun 3;5(3):327-35. Epub 2012 Apr 3.

Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, OH, USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.111.961631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380143PMC
June 2012

Comparing variation in Medicare and private insurance spending in Texas.

Am J Manag Care 2011 Dec 1;17(12):e488-95. Epub 2011 Dec 1.

University of Texas School of Public Health, 1200 Pressler Dr, Houston, TX 77030, USA.

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December 2011

Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels.

J Biol Chem 2012 Jan 30;287(3):2032-44. Epub 2011 Nov 30.

Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.295451
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http://dx.doi.org/10.1074/jbc.M111.295451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265883PMC
January 2012

Changes in whole blood gene expression in obese subjects with type 2 diabetes following bariatric surgery: a pilot study.

PLoS One 2011 Mar 10;6(3):e16729. Epub 2011 Mar 10.

Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016729PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053356PMC
March 2011

Zymosan-mediated inflammation impairs in vivo reverse cholesterol transport.

J Lipid Res 2011 May 19;52(5):951-7. Epub 2011 Feb 19.

Department of Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1194/jlr.M011122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073469PMC
May 2011

Combining genome-wide data from humans and animal models of dyslipidemia and atherosclerosis.

Curr Opin Lipidol 2011 Apr;22(2):100-5

Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Ohio, USA.

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http://dx.doi.org/10.1097/MOL.0b013e328342a375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347921PMC
April 2011

Myeloperoxidase, inflammation, and dysfunctional high-density lipoprotein.

Authors:
Jonathan D Smith

J Clin Lipidol 2010 Sep-Oct;4(5):382-8

Department of Cell Biology, Box NC10, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1016/j.jacl.2010.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976566PMC
July 2011

Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis.

Arterioscler Thromb Vasc Biol 2011 Jan 14;31(1):81-5. Epub 2010 Oct 14.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1161/ATVBAHA.110.213496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013369PMC
January 2011

Thrombospondin-4 regulates vascular inflammation and atherogenesis.

Circ Res 2010 Nov 30;107(11):1313-25. Epub 2010 Sep 30.

Department of Molecular Cardiology and Joseph J. Jacob Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Ohio 44195, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.110.23237
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http://dx.doi.org/10.1161/CIRCRESAHA.110.232371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993182PMC
November 2010

Apolipoprotein A-I and its mimetics for the treatment of atherosclerosis.

Authors:
Jonathan D Smith

Curr Opin Investig Drugs 2010 Sep;11(9):989-96

Cleveland Clinic, Department of Cell Biology, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074469PMC
September 2010

A simple and sensitive enzymatic method for cholesterol quantification in macrophages and foam cells.

J Lipid Res 2010 Nov 4;51(11):3364-9. Epub 2010 Aug 4.

Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1194/jlr.D007336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952578PMC
November 2010

Synthesis and biological evaluation of analogues of a novel inhibitor of beta-amyloid secretion.

J Med Chem 2010 Jul;53(14):5302-19

Department of Cell Biology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.

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July 2010