Publications by authors named "Jonathan D Powell"

100Publications

Inhibition of the Adenosine Pathway to Potentiate Cancer Immunotherapy: Potential for Combinatorial Approaches.

Annu Rev Med 2020 Sep 9. Epub 2020 Sep 9.

Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA; email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-med-060619-023155DOI Listing
September 2020

Rethinking the adenosine-AR checkpoint: implications for enhancing anti-tumor immunotherapy.

Curr Opin Pharmacol 2020 Aug 8;53:77-83. Epub 2020 Aug 8.

The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, 1650 Orleans Street, CRB-I Rm443, Baltimore, MD, 21231, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coph.2020.07.003DOI Listing
August 2020

Metabolism of immune cells in cancer.

Nat Rev Cancer 2020 Sep 6;20(9):516-531. Epub 2020 Jul 6.

Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41568-020-0273-yDOI Listing
September 2020

Manipulation of Metabolic Pathways and Its Consequences for Anti-Tumor Immunity: A Clinical Perspective.

Int J Mol Sci 2020 Jun 4;21(11). Epub 2020 Jun 4.

Department of Medical Education, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21114030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312891PMC
June 2020

Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression.

Front Immunol 2020 9;11:572. Epub 2020 Apr 9.

Sidney∼Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.00572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161684PMC
April 2020

Targeting metabolism to regulate immune responses in autoimmunity and cancer.

Nat Rev Drug Discov 2019 09 30;18(9):669-688. Epub 2019 Jul 30.

Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41573-019-0032-5DOI Listing
September 2019

Peeking under the Hood of Naive T Cells.

Cell Metab 2018 12;28(6):801-802

Bloomberg-Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15504131183068
Publisher Site
http://dx.doi.org/10.1016/j.cmet.2018.11.008DOI Listing
December 2018

MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.

Proc Natl Acad Sci U S A 2018 12 4;115(51):E12024-E12033. Epub 2018 Dec 4.

Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD 20892;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1812909115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304986PMC
December 2018

Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models.

Cancer Immunol Immunother 2018 Aug 19;67(8):1271-1284. Epub 2018 Jun 19.

Department of Oncology, Sidney-Kimmel Comprehensive Cancer Research Center, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, 1650 Orleans Street, CRB1 Room 453, Baltimore, MD, 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00262-018-2186-0DOI Listing
August 2018

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3 Regulatory T Cells.

J Immunol 2018 07 8;201(2):481-492. Epub 2018 Jun 8.

Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1701477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089237PMC
July 2018

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.

Cell 2018 06 31;174(1):72-87.e32. Epub 2018 May 31.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Wistar Institute, Philadelphia, PA 19104, USA; Ludwig Institute for Cancer Research, New York, NY 10017, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2018.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398937PMC
June 2018

mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages.

Cell Rep 2017 Sep;20(10):2439-2454

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2017.08.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659290PMC
September 2017

Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease.

Curr Opin Immunol 2017 Jun 15;46:82-88. Epub 2017 May 15.

Bloomberg-Kimmel Institute for Cancer Immunotherapy , Baltimore, MD, USA; Sidney-Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, CRB I Rm 443, Baltimore, MD, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coi.2017.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554728PMC
June 2017

mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation.

J Immunol 2017 05 19;198(10):3939-3948. Epub 2017 Apr 19.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1601078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458608PMC
May 2017

Murine Full-thickness Skin Transplantation.

J Vis Exp 2017 01 2(119). Epub 2017 Jan 2.

Vascularized Composite Allotransplantation Laboratory, Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/55105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408726PMC
January 2017

Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation.

J Immunol 2017 02;198(3):999-1005

Department of Oncology, Bloomberg-Kimmel Institute for Cancer Immunotherapy, The Sidney-Kimmel Comprehensive Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1601318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300074PMC
February 2017

The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment.

J Exp Med 2017 02 23;214(2):381-400. Epub 2017 Jan 23.

Departments of Pathology, Section of Hematology/Oncology, the University of Chicago, Chicago, IL 60637

View Article

Download full-text PDF

Source
http://www.jem.org/lookup/doi/10.1084/jem.20160485
Publisher Site
http://dx.doi.org/10.1084/jem.20160485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294847PMC
February 2017

Warburg meets epigenetics.

Science 2016 10;354(6311):419-420

Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Immunology CRB I Rm 443, Baltimore, MD 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aak9776DOI Listing
October 2016

An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor.

Chembiochem 2016 10 26;17(20):1951-1960. Epub 2016 Aug 26.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 302 Wood Basic Science Building, 725 N Wolfe St., Baltimore, MD, 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201600337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292873PMC
October 2016

Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells.

PLoS One 2016 20;11(9):e0163288. Epub 2016 Sep 20.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163288PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029914PMC
August 2017

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation.

Proc Natl Acad Sci U S A 2016 09 31;113(38):10631-6. Epub 2016 Aug 31.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231;

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035851PMC
http://dx.doi.org/10.1073/pnas.1524490113DOI Listing
September 2016

Leucine Metabolism in T Cell Activation: mTOR Signaling and Beyond.

Adv Nutr 2016 07 15;7(4):798S-805S. Epub 2016 Jul 15.

Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3945/an.115.011221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942864PMC
July 2016

Hunger Pains: Stimulating the Appetite of the Immune System for Cancer.

Cancer Cell 2016 07;30(1):13-15

Department of Oncology, Sidney-Kimmel Comprehensive Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2016.06.019DOI Listing
July 2016

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells.

Science 2016 Apr;352(6283):366-70

Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA. Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://www.sciencemag.org/cgi/doi/10.1126/science.aad9272
Publisher Site
http://dx.doi.org/10.1126/science.aad9272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866509PMC
April 2016

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation.

Nat Immunol 2016 06 11;17(6):704-11. Epub 2016 Apr 11.

Sidney-Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ni.3438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873361PMC
June 2016

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment.

Sci Adv 2015 Nov 6;1(10):e1500845. Epub 2015 Nov 6.

Cancer Center, Georgia Regents University, Augusta, GA 30912, USA. ; Department of Pediatrics, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.1500845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640592PMC
November 2015

Preventing Allograft Rejection by Targeting Immune Metabolism.

Cell Rep 2015 Oct 17;13(4):760-770. Epub 2015 Oct 17.

Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.09.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626381PMC
October 2015

Targeting glutamine metabolism rescues mice from late-stage cerebral malaria.

Proc Natl Acad Sci U S A 2015 Oct 5;112(42):13075-80. Epub 2015 Oct 5.

Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1516544112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620853PMC
October 2015

Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion.

Mol Immunol 2015 Dec;68(2 Pt C):492-6

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21223, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molimm.2015.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837657PMC
December 2015

Dysregulated Macrophages Are Present in Bleomycin-Induced Murine Laryngotracheal Stenosis.

Otolaryngol Head Neck Surg 2015 Aug 17;153(2):244-50. Epub 2015 Jun 17.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/0194599815589106
Publisher Site
http://dx.doi.org/10.1177/0194599815589106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640676PMC
August 2015

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy.

Comput Struct Biotechnol J 2015 8;13:265-72. Epub 2015 Apr 8.

Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.csbj.2015.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415113PMC
May 2015

Something in the air: hyperoxic conditioning of the tumor microenvironment for enhanced immunotherapy.

Cancer Cell 2015 Apr;27(4):435-6

Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2015.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696011PMC
April 2015

Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition.

PLoS One 2015 7;10(4):e0121710. Epub 2015 Apr 7.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121710PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388710PMC
March 2016

Rapamycin inhibits human laryngotracheal stenosis-derived fibroblast proliferation, metabolism, and function in vitro.

Otolaryngol Head Neck Surg 2015 May 9;152(5):881-8. Epub 2015 Mar 9.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0194599815573708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648293PMC
May 2015

Sugar, fat, and protein: new insights into what T cells crave.

Curr Opin Immunol 2015 Apr 6;33:49-54. Epub 2015 Feb 6.

Sidney-Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coi.2015.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397153PMC
April 2015

Regulation of T cells by mTOR: the known knowns and the known unknowns.

Trends Immunol 2015 Jan 16;36(1):13-20. Epub 2014 Dec 16.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.it.2014.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290883PMC
January 2015

Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.

J Immunol 2015 Jan 17;194(1):223-30. Epub 2014 Nov 17.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1401985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315517PMC
January 2015

Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype.

JAMA 2014 Jul;312(1):48-56

Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland2National Heart, Lung, and Blood Institute, Bethesda, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2014.7192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698790PMC
July 2014

Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection.

Curr Opin Organ Transplant 2014 Aug;19(4):363-71

aDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA bChang-Gung Transplantation Institute, Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan *These authors contributed equally to the writing of this article.

View Article

Download full-text PDF

Source
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/MOT.0000000000000098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216568PMC
August 2014

Integrating canonical and metabolic signalling programmes in the regulation of T cell responses.

Nat Rev Immunol 2014 Jul;14(7):435-46

Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri3701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390057PMC
July 2014

Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells.

J Biol Chem 2014 Jul 20;289(27):18793-804. Epub 2014 May 20.

From the Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, Virginia 24061 and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.554113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081922PMC
July 2014

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.

Nat Immunol 2014 May 6;15(5):457-64. Epub 2014 Apr 6.

Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ni.2867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267697PMC
May 2014

An Fc domain protein-small molecule conjugate as an enhanced immunomodulator.

J Am Chem Soc 2014 Mar 24;136(9):3370-3. Epub 2014 Feb 24.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine , Baltimore, Maryland 21205, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja5006674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954559PMC
March 2014

Egr3 induces a Th17 response by promoting the development of γδ T cells.

PLoS One 2014 24;9(1):e87265. Epub 2014 Jan 24.

The Sidney-Kimmel Cancer Research Center, The Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087265PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901773PMC
February 2015

A modified model of T-cell differentiation based on mTOR activity and metabolism.

Cold Spring Harb Symp Quant Biol 2013 7;78:125-30. Epub 2013 Oct 7.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/sqb.2013.78.020214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979500PMC
March 2015

Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles.

J Immunol 2013 Nov 4;191(10):5107-14. Epub 2013 Oct 4.

Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21231;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1301433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831631PMC
November 2013

Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway.

J Inflamm (Lond) 2013 May 30;10(1):23. Epub 2013 May 30.

Department of Medicine, John Hopkins University School of Medicine, Baltimore, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1476-9255-10-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682892PMC
May 2013

Slc7a5 helps T cells get with the program.

Nat Immunol 2013 May;14(5):422-4

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ni.2594DOI Listing
May 2013

Sensing the immune microenvironment to coordinate T cell metabolism, differentiation & function.

Semin Immunol 2012 Dec 14;24(6):414-20. Epub 2013 Jan 14.

Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.smim.2012.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582714PMC
December 2012

Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1.

PLoS One 2012 15;7(11):e49801. Epub 2012 Nov 15.

Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049801PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499516PMC
June 2013

All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells.

Front Immunol 2012 9;3:312. Epub 2012 Oct 9.

Department of Oncology, Johns Hopkins University Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2012.00312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466461PMC
October 2012

mTOR, metabolism, and the regulation of T-cell differentiation and function.

Immunol Rev 2012 Sep;249(1):43-58

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1600-065X.2012.01152.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419491PMC
September 2012

De novo DNA methylation is required to restrict T helper lineage plasticity.

J Biol Chem 2012 Jun 14;287(27):22900-9. Epub 2012 May 14.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.312785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391093PMC
June 2012

Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells.

J Immunol 2012 May;188(10):4721-9

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1103143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347776PMC
May 2012

Pulmonary vaccination as a novel treatment for lung fibrosis.

PLoS One 2012 17;7(2):e31299. Epub 2012 Feb 17.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031299PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281950PMC
June 2012

Fueling memories.

Immunity 2012 Jan;36(1):3-5

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2012.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273990PMC
January 2012

Regulation of immune responses by mTOR.

Annu Rev Immunol 2012 29;30:39-68. Epub 2011 Nov 29.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

View Article

Download full-text PDF

Source
http://www.annualreviews.org/doi/10.1146/annurev-immunol-020
Publisher Site
http://dx.doi.org/10.1146/annurev-immunol-020711-075024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616892PMC
July 2012

Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes.

Methods Mol Biol 2012 ;821:317-27

Sidney-Kimmel Comprehensive Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-61779-430-8_20
Publisher Site
http://dx.doi.org/10.1007/978-1-61779-430-8_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571700PMC
March 2012

Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor.

Cancer Immunol Immunother 2012 Jun 25;61(6):917-26. Epub 2011 Nov 25.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00262-011-1155-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589752PMC
June 2012

Targeted immunosuppression: no longer naïve.

Clin Immunol 2012 Feb 25;142(2):95-6. Epub 2011 Oct 25.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2011.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598017PMC
February 2012

PI3K/mTOR signaling regulates prostatic branching morphogenesis.

Dev Biol 2011 Dec 8;360(2):329-42. Epub 2011 Oct 8.

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S001216061101271
Publisher Site
http://dx.doi.org/10.1016/j.ydbio.2011.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225010PMC
December 2011

A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity.

Immunity 2011 Apr;34(4):541-53

Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2011.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083826PMC
April 2011

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

Nat Immunol 2011 Apr 27;12(4):295-303. Epub 2011 Feb 27.

Sidney-Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ni.2005
Publisher Site
http://dx.doi.org/10.1038/ni.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077821PMC
April 2011

Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor.

Am J Respir Cell Mol Biol 2011 Oct 21;45(4):675-83. Epub 2011 Jan 21.

Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2010-0387OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208614PMC
October 2011

The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism.

Immunity 2010 Sep;33(3):301-11

Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747613100032
Publisher Site
http://dx.doi.org/10.1016/j.immuni.2010.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962404PMC
September 2010

Quieting T cells with Slfn2.

Nat Immunol 2010 Apr;11(4):281-2

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ni0410-281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893761PMC
April 2010

Genetic and biochemical regulation of CD4 T cell effector differentiation: insights from examination of T cell clonal anergy.

Immunol Res 2010 Jul;47(1-3):162-71

Department of Oncology, Sidney Kimmel Cancer Center, School of Medicine, Johns Hopkins University, CRB 1, Room 443, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12026-009-8147-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892254PMC
July 2010

Allogeneic hematopoietic stem-cell transplantation for sickle cell disease.

N Engl J Med 2009 Dec;361(24):2309-17

Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa0904971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627532PMC
December 2009

Anergic T cells are metabolically anergic.

J Immunol 2009 Nov 19;183(10):6095-101. Epub 2009 Oct 19.

The Sidney-Kimmel Cancer Research Center, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0803510
Publisher Site
http://dx.doi.org/10.4049/jimmunol.0803510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884282PMC
November 2009

Identification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiation.

J Immunol 2009 Aug 22;183(4):2267-76. Epub 2009 Jul 22.

Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0802960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818975PMC
August 2009

mTOR: taking cues from the immune microenvironment.

Immunology 2009 Aug;127(4):459-65

Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2567.2009.03125.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729523PMC
August 2009

Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation.

Mol Immunol 2009 Aug 7;46(13):2694-8. Epub 2009 Jul 7.

Sidney-Kimmel Comprehensive Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molimm.2009.05.185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768125PMC
August 2009

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.

Immunity 2009 Jun;30(6):832-44

Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2009.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768135PMC
June 2009

The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion.

Am J Respir Cell Mol Biol 2009 Mar 14;40(3):251-9. Epub 2008 Aug 14.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://www.atsjournals.org/doi/abs/10.1165/rcmb.2008-0168OC
Publisher Site
http://dx.doi.org/10.1165/rcmb.2008-0168OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645524PMC
March 2009

Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3.

Eur J Immunol 2008 Feb;38(2):528-36

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200737157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598016PMC
February 2008

A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.

Blood 2008 Jan 1;111(1):251-9. Epub 2007 Oct 1.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2007-03-081646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200810PMC
January 2008

Adenosine and anergy.

Autoimmunity 2007 Sep;40(6):425-32

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08916930701464939DOI Listing
September 2007

A role for mammalian target of rapamycin in regulating T cell activation versus anergy.

J Immunol 2007 Feb;178(4):2163-70

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.178.4.2163DOI Listing
February 2007

Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse.

Blood 2007 May 16;109(10):4564-74. Epub 2007 Jan 16.

Divisions of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2006-09-048124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885486PMC
May 2007

Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription.

J Immunol 2006 Dec;177(12):8301-5

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.177.12.8301DOI Listing
December 2006

Dissecting the mechanism of T-cell anergy with immunophilin ligands.

Curr Opin Investig Drugs 2006 Nov;7(11):1002-7

Department of Oncology - Immunology/Hematopoiesis, Johns Hopkins School of Medicine, 1650 Orleans St, CRB 443, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
November 2006

Hyaluronan fragments act as an endogenous danger signal by engaging TLR2.

J Immunol 2006 Jul;177(2):1272-81

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.177.2.1272DOI Listing
July 2006