Jonathan D Licht

Jonathan D Licht

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Jonathan D Licht

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FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML.

Nat Commun 2020 Feb 17;11(1):928. Epub 2020 Feb 17.

Division of Hematology/Oncology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1038/s41467-020-14590-9DOI Listing
February 2020

Twist-1 is upregulated by NSD2 and contributes to tumour dissemination and an epithelial-mesenchymal transition-like gene expression signature in t(4;14)-positive multiple myeloma.

Cancer Lett 2020 Jan 31;475:99-108. Epub 2020 Jan 31.

Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia; Precision Medicine Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2020.01.040DOI Listing
January 2020

Decitabine limits escape from MEK inhibition in uveal melanoma.

Pigment Cell Melanoma Res 2019 Nov 23. Epub 2019 Nov 23.

The Department of Tumor Biology, Moffitt Cancer Center, Tampa, FL, USA.

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http://dx.doi.org/10.1111/pcmr.12849DOI Listing
November 2019

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.

J Biol Chem 2019 Aug 27;294(33):12459-12471. Epub 2019 Jun 27.

Division of Hematology/Oncology, University of Florida Health Cancer Center, Gainesville, Florida 32608

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http://dx.doi.org/10.1074/jbc.RA118.006159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699848PMC
August 2019

Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury.

Basic Res Cardiol 2019 01 11;114(2). Epub 2019 Jan 11.

Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, P. O. BOX 5000, 90014, Oulu, Finland.

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http://link.springer.com/10.1007/s00395-018-0713-y
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http://dx.doi.org/10.1007/s00395-018-0713-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329741PMC
January 2019

DISORDERED HISTONE METHYLATION IN HEMATOLOGICAL MALIGNANCIES THE CASE OF UTX/KDM6A.

Authors:
Jonathan D Licht

Trans Am Clin Climatol Assoc 2018 ;129:24-36

GAINESVILLE, FLORIDA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116604PMC
December 2018

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator.

Cell Rep 2018 12;25(10):2808-2820.e4

Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183179
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http://dx.doi.org/10.1016/j.celrep.2018.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342284PMC
December 2018

Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity.

Epigenomes 2018 Sep 3;2(3). Epub 2018 Sep 3.

Division of Hematology and Oncology, Department of Medicine, University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610, USA;

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http://dx.doi.org/10.3390/epigenomes2030016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370027PMC
September 2018

Loss of Spry1 attenuates vascular smooth muscle proliferation by impairing mitogen-mediated changes in cell cycle regulatory circuits.

J Cell Biochem 2018 04 26;119(4):3267-3279. Epub 2017 Dec 26.

Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine.

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http://dx.doi.org/10.1002/jcb.26486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826877PMC
April 2018

Targeting Epigenetics in Cancer.

Annu Rev Pharmacol Toxicol 2018 01 6;58:187-207. Epub 2017 Oct 6.

Division of Hematology & Oncology, Department of Medicine, University of Florida Health Cancer Center, University of Florida, Gainesville, Florida 32606, USA; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010716-105106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800772PMC
January 2018

SETD2: a complex role in blood malignancy.

Authors:
Jonathan D Licht

Blood 2017 12;130(24):2576-2578

UNIVERSITY OF FLORIDA HEALTH CANCER CENTER.

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http://dx.doi.org/10.1182/blood-2017-10-811927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731090PMC
December 2017

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.

Cell Rep 2017 Oct;21(3):628-640

Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Division of Hematology/Oncology, University of Florida Health Cancer Center, Gainesville, FL 2033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.09.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706555PMC
October 2017

Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis.

PLoS One 2016 9;11(9):e0162515. Epub 2016 Sep 9.

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162515PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017600PMC
August 2017

Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma.

Curr Opin Hematol 2017 Jul;24(4):336-344

Department of Medicine, Division of Hematology-Oncology and The University of Florida Health Cancer Center University of Florida, Gainesville, Florida, USA.

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http://Insights.ovid.com/crossref?an=00062752-201707000-0000
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http://dx.doi.org/10.1097/MOH.0000000000000358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767522PMC
July 2017

The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.

Cold Spring Harb Perspect Med 2017 Jun 1;7(6). Epub 2017 Jun 1.

Departments of Medicine, Biochemistry and Molecular Biology and University of Florida Health Cancer Center, The University of Florida, Gainesville, Florida 32610.

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http://dx.doi.org/10.1101/cshperspect.a026708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453381PMC
June 2017

Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells.

J Biol Chem 2017 02 29;292(6):2237-2254. Epub 2016 Dec 29.

the Department of Pathology, Virginia Commonwealth University, Richmond, Virginia 23298

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http://dx.doi.org/10.1074/jbc.M116.764233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313097PMC
February 2017

Sabotaging of the oxidative stress response by an oncogenic noncoding RNA.

FASEB J 2017 02 24;31(2):482-490. Epub 2016 Oct 24.

Division of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, USA;

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http://dx.doi.org/10.1096/fj.201600654RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240659PMC
February 2017

FQI1: a transcription-methylation switch for cancer.

Oncotarget 2017 02;8(8):12536-12537

Department of Medicine, Division of Hematology and Oncology, University of Florida College of Medicine, Gainesville, Florida, USA.

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http://dx.doi.org/10.18632/oncotarget.15087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355025PMC
February 2017

Strong expression of EZH2 and accumulation of trimethylated H3K27 in diffuse large B-cell lymphoma independent of cell of origin and EZH2 codon 641 mutation.

Leuk Lymphoma 2015 8;56(10):2895-901. Epub 2015 Mar 8.

b Department of Pathology , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.

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http://dx.doi.org/10.3109/10428194.2015.1006220DOI Listing
September 2016

Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.

Mol Cell Proteomics 2016 Mar 13;15(3):776-90. Epub 2015 Aug 13.

From the ‡Departments of Chemistry and Molecular Biosciences, and the Proteomics Center of Excellence, Northwestern University, 2145 N. Sheridan Road, Evanston, Illinois 60208;

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http://dx.doi.org/10.1074/mcp.M115.053819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813700PMC
March 2016

Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases.

Epigenetics Chromatin 2015 24;8:38. Epub 2015 Sep 24.

INSERM UMRS-1131, Institut universitaire d'Hématologie, Université Paris Diderot, 1 avenue Claude Vellefaux, hôpital Saint-Louis, 75010 Paris, France.

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http://dx.doi.org/10.1186/s13072-015-0030-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581162PMC
September 2015

DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.

Authors:
Jonathan D Licht

Cell 2015 Aug;162(5):938-9

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, 303 East Superior Street, Lurie 5-123, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.08.005DOI Listing
August 2015

GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1.

Sci Rep 2015 Mar 25;5:9489. Epub 2015 Mar 25.

1] Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 E. Superior Ave, Chicago, IL 60611 [2] Jesse Brown VA Medical Center, 820 S. Damen Ave, Chicago, IL 60612 [3] The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, 303 E. Superior Ave, Chicago, IL 60611.

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http://dx.doi.org/10.1038/srep09489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452877PMC
March 2015

Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination.

Clin Cancer Res 2014 Oct 1;20(19):5001-8. Epub 2014 Jul 1.

Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://clincancerres.aacrjournals.org/content/early/2014/09/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-2499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184969PMC
October 2014

Promyelocytic leukemia zinc finger-retinoic acid receptor α (PLZF-RARα), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes.

J Biol Chem 2014 Jul 12;289(27):18641-56. Epub 2014 May 12.

From the Department of Biochemistry and Molecular Biology, Brain Korea 21 Plus Project for Medical Science, Severance Biomedical Science Institute, Yonsei University School of Medicine, 50 Yonsei-Ro, SeoDaeMoon-Gu, Seoul 120-752, Korea and

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http://dx.doi.org/10.1074/jbc.M113.538777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081909PMC
July 2014

Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity.

Proc Natl Acad Sci U S A 2014 Jun 2;111(24):E2462-71. Epub 2014 Jun 2.

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611;

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http://dx.doi.org/10.1073/pnas.1400517111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066511PMC
June 2014

From anecdote to targeted therapy: the curious case of thalidomide in multiple myeloma.

Cancer Cell 2014 Jan;25(1):9-11

Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia.

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http://dx.doi.org/10.1016/j.ccr.2013.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984916PMC
January 2014

Ponatinib--a step forward in overcoming resistance in chronic myeloid leukemia.

Clin Cancer Res 2013 Nov 9;19(21):5828-34. Epub 2013 Aug 9.

Authors' Affiliation: Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0258DOI Listing
November 2013

Spry1 and Spry2 are necessary for eyelid closure.

Dev Biol 2013 Nov 17;383(2):227-38. Epub 2013 Sep 17.

Department of Surgery, 253 Criss III, Cancer Center, 2500 California Plaza, Creighton University, Omaha, NE 68178, USA.

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http://dx.doi.org/10.1016/j.ydbio.2013.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857020PMC
November 2013

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Authors:
David B Agus Jenolyn F Alexander Wadih Arap Shashanka Ashili Joseph E Aslan Robert H Austin Vadim Backman Kelly J Bethel Richard Bonneau Wei-Chiang Chen Chira Chen-Tanyolac Nathan C Choi Steven A Curley Matthew Dallas Dhwanil Damania Paul C W Davies Paolo Decuzzi Laura Dickinson Luis Estevez-Salmeron Veronica Estrella Mauro Ferrari Claudia Fischbach Jasmine Foo Stephanie I Fraley Christian Frantz Alexander Fuhrmann Philippe Gascard Robert A Gatenby Yue Geng Sharon Gerecht Robert J Gillies Biana Godin William M Grady Alex Greenfield Courtney Hemphill Barbara L Hempstead Abigail Hielscher W Daniel Hillis Eric C Holland Arig Ibrahim-Hashim Tyler Jacks Roger H Johnson Ahyoung Joo Jonathan E Katz Laimonas Kelbauskas Carl Kesselman Michael R King Konstantinos Konstantopoulos Casey M Kraning-Rush Peter Kuhn Kevin Kung Brian Kwee Johnathon N Lakins Guillaume Lambert David Liao Jonathan D Licht Jan T Liphardt Liyu Liu Mark C Lloyd Anna Lyubimova Parag Mallick John Marko Owen J T McCarty Deirdre R Meldrum Franziska Michor Shannon M Mumenthaler Vivek Nandakumar Thomas V O'Halloran Steve Oh Renata Pasqualini Matthew J Paszek Kevin G Philips Christopher S Poultney Kuldeepsinh Rana Cynthia A Reinhart-King Robert Ros Gregg L Semenza Patti Senechal Michael L Shuler Srimeenakshi Srinivasan Jack R Staunton Yolanda Stypula Hariharan Subramanian Thea D Tlsty Garth W Tormoen Yiider Tseng Alexander van Oudenaarden Scott S Verbridge Jenny C Wan Valerie M Weaver Jonathan Widom Christine Will Denis Wirtz Jonathan Wojtkowiak Pei-Hsun Wu

Sci Rep 2013 ;3:1449

Center for Applied Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1038/srep01449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636513PMC
October 2013

Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis.

Mol Cancer Ther 2013 Aug 27;12(8):1591-604. Epub 2013 Mar 27.

Lady Davis Institute for Medical Research, Segal Cancer Center, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-1039DOI Listing
August 2013

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

Mol Cell 2013 Jul 6;51(2):236-48. Epub 2013 Jun 6.

Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775267PMC
July 2013

Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1.

PLoS One 2012 15;7(11):e49801. Epub 2012 Nov 15.

Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049801PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499516PMC
June 2013

Epigenetic therapy of hematological malignancies: where are we now?

Ther Adv Hematol 2013 Apr;4(2):81-91

Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

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http://tah.sagepub.com/content/4/2/81.full.pdf
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http://tah.sagepub.com/lookup/doi/10.1177/2040620712466864
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http://dx.doi.org/10.1177/2040620712466864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629753PMC
April 2013

Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses.

J Biol Chem 2012 Dec 16;287(50):42352-60. Epub 2012 Oct 16.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M112.400721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516778PMC
December 2012

New strategies in acute myeloid leukemia: redefining prognostic markers to guide therapy.

Clin Cancer Res 2012 Oct 14;18(19):5163-71. Epub 2012 Aug 14.

Division of Hematology/Oncology, Northwestern University-Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902112PMC
October 2012

Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.

Blood 2012 Jun 16;119(23):5522-31. Epub 2012 Apr 16.

Stem and Progenitor Cell Biology Program, Maine Medical Center Research Institute, Scarborough, ME, USA.

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http://dx.doi.org/10.1182/blood-2011-11-392571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369686PMC
June 2012

Emerging epigenetic targets and therapies in cancer medicine.

Cancer Discov 2012 May 23;2(5):405-13. Epub 2012 Apr 23.

Division of Hematology/Oncology, Robert. H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-12-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381982PMC
May 2012

miR-27b controls venous specification and tip cell fate.

Blood 2012 Mar 29;119(11):2679-87. Epub 2011 Dec 29.

Urology Department, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1182/blood-2011-07-370635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311282PMC
March 2012

Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation.

Invest Ophthalmol Vis Sci 2011 Aug 29;52(9):6887-97. Epub 2011 Aug 29.

Department of Surgery, Creighton University, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1167/iovs.11-7531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176024PMC
August 2011

DNMT3A mutations in acute myeloid leukemia.

Nat Genet 2011 Mar 29;43(4):289-90. Epub 2011 Mar 29.

Division of Hematology and Oncology, Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/ng0411-289DOI Listing
March 2011

MEK and MAF in myeloma therapy.

Blood 2011 Feb;117(8):2300-2

Northwestern University.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-01-32
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http://dx.doi.org/10.1182/blood-2011-01-327262DOI Listing
February 2011

Partners in crime: Genes within an amplicon collude to globally deregulate chromatin in lymphoma.

Cancer Cell 2010 Dec;18(6):539-41

Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032418PMC
December 2010

HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.

J Clin Invest 2010 May 12;120(5):1535-50. Epub 2010 Apr 12.

Department of Pathology, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI39534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860938PMC
May 2010

Deregulation of H3K27 methylation in cancer.

Nat Genet 2010 Feb;42(2):100-1

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http://dx.doi.org/10.1038/ng0210-100DOI Listing
February 2010

Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration.

Cell Stem Cell 2010 Feb;6(2):117-29

Massachusetts General Hospital, Center of Regenerative Medicine, Harvard University, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.stem.2009.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846417PMC
February 2010

Kidney development in the absence of Gdnf and Spry1 requires Fgf10.

PLoS Genet 2010 Jan 15;6(1):e1000809. Epub 2010 Jan 15.

Department of Genetics and Development, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1371/journal.pgen.1000809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797609PMC
January 2010

The molecular pathology of acute myeloid leukemia.

Hematology Am Soc Hematol Educ Program 2005 :137-42

Mt. Sinai School of Medicine, Division of Hematology/Oncology, One Gustave L. Levy Pl., Box 1079, New York, NY 10029-6504, USA.

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http://dx.doi.org/10.1182/asheducation-2005.1.137DOI Listing
November 2009

PLZF is a regulator of homeostatic and cytokine-induced myeloid development.

Genes Dev 2009 Sep;23(17):2076-87

Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1101/gad.1788109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751973PMC
September 2009

Survivin is not required for the endomitotic cell cycle of megakaryocytes.

Blood 2009 Jul 1;114(1):153-6. Epub 2009 Apr 1.

Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1182/blood-2008-11-190801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710943PMC
July 2009

An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1.

Proc Natl Acad Sci U S A 2009 Jul 22;106(27):11154-9. Epub 2009 Jun 22.

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1073/pnas.0901591106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708714PMC
July 2009

Acute promyelocytic leukemia--weapons of mass differentiation.

Authors:
Jonathan D Licht

N Engl J Med 2009 Feb;360(9):928-30

Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, USA.

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http://dx.doi.org/10.1056/NEJMcibr0810371DOI Listing
February 2009

Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells.

Blood 2008 Aug 16;112(3):644-51. Epub 2008 May 16.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.1182/blood-2008-01-131813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481532PMC
August 2008

WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression.

Mol Cancer Res 2008 Jul;6(7):1225-31

Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-08-0078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587040PMC
July 2008

New molecular concepts and targets in acute myeloid leukemia.

Curr Opin Hematol 2008 Mar;15(2):82-7

Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1097/MOH.0b013e3282f3ded0DOI Listing
March 2008

A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16.

Neoplasia 2008 Jan;10(1):69-78

Division of Hematology/Oncology, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213901PMC
http://dx.doi.org/10.1593/neo.07869DOI Listing
January 2008

Molecular characterization of acute myeloid leukemia and its impact on treatment.

Curr Opin Oncol 2007 Nov;19(6):635-49

Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1097/CCO.0b013e3282f10e55DOI Listing
November 2007

Chromatin modulation by oncogenic transcription factors: new complexity, new therapeutic targets.

Cancer Cell 2007 Jun;11(6):475-8

Division of Hematology/Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.05.005DOI Listing
June 2007

HOX deregulation in acute myeloid leukemia.

J Clin Invest 2007 Apr;117(4):865-8

Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1172/JCI31861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838955PMC
April 2007

Computational identification of Ftz/Ftz-F1 downstream target genes.

Dev Biol 2006 Nov 12;299(1):78-90. Epub 2006 Jul 12.

Department of Biochemistry, Cellular and Developmental Biology, Mount Sinai Medical School, New York, NY 10029, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060600989
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http://dx.doi.org/10.1016/j.ydbio.2006.07.007DOI Listing
November 2006

Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.

Dev Biol 2006 Nov 25;299(2):466-77. Epub 2006 Aug 25.

Division of Hematology/Oncology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.08.051DOI Listing
November 2006

Reconstructing a disease: What essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia?

Authors:
Jonathan D Licht

Cancer Cell 2006 Feb;9(2):73-4

Division of Hematology/Oncology, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.01.024DOI Listing
February 2006

Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling.

Trends Cell Biol 2006 Jan 7;16(1):45-54. Epub 2005 Dec 7.

Mount Sinai School of Medicine, Department of Medicine, Division of Hematology and Oncology, Box 1079, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.tcb.2005.11.004DOI Listing
January 2006

WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak.

Cancer Res 2005 Sep;65(18):8174-82

Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3657DOI Listing
September 2005

Over-expression of Flt3 induces NF-kappaB pathway and increases the expression of IL-6.

Leuk Res 2005 Aug 24;29(8):893-9. Epub 2005 Feb 24.

Department of Clinical Laboratory Medicine, Tohoku University School of Medicine, 1-1 Seiryou-machi, Aobaku, Sendai 980-8574, Japan.

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http://dx.doi.org/10.1016/j.leukres.2005.01.008DOI Listing
August 2005

The theoretical basis of transcriptional therapy of cancer: can it be put into practice?

J Clin Oncol 2005 Jun 2;23(17):3957-70. Epub 2005 May 2.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.1200/JCO.2005.14.498DOI Listing
June 2005

Therapeutic intervention in leukemias that express the activated fms-like tyrosine kinase 3 (FLT3): opportunities and challenges.

Curr Opin Hematol 2005 Jan;12(1):7-13

Division of Hematology/Oncology, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1097/01.moh.0000147891.06584.d7DOI Listing
January 2005

Despite WT1 binding sites in the promoter region of human and mouse nucleoporin glycoprotein 210, WT1 does not influence expression of GP210.

J Negat Results Biomed 2004 Dec 21;3. Epub 2004 Dec 21.

Department of Cell and Molecular Biology, Section for Cell and Developmental Biology, Lund University, Sweden.

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http://dx.doi.org/10.1186/1477-5751-3-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544869PMC
December 2004