Jonathan D Licht

Jonathan D Licht

UNVERIFIED PROFILE

Are you Jonathan D Licht?   Register this Author

Register author
Jonathan D Licht

Jonathan D Licht

Publications by authors named "Jonathan D Licht"

Are you Jonathan D Licht?   Register this Author

100Publications

2439Reads

8Profile Views

FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML.

Authors:
Yue Sheng Chunjie Yu Yin Liu Chao Hu Rui Ma Xinyan Lu Peng Ji Jianjun Chen Benjamin Mizukawa Yong Huang Jonathan D Licht Zhijian Qian

Nat Commun 2020 Feb 17;11(1):928. Epub 2020 Feb 17.

Division of Hematology/Oncology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41467-020-14590-9DOI Listing
February 2020

Twist-1 is upregulated by NSD2 and contributes to tumour dissemination and an epithelial-mesenchymal transition-like gene expression signature in t(4;14)-positive multiple myeloma.

Authors:
Chee Man Cheong Krzysztof M Mrozik Duncan R Hewett Elyse Bell Vasilios Panagopoulos Jacqueline E Noll Jonathan D Licht Stan Gronthos Andrew C W Zannettino Kate Vandyke

Cancer Lett 2020 Jan 31;475:99-108. Epub 2020 Jan 31.

Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia; Precision Medicine Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, Australia. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.canlet.2020.01.040DOI Listing
January 2020

MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma.

Authors:
Yue Jiang Ruli Gao Chunxia Cao Lauren Forbes Jianping Li Shelby Freeberg Kristianna M Fredenburg Jeb M Justice Natalie L Silver Lizi Wu Sushama Varma Robert West Jonathan D Licht Maria Zajac-Kaye Alex Kentsis Frederic J Kaye

Oral Oncol 2019 Nov 10;98:147-155. Epub 2019 Oct 10.

Department Medicine, University of Florida, Gainesville, FL 32608, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.oraloncology.2019.09.005DOI Listing
November 2019

Decitabine limits escape from MEK inhibition in uveal melanoma.

Authors:
Jessica Gonçalves Michael F Emmons Fernanda Faião-Flores Andrew E Aplin J William Harbour Jonathan D Licht Márcia R Wink Keiran S M Smalley

Pigment Cell Melanoma Res 2019 Nov 23. Epub 2019 Nov 23.

The Department of Tumor Biology, Moffitt Cancer Center, Tampa, FL, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1111/pcmr.12849DOI Listing
November 2019

A Mutation in Histone H2B Represents a New Class of Oncogenic Driver.

Authors:
Richard L Bennett Aditya Bele Eliza C Small Christine M Will Behnam Nabet Jon A Oyer Xiaoxiao Huang Rajarshi P Ghosh Adrian T Grzybowski Tao Yu Qiao Zhang Alberto Riva Tanmay P Lele George C Schatz Neil L Kelleher Alexander J Ruthenburg Jan Liphardt Jonathan D Licht

Cancer Discov 2019 Oct 23;9(10):1438-1451. Epub 2019 Jul 23.

Division of Hematology/Oncology, University of Florida Health Cancer Center, Gainesville, Florida.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/2159-8290.CD-19-0393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774836PMC
October 2019

HDAC Inhibition Enhances the Efficacy of MEK Inhibitor Therapy in Uveal Melanoma.

Authors:
Fernanda Faião-Flores Michael F Emmons Michael A Durante Fumi Kinose Biswarup Saha Bin Fang John M Koomen Srikumar P Chellappan Silvya Stuchi Maria-Engler Uwe Rix Jonathan D Licht J William Harbour Keiran S M Smalley

Clin Cancer Res 2019 Sep 21;25(18):5686-5701. Epub 2019 Jun 21.

The Department of Tumor Biology, The Moffitt Cancer Center & Research Institute, Tampa, Florida.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1078-0432.CCR-18-3382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744978PMC
September 2019

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.

Authors:
Xiaoxiao Huang Richard D LeDuc Luca Fornelli Alissa J Schunter Richard L Bennett Neil L Kelleher Jonathan D Licht

J Biol Chem 2019 Aug 27;294(33):12459-12471. Epub 2019 Jun 27.

Division of Hematology/Oncology, University of Florida Health Cancer Center, Gainesville, Florida 32608

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.RA118.006159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699848PMC
August 2019

Sprouty1 Controls Genitourinary Development via its N-Terminal Tyrosine.

Authors:
Marta Vaquero Sara Cuesta Carlos Anerillas Gisela Altés Joan Ribera M Albert Basson Jonathan D Licht Joaquim Egea Mario Encinas

J Am Soc Nephrol 2019 Aug 12;30(8):1398-1411. Epub 2019 Jul 12.

Departments of Experimental Medicine and

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1681/ASN.2018111085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683709PMC
August 2019

HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy.

Authors:
Michael F Emmons Fernanda Faião-Flores Ritin Sharma Ram Thapa Jane L Messina Jurgen C Becker Dirk Schadendorf Edward Seto Vernon K Sondak John M Koomen Yian A Chen Eric K Lau Lixin Wan Jonathan D Licht Keiran S M Smalley

Cancer Res 2019 06 15;79(11):2947-2961. Epub 2019 Apr 15.

The Department of Tumor Biology, The Moffitt Cancer Center and Research Institute, Tampa, Florida.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-19-0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548652PMC
June 2019

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia.

Authors:
Alok Swaroop Jon A Oyer Christine M Will Xiaoxiao Huang Wenbo Yu Catalina Troche Marinka Bulic Benjamin H Durham Qiang Jeremy Wen John D Crispino Alexander D MacKerell Richard L Bennett Neil L Kelleher Jonathan D Licht

Oncogene 2019 01 31;38(5):671-686. Epub 2018 Aug 31.

Division of Hematology/Oncology, University of Florida Health Cancer Center, Gainesville, FL, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41388-018-0474-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358490PMC
January 2019

Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury.

Authors:
Tarja Alakoski Johanna Ulvila Raisa Yrjölä Laura Vainio Johanna Magga Zoltan Szabo Jonathan D Licht Risto Kerkelä

Basic Res Cardiol 2019 01 11;114(2). Epub 2019 Jan 11.

Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, P. O. BOX 5000, 90014, Oulu, Finland.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/s00395-018-0713-y
Publisher Site
http://dx.doi.org/10.1007/s00395-018-0713-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329741PMC
January 2019

DISORDERED HISTONE METHYLATION IN HEMATOLOGICAL MALIGNANCIES THE CASE OF UTX/KDM6A.

Authors:
Jonathan D Licht

Trans Am Clin Climatol Assoc 2018 ;129:24-36

GAINESVILLE, FLORIDA.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116604PMC
December 2018

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator.

Authors:
Jung Kim Yongik Lee Xiaodong Lu Bing Song Ka-Wing Fong Qi Cao Jonathan D Licht Jonathan C Zhao Jindan Yu

Cell Rep 2018 12;25(10):2808-2820.e4

Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247183179
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2018.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342284PMC
December 2018

Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity.

Authors:
Mohammad Alzrigat Helena Jernberg-Wiklund Jonathan D Licht

Epigenomes 2018 Sep 3;2(3). Epub 2018 Sep 3.

Division of Hematology and Oncology, Department of Medicine, University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610, USA;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3390/epigenomes2030016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370027PMC
September 2018

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.

Authors:
Johanna Melo-Cardenas Yuanming Xu Juncheng Wei Can Tan Sinyi Kong Beixue Gao Elena Montauti Gina Kirsammer Jonathan D Licht Jindan Yu Peng Ji John D Crispino Deyu Fang

Blood 2018 07 29;132(4):423-434. Epub 2018 May 29.

Department of Pathology.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/blood-2017-10-811760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071563PMC
July 2018

Loss of Spry1 attenuates vascular smooth muscle proliferation by impairing mitogen-mediated changes in cell cycle regulatory circuits.

Authors:
Xuehui Yang Yan Gong Qing He Jonathan D Licht Lucy Liaw Robert E Friesel

J Cell Biochem 2018 04 26;119(4):3267-3279. Epub 2017 Dec 26.

Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/jcb.26486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826877PMC
April 2018

A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer.

Authors:
Damiano Fantini Alexander P Glaser Kalen J Rimar Yiduo Wang Matthew Schipma Nobish Varghese Alfred Rademaker Amir Behdad Aparna Yellapa Yanni Yu Christie Ching-Lin Sze Lu Wang Zibo Zhao Susan E Crawford Deqing Hu Jonathan D Licht Clayton K Collings Elizabeth Bartom Dan Theodorescu Ali Shilatifard Joshua J Meeks

Oncogene 2018 04 25;37(14):1911-1925. Epub 2018 Jan 25.

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

View Article

Download full-text PDF

 Source
http://www.nature.com/articles/s41388-017-0099-6
Publisher Site
http://dx.doi.org/10.1038/s41388-017-0099-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886988PMC
April 2018

The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells.

Authors:
Vincent J Tocco Yuan Li Keith G Christopher James H Matthews Varun Aggarwal Lauren Paschall Hendrik Luesch Jonathan D Licht Richard B Dickinson Tanmay P Lele

J Cell Physiol 2018 Feb 31;233(2):1446-1454. Epub 2017 Jul 31.

Department of Chemical Engineering, University of Florida, Gainesville, Florida.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/jcp.26031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673577PMC
February 2018

Targeting Epigenetics in Cancer.

Authors:
Richard L Bennett Jonathan D Licht

Annu Rev Pharmacol Toxicol 2018 01 6;58:187-207. Epub 2017 Oct 6.

Division of Hematology & Oncology, Department of Medicine, University of Florida Health Cancer Center, University of Florida, Gainesville, Florida 32606, USA; email:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1146/annurev-pharmtox-010716-105106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800772PMC
January 2018

SETD2: a complex role in blood malignancy.

Authors:
Jonathan D Licht

Blood 2017 12;130(24):2576-2578

UNIVERSITY OF FLORIDA HEALTH CANCER CENTER.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/blood-2017-10-811927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731090PMC
December 2017

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.

Authors:
Teresa Ezponda Daphné Dupéré-Richer Christine M Will Eliza C Small Nobish Varghese Tej Patel Behnam Nabet Relja Popovic Jon Oyer Marinka Bulic Yupeng Zheng Xiaoxiao Huang Mrinal Y Shah Sayantan Maji Alberto Riva Manuela Occhionorelli Giovanni Tonon Neil Kelleher Jonathan Keats Jonathan D Licht

Cell Rep 2017 Oct;21(3):628-640

Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Division of Hematology/Oncology, University of Florida Health Cancer Center, Gainesville, FL 2033, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.celrep.2017.09.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706555PMC
October 2017

Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis.

Authors:
Kelly M Arcipowski Marinka Bulic Sandeep Gurbuxani Jonathan D Licht

PLoS One 2016 9;11(9):e0162515. Epub 2016 Sep 9.

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162515PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017600PMC
August 2017

Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma.

Authors:
Daphné Dupéré-Richer Jonathan D Licht

Curr Opin Hematol 2017 Jul;24(4):336-344

Department of Medicine, Division of Hematology-Oncology and The University of Florida Health Cancer Center University of Florida, Gainesville, Florida, USA.

View Article

Download full-text PDF

 Source
http://Insights.ovid.com/crossref?an=00062752-201707000-0000
Publisher Site
http://dx.doi.org/10.1097/MOH.0000000000000358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767522PMC
July 2017

The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.

Authors:
Richard L Bennett Alok Swaroop Catalina Troche Jonathan D Licht

Cold Spring Harb Perspect Med 2017 Jun 1;7(6). Epub 2017 Jun 1.

Departments of Medicine, Biochemistry and Molecular Biology and University of Florida Health Cancer Center, The University of Florida, Gainesville, Florida 32610.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1101/cshperspect.a026708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453381PMC
June 2017

Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells.

Authors:
Suzanne M Schauwecker J Julie Kim Jonathan D Licht Charles V Clevenger

J Biol Chem 2017 02 29;292(6):2237-2254. Epub 2016 Dec 29.

the Department of Pathology, Virginia Commonwealth University, Richmond, Virginia 23298

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.M116.764233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313097PMC
February 2017

Sabotaging of the oxidative stress response by an oncogenic noncoding RNA.

Authors:
Nitin Mahajan Hua-Jun Wu Richard L Bennett Catalina Troche Jonathan D Licht Jason D Weber Leonard B Maggi Michael H Tomasson

FASEB J 2017 02 24;31(2):482-490. Epub 2016 Oct 24.

Division of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, USA;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1096/fj.201600654RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240659PMC
February 2017

FQI1: a transcription-methylation switch for cancer.

Authors:
Olga A Guryanova Jonathan D Licht

Oncotarget 2017 02;8(8):12536-12537

Department of Medicine, Division of Hematology and Oncology, University of Florida College of Medicine, Gainesville, Florida, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.15087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355025PMC
February 2017

Increased protein processing gene signature in HDACi-resistant cells predicts response to proteasome inhibitors.

Authors:
Daphné Dupéré-Richer Mena Kinal Filippa Pettersson Audrey Emond M Nieves Calvo-Vidal Jessica N Nichol Cynthia Guilbert Dany Plourde Kathleen Klein Oros Torsten H Nielsen Teresa Ezponda Jonathan D Licht Nathalie A Johnson Sarit Assouline Leandro Cerchietti Wilson H Miller Koren K Mann

Leuk Lymphoma 2017 01 17;58(1):218-221. Epub 2016 May 17.

a Segal Cancer Center, Lady Davis Institute for Medical Research , McGill University , Montréal , QC , Canada.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1080/10428194.2016.1180684DOI Listing
January 2017

Strong expression of EZH2 and accumulation of trimethylated H3K27 in diffuse large B-cell lymphoma independent of cell of origin and EZH2 codon 641 mutation.

Authors:
Zheng Zhou Juehua Gao Relja Popovic Kristy Wolniak Vamsi Parimi Jane N Winter Jonathan D Licht Yi-Hua Chen

Leuk Lymphoma 2015 8;56(10):2895-901. Epub 2015 Mar 8.

b Department of Pathology , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3109/10428194.2015.1006220DOI Listing
September 2016

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.

Authors:
Wendy Béguelin Matt Teater Micah D Gearhart María Teresa Calvo Fernández Rebecca L Goldstein Mariano G Cárdenas Katerina Hatzi Monica Rosen Hao Shen Connie M Corcoran Michelle Y Hamline Randy D Gascoyne Ross L Levine Omar Abdel-Wahab Jonathan D Licht Rita Shaknovich Olivier Elemento Vivian J Bardwell Ari M Melnick

Cancer Cell 2016 08;30(2):197-213

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, Cornell University, 413 E 69(th) Street, New York, NY 10021, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ccell.2016.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000552PMC
August 2016

Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.

Authors:
Yupeng Zheng Luca Fornelli Philip D Compton Seema Sharma Jesse Canterbury Christopher Mullen Vlad Zabrouskov Ryan T Fellers Paul M Thomas Jonathan D Licht Michael W Senko Neil L Kelleher

Mol Cell Proteomics 2016 Mar 13;15(3):776-90. Epub 2015 Aug 13.

From the ‡Departments of Chemistry and Molecular Biosciences, and the Proteomics Center of Excellence, Northwestern University, 2145 N. Sheridan Road, Evanston, Illinois 60208;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/mcp.M115.053819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813700PMC
March 2016

Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases.

Authors:
Melanie J McConnell Laetitia Durand Emma Langley Lise Coste-Sarguet Arthur Zelent Christine Chomienne Tony Kouzarides Jonathan D Licht Fabien Guidez

Epigenetics Chromatin 2015 24;8:38. Epub 2015 Sep 24.

INSERM UMRS-1131, Institut universitaire d'Hématologie, Université Paris Diderot, 1 avenue Claude Vellefaux, hôpital Saint-Louis, 75010 Paris, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s13072-015-0030-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581162PMC
September 2015

Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape.

Authors:
Behnam Nabet Pilib Ó Broin Jaime M Reyes Kevin Shieh Charles Y Lin Christine M Will Relja Popovic Teresa Ezponda James E Bradner Aaron A Golden Jonathan D Licht

Cell Rep 2015 Aug 13;12(8):1300-13. Epub 2015 Aug 13.

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://www.cell.com/cell-reports/pdf/S2211-1247(15)00822-0.p
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S221112471500822
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2015.06.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551578PMC
August 2015

DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.

Authors:
Jonathan D Licht

Cell 2015 Aug;162(5):938-9

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, 303 East Superior Street, Lurie 5-123, Chicago, IL 60611, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.cell.2015.08.005DOI Listing
August 2015

GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1.

Authors:
Krishan Kumar Sania S Raza Lawrence M Knab Christina R Chow Benjamin Kwok David J Bentrem Relja Popovic Kazumi Ebine Jonathan D Licht Hidayatullah G Munshi

Sci Rep 2015 Mar 25;5:9489. Epub 2015 Mar 25.

1] Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 E. Superior Ave, Chicago, IL 60611 [2] Jesse Brown VA Medical Center, 820 S. Damen Ave, Chicago, IL 60612 [3] The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, 303 E. Superior Ave, Chicago, IL 60611.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep09489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452877PMC
March 2015

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.

Authors:
Raajit Rampal Altuna Alkalin Jozef Madzo Aparna Vasanthakumar Elodie Pronier Jay Patel Yushan Li Jihae Ahn Omar Abdel-Wahab Alan Shih Chao Lu Patrick S Ward Jennifer J Tsai Todd Hricik Valeria Tosello Jacob E Tallman Xinyang Zhao Danette Daniels Qing Dai Luisa Ciminio Iannis Aifantis Chuan He Francois Fuks Martin S Tallman Adolfo Ferrando Stephen Nimer Elisabeth Paietta Craig B Thompson Jonathan D Licht Christopher E Mason Lucy A Godley Ari Melnick Maria E Figueroa Ross L Levine

Cell Rep 2014 Dec 4;9(5):1841-1855. Epub 2014 Dec 4.

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.celrep.2014.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267494PMC
December 2014

Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination.

Authors:
Teresa Ezponda Jonathan D Licht

Clin Cancer Res 2014 Oct 1;20(19):5001-8. Epub 2014 Jul 1.

Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article

Download full-text PDF

 Source
http://clincancerres.aacrjournals.org/content/early/2014/09/
Web Search
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-13-2499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184969PMC
October 2014

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation.

Authors:
Relja Popovic Eva Martinez-Garcia Eugenia G Giannopoulou Quanwei Zhang Qingyang Zhang Teresa Ezponda Mrinal Y Shah Yupeng Zheng Christine M Will Eliza C Small Youjia Hua Marinka Bulic Yanwen Jiang Matteo Carrara Raffaele A Calogero William L Kath Neil L Kelleher Ji-Ping Wang Olivier Elemento Jonathan D Licht

PLoS Genet 2014 Sep 4;10(9):e1004566. Epub 2014 Sep 4.

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1371/journal.pgen.1004566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154646PMC
September 2014

Promyelocytic leukemia zinc finger-retinoic acid receptor α (PLZF-RARα), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes.

Authors:
Won-Il Choi Jae-Hyeon Yoon Min-Young Kim Dong-In Koh Jonathan D Licht Kunhong Kim Man-Wook Hur

J Biol Chem 2014 Jul 12;289(27):18641-56. Epub 2014 May 12.

From the Department of Biochemistry and Molecular Biology, Brain Korea 21 Plus Project for Medical Science, Severance Biomedical Science Institute, Yonsei University School of Medicine, 50 Yonsei-Ro, SeoDaeMoon-Gu, Seoul 120-752, Korea and

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.M113.538777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081909PMC
July 2014

Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity.

Authors:
Eliza C Small Liqun Xi Ji-Ping Wang Jonathan Widom Jonathan D Licht

Proc Natl Acad Sci U S A 2014 Jun 2;111(24):E2462-71. Epub 2014 Jun 2.

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1073/pnas.1400517111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066511PMC
June 2014

From anecdote to targeted therapy: the curious case of thalidomide in multiple myeloma.

Authors:
Jonathan D Licht Jake Shortt Ricky Johnstone

Cancer Cell 2014 Jan;25(1):9-11

Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ccr.2013.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984916PMC
January 2014

Ponatinib--a step forward in overcoming resistance in chronic myeloid leukemia.

Authors:
Olga Frankfurt Jonathan D Licht

Clin Cancer Res 2013 Nov 9;19(21):5828-34. Epub 2013 Aug 9.

Authors' Affiliation: Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1078-0432.CCR-13-0258DOI Listing
November 2013

Spry1 and Spry2 are necessary for eyelid closure.

Authors:
Murali R Kuracha Ed Siefker Jonathan D Licht Venkatesh Govindarajan

Dev Biol 2013 Nov 17;383(2):227-38. Epub 2013 Sep 17.

Department of Surgery, 253 Criss III, Cancer Center, 2500 California Plaza, Creighton University, Omaha, NE 68178, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ydbio.2013.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857020PMC
November 2013

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Authors:
David B Agus Jenolyn F Alexander Wadih Arap Shashanka Ashili Joseph E Aslan Robert H Austin Vadim Backman Kelly J Bethel Richard Bonneau Wei-Chiang Chen Chira Chen-Tanyolac Nathan C Choi Steven A Curley Matthew Dallas Dhwanil Damania Paul C W Davies Paolo Decuzzi Laura Dickinson Luis Estevez-Salmeron Veronica Estrella Mauro Ferrari Claudia Fischbach Jasmine Foo Stephanie I Fraley Christian Frantz Alexander Fuhrmann Philippe Gascard Robert A Gatenby Yue Geng Sharon Gerecht Robert J Gillies Biana Godin William M Grady Alex Greenfield Courtney Hemphill Barbara L Hempstead Abigail Hielscher W Daniel Hillis Eric C Holland Arig Ibrahim-Hashim Tyler Jacks Roger H Johnson Ahyoung Joo Jonathan E Katz Laimonas Kelbauskas Carl Kesselman Michael R King Konstantinos Konstantopoulos Casey M Kraning-Rush Peter Kuhn Kevin Kung Brian Kwee Johnathon N Lakins Guillaume Lambert David Liao Jonathan D Licht Jan T Liphardt Liyu Liu Mark C Lloyd Anna Lyubimova Parag Mallick John Marko Owen J T McCarty Deirdre R Meldrum Franziska Michor Shannon M Mumenthaler Vivek Nandakumar Thomas V O'Halloran Steve Oh Renata Pasqualini Matthew J Paszek Kevin G Philips Christopher S Poultney Kuldeepsinh Rana Cynthia A Reinhart-King Robert Ros Gregg L Semenza Patti Senechal Michael L Shuler Srimeenakshi Srinivasan Jack R Staunton Yolanda Stypula Hariharan Subramanian Thea D Tlsty Garth W Tormoen Yiider Tseng Alexander van Oudenaarden Scott S Verbridge Jenny C Wan Valerie M Weaver Jonathan Widom Christine Will Denis Wirtz Jonathan Wojtkowiak Pei-Hsun Wu

Sci Rep 2013 ;3:1449

Center for Applied Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep01449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636513PMC
October 2013

Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis.

Authors:
Luca A Petruccelli Filippa Pettersson Sonia V Del Rincón Cynthia Guilbert Jonathan D Licht Wilson H Miller

Mol Cancer Ther 2013 Aug 27;12(8):1591-604. Epub 2013 Mar 27.

Lady Davis Institute for Medical Research, Segal Cancer Center, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1535-7163.MCT-12-1039DOI Listing
August 2013

Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors.

Authors:
Swarna Mehrotra Bhumika Sharma Sonali Joshi Barbara Kroczynska Beata Majchrzak Brady L Stein Brandon McMahon Jessica K Altman Jonathan D Licht Darren P Baker Elizabeth A Eklund Amittha Wickrema Amit Verma Eleanor N Fish Leonidas C Platanias

J Biol Chem 2013 Aug 28;288(33):23814-22. Epub 2013 Jun 28.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.M113.476192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745328PMC
August 2013

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

Authors:
Lucas B Sullivan Eva Martinez-Garcia Hien Nguyen Andrew R Mullen Eric Dufour Sunil Sudarshan Jonathan D Licht Ralph J Deberardinis Navdeep S Chandel

Mol Cell 2013 Jul 6;51(2):236-48. Epub 2013 Jun 6.

Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molcel.2013.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775267PMC
July 2013

Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1.

Authors:
Sam Collins Adam Waickman Albert Basson Abraham Kupfer Jonathan D Licht Maureen R Horton Jonathan D Powell

PLoS One 2012 15;7(11):e49801. Epub 2012 Nov 15.

Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049801PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499516PMC
June 2013

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.

Authors:
Wendy Béguelin Relja Popovic Matt Teater Yanwen Jiang Karen L Bunting Monica Rosen Hao Shen Shao Ning Yang Ling Wang Teresa Ezponda Eva Martinez-Garcia Haikuo Zhang Yupeng Zheng Sharad K Verma Michael T McCabe Heidi M Ott Glenn S Van Aller Ryan G Kruger Yan Liu Charles F McHugh David W Scott Young Rock Chung Neil Kelleher Rita Shaknovich Caretha L Creasy Randy D Gascoyne Kwok-Kin Wong Leandro Cerchietti Ross L Levine Omar Abdel-Wahab Jonathan D Licht Olivier Elemento Ari M Melnick

Cancer Cell 2013 May;23(5):677-92

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ccr.2013.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681809PMC
May 2013

Epigenetic therapy of hematological malignancies: where are we now?

Authors:
Relja Popovic Mrinal Y Shah Jonathan D Licht

Ther Adv Hematol 2013 Apr;4(2):81-91

Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

View Article

Download full-text PDF

 Source
http://tah.sagepub.com/content/4/2/81.full.pdf
Web Search
http://tah.sagepub.com/lookup/doi/10.1177/2040620712466864
Publisher Site
http://dx.doi.org/10.1177/2040620712466864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629753PMC
April 2013

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

Authors:
Laura A Sena Sha Li Amit Jairaman Murali Prakriya Teresa Ezponda David A Hildeman Chyung-Ru Wang Paul T Schumacker Jonathan D Licht Harris Perlman Paul J Bryce Navdeep S Chandel

Immunity 2013 Feb 15;38(2):225-36. Epub 2013 Feb 15.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.immuni.2012.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582741PMC
February 2013

Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses.

Authors:
Bhumika Sharma Sonali Joshi Antonella Sassano Beata Majchrzak Surinder Kaur Priya Aggarwal Behnam Nabet Marinka Bulic Brady L Stein Brandon McMahon Darren P Baker Rikiro Fukunaga Jessica K Altman Jonathan D Licht Eleanor N Fish Leonidas C Platanias

J Biol Chem 2012 Dec 16;287(50):42352-60. Epub 2012 Oct 16.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.M112.400721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516778PMC
December 2012

New strategies in acute myeloid leukemia: redefining prognostic markers to guide therapy.

Authors:
Irum Khan Jessica K Altman Jonathan D Licht

Clin Cancer Res 2012 Oct 14;18(19):5163-71. Epub 2012 Aug 14.

Division of Hematology/Oncology, Northwestern University-Feinberg School of Medicine, Chicago, IL, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1078-0432.CCR-12-0313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902112PMC
October 2012

Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3.

Authors:
Yupeng Zheng Steve M M Sweet Relja Popovic Eva Martinez-Garcia Jeremiah D Tipton Paul M Thomas Jonathan D Licht Neil L Kelleher

Proc Natl Acad Sci U S A 2012 Aug 6;109(34):13549-54. Epub 2012 Aug 6.

Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1073/pnas.1205707109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427122PMC
August 2012

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.

Authors:
Alex Kentsis Casie Reed Kim L Rice Takaomi Sanda Scott J Rodig Eleni Tholouli Amanda Christie Peter J M Valk Ruud Delwel Vu Ngo Jeffery L Kutok Suzanne E Dahlberg Lisa A Moreau Richard J Byers James G Christensen George Vande Woude Jonathan D Licht Andrew L Kung Louis M Staudt A Thomas Look

Nat Med 2012 Jul;18(7):1118-22

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/nm.2819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438345PMC
July 2012

Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.

Authors:
Pradeep Sathyanarayana Arvind Dev Anamika Pradeep Melanie Ufkin Jonathan D Licht Don M Wojchowski

Blood 2012 Jun 16;119(23):5522-31. Epub 2012 Apr 16.

Stem and Progenitor Cell Biology Program, Maine Medical Center Research Institute, Scarborough, ME, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/blood-2011-11-392571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369686PMC
June 2012

Emerging epigenetic targets and therapies in cancer medicine.

Authors:
Relja Popovic Jonathan D Licht

Cancer Discov 2012 May 23;2(5):405-13. Epub 2012 Apr 23.

Division of Hematology/Oncology, Robert. H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.

View Article

Download full-text PDF

 Source
http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
Publisher Site
http://dx.doi.org/10.1158/2159-8290.CD-12-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381982PMC
May 2012

G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation.

Authors:
Tracy Anh Hwangpo J Dedrick Jordan Prem K Premsrirut Gomathi Jayamaran Jonathan D Licht Ravi Iyengar Susana R Neves

J Biol Chem 2012 Apr 1;287(17):13674-85. Epub 2012 Mar 1.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.M111.320705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340172PMC
April 2012

miR-27b controls venous specification and tip cell fate.

Authors:
Dauren Biyashev Dorina Veliceasa Jacek Topczewski Jolanta M Topczewska Igor Mizgirev Elena Vinokour Alagarsamy L Reddi Jonathan D Licht Sergei Y Revskoy Olga V Volpert

Blood 2012 Mar 29;119(11):2679-87. Epub 2011 Dec 29.

Urology Department, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/blood-2011-07-370635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311282PMC
March 2012

Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation.

Authors:
Murali R Kuracha Daniel Burgess Ed Siefker Jake T Cooper Jonathan D Licht Michael L Robinson Venkatesh Govindarajan

Invest Ophthalmol Vis Sci 2011 Aug 29;52(9):6887-97. Epub 2011 Aug 29.

Department of Surgery, Creighton University, Omaha, Nebraska, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1167/iovs.11-7531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176024PMC
August 2011

DNMT3A mutations in acute myeloid leukemia.

Authors:
Mrinal Y Shah Jonathan D Licht

Nat Genet 2011 Mar 29;43(4):289-90. Epub 2011 Mar 29.

Division of Hematology and Oncology, Northwestern University, Chicago, Illinois, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ng0411-289DOI Listing
March 2011

MEK and MAF in myeloma therapy.

Authors:
Relja Popovic Jonathan D Licht

Blood 2011 Feb;117(8):2300-2

Northwestern University.

View Article

Download full-text PDF

 Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-01-32
Publisher Site
http://dx.doi.org/10.1182/blood-2011-01-327262DOI Listing
February 2011

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

Authors:
Eva Martinez-Garcia Relja Popovic Dong-Joon Min Steve M M Sweet Paul M Thomas Leonid Zamdborg Aaron Heffner Christine Will Laurence Lamy Louis M Staudt David L Levens Neil L Kelleher Jonathan D Licht

Blood 2011 Jan 25;117(1):211-20. Epub 2010 Oct 25.

Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

View Article

Download full-text PDF

 Source
http://www.bloodjournal.org/content/117/1/211.full.pdf
Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-07-29
Publisher Site
http://dx.doi.org/10.1182/blood-2010-07-298349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037745PMC
January 2011

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

Authors:
Maria E Figueroa Omar Abdel-Wahab Chao Lu Patrick S Ward Jay Patel Alan Shih Yushan Li Neha Bhagwat Aparna Vasanthakumar Hugo F Fernandez Martin S Tallman Zhuoxin Sun Kristy Wolniak Justine K Peeters Wei Liu Sung E Choe Valeria R Fantin Elisabeth Paietta Bob Löwenberg Jonathan D Licht Lucy A Godley Ruud Delwel Peter J M Valk Craig B Thompson Ross L Levine Ari Melnick

Cancer Cell 2010 Dec 9;18(6):553-67. Epub 2010 Dec 9.

Weill Cornell Medical College, New York, NY 10065, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ccr.2010.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105845PMC
December 2010

Partners in crime: Genes within an amplicon collude to globally deregulate chromatin in lymphoma.

Authors:
Dong-Joon Min Jonathan D Licht

Cancer Cell 2010 Dec;18(6):539-41

Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ccr.2010.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032418PMC
December 2010

Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.

Authors:
Simge Akbulut Alagarsamy L Reddi Priya Aggarwal Charuta Ambardekar Barbara Canciani Marianne K H Kim Laura Hix Tomas Vilimas Jacqueline Mason M Albert Basson Matthew Lovatt Jonathan Powell Samuel Collins Steven Quatela Mark Phillips Jonathan D Licht

Mol Biol Cell 2010 Oct 18;21(19):3487-96. Epub 2010 Aug 18.

Division of Hematology and Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1091/mbc.E10-02-0123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947483PMC
October 2010

Transcriptional profiling of polycythemia vera identifies gene expression patterns both dependent and independent from the action of JAK2V617F.

Authors:
Windy Berkofsky-Fessler Monica Buzzai Marianne K-H Kim Steven Fruchtman Vesna Najfeld Dong-Joon Min Fabricio F Costa Jared M Bischof Marcelo B Soares Melanie Jane McConnell Weijia Zhang Ross Levine D Gary Gilliland Raffaele Calogero Jonathan D Licht

Clin Cancer Res 2010 Sep 2;16(17):4339-52. Epub 2010 Jul 2.

Translational Research Sciences, Hoffmann-La Roche, Inc., Nutley, NJ, USA.

View Article

Download full-text PDF

 Source
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-10-1092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947624PMC
September 2010

HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.

Authors:
Penney M Gilbert Janna K Mouw Meredith A Unger Johnathon N Lakins Mawuse K Gbegnon Virginia B Clemmer Miriam Benezra Jonathan D Licht Nancy J Boudreau Kelvin K C Tsai Alana L Welm Michael D Feldman Barbara L Weber Valerie M Weaver

J Clin Invest 2010 May 12;120(5):1535-50. Epub 2010 Apr 12.

Department of Pathology, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1172/JCI39534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860938PMC
May 2010

Deregulation of H3K27 methylation in cancer.

Authors:
Eva Martinez-Garcia Jonathan D Licht

Nat Genet 2010 Feb;42(2):100-1

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ng0210-100DOI Listing
February 2010

Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration.

Authors:
Kelly L Shea Wanyi Xiang Vincent S LaPorta Jonathan D Licht Charles Keller M Albert Basson Andrew S Brack

Cell Stem Cell 2010 Feb;6(2):117-29

Massachusetts General Hospital, Center of Regenerative Medicine, Harvard University, Boston, MA 02114, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.stem.2009.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846417PMC
February 2010

Kidney development in the absence of Gdnf and Spry1 requires Fgf10.

Authors:
Odyssé Michos Cristina Cebrian Deborah Hyink Uta Grieshammer Linda Williams Vivette D'Agati Jonathan D Licht Gail R Martin Frank Costantini

PLoS Genet 2010 Jan 15;6(1):e1000809. Epub 2010 Jan 15.

Department of Genetics and Development, Columbia University, New York, New York, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1371/journal.pgen.1000809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797609PMC
January 2010

Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.

Authors:
Kim L Rice Itsaso Hormaeche Sergei Doulatov Jared M Flatow David Grimwade Ken I Mills Magdalena Leiva Julien Ablain Charuta Ambardekar Melanie J McConnell John E Dick Jonathan D Licht

Blood 2009 Dec 23;114(27):5499-511. Epub 2009 Oct 23.

Division of Hematology/Oncology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA.

View Article

Download full-text PDF

 Source
http://www.bloodjournal.org/content/114/27/5499.full.pdf
Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-03-20
Publisher Site
http://dx.doi.org/10.1182/blood-2009-03-206524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798864PMC
December 2009

The molecular pathology of acute myeloid leukemia.

Authors:
Jonathan D Licht David W Sternberg

Hematology Am Soc Hematol Educ Program 2005 :137-42

Mt. Sinai School of Medicine, Division of Hematology/Oncology, One Gustave L. Levy Pl., Box 1079, New York, NY 10029-6504, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/asheducation-2005.1.137DOI Listing
November 2009

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation.

Authors:
Maria E Figueroa Lucy Skrabanek Yushan Li Anchalee Jiemjit Tamer E Fandy Elisabeth Paietta Hugo Fernandez Martin S Tallman John M Greally Hetty Carraway Jonathan D Licht Steven D Gore Ari Melnick

Blood 2009 Oct 3;114(16):3448-58. Epub 2009 Aug 3.

Department of Medicine (Hematology Oncology Division), Weill Cornell Medical College, New York, NY 10065, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/blood-2009-01-200519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765680PMC
October 2009

PLZF is a regulator of homeostatic and cytokine-induced myeloid development.

Authors:
Sergei Doulatov Faiyaz Notta Kim L Rice Louise Howell Arthur Zelent Jonathan D Licht John E Dick

Genes Dev 2009 Sep;23(17):2076-87

Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario M5G 1L7, Canada.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1101/gad.1788109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751973PMC
September 2009

Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis.

Authors:
Xuan Chi Odyssé Michos Reena Shakya Paul Riccio Hideki Enomoto Jonathan D Licht Naoya Asai Masahide Takahashi Nobutaka Ohgami Masashi Kato Cathy Mendelsohn Frank Costantini

Dev Cell 2009 Aug;17(2):199-209

Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.devcel.2009.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762206PMC
August 2009

Survivin is not required for the endomitotic cell cycle of megakaryocytes.

Authors:
Qiang Wen Cindy Leung Zan Huang Sara Small Alagarsamy Lakku Reddi Jonathan D Licht John D Crispino

Blood 2009 Jul 1;114(1):153-6. Epub 2009 Apr 1.

Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/blood-2008-11-190801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710943PMC
July 2009

An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1.

Authors:
Marianne K-H Kim Thomas J McGarry Pilib O Broin Jared M Flatow Aaron A-J Golden Jonathan D Licht

Proc Natl Acad Sci U S A 2009 Jul 22;106(27):11154-9. Epub 2009 Jun 22.

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1073/pnas.0901591106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708714PMC
July 2009

Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.

Authors:
Dakang Xu Michelle Holko Anthony J Sadler Bernadette Scott Shigeki Higashiyama Windy Berkofsky-Fessler Melanie J McConnell Pier Paolo Pandolfi Jonathan D Licht Bryan R G Williams

Immunity 2009 Jun 11;30(6):802-16. Epub 2009 Jun 11.

Monash Institute of Medical Research, Monash University, Melbourne, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.immuni.2009.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711215PMC
June 2009

Acute promyelocytic leukemia--weapons of mass differentiation.

Authors:
Jonathan D Licht

N Engl J Med 2009 Feb;360(9):928-30

Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1056/NEJMcibr0810371DOI Listing
February 2009

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.

Authors:
Thomas Thum Carina Gross Jan Fiedler Thomas Fischer Stephan Kissler Markus Bussen Paolo Galuppo Steffen Just Wolfgang Rottbauer Stefan Frantz Mirco Castoldi Jürgen Soutschek Victor Koteliansky Andreas Rosenwald M Albert Basson Jonathan D Licht John T R Pena Sara H Rouhanifard Martina U Muckenthaler Thomas Tuschl Gail R Martin Johann Bauersachs Stefan Engelhardt

Nature 2008 Dec 30;456(7224):980-4. Epub 2008 Nov 30.

Department of Medicine I, Interdisziplinäres Zentrum für Klinische Forschung (IZKF), University of Wuerzburg, 97080 Wuerzburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/nature07511DOI Listing
December 2008

Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells.

Authors:
Jose M Polo Weimin Ci Jonathan D Licht Ari Melnick

Blood 2008 Aug 16;112(3):644-51. Epub 2008 May 16.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/blood-2008-01-131813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481532PMC
August 2008

WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression.

Authors:
Debra J Morrison Marianne K H Kim Windy Berkofsky-Fessler Jonathan D Licht

Mol Cancer Res 2008 Jul;6(7):1225-31

Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1541-7786.MCR-08-0078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587040PMC
July 2008

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor.

Authors:
Jotin Marango Manabu Shimoyama Hitomi Nishio Julia A Meyer Dong-Joon Min Andres Sirulnik Yolanda Martinez-Martinez Marta Chesi P Leif Bergsagel Ming-Ming Zhou Samuel Waxman Boris A Leibovitch Martin J Walsh Jonathan D Licht

Blood 2008 Mar 21;111(6):3145-54. Epub 2007 Dec 21.

Division of Hematology/Oncology, Mount Sinai School of Medicine, New York, NY, USA.

View Article

Download full-text PDF

 Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-06-09
Publisher Site
http://dx.doi.org/10.1182/blood-2007-06-092122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265454PMC
March 2008

New molecular concepts and targets in acute myeloid leukemia.

Authors:
Monica Buzzai Jonathan D Licht

Curr Opin Hematol 2008 Mar;15(2):82-7

Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/MOH.0b013e3282f3ded0DOI Listing
March 2008

A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16.

Authors:
Marianne K-H Kim Jacqueline M Mason Chi-Ming Li Windy Berkofsky-Fessler Le Jiang Divaker Choubey Paul E Grundy Benjamin Tycko Jonathan D Licht

Neoplasia 2008 Jan;10(1):69-78

Division of Hematology/Oncology, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213901PMC
http://dx.doi.org/10.1593/neo.07869DOI Listing
January 2008

Molecular characterization of acute myeloid leukemia and its impact on treatment.

Authors:
Olga Frankfurt Jonathan D Licht Martin S Tallman

Curr Opin Oncol 2007 Nov;19(6):635-49

Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/CCO.0b013e3282f10e55DOI Listing
November 2007

Physical and functional interactions of human endogenous retrovirus proteins Np9 and rec with the promyelocytic leukemia zinc finger protein.

Authors:
Miriam Denne Marlies Sauter Vivienne Armbruester Jonathan D Licht Klaus Roemer Nikolaus Mueller-Lantzsch

J Virol 2007 Jun 14;81(11):5607-16. Epub 2007 Mar 14.

Institute of Virology, University of Saarland Medical School, Homburg/Saar D-66421, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1128/JVI.02771-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900259PMC
June 2007

Chromatin modulation by oncogenic transcription factors: new complexity, new therapeutic targets.

Authors:
Itsaso Hormaeche Jonathan D Licht

Cancer Cell 2007 Jun;11(6):475-8

Division of Hematology/Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ccr.2007.05.005DOI Listing
June 2007

HOX deregulation in acute myeloid leukemia.

Authors:
Kim L Rice Jonathan D Licht

J Clin Invest 2007 Apr;117(4):865-8

Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1172/JCI31861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838955PMC
April 2007

Computational identification of Ftz/Ftz-F1 downstream target genes.

Authors:
Timothy Bowler David Kosman Jonathan D Licht Leslie Pick

Dev Biol 2006 Nov 12;299(1):78-90. Epub 2006 Jul 12.

Department of Biochemistry, Cellular and Developmental Biology, Mount Sinai Medical School, New York, NY 10029, USA.

View Article

Download full-text PDF

 Source
http://linkinghub.elsevier.com/retrieve/pii/S001216060600989
Publisher Site
http://dx.doi.org/10.1016/j.ydbio.2006.07.007DOI Listing
November 2006

Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.

Authors:
M Albert Basson Judy Watson-Johnson Reena Shakya Simge Akbulut Deborah Hyink Frank D Costantini Patricia D Wilson Ivor J Mason Jonathan D Licht

Dev Biol 2006 Nov 25;299(2):466-77. Epub 2006 Aug 25.

Division of Hematology/Oncology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ydbio.2006.08.051DOI Listing
November 2006

Reconstructing a disease: What essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia?

Authors:
Jonathan D Licht

Cancer Cell 2006 Feb;9(2):73-4

Division of Hematology/Oncology, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ccr.2006.01.024DOI Listing
February 2006

Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling.

Authors:
Jacqueline M Mason Debra J Morrison M Albert Basson Jonathan D Licht

Trends Cell Biol 2006 Jan 7;16(1):45-54. Epub 2005 Dec 7.

Mount Sinai School of Medicine, Department of Medicine, Division of Hematology and Oncology, Box 1079, One Gustave L. Levy Place, New York, NY 10029, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.tcb.2005.11.004DOI Listing
January 2006

WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak.

Authors:
Debra J Morrison Milton A English Jonathan D Licht

Cancer Res 2005 Sep;65(18):8174-82

Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-04-3657DOI Listing
September 2005

Over-expression of Flt3 induces NF-kappaB pathway and increases the expression of IL-6.

Authors:
Shinichiro Takahashi Hideo Harigae Keiko Kumura Ishii Mitsue Inomata Tohru Fujiwara Hisayuki Yokoyama Kenichi Ishizawa Junichi Kameoka Jonathan D Licht Takeshi Sasaki Mitsuo Kaku

Leuk Res 2005 Aug 24;29(8):893-9. Epub 2005 Feb 24.

Department of Clinical Laboratory Medicine, Tohoku University School of Medicine, 1-1 Seiryou-machi, Aobaku, Sendai 980-8574, Japan.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.leukres.2005.01.008DOI Listing
August 2005

The theoretical basis of transcriptional therapy of cancer: can it be put into practice?

Authors:
Ari M Melnick Kerin Adelson Jonathan D Licht

J Clin Oncol 2005 Jun 2;23(17):3957-70. Epub 2005 May 2.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1200/JCO.2005.14.498DOI Listing
June 2005

Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction.

Authors:
M Albert Basson Simge Akbulut Judy Watson-Johnson Ruth Simon Thomas J Carroll Reena Shakya Isabelle Gross Gail R Martin Thomas Lufkin Andrew P McMahon Patricia D Wilson Frank D Costantini Ivor J Mason Jonathan D Licht

Dev Cell 2005 Feb;8(2):229-39

Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.devcel.2004.12.004DOI Listing
February 2005

Therapeutic intervention in leukemias that express the activated fms-like tyrosine kinase 3 (FLT3): opportunities and challenges.

Authors:
David W Sternberg Jonathan D Licht

Curr Opin Hematol 2005 Jan;12(1):7-13

Division of Hematology/Oncology, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/01.moh.0000147891.06584.d7DOI Listing
January 2005

Despite WT1 binding sites in the promoter region of human and mouse nucleoporin glycoprotein 210, WT1 does not influence expression of GP210.

Authors:
Magnus Olsson Milton A English Jacqueline Mason Jonathan D Licht Peter Ekblom

J Negat Results Biomed 2004 Dec 21;3. Epub 2004 Dec 21.

Department of Cell and Molecular Biology, Section for Cell and Developmental Biology, Lund University, Sweden.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1477-5751-3-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544869PMC
December 2004